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Human Brain Proteome
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Download or read book Human Brain Proteome written by and published by Elsevier. This book was released on 2004-12-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic. * Describes the latest databases and techniques for analyzing the data generated by proteomics* Outlines the latest developments in proteomic methods* Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers
Book Synopsis The human brain proteome project by : Michael Hamacher
Download or read book The human brain proteome project written by Michael Hamacher and published by . This book was released on 2008 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Subcellular Proteomics by : Eric Bertrand
Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Book Synopsis Human Brain Proteomics by : Michael Hamacher
Download or read book Human Brain Proteomics written by Michael Hamacher and published by . This book was released on 2008 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Discovering the Brain by : National Academy of Sciences
Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Book Synopsis Proteomics and Transcriptomics of the Betz Cell in the Human Brain by : Connor Scott
Download or read book Proteomics and Transcriptomics of the Betz Cell in the Human Brain written by Connor Scott and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Long-lived Proteins in Human Aging and Disease by : Roger J. W. Truscott
Download or read book Long-lived Proteins in Human Aging and Disease written by Roger J. W. Truscott and published by John Wiley & Sons. This book was released on 2021-04-19 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
Book Synopsis The Isolation and Characterisation of Human Brain Proteins by : Olivia Rachel-Rose Matthai
Download or read book The Isolation and Characterisation of Human Brain Proteins written by Olivia Rachel-Rose Matthai and published by . This book was released on 1983 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functional Genomics and Proteomics in the Clinical Neurosciences by : Scott E. Hemby
Download or read book Functional Genomics and Proteomics in the Clinical Neurosciences written by Scott E. Hemby and published by Elsevier. This book was released on 2006-10-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques
Book Synopsis The Isolation Nd Characterisation of Human Brain Proteins by : Olivia Rachel-Rose Matthai
Download or read book The Isolation Nd Characterisation of Human Brain Proteins written by Olivia Rachel-Rose Matthai and published by . This book was released on 1983 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Population Neuroscience by : Tomas Paus
Download or read book Population Neuroscience written by Tomas Paus and published by Springer Science & Business Media. This book was released on 2013-03-23 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is Newton’s brain different from Rembrandt’s? Does a mother’s diet during pregnancy impact brain growth? Do adolescent peers leave a signature in the social brain? Does the way we live in our middle years affect how our brains age? To answer these and many other questions, we can now turn to population neuroscience. Population neuroscience endeavors to identify environmental and genetic factors that shape the function and structure of the human brain; it uses the tools and knowledge of genetics (and the “omics” sciences), epidemiology and neuroscience. This text attempts to provide a bridge spanning these three disciplines so that their practitioners can communicate easily with each other when working together on large-scale imaging studies of the developing, mature and aging brain. By understanding the processes driving variations in brain function and structure across individuals, we will also be able to predict an individual’s risk of (or resilience against) developing a brain disorder. In the long term, the hope is that population neuroscience will lay the foundation for personalized preventive medicine and, in turn, reduce the burden associated with complex, chronic disorders of brain and body.
Book Synopsis The Molecular Biology of Down Syndrome by : G. Lubec
Download or read book The Molecular Biology of Down Syndrome written by G. Lubec and published by Springer Science & Business Media. This book was released on 1999-12-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.
Download or read book Brain Banking written by and published by Elsevier. This book was released on 2018-02-27 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more Serves as a valuable resource for staff in existing brain banks by highlighting best practices Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers Authored by leaders from brain banks around the globe – the broadest, most expert coverage available
Book Synopsis Molecular Biology of Neurodegenerative Diseases: Visions for the Future by :
Download or read book Molecular Biology of Neurodegenerative Diseases: Visions for the Future written by and published by Academic Press. This book was released on 2019-11-05 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Book Synopsis Protein Biochemistry of the Human Brain in Neurodegeneration with Emphasis on Alzheimer's Disease by :
Download or read book Protein Biochemistry of the Human Brain in Neurodegeneration with Emphasis on Alzheimer's Disease written by and published by . This book was released on 2001 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Juvenile Huntington’s Disease Human Brain Proteomics Analyses Reveals Dysregulated Mitochondrial Systems with Alterations in Neuropeptides by : William Poon
Download or read book Juvenile Huntington’s Disease Human Brain Proteomics Analyses Reveals Dysregulated Mitochondrial Systems with Alterations in Neuropeptides written by William Poon and published by . This book was released on 2021 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Huntington's disease is a heritable neurodegenerative disease caused by an autosomal dominant trinucleotide expansion of 35+ CAG repeats in the HTT gene while juvenile HD results from a trinucleotide expansion of 60+ CAG repeats. In both cases, an increased number of CAG repeats can increase the severity and onset of the disease. Additionally, there is a substantial dysregulation in protein interactions and cellular pathways in the putamen as well as global brain degeneration. Previous findings in proteomic analysis of expanded allele HTT knock-in mice have suggested mitochondrial toxicity and downregulated vesicle trafficking are some of the main causes of HD pathology, but this analysis has not been done with juvenile HD human brain tissue. To discover the dysregulated proteins in the cortex areas of Brodmann Area 4 and Brodmann Area 6 combined with the putamen, regions that regulate motor function, we performed mass spectrometry and proteomic analysis on trypsin-digested postmortem juvenile HD brain tissue and postmortem human control brain tissue to find dysregulated proteins in both conditions. Our findings showed: (1) proteins in juvenile HD only, (2) control only, (3) dysregulated proteins, (4) dysregulation of mitochondrial components in juvenile HD, (5) distinct neuropeptides in the juvenile HD and control proteome. The data suggest that mutant Htt causes gain and loss of expression of proteins in the human brain. In the cortex, the absence of mitochondrial pathway components indicates loss of function in this system. Furthermore, neuropeptides were found only in juvenile HD and control, shared, and dysregulated in juvenile HD.
