Imaging Biomarkers Of Response To Radiation And Anti Angiogenic Agents In Brain Tumors

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Imaging Biomarkers of Response to Radiation and Anti-angiogenic Agents in Brain Tumors

Author : Caroline Chung
Publisher :
ISBN 13 : 9780494762431
Total Pages : 338 pages
Book Rating : 4.7/5 (624 download)

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Book Synopsis Imaging Biomarkers of Response to Radiation and Anti-angiogenic Agents in Brain Tumors by : Caroline Chung

Download or read book Imaging Biomarkers of Response to Radiation and Anti-angiogenic Agents in Brain Tumors written by Caroline Chung and published by . This book was released on 2011 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is mounting evidence to support combined therapy with radiation (RT) and anti-angiogenic agents (AA) for the treatment of brain tumors. However, the therapeutic benefit of this combined treatment hinges on the specific dose, schedule, and duration of each treatment. Early biomarkers that reflect tumor physiological responses provide key information that could guide these aspects of treatment. Pre-clinical tumor models are invaluable tools for identifying potential biomarkers, their optimal timing for measurement and their ability to guide therapy in clinical translation. This thesis demonstrates the feasibility and potential of serial MRI to guide the design, delivery and measure of early response to combined AA and RT in a murine intracranial glioma model. We identified promising biomarker changes reflecting early treatment response that may ultimately facilitate individualized spatio-temporal delivery of radiotherapy (RT) and anti-angiogenic agents (AA) for brain tumors.

Imaging of Brain Tumors, An Issue of Magnetic Resonance Imaging Clinics of North America

Author : Rivka R. Colen
Publisher : Elsevier Health Sciences
ISBN 13 : 0323459765
Total Pages : 311 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Imaging of Brain Tumors, An Issue of Magnetic Resonance Imaging Clinics of North America by : Rivka R. Colen

Download or read book Imaging of Brain Tumors, An Issue of Magnetic Resonance Imaging Clinics of North America written by Rivka R. Colen and published by Elsevier Health Sciences. This book was released on 2016-10-15 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on Imaging of Brain Tumors, and is edited by Dr. Rivka Colen. Articles will include: Multiparametric Imaging Analysis: MR Spectroscopy; Genomics and MicroRNAs in Glioma; Metabolomics and Hyperpolarization MRI in Brain Tumors; Imaging Genomics in Glioma; Radiomics and Big Data in Imaging; RANO Criteria and Clinical Endpoints; Gliomas: The New WHO Brain Tumor Pathological/Molecular Classification and Clinical and Radiographic Classifications; Liposomal Contrast Agents and Nanoparticles in Brain Tumor Imaging; Multiparametric Imaging Analysis: Perfusion, and more!

Brain Tumor Imaging

Author : Rajan Jain
Publisher : Thieme
ISBN 13 : 1604068302
Total Pages : 785 pages
Book Rating : 4.6/5 (4 download)

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Book Synopsis Brain Tumor Imaging by : Rajan Jain

Download or read book Brain Tumor Imaging written by Rajan Jain and published by Thieme. This book was released on 2015-08-19 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise yet in-depth analysis of imaging modalities for brain tumors FOUR STARS from Doody's Star Ratings™ Brain Tumor Imaging is a practical, comprehensive reference that covers all the methods of imaging used in the diagnosis and assessment of brain tumors. It includes key information on the use of advanced imaging technologies in the clinical setting for the successful treatment of patients with brain tumors. Key Features: Includes more than 500 high-quality images (color as well as black and white) that help illustrate the latest imaging modalities used in neuro-oncology Covers advanced, functional imaging techniques, giving readers the latest information on clinically advanced imaging tools for brain tumor assessment Provides details on how to accurately evaluate treatment effects and differentiate from tumor progression This book is an essential guide to advanced imaging modalities for all radiologists, neuro-radiologists, neuro-oncologists, and neurosurgeons involved in the treatment and evaluation of patients with brain tumors.

Brain Tumor Imaging

Author : Elke Hattingen
Publisher : Springer
ISBN 13 : 3642450407
Total Pages : 166 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Brain Tumor Imaging by : Elke Hattingen

Download or read book Brain Tumor Imaging written by Elke Hattingen and published by Springer. This book was released on 2015-09-02 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.

Brain Tumor Imaging

Author : Rajan Jain
Publisher : Thieme
ISBN 13 : 1638532435
Total Pages : 784 pages
Book Rating : 4.6/5 (385 download)

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Book Synopsis Brain Tumor Imaging by : Rajan Jain

Download or read book Brain Tumor Imaging written by Rajan Jain and published by Thieme. This book was released on 2015-08-19 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise yet in-depth analysis of imaging modalities for brain tumors FOUR STARS from Doody's Star Ratings™ Brain Tumor Imaging is a practical, comprehensive reference that covers all the methods of imaging used in the diagnosis and assessment of brain tumors. It includes key information on the use of advanced imaging technologies in the clinical setting for the successful treatment of patients with brain tumors. Key Features: Includes more than 500 high-quality images (color as well as black and white) that help illustrate the latest imaging modalities used in neuro-oncology Covers advanced, functional imaging techniques, giving readers the latest information on clinically advanced imaging tools for brain tumor assessment Provides details on how to accurately evaluate treatment effects and differentiate from tumor progression This book is an essential guide to advanced imaging modalities for all radiologists, neuro-radiologists, neuro-oncologists, and neurosurgeons involved in the treatment and evaluation of patients with brain tumors.

Magenetic Resonance Imaging for Prediction and Assessment of Treatment Response in Bevacizumab-treated Recurrent Glioblastoma

Author : Rifaquat M. Rahman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (883 download)

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Book Synopsis Magenetic Resonance Imaging for Prediction and Assessment of Treatment Response in Bevacizumab-treated Recurrent Glioblastoma by : Rifaquat M. Rahman

Download or read book Magenetic Resonance Imaging for Prediction and Assessment of Treatment Response in Bevacizumab-treated Recurrent Glioblastoma written by Rifaquat M. Rahman and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastoma is the most common primary brain tumor in adults, and it is associated with a dismal prognosis with a median survival of 15 months. Despite treatment with chemotherapy, radiation therapy and surgery, patients inevitably have disease recurrence. Bevacizumab is a monoclonal humanized antibody that inhibits vascular endothelial growth factor signaling, and it has been shown to be effective in recurrent glioblastoma with respect to prolonging progression-free survival (PFS). The use of bevacizumab and other anti-angiogenic agents in recurrent glioblastoma have created novel challenges in interpreting magnetic resonance imaging (MRI) of patients. Furthermore, since only some patients appear to have a durable benefit from bevacizumab, there is a need for imaging biomarkers that can reliably identify this subgroup of patients.

Imaging Biomarkers of Treatment Response

Author :
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (934 download)

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Book Synopsis Imaging Biomarkers of Treatment Response by :

Download or read book Imaging Biomarkers of Treatment Response written by and published by . This book was released on 2015 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative imaging biomarkers -- numerical measurements derived from medical imaging that can be interpreted by clinicians - are a critical component of treatment response assessment in oncology. They can also play an important role in the design and interpretation of clinical trials, provided that they are measured following a standardized set of best practices. In this thesis, we have demonstrated the successful application of imaging biomarkers of treatment response to a clinical trial assessing the pharmacodynamics and pharmacokinetics of the anti-angiogenic TKI therapeutic Axitinib. We have illustrated the challenges facing quantitative imaging biomarkers in general, and gained valuable insights into anti-angiogenic therapy in particular. We have characterized the pharmacodynamics of "withdrawal flare," a rapid increase in tumor proliferation following cessation of anti-angiogenic therapy, using quantitative imaging biomarkers derived from FLT PET. This is the first time in humans that the temporal dynamics of Axitinib withdrawal flare have been characterized, a critical step in optimizing the use of this drug in combination therapy. Although we demonstrated that significant flare occurs in patients treated with Axitinib, we also observed substantial inter-patient heterogeneity in imaging response during withdrawal. Among the sub-set of patients experiencing withdrawal flare, it was found to occur at two days post-cessation of Axitinib, with relatively little additional flare between days 2 and 7 of withdrawal. Moreover, withdrawal flare was found to be associated with poor clinical outcome. We directly compared the results of the Axitinib trial with an earlier trial of a related anti-angiogenic drug, Sunitinib, which had used the same imaging biomarkers of treatment response. The proliferative and vascular response during withdrawal of Axitinib and Sunitinib was found to be nearly identical, and there is not sufficient evidence to support any significant difference in proliferative response during treatment. We also explored intra-patient, inter-lesion response heterogeneity. However, when comparing the imaging response with pre-treatment phenotypes, no significant correlations were observed, suggesting that some underlying biological mechanisms may be driving the inter-lesion differences in response. The insights gained from this original work support several hypotheses for how to improve patient treatment. These hypotheses will be partially addressed in three new ongoing clinical trials at the University of Wisconsin.

Radiomics and Radiogenomics

Author : Ruijiang Li
Publisher : CRC Press
ISBN 13 : 1351208268
Total Pages : 420 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Radiomics and Radiogenomics by : Ruijiang Li

Download or read book Radiomics and Radiogenomics written by Ruijiang Li and published by CRC Press. This book was released on 2019-07-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

Nuclear Oncology

Author : H. William Strauss
Publisher : Springer Science & Business Media
ISBN 13 : 0387488944
Total Pages : 873 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Nuclear Oncology by : H. William Strauss

Download or read book Nuclear Oncology written by H. William Strauss and published by Springer Science & Business Media. This book was released on 2012-11-27 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.

Clinical Applications of Magnetic Resonance Spectroscopy

Author : Suresh K. Mukherji
Publisher : Wiley-Liss
ISBN 13 : 9780471161783
Total Pages : 0 pages
Book Rating : 4.1/5 (617 download)

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Book Synopsis Clinical Applications of Magnetic Resonance Spectroscopy by : Suresh K. Mukherji

Download or read book Clinical Applications of Magnetic Resonance Spectroscopy written by Suresh K. Mukherji and published by Wiley-Liss. This book was released on 1998-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Applications of MR Spectroscopy Edited by Suresh K. Mukherji, M.D. Magnetic resonance spectroscopy (MRS) is a powerful diagnostic tool for a variety of brain disorders—from epilepsy and tumors to age-related degeneration and strokes. Unlike magnetic resonance imaging (MRI), which gives us a picture of anatomical and physiological conditions, MRS generates a frequency domain spectrum that provides information about biochemical and metabolic processes occurring within tissues. Clinical Applications of MR Spectroscopy presents a short, practical treatment of MRS today. Comprising contributions by leading authorities in the field, the book discusses MRS techniques used for diagnostic purposes and research, terminologies and examples drawn from clinical experience, and ways to correlate MRS results with other modalities to enhance our understanding of disease processes and the outcomes of particular treatments. Topics include: Basic principles of clinical proton magnetic resonance spectroscopy MRS in the evaluation of epilepsy Proton MRS of brain tumors Proton MRS in selected childhood disorders MRS and spectroscopic imaging for cerebrovascular disease MRS of degenerative brain disease in the elderly MRS of the head and neck Potential clinical applications of new techniques in MRS Correlation of functional brain imaging with MRS Clinical Applications of MR Spectroscopy provides 150 photographs and figures to illustrate the interpretation of MRS signals, as well as fully referenced chapters for those wishing to expand their knowledge of the underlying science. It is an essential guide to the state of the art for radiologists and neurologists using this technology to improve patient care.

Metronomic Chemotherapy

Author : Guido Bocci
Publisher : Springer
ISBN 13 : 3662436043
Total Pages : 302 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Metronomic Chemotherapy by : Guido Bocci

Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Radiation Injury to the Nervous System

Author : Philip H. Gutin
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Radiation Injury to the Nervous System by : Philip H. Gutin

Download or read book Radiation Injury to the Nervous System written by Philip H. Gutin and published by Lippincott Williams & Wilkins. This book was released on 1991 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Imaging for Clinical Oncology

Author : Peter Hoskin
Publisher : Oxford University Press
ISBN 13 : 0198818505
Total Pages : 401 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Imaging for Clinical Oncology by : Peter Hoskin

Download or read book Imaging for Clinical Oncology written by Peter Hoskin and published by Oxford University Press. This book was released on 2021 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging is a critical component of the management of patients having radiotherapy. This book covers the basic principles of the main imaging modalities; site specific chapters give best practice for individual tumour sites, and it also contains information on radioprotection and regulatory issues.

Machine Learning in Clinical Neuroimaging and Radiogenomics in Neuro-oncology

Author : Seyed Mostafa Kia
Publisher : Springer Nature
ISBN 13 : 3030668436
Total Pages : 319 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Machine Learning in Clinical Neuroimaging and Radiogenomics in Neuro-oncology by : Seyed Mostafa Kia

Download or read book Machine Learning in Clinical Neuroimaging and Radiogenomics in Neuro-oncology written by Seyed Mostafa Kia and published by Springer Nature. This book was released on 2020-12-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the Third International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2020, and the Second International Workshop on Radiogenomics in Neuro-oncology, RNO-AI 2020, held in conjunction with MICCAI 2020, in Lima, Peru, in October 2020.* For MLCN 2020, 18 papers out of 28 submissions were accepted for publication. The accepted papers present novel contributions in both developing new machine learning methods and applications of existing methods to solve challenging problems in clinical neuroimaging. For RNO-AI 2020, all 8 submissions were accepted for publication. They focus on addressing the problems of applying machine learning to large and multi-site clinical neuroimaging datasets. The workshop aimed to bring together experts in both machine learning and clinical neuroimaging to discuss and hopefully bridge the existing challenges of applied machine learning in clinical neuroscience. *The workshops were held virtually due to the COVID-19 pandemic.

Angiogenesis Assays

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Angiogenesis Assays by : Carolyn A. Staton

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

MRI

Author : Brian M. Dale
Publisher : John Wiley & Sons
ISBN 13 : 1119013038
Total Pages : 246 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis MRI by : Brian M. Dale

Download or read book MRI written by Brian M. Dale and published by John Wiley & Sons. This book was released on 2015-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth edition of the most accessible introduction to MRI principles and applications from renowned teachers in the field provides an understandable yet comprehensive update. Accessible introductory guide from renowned teachers in the field Provides a concise yet thorough introduction for MRI focusing on fundamental physics, pulse sequences, and clinical applications without presenting advanced math Takes a practical approach, including up-to-date protocols, and supports technical concepts with thorough explanations and illustrations Highlights sections that are directly relevant to radiology board exams Presents new information on the latest scan techniques and applications including 3 Tesla whole body scanners, safety issues, and the nephrotoxic effects of gadolinium-based contrast media

MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles

Author : Roland Bammer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469889625
Total Pages : 2558 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles by : Roland Bammer

Download or read book MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles written by Roland Bammer and published by Lippincott Williams & Wilkins. This book was released on 2016-03-03 with total page 2558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential reading for both clinicians and researchers, this comprehensive resource covers what you need to know about the basic principles of perfusion, as well as its many clinical applications. Broad coverage outlines the overarching framework that interlinks methods such as DSC, DCE, CTP, and ASL. International experts in the field demonstrate how perfusion and pharmacokinetic imaging can be effectively used to analyze medical conditions, helping you reach accurate diagnoses and monitor disease progression and response to therapy.