Human Caspases And Neuronal Apoptosis In Neurodegenerative Diseases

Download Human Caspases And Neuronal Apoptosis In Neurodegenerative Diseases full books in PDF, epub, and Kindle. Read online Human Caspases And Neuronal Apoptosis In Neurodegenerative Diseases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Author : Anil Gupta
Publisher : Academic Press
ISBN 13 : 0128204435
Total Pages : 244 pages
Book Rating : 4.1/5 (282 download)

DOWNLOAD NOW!

Book Synopsis Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases by : Anil Gupta

Download or read book Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases written by Anil Gupta and published by Academic Press. This book was released on 2021-12-03 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial a 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of a-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and several other factors Explains etiopathogenesis of Huntington’s disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1a gene, advanced glycation end-products, autophagy, and many other significant topics

Neuronal Cell Death

Author : Laura Lossi
Publisher : Humana
ISBN 13 : 9781493944644
Total Pages : 0 pages
Book Rating : 4.9/5 (446 download)

DOWNLOAD NOW!

Book Synopsis Neuronal Cell Death by : Laura Lossi

Download or read book Neuronal Cell Death written by Laura Lossi and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents a valuable and readily reproducible collection of established and emerging techniques for neuronal cell death research. Conveniently divided into four parts, sections cover a series of techniques for the molecular, structural, functional and genomic characterization of dying neurons, a number of protocols that are of primary interest in neuropathology and in experimental neuropathology, a series of gene engineering techniques to obtain and manipulate neuronal stem cells and progenitors, to prepare HSV-1 vectors for the gene therapy, and to CNS transplantation of bone marrow stem cells, and finally, some very interesting protocols for the study of cell death in non-mammalian models. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neuronal Cell Death: Methods and Protocols seeks to serve a large audience of scientists that are currently active in the field or are willing to enter such an exciting and still expanding area of neurobiology.

Pathogenesis of Neurodegenerative Disorders

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
ISBN 13 : 159259106X
Total Pages : 296 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Pathogenesis of Neurodegenerative Disorders by : Mark P. Mattson

Download or read book Pathogenesis of Neurodegenerative Disorders written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2001-06-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

Apoptosis in Health and Disease

Author : Martin Holcik
Publisher : Cambridge University Press
ISBN 13 : 052115944X
Total Pages : 265 pages
Book Rating : 4.5/5 (211 download)

DOWNLOAD NOW!

Book Synopsis Apoptosis in Health and Disease by : Martin Holcik

Download or read book Apoptosis in Health and Disease written by Martin Holcik and published by Cambridge University Press. This book was released on 2012-01-26 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 2005 survey of the role of apoptosis in the pathogenesis of many significant human illnesses and injury states.

Apoptosis Techniques and Protocols

Author : Andréa C. LeBlanc
Publisher : Springer Science & Business Media
ISBN 13 : 1592591884
Total Pages : 259 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Apoptosis Techniques and Protocols by : Andréa C. LeBlanc

Download or read book Apoptosis Techniques and Protocols written by Andréa C. LeBlanc and published by Springer Science & Business Media. This book was released on 2008-02-06 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis.

Neuronal Death by Accident or by Design

Author : C.E. Henderson
Publisher : Springer Science & Business Media
ISBN 13 : 3662043335
Total Pages : 162 pages
Book Rating : 4.6/5 (62 download)

DOWNLOAD NOW!

Book Synopsis Neuronal Death by Accident or by Design by : C.E. Henderson

Download or read book Neuronal Death by Accident or by Design written by C.E. Henderson and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

Neurodegenerative Diseases

Author : Uday Kishore
Publisher : BoD – Books on Demand
ISBN 13 : 9535110888
Total Pages : 642 pages
Book Rating : 4.5/5 (351 download)

DOWNLOAD NOW!

Book Synopsis Neurodegenerative Diseases by : Uday Kishore

Download or read book Neurodegenerative Diseases written by Uday Kishore and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

DOWNLOAD NOW!

Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Neuropsychiatric Disorders

Author : Manfred Gerlach
Publisher : Springer Science & Business Media
ISBN 13 : 3211735747
Total Pages : 326 pages
Book Rating : 4.2/5 (117 download)

DOWNLOAD NOW!

Book Synopsis Neuropsychiatric Disorders by : Manfred Gerlach

Download or read book Neuropsychiatric Disorders written by Manfred Gerlach and published by Springer Science & Business Media. This book was released on 2007-12-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

The Role of Oxidative Stress in Neuronal Death

Author : Irene Ceballos-Picot
Publisher : Springer Science & Business Media
ISBN 13 : 3662225166
Total Pages : 203 pages
Book Rating : 4.6/5 (622 download)

DOWNLOAD NOW!

Book Synopsis The Role of Oxidative Stress in Neuronal Death by : Irene Ceballos-Picot

Download or read book The Role of Oxidative Stress in Neuronal Death written by Irene Ceballos-Picot and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.

Molecular Mechanisms of Dementia

Author : Wilma Wasco
Publisher : Springer Science & Business Media
ISBN 13 : 1592594719
Total Pages : 313 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Molecular Mechanisms of Dementia by : Wilma Wasco

Download or read book Molecular Mechanisms of Dementia written by Wilma Wasco and published by Springer Science & Business Media. This book was released on 1996-11-01 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Apoptosis in Neurobiology

Author : Yusuf A. Hannun
Publisher : CRC Press
ISBN 13 : 9781420048490
Total Pages : 302 pages
Book Rating : 4.0/5 (484 download)

DOWNLOAD NOW!

Book Synopsis Apoptosis in Neurobiology by : Yusuf A. Hannun

Download or read book Apoptosis in Neurobiology written by Yusuf A. Hannun and published by CRC Press. This book was released on 1998-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical access to the study of apoptosis, with special consideration to the nervous system. The first section concentrates on conceptual approaches to the study of apoptosis in neurobiology and its significance to the nervous system. The second section provides a user-friendly approach to methods and techniques in the study of apoptosis as applied to neurobiology.

Metal-based Neurodegeneration

Author : Robert Crichton
Publisher : John Wiley & Sons
ISBN 13 : 0470022566
Total Pages : 240 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Metal-based Neurodegeneration by : Robert Crichton

Download or read book Metal-based Neurodegeneration written by Robert Crichton and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting new book opens a window into the causes ofdebilitating neurological disorders such as Parkinson’sdisease, CJD and Huntington’s disease, and gives indicationsof the prospects for therapy, based on the understanding ofmolecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the bookoutlines the role of metals in human biology, in particular in thebrain and explores tools for testing potential therapeuticstrategies. It concludes with an overview of the potential of bothchelation and antioxidant therapy and outlines some perspectivesfor the future.

The Aging Mind

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309172195
Total Pages : 285 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis The Aging Mind by : National Research Council

Download or read book The Aging Mind written by National Research Council and published by National Academies Press. This book was released on 2000-04-18 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.

Cyclin Dependent Kinase 5 (Cdk5)

Author : Nancy Y. Ip
Publisher : Springer Science & Business Media
ISBN 13 : 0387788875
Total Pages : 326 pages
Book Rating : 4.3/5 (877 download)

DOWNLOAD NOW!

Book Synopsis Cyclin Dependent Kinase 5 (Cdk5) by : Nancy Y. Ip

Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Hypothalamus in Health and Diseases

Author : Stavros Baloyannis
Publisher : BoD – Books on Demand
ISBN 13 : 1789844444
Total Pages : 144 pages
Book Rating : 4.7/5 (898 download)

DOWNLOAD NOW!

Book Synopsis Hypothalamus in Health and Diseases by : Stavros Baloyannis

Download or read book Hypothalamus in Health and Diseases written by Stavros Baloyannis and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.