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Immunotherapy Of Type 1 Diabetes
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Book Synopsis Immunotherapy of Type 1 Diabetes by : Domenico Andreani
Download or read book Immunotherapy of Type 1 Diabetes written by Domenico Andreani and published by John Wiley & Sons. This book was released on 1989 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent national, European and international diabetes meetings have seen controversial discussions on the potential benefit and also on ethical aspects of immune intervention in patients with Type 1 diabetes or in persons with a high risk of developing the disease.
Book Synopsis Defining Optimal Immunotherapies for Type 1 Diabetes by : Gregory R. Bock
Download or read book Defining Optimal Immunotherapies for Type 1 Diabetes written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-07-31 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D). Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials. The book integrates information from human and animal studies. The book considers T1D within the broader context of autoimmune disease. The format contains several discussions, which address specific questions and provides guidelines for future strategies and solutions for discovering a cure.
Book Synopsis Immunotherapy of Diabetes and Selected Autoimmune Diseases by : George S. Eisenbarth
Download or read book Immunotherapy of Diabetes and Selected Autoimmune Diseases written by George S. Eisenbarth and published by CRC Press. This book was released on 2019-08-08 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important text will be the first devoted to a detailed analysis of immunotherapy as it applies to Type I diabetes and the pathogenesis and therapy of other specific autoimmune diseases (including uveitis, multiple sclerosis, myasthenia gravis, Cogan's syndrome, Graves' ophthalmopathy, and gonadal disorders).
Book Synopsis Stem Cells – From Hype to Real Hope by : Khawaja Husnain Haider
Download or read book Stem Cells – From Hype to Real Hope written by Khawaja Husnain Haider and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
Book Synopsis Therapeutic Immunology by : Terry B. Strom
Download or read book Therapeutic Immunology written by Terry B. Strom and published by Wiley-Blackwell. This book was released on 2001-03-30 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Immunology is a comprehensive review of the clinical application of the drugs, biologic agents, and procedures used to treat immunologic diseases. It is the only reference that provides current information on antibodies, cytokines, gene and cell therapies, vaccines, and other therapeutic approaches in the managament of immune system disorders. This book will show how immunology has come of age as a clinical discipline and is now able to provide treatment strategies for many previously incurable diseases.
Download or read book Type 1 Diabetes written by David Wagner and published by BoD – Books on Demand. This book was released on 2011-11-25 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.
Book Synopsis Diabetes Mellitus in Children by : Mark A. Sperling
Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medical Management of Type 1 Diabetes by : Cecilia C. Low Wang
Download or read book Medical Management of Type 1 Diabetes written by Cecilia C. Low Wang and published by American Diabetes Association. This book was released on 2016-11-15 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 1 diabetes, formerly known as juvenile diabetes, is a complex disorder that requires a great deal of patient-guided self-care. In recent years, advances in diabetes treatment have dramatically shifted potential outcomes in the favor of the patient with diabetes. The challenge for health care professionals is to realize this potential through an individualized, flexible, and responsive treatment plan for patients with type 1 diabetes. Now in its seventh edition, Medical Management of Type 1 Diabetes offers health care providers the newest information and guidelines for the treatment of type 1 diabetes. Built on the foundation of multiple daily insulin injections and insulin pump therapy, this book guides health care providers in helping their patients continually strive for optimal blood glucose control. This new edition focuses on the latest molecular advances, new treatment methods, recent clinical trials, and the American Diabetes Association's Standards of Care. Key topics also include new insulins and administration protocols, advanced carbohydrate counting, and emphasis on continuing patient education. Individual sections address all of the topics in managing type 1 diabetes, including diagnosis and classification/pathogenesis, diabetes standards and education, tools of therapy, special situations, psychosocial factors affecting adherence, quality of life, and well-being and complications. Medical Management of Type 1 Diabetes is an essential addition to any clinician's library for the treatment and understanding of type 1 diabetes.
Book Synopsis Type 1 Diabetes Mellitus Following Anti-programmed Cell Death-1 Therapy by : De Block Christophe
Download or read book Type 1 Diabetes Mellitus Following Anti-programmed Cell Death-1 Therapy written by De Block Christophe and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 1 diabetes mellitus following anti-programmed cell death-1 therapy K. Clotman, K. Janssens, P. Specenier, I. Weets, C. De Block,Background:Cancer immunotherapy is a successful and fast growing field. Pembrolizumab (Keytruda) and nivolumab (Opdivo) are approved for malignant melanoma and several other cancer types. They are two IgG4 monoclonal antibodies targeting the programmed cell death-1 (PD-1) receptor. This receptor is important in maintaining selftolerance and is therapeutically targeted by immune checkpoint inhibiting monoclonal antibodies (mAb) to enhance antitumor immune responses. However, immune checkpoint blockade is associated with a risk for immune-related adverse events (irAE) potentially affecting the endocrine organs. Auto-immune diabetes mellitus and the associated diabetic ketoacidosis (DKA) are examples of rare irAEs. Since the use of immunotherapy is expected to increase, the incidence of immune-related adverse events is also expected to rise. Therefore, it is essential that all clinicians are aware of diabetic ketoacidosis as a rare and life-threatening side effect of immunotherapy.AimsTo provide a timely review of all listed cases of anti-PD-1 induced autoimmune diabetes, discuss pathogenetic mechanisms, and propose a screening and management protocol. Methods A literature search was conducted on Pubmed and Web of Science. A search with the following keywords was performed: u2018Diabetes Mellitus'; u2018cancer immunotherapyu2019; 'anti-PD-1 therapy'; u2018pembrolizumabu2019 and u2018nivolumabu2019.ResultsSo far 38 cases