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Identification And Role Of Cytochrome P450 In Xenobiotic Metabolism By The White Rot Fungus Phanerochaete Chrysosporium
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Book Synopsis Identification and Role of Cytochrome P450 in Xenobiotic Metabolism by the White Rot Fungus Phanerochaete Chrysosporium by : Seth William Kullman
Download or read book Identification and Role of Cytochrome P450 in Xenobiotic Metabolism by the White Rot Fungus Phanerochaete Chrysosporium written by Seth William Kullman and published by . This book was released on 1996 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functional Genomics of Xenobiotic Detoxifying Fungal Cytochrome P450 System by : Venkataramanan Subramanian
Download or read book Functional Genomics of Xenobiotic Detoxifying Fungal Cytochrome P450 System written by Venkataramanan Subramanian and published by . This book was released on 2008 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The white rot fungus Phanerochaete chrysosporiumis primarily known for its ability to degrade a wide range of xenobiotic compounds including the highly recalcitrant polycyclic aromatic hydrocarbons. The natural substrate of this basidiomycete fungus is however, lignin, the most abundant aromatic polymer on earth. The versatililty of this fungus in breaking down a wide array of compounds arises from the presence of a highly nonspecific enzyme system (peroxidase enzyme system) in its repertoire. Most of the research involving degradation of toxic chemicals has focused on this biodegrading enzyme machinery. Cytochrome P450 monooxygenases (P450s) on the other hand, are heme-thiolate proteins that are known to be involved in metabolism of endogenous compounds as well as xenobiotic compounds in higher eukaryotes. Nearly 150 P450s are present in this organism, which is the highest number known till date among fungal species. Based on the sequence similarity criteria and our phylogenetic analysis, these P450s have been classified under 12 families and 23 sub-families. Despite indirect evidences suggesting the role of P450s in oxidation of xenobiotics, there have been hardly any reports on characterization and role of individual P450s either in regulation of physiological processes or in direct metabolism of xenobiotics in this organism. Here we characterized and investigated the role of P450 enzymes in two different mechanisms in this fungus. One, indirect involvement of P450s in peroxidase-mediated oxidation of xenobiotics, and two, direct involvement of P450s in metabolism of xenobiotics. In order to achieve the first objective, we investigated the role of PC-bphgene, the only member of the P450 CYP53 in synthesis of a secondary metabolite, veratryl alcohol, which regulates the activity of the peroxidase enzyme system of this fungus. In order to achieve the second objective, we used the functional genomic approach based on a custom-designed microarray and heterologous expression of the components of the P450 enzyme system (P450 and its associated electron transfer proteins) in this white rot fungus.
Book Synopsis Cytochrome P450 by : Paul R. Ortiz de Montellano
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer. This book was released on 2015-03-13 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1902 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Applied and Environmental Microbiology by :
Download or read book Applied and Environmental Microbiology written by and published by . This book was released on 1997 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in Environmental Management by : Ram Naresh Bharagava
Download or read book Recent Advances in Environmental Management written by Ram Naresh Bharagava and published by CRC Press. This book was released on 2018-10-25 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the toxicity of various organic and inorganic pollutants, their eco-toxicological effects and eco-friendly approaches for remediation of environmental pollutants. Extensive focus has been relied on the recent advances in ecofriendly approaches such as bioremediation and phytoremediation technologies, including the use of various group of microbes for remediation of environmental pollutants, etc. Researchers working in the field of bioremediation, phytoremediation, waste management and related fields will find this compilation most useful for further study to learn about the subject matter.
Book Synopsis Advances in Microbial Physiology by :
Download or read book Advances in Microbial Physiology written by and published by Elsevier. This book was released on 2003-09-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Editors of the Advances in Microbial Physiology series have always striven to provide a diverse range of top-quality papers on all aspects of microbial physiology. Coverage of 'holistic' topics or whole cell studies such as ion fluxes, stress responses and motility have gone hand-in-hand with detailed biochemical analyses of individual transport systems, electron transport pathways and many aspects of metabolism. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to publish topical and important reviews, interpreting physiology in its broadest context, to include all material that contributes to our understanding of how microorganisms and their component parts work. - The Biodiversity of Microbial Cytochromes P450 - The Tat protein translocation pathway and its role in microbial physiology - Microbial Globins
Book Synopsis Bioprospecting of Microorganism-Based Industrial Molecules by : Sudhir P. Singh
Download or read book Bioprospecting of Microorganism-Based Industrial Molecules written by Sudhir P. Singh and published by John Wiley & Sons. This book was released on 2021-12-13 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover a comprehensive and current overview of microbial bioprospecting written by leading voices in the field In Bioprospecting of Microorganism-Based Industrial Molecules, distinguished researchers and authors Sudhir P. Singh and Santosh Kumar Upadhyay deliver global perspectives of bioprospecting of biodiversity. The book covers diverse aspects of bioprospecting of microorganisms demonstrating biomass value of nutraceutical, pharmaceutical, biomedical, and bioenergetic importance. The authors present an amalgamation of translational research on bioresource utilization and ecological sustainability that will further the reader’s knowledge of the applications of different microbial diversity and reveal new avenues of research investigation. Readers will also benefit from: A thorough introduction to microbial biodiversity and bioprospecting An exploration of anti-ageing and skin lightening microbial products and microbial production of anti-cancerous biomolecules A treatment of UV protective compounds from algal biodiversity and polysaccharides from marine microalgal sources Discussions of microbial sources of insect toxic proteins and the role of microbes in bio-surfactants production Perfect for academics, scientists, researchers, graduate and post-graduate students working and studying in the areas of microbiology, food biotechnology, industrial microbiology, plant biotechnology, and microbial biotechnology, Bioprospecting of Microorganism-Based Industrial Molecules is an indispensable guide for anyone looking for a comprehensive overview of the subject.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 by : Eugene G. Hrycay
Download or read book Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 written by Eugene G. Hrycay and published by Springer. This book was released on 2015-05-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Book Synopsis Biotechnological Production and Conversion of Aromatic Compounds and Natural Products by : Nils Jonathan Helmuth Averesch
Download or read book Biotechnological Production and Conversion of Aromatic Compounds and Natural Products written by Nils Jonathan Helmuth Averesch and published by Frontiers Media SA. This book was released on 2020-07-31 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1992 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Abstracts of the ... General Meeting of the American Society for Microbiology by : American Society for Microbiology. General Meeting
Download or read book Abstracts of the ... General Meeting of the American Society for Microbiology written by American Society for Microbiology. General Meeting and published by . This book was released on 2007 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Freshwater Fungi by : E. B. Gareth Jones
Download or read book Freshwater Fungi written by E. B. Gareth Jones and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-08-27 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The available literature on freshwater fungi is limited. Over the subsequent years a considerable volume of scientific papers have appeared scattered throughout numerous journals. There is therefore no recent synthesis of the subject and this is the objective of the proposed book. Freshwater habitats are rich in fungi with some 3,000 described species, most of papers focussing on their identification, substrata they grow on and world distribution. However, these fungi play an important role in the freshwater ecosystem, and are primarily involved in the breakdown of leaf litter contributing food for detritus feeders. Our book will bring together a wide range of acclaimed mycologists to review recent developments on the biology and ecology of freshwater fungi, particularly their molecular phylogeny, biodiversity, causative diseases of freshwater amphibians, fishes and invertebrate animals, decomposition of leaf litter, stream pollution and their potential role in bioremediation.
Author :Paul R. Ortiz de Montellano Publisher :Springer Science & Business Media ISBN 13 :0387274472 Total Pages :702 pages Book Rating :4.3/5 (872 download)
Book Synopsis Cytochrome P450 by : Paul R. Ortiz de Montellano
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Download or read book Herbicides written by Andrew Price and published by BoD – Books on Demand. This book was released on 2013-05-29 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbicides represent one of the most widely used groups of pesticides worldwide for control of weed species in agricultural and non-crop settings. Due to the extensive use of herbicides and their value in weed management, herbicide research remains crucial for ensuring continued, effective use of herbicides while minimizing detrimental effects to ecosystems. Presently, a wide range of research continues to focus on improved herbicide use, environmental impact of herbicides, and even medicinal application of herbicide chemistries. In Herbicides - Advances in Research, authors cover multiple topics concerning current, valuable herbicide research.
Book Synopsis Microbial Communities Utilizing Hydrocarbons and Lipids: Members, Metagenomics and Ecophysiology by : Terry J. McGenity
Download or read book Microbial Communities Utilizing Hydrocarbons and Lipids: Members, Metagenomics and Ecophysiology written by Terry J. McGenity and published by Springer. This book was released on 2019-07-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive, authoritative discussions about microbial communities in environments that are rich in hydrocarbons, crude oil or lipids. It encompasses natural environments, such as tar sands, oil seeps and reservoirs, as well as habitats where methane is produced. Equally, the book deals with habitats that have been influenced by human activity, including oil-contaminated soils, aquifers, coast and seas. The book opens with a series of chapters considering the contemporary approaches used to investigate microbial communities.
