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Identification And Isolation Of A Mammary Epithelial Subpopulation Expressing Mouse Mammary Tumor Virus
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Book Synopsis Identification and Isolation of a Mammary Epithelial Subpopulation Expressing Mouse Mammary Tumor Virus by : Judith Ann St. George
Download or read book Identification and Isolation of a Mammary Epithelial Subpopulation Expressing Mouse Mammary Tumor Virus written by Judith Ann St. George and published by . This book was released on 1982 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Analysis of Multistep Mammary Tumorigenesis in Wnt-1 Transgenic Mice by : Deepa Shankar
Download or read book Analysis of Multistep Mammary Tumorigenesis in Wnt-1 Transgenic Mice written by Deepa Shankar and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse mammary tumor virus (MMTV) is used as an insertion mutagen in transgenic mice that express the Wnt1 gene in their mammary gland, to produce additional events like activation of a second oncogene. Cloning cellular sequences flanking new proviral insertion from tumor 76 identified a common insertion locus for MMTV. Further analyses of this region identified Fgf3 as the gene activated over a long distance by MMTV. Fgf8 is another oncogene that I identified was activated in 10% of the mammary tumors form these infected Wnt1 transgenic mice. Fgf8 encodes for at least seven different protein isoforms, three of which were isolated by us. These three isoforms (Fgf8a, b & c) differ in their NIH3T3 cell transforming abilities. Fgf8b induces programmed cell death of mammary epithelial cells. This apoptotic property is not confined to Fgf8b but is also seen when mammary epithelial cells are treated with purified human FGF proteins (FGF 1, 2, 4, 6, & 9). Over expression of BCL2 in the mammary epithelial cells delays the onset of FGF induced apoptosis. Female transgenic mice expressing the Fgf8 gene in the mammary gland developed tumors with a latency of 5-6 months. These tumors were found to be adenocarcinomas: benign adenomas to invasive ductal carcinomas. Northern analyses of tumor RNAs show high expression of the transgene.
Book Synopsis Analysis of Multistep Mammary Tumorigenesis in Wnt1 Transgenic Mice by : Deepa Bhavani Shankar
Download or read book Analysis of Multistep Mammary Tumorigenesis in Wnt1 Transgenic Mice written by Deepa Bhavani Shankar and published by . This book was released on 1997 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse mammary tumor virus (MMTV) is used as an insertion mutagen in transgenic mice that express the Wnt1 gene in their mammary gland, to produce additional events like activation of a second oncogene. Cloning cellular sequences flanking new proviral insertion from tumor 76 identified a common insertion locus for MMTV. Further analyses of this region identified Fgf3 as the gene activated over a long distance by MMTV. Fgf8 is another oncogene that I identified was activated in 10% of the mammary tumors form these infected Wnt1 transgenic mice. Fgf8 encodes for at least seven different protein isoforms, three of which were isolated by us. These three isoforms (Fgf8a, b & c) differ in their NIH3T3 cell transforming abilities. Fgf8b induces programmed cell death of mammary epithelial cells. This apoptotic property is not confined to Fgf8b but is also seen when mammary epithelial cells are treated with purified human FGF proteins (FGF 1, 2, 4, 6, & 9). Over expression of BCL2 in the mammary epithelial cells delays the onset of FGF induced apoptosis. Female transgenic mice expressing the Fgf8 gene in the mammary gland developed tumors with a latency of 5-6 months. These tumors were found to be adenocarcinomas: benign adenomas to invasive ductal carcinomas. Northern analyses of tumor RNAs show high expression of the transgene.
Book Synopsis Identification of Mouse Mammary Tumor Virus-like Sequences in Human Breast Cancer by : Yue Wang
Download or read book Identification of Mouse Mammary Tumor Virus-like Sequences in Human Breast Cancer written by Yue Wang and published by . This book was released on 2001 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vivo Characterization of Mouse Mammary Tumor Virus Transcription and Superantigen Activity by : Kiho Cho
Download or read book In Vivo Characterization of Mouse Mammary Tumor Virus Transcription and Superantigen Activity written by Kiho Cho and published by . This book was released on 1994 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Isolation and Characterization of Proteins of the Mouse Mammary Tumor Virus by : F. Westenbrink
Download or read book Isolation and Characterization of Proteins of the Mouse Mammary Tumor Virus written by F. Westenbrink and published by . This book was released on 1980 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Characterization and Expression of Genetically Acquired Mouse Mammary Tumor Virus Sequences in the Mouse by : Vicki Lynne Traina-Dorge
Download or read book The Characterization and Expression of Genetically Acquired Mouse Mammary Tumor Virus Sequences in the Mouse written by Vicki Lynne Traina-Dorge and published by . This book was released on 1983 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression of the Mouse Mammary Tumor Virus (MMTV) Surface Glycoprotein Gp52 with a Recombinant Vaccinia Virus by : Regula Cardinaux-Fuchs
Download or read book Expression of the Mouse Mammary Tumor Virus (MMTV) Surface Glycoprotein Gp52 with a Recombinant Vaccinia Virus written by Regula Cardinaux-Fuchs and published by . This book was released on 1995 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Viral Gastroenteritis by : Shunzo Chiba
Download or read book Viral Gastroenteritis written by Shunzo Chiba and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Book Synopsis Viral Superantigens by : Kyuhei Tomonari
Download or read book Viral Superantigens written by Kyuhei Tomonari and published by CRC Press. This book was released on 1997-05-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.
Book Synopsis Culture of Epithelial Cells by : R. Ian Freshney
Download or read book Culture of Epithelial Cells written by R. Ian Freshney and published by John Wiley & Sons. This book was released on 2004-03-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: "...a wonderful compendium of current in vitro approaches that will be a useful resource to those just starting to work with an epithelial cell system as well as those that have been working with them for years and years." --Pharmaceutical Research This completely revised and expanded new edition provides detailed descriptions of fundamental and practical aspects relating to the in vitro cultivation of disparate types of epithelia. In recent years, the use of epithelial cell culture in cell biology and tissue engineering has increased dramatically. This revision reflects those advances by including new chapters on the culture of animal and human hepatocytes, kidney epithelium, and bladder epithelium. Each chapter provides an introductory review of the principles and advantages of the particular method, followed by detailed protocols, practical tips, alternate methods, and a useful list of materials and suppliers.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Hormone Action by : Bert W. O'Malley
Download or read book Hormone Action written by Bert W. O'Malley and published by . This book was released on 1974 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone assays; Hormone receptors; Evaluation of biological effects of hormones; Purification and synthesis of hormones.
Book Synopsis Cancer: Cell Structures, Carcinogens and Genomic Instability by : Leon P. Bignold
Download or read book Cancer: Cell Structures, Carcinogens and Genomic Instability written by Leon P. Bignold and published by Springer Science & Business Media. This book was released on 2006 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.
