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Author : Macfarlane Burnet
Publisher : Elsevier
ISBN 13 : 1483159221
Total Pages : 289 pages
Book Rating : 4.4/5 (831 download)
Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance
Author : Richard T. Smith
Publisher : Elsevier
ISBN 13 : 0323146260
Total Pages : 553 pages
Book Rating : 4.3/5 (231 download)
Download or read book Immune Surveillance written by Richard T. Smith and published by Elsevier. This book was released on 2012-12-02 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : John A. Mol
Publisher : Springer Science & Business Media
ISBN 13 : 0306468328
Total Pages : 309 pages
Book Rating : 4.3/5 (64 download)
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Download or read book Experiments and the concept of immunological surveillance written by and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (946 download)
Download or read book Immunological Survillance Against Neoplasia written by and published by . This book was released on 1971 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Katrin Hönig
Publisher :
ISBN 13 : 9783832549398
Total Pages : 0 pages
Book Rating : 4.5/5 (493 download)
Download or read book Immune Surveillance in a Novel Transplantation Model Mimicking the Immune Response to Sporadic Cancer written by Katrin Hönig and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since decades cancer immune surveillance is a topic of hot debates and there is still controversy about the role of the immune system in controlling tumor growth and eliminating transformed cells. For viral induced cancers it has been shown that the immune system is able to surveil tumor growth, but it remains unclear whether sporadic cancers are recognized by immune cells resulting in a destructive T cell response. This study investigated de novo T cell responses against a neoantigen expressed by cancer cells under non-acute inflammatory conditions. Therefore, a novel transplantation mouse model was established which closely simulated human sporadic cancer development. In this model, expression of the cancerdriving antigen and oncogene was tightly regulated by the Tet system. Cancer cells could be reversibly arrested after switching off the oncogene/antigen, but, surprisingly, the oncogene/antigen could be reexpressed at later time points in vitro and in vivo. By applying this model, the question at which time point during tumorigenesis the immune system interacts with nascent cancer cells was answered. Results of this study demonstrated that neoantigenspecific CD8^{+T cells were induced in the absence of acute inflammation and rejected nascent cancer cells thereby strongly arguing for existence of immune surveillance. The relevance of direct priming for inducing cytotoxic T cell responses against neoantigens expressed by sporadic cancer was confirmed by further experiments of this study.
Author : Frank Mac Farlane Burnet
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Immunological Surveillance written by Frank Mac Farlane Burnet and published by . This book was released on 1970 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Masayasu Kitagawa
Publisher :
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cancer Immunology written by Masayasu Kitagawa and published by . This book was released on 1975 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Larry W. Moreland
Publisher : Springer Science & Business Media
ISBN 13 : 3540206256
Total Pages : 933 pages
Book Rating : 4.5/5 (42 download)
Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
Author : Alan S. Perelson
Publisher : CRC Press
ISBN 13 : 0429972326
Total Pages : 318 pages
Book Rating : 4.4/5 (299 download)
Download or read book Theoretical Immunology, Part Two written by Alan S. Perelson and published by CRC Press. This book was released on 2018-02-19 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology." The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Author : Ian McColl
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book Immunological Surveillance written by Ian McColl and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Naor
Publisher : Springer Science & Business Media
ISBN 13 : 146124496X
Total Pages : 279 pages
Book Rating : 4.4/5 (612 download)
Download or read book Immunosuppression and Human Malignancy written by David Naor and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system can deal effectively with the majority of viruses and bacteria, less effectively with parasites, and very poorly with cancer. Why is this so? Why are McFarlane Burnet's and Lewis Thomas' predictions that the immune system is in volved in ridding the body of cancer cells, encapsulated in the catchy phrase "immunologic surveillance," so difficult to experi mentally establish? Cancer differs from infectious agents in being derived from the host. Hence, it has been postulated that cancer cells lack anti gens that the immune system can recognize. They are not "im munogenic. " However, this argument is seriously weakened by the existence of numerous human autoimmune diseases, in which the immune system effectively recognizes and attacks a va riety of self tissues. Thus, the potential clearly exists for recogni tion of the surfaces of tumor cells. Professor Naor and his colleagues have written a book that explores another possible reason: cancer cells are recognized by the immune system-but is it possible that the consequence of recognition is inhibition of the immune system-by suppressor T cells or macrophages? The evolution of the malignant state may only occur in individuals who develop this suppression. This book reviews the evidence that suppressor cells, poorly characterized and difficult to study, may be of fundamental im portance in cancer. In fact, our incapacity to understand the na ture of suppressor cells and their mode of action is one of the ma jor problems in immunology research today.
Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.8/5 (113 download)
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Author : Jerry Y. Niederkorn
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805581874
Total Pages : 357 pages
Book Rating : 4.8/5 (55 download)
Download or read book Immune Response and the Eye written by Jerry Y. Niederkorn and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: In memory of J. Wayne Streilein, the pioneer in ocular immunology The second edition of Immune Response and the Eye' highlights recent insights into the dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in Immune Response and the Eye'
Author : Jon Schmidtke
Publisher : Springer Science & Business Media
ISBN 13 : 1461588103
Total Pages : 160 pages
Book Rating : 4.4/5 (615 download)
Download or read book Immunology for the Practicing Physician written by Jon Schmidtke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immunology has grown extensively during the past decadeo The basic concepts and importance of these findings may have clinical application in the management, detection, and ex planation of human diseases. Therefore, when a topic was to be chosen for the dedication of the new Metropol itan Medical Center, in Minneapolis, Minnesota, immunology, and its relation to medi cine, was selected. In fact, "applied immunology has had great impact on all aspects of medical practice. This impact has taken several forms: modern immunology has defined areaS of new medical practice (in the immunodeficiency disease, for example); has lent strength to the development of other areaS (such as transplantation and tumor immunology); has provided understanding of the etiology and pathogenesis of certain diseases; has provided investigative ap proaches in laboratory methods for the study of diseases; and may playa major role in diagnosis of treatment and cancer" (Lancet, April 19, 1976). The purpose of this symposium was to bring to the practicing phy sician the current "state of the art" of immunological research in an interesting and comprehensible manner. It waS our hope that practic ing physicians would be updated regarding new aspects of basic and clinical concepts of cellular immunology.
Author : Isaac Witz
Publisher : Springer Science & Business Media
ISBN 13 : 1468436775
Total Pages : 361 pages
Book Rating : 4.4/5 (684 download)
Download or read book In Situ Expression of Tumor Immunity written by Isaac Witz and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of several valid (and some invalid) reasons, the research field of tumor immunology has been declining in popularity. The Simplistic dogmas, articles of faith, and theories of the late 1960s and early 1970s on the immuno logical mechanisms of the host-tumor interrelationships have frequently been refuted by some of the new developments in cancer biology, cancer biochem istry, and immunology. Furthermore, some of the conventional assays used to monitor "tumor-host immune relations" did not always reflect the host's true clinical situation or his prognosis. Several approaches to immunological interven tion were less successful than expected. In addition, the concept of "immune surveillance," which was basic to many researchers in the field of cancer im munology, seemed to fall apart. Much of the criticism was based on results from solid, well-performed, and well-controlled experiments, but there was also un just criticism based on ill-conceived and badly performed studies, and on misin terpretations of experimental data. There are many misconceptions about the tumor-host relationship. It is very often assumed that tumor immunity, as expressed systemically, is truly reflected at the tumor site. Several studies reported in this volume and elsewhere indicate that such is not always the case. Certain immune effectors may be selectively prevented from reaching the tumor site or the close vicinity of the tumor cells because of mechanical or chemical barriers, whereas others may be selectively attracted to the site by chemotaxis or other mechanisms.