of anti-PD1-induced type 1 diabetes mellitus have been reported. The incidence of autoimmune diabetes in patients receiving pembrolizumab monotherapy is 0.2%, and 0.9% in nivolumab monotherapy. However, the incidence increases to 1.5% in nivolumab and ipilimumab combination therapy. Patients presented with variable symptoms, ranging from asymptomatic hyperglycemia, to polyuria and polydipsia to severe diabetic ketoacidosis. Diabetic ketoacidosis was the first sign of diabetes in 25 out of 34 (73.5%) reported cases. Time from initiation of anti-PD1 therapy to diagnosis of diabetes mellitus ranged from 1 week to 52 weeks and this corresponded to 1 to 17 infusions of immune checkpoint inhibitors. The median age at diagnosis was 61 years (range 28-83), an atypical age of onset for type 1 diabetes mellitus. C-peptide was low or undetectable in 28 of 30 tested patients. HbA1c levels varied from 6.4% to 10.7% (46-93 mmol/mol). The low or undetectable c-peptide combined with the moderately low HbA1c levels probably indicate the fulminant onset of diabetes with rapid u03b2-cell destruction and a shorter duration of hyperglycemia. Every patient had to be treated with intensive insulin therapy.Eleven out of 16 tested patients had a high risk HLA type (HLA DR3-DQ2, HLA DR4-DQ8). We hypothesize that patients with high risk HLA types have an increased risk for the development of immune checkpoint inhibitor induced diabetes. There is no clear pattern of diabetes related autoantibodies. Approximately half of the tested cases (19/34 or 55.9%) had detectable diabetes related autoantibodies. In those 19 cases, glutamic acid decarboxylase antibodies (GADA) were positive in all subjects, tyrosine phosphatase autoantibodies (IA2A) in 5/19, insulin autoantibodies in 2, ICA in 2 patients, and ZnT8 antibodies in only one subject. Four other cases have been reported, however, without antibody status. The interval between the start of anti-PD-1 antibodies to the onset of autoimmune diabetes might be related to the presence or absence of GADA. The median interval from immunotherapy initiation to diagnosis of diabetes was 4 weeks in GADA positive cases versus 10 weeks in GADA negative cases (data from 32 patients).PD-1 reduction might cause activation of autoreactive T cells resulting in autoimmune responses against pancreatic islet cells. We hypothesize that the presence of diabetes autoantibodies prior to the start of anti-PD1 therapy and certain high risk HLA types, can predispose patients to the development of immune checkpoint inhibitors related autoimmune diabetes.We propose to educate the patients about hyperglycemic symptoms and instruct oncologists to measure glucose at each administration of a checkpoint inhibitor, thereby minimizing long delays in diagnosis and possibly avoiding the development of potentially life threatening diabetic ketoacidosis.DiscussionSince the use of immunotherapy is expected to increase, the incidence of immune-related adverse events is also expected to rise. The incidence of autoimmune diabetes in patients receiving pembrolizumab monotherapy is 0.2%, and 0.9% in nivolumab monotherapy, increasing to 1.5% in nivolumab and ipilimumab combination therapy.Therefore, it is essential that all clinicians are aware of diabetic ketoacidosis as a rare and life-threatening side effect of immunotherapy. Blood glucose monitoring during anti-PD-1 therapy is necessary.
Author :George S. Eisenbarth Publisher :Springer Science & Business Media ISBN 13 :9780306478710 Total Pages :364 pages Book Rating :4.4/5 (787 download)
Book Synopsis Type 1 Diabetes by : George S. Eisenbarth
Download or read book Type 1 Diabetes written by George S. Eisenbarth and published by Springer Science & Business Media. This book was released on 2004-11-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the field of immunology, type 1 diabetes has become one of the major areas of investigation with studies that span from characterization of key molecules to trials for the prevention of the disease. Type 1 Diabetes : Molecular, Cellular and Clinical Immunology communicates both the background and the most recent understanding of this disorder, which will almost certainly be central to elucidating the etiology of autoimmunity, and in particular of organ specific autoimmunity. The book covers immunogenetics, immunopathogenesis, epidemiology, disease prediction and clinical application of current knowledge. Both scientists seeking to understand and prevent type 1 diabetes/autoimmunity as well as physicians caring for families with type 1 diabetes will be interested in this book.
Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Download or read book Atlas of Diabetes written by Jay Skyler and published by Springer Science & Business Media. This book was released on 2012-04-04 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is an invaluable resource for improving the management of diabetes. Chapters cover the fundamentals, including epidemiology, history and physical examination, and functional evaluations. Diabetes in children, adolescents, adults, and geriatrics are addressed. Differential diagnosis is emphasized, and evidence-based guidelines and patient-specific considerations aid the reader with injury evaluation and care. Notably, the book highlights the importance of understanding diabetic symptoms when determining the source of illnesses. In addition, the text presents the spectrum of treatment options for diabetes. The book is complete with appendices that explain the evidence-based approach used throughout and the science behind therapeutic modalities.
Book Synopsis CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential by : B. Kyewski
Download or read book CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
Book Synopsis Immunotherapy for Type 1 Diabetes - Preclinical and Clinical Trials by : Alice Li
Download or read book Immunotherapy for Type 1 Diabetes - Preclinical and Clinical Trials written by Alice Li and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Sclerosis written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nutrition and Diabetes by : Emmanuel C. Opara
Download or read book Nutrition and Diabetes written by Emmanuel C. Opara and published by CRC Press. This book was released on 2019-01-03 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. Features Highlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes Features emerging therapeutic approaches for management of obesity and diabetes Discusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome them The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes.
Book Synopsis SITC’s Guide to Managing Immunotherapy Toxicity by : Marc S. Ernstoff, MD
Download or read book SITC’s Guide to Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and published by Springer Publishing Company. This book was released on 2019-03-15 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer