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The IGF System

Author : Ron G. Rosenfeld
Publisher : Springer Science & Business Media
ISBN 13 : 1592597122
Total Pages : 883 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis The IGF System by : Ron G. Rosenfeld

Download or read book The IGF System written by Ron G. Rosenfeld and published by Springer Science & Business Media. This book was released on 1999-06-01 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Insulin and IGFs

Author :
Publisher : Academic Press
ISBN 13 : 0080922155
Total Pages : 766 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Insulin and IGFs by :

Download or read book Insulin and IGFs written by and published by Academic Press. This book was released on 2009-03-10 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. Longest running series published by Academic Press Contributions by leading international authorities

IGFs:Local Repair and Survival Factors Throughout Life Span

Author : David Clemmons
Publisher : Springer Science & Business Media
ISBN 13 : 364204302X
Total Pages : 166 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis IGFs:Local Repair and Survival Factors Throughout Life Span by : David Clemmons

Download or read book IGFs:Local Repair and Survival Factors Throughout Life Span written by David Clemmons and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

IGF and Nutrition in Health and Disease

Author : M. Sue Houston
Publisher : Springer Science & Business Media
ISBN 13 : 1592597955
Total Pages : 363 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis IGF and Nutrition in Health and Disease by : M. Sue Houston

Download or read book IGF and Nutrition in Health and Disease written by M. Sue Houston and published by Springer Science & Business Media. This book was released on 2004-08-04 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

The Diabetes in Pregnancy Dilemma

Author : Oded Langer
Publisher : PMPH-USA
ISBN 13 : 1607951827
Total Pages : 476 pages
Book Rating : 4.6/5 (79 download)

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Book Synopsis The Diabetes in Pregnancy Dilemma by : Oded Langer

Download or read book The Diabetes in Pregnancy Dilemma written by Oded Langer and published by PMPH-USA. This book was released on 2015-04-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is approaching epidemic proportions worldwide, and the effects and treatment of diabetes in pregnancy are not well enough understood by many doctors who see pregnant women in their practices. The goal of this book is to provide much-needed information to clinicians about pregestational and gestational diabetes in pregnancy and help them develop the tools and skills to improve the outcome of these pregnancies. This is the second edition of a highly regarded book on diabetes in pregnancy, strongly recommended in JAMA to anyone involved in the care of pregnant women with diabetes mellitus. The second edition will be organized similarly to the first edition, but all of the chapters have been updated with new information and references. The book emphasizes diagnosis and treatment, making it particularly valuable to clinicians. An evidence-based approach supplements the standard expert-opinion approach wherever clinical trials have provided sufficient evidence, and strong evidence is given for close nutritional management. Like the first edition, the book is organized into two major sections: I. The Scientific Rationale for Global Issues Affecting Diabetes in Pregnancy and II. The Scientific Rationale for the Management of Diabetes in Pregnancy.

The Aging Skeleton

Author : Clifford Rosen
Publisher : Elsevier
ISBN 13 : 0080542379
Total Pages : 667 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Aging Skeleton by : Clifford Rosen

Download or read book The Aging Skeleton written by Clifford Rosen and published by Elsevier. This book was released on 1999-08-19 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. Covers all aspects of the aging skeleton in one comprehensive volume Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton Reviews current therapeutic approaches and methods Written by internationally renowned authors and edited by leaders in the field Is the only book available on this subject

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2000 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insulin-like Growth Factors

Author : Derek LeRoith
Publisher : CRC Press
ISBN 13 : 9780849357121
Total Pages : 328 pages
Book Rating : 4.3/5 (571 download)

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Book Synopsis Insulin-like Growth Factors by : Derek LeRoith

Download or read book Insulin-like Growth Factors written by Derek LeRoith and published by CRC Press. This book was released on 1991-05-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

Insulin-like Growth Factor Receptor Signalling

Author : Derek Leroith
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478468
Total Pages : 524 pages
Book Rating : 4.4/5 (784 download)

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Book Synopsis Insulin-like Growth Factor Receptor Signalling by : Derek Leroith

Download or read book Insulin-like Growth Factor Receptor Signalling written by Derek Leroith and published by Springer Science & Business Media. This book was released on 2003-07-31 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Basic and Applied Bone Biology

Author : David B. Burr
Publisher : Academic Press
ISBN 13 : 0128132604
Total Pages : 478 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Basic and Applied Bone Biology by : David B. Burr

Download or read book Basic and Applied Bone Biology written by David B. Burr and published by Academic Press. This book was released on 2019-02-20 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic and Applied Bone Biology, Second Edition, provides an overview of skeletal biology, from the molecular level, to the organ level, including cellular control, interaction and response, adaptive responses to various external stimuli, and the interaction of the skeletal system with other metabolic processes in the body. The book includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically-modified animal models. Each chapter delves deep into the important details of topics covered to provide a solid understanding of the basics of bone biology. Bone biology researchers who also train undergraduate and graduate students in the lab will use this book constantly to orient new students on the basics of the field and as a background reference for many of the technical aspects of qualification in bone biology (e.g., mechanics, histomorphometry, genetic modification, biochemistry, etc.). Presents an in-depth overview of skeletal biology, from molecular to organ level Offers refresher level content for clinicians or researchers outside their areas of expertise Includes updated and complete references Incorporates expanded study questions at the end of each chapter for further exploration Covers topics relevant to a modern course in skeletal biology

Physiology of the Gastrointestinal Tract, Two Volume Set

Author : Hamid M. Said
Publisher : Academic Press
ISBN 13 : 0123820278
Total Pages : 2250 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Physiology of the Gastrointestinal Tract, Two Volume Set by : Hamid M. Said

Download or read book Physiology of the Gastrointestinal Tract, Two Volume Set written by Hamid M. Said and published by Academic Press. This book was released on 2012-07-04 with total page 2250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn’s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. 2013 Highly Commended BMA Medical Book Award for Internal Medicine Discusses the multiple processes governing gastrointestinal function Each section edited by preeminent scientist in the field Updated, four-color illustrations

Essential Medical Physiology

Author : Leonard R. Johnson
Publisher : Academic Press
ISBN 13 : 0123875846
Total Pages : 1026 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Essential Medical Physiology by : Leonard R. Johnson

Download or read book Essential Medical Physiology written by Leonard R. Johnson and published by Academic Press. This book was released on 2003-09-18 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook covering the principal subjects in a modern medical school physiology course.

New Insights Into Prostate Cancer: New Biomarkers, Molecular Mechanisms, and Therapeutic Approaches

Author : Anna Perri
Publisher : Frontiers Media SA
ISBN 13 : 2832552587
Total Pages : 133 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis New Insights Into Prostate Cancer: New Biomarkers, Molecular Mechanisms, and Therapeutic Approaches by : Anna Perri

Download or read book New Insights Into Prostate Cancer: New Biomarkers, Molecular Mechanisms, and Therapeutic Approaches written by Anna Perri and published by Frontiers Media SA. This book was released on 2024-08-05 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the second most common cancer in men, and prognosis varies with age, ethnicity, genetic background, and stage of progression. Disease progression that has been observed in a substantial proportion of patients despite androgen ablation, can arise from many factors, such as the presence of cells that are resistant de novo or acquire resistance induced by androgen-deprivation therapy (ADT) or androgen receptor antagonists.

IGFs in the Nervous System

Author : E. E. Müller
Publisher : Springer
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis IGFs in the Nervous System by : E. E. Müller

Download or read book IGFs in the Nervous System written by E. E. Müller and published by Springer. This book was released on 1998 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.

Endocrine and Reproductive Physiology E-Book

Author : Bruce White
Publisher : Elsevier Health Sciences
ISBN 13 : 0323088287
Total Pages : 352 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Endocrine and Reproductive Physiology E-Book by : Bruce White

Download or read book Endocrine and Reproductive Physiology E-Book written by Bruce White and published by Elsevier Health Sciences. This book was released on 2012-10-22 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine and Reproductive Physiology, a volume in the Mosby Physiology Monograph Series, explains the fundamentals of endocrine and reproductive physiology in a clear and concise manner. This medical textbook gives you a basic understanding of how endocrine and metabolic physiology affects other body systems in health and disease, including the clinical dimensions of reproductive endocrinology. Bridge the gap between normal function and disease with pathophysiology content throughout the book. Easily master the material in your systems-based curriculum with learning objectives, Clinical Concept boxes, chapter summaries, and self-study questions. Understand complex concepts by examining almost 200 clear, 2-color diagrams. Apply what you've learned to real-life clinical situations using featured clinical commentaries. Take your learning wherever you go! Stay abreast of recent advances in endocrine physiology with expanded material on reproductive endocrinology and metabolism, and many updates at the molecular and cellular level. Learn the latest developments in fertilization, pregnancy, and lactation, as well as fetal development, puberty, and the decline of reproductive function with age.

Cancer Biology

Author : Raymond W. Ruddon
Publisher : Oxford University Press
ISBN 13 : 0195175433
Total Pages : 570 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Cancer Biology by : Raymond W. Ruddon

Download or read book Cancer Biology written by Raymond W. Ruddon and published by Oxford University Press. This book was released on 2007-04-05 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this classic text provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well written and well illustrated, with schematic diagrams and actual research data to demonstrate points made in the text. There is also an extensive, up-to-date bibliography, making the book valuable to scientists, and to physicians, students, and nurses interested in the field of cancer biology. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular phenotypic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products, growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis and treatment of cancer in the future.

Handbook of Growth Factors

Author : Enrique Pimentel
Publisher : CRC Press
ISBN 13 : 9780849325069
Total Pages : 384 pages
Book Rating : 4.3/5 (25 download)

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Book Synopsis Handbook of Growth Factors by : Enrique Pimentel

Download or read book Handbook of Growth Factors written by Enrique Pimentel and published by CRC Press. This book was released on 1994-06-02 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II of Handbook of Growth Factors presents a stimulating discussion of the best-characterized polypeptide growth factors, including insulin, insulin-like growth factors, epidermal growth factor, fibroblast growth factors, neurotrophic growth factors, and transforming growth factors. The structure and function of each growth factor is discussed, as well as its receptor and postreceptor mechanism of action and its role in neoplastic processes. Regulatory peptides with growth factor-like properties such as bombesin, angiotensin, endothelin, atrial natriuretic factor, vasoactive intestinal peptide, and bradykinin are examined in depth. Factors related to the growth of organs such as the prostate, the heart, and the mammary gland are also covered.