Human African Trypanosomiasis Sleeping Sickness

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Progress in Human African Trypanosomiasis, Sleeping Sickness

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Author : Michel Dumas
Publisher : Springer Science & Business Media
ISBN 13 : 2817808576
Total Pages : 347 pages
Book Rating : 4.8/5 (178 download)

Book Synopsis Progress in Human African Trypanosomiasis, Sleeping Sickness by : Michel Dumas

Download or read book Progress in Human African Trypanosomiasis, Sleeping Sickness written by Michel Dumas and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

Human Emerging and Re-emerging Infections

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Author : Sunit Kumar Singh
Publisher : John Wiley & Sons
ISBN 13 : 1118644646
Total Pages : 1072 pages
Book Rating : 4.1/5 (186 download)

Book Synopsis Human Emerging and Re-emerging Infections by : Sunit Kumar Singh

Download or read book Human Emerging and Re-emerging Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.

WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis

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Author : World Health Organization
Publisher :
ISBN 13 :
Total Pages : 44 pages
Book Rating : 4.:/5 (113 download)

Book Synopsis WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis by : World Health Organization

Download or read book WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis written by World Health Organization and published by . This book was released on 2019 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African trypanosomiasis (HAT), or sleeping sickness, is a parasitic infection that is almost invariably fatal unless treated. It is a neglected tropical disease that occurs in sub-Saharan Africa. The incidence of the disease is declining in response to intensive surveillance and control in endemic areas. As a result, HAT is among the neglected tropical diseases targeted by the World Health Organization (WHO) for elimination. WHO maintains exhaustive records of all declared cases; in 2018, a historically low number of cases (less than 1000) was reported. The remarkable progress in the control of gambiense HAT has relied on case-finding and curative treatment, a strategy that interrupts transmission by depleting the reservoir of parasites in humans. This has been combined occasionally with vector control activities. The subject of these guidelines, therefore, is of utmost importance for the continuation of progress to eliminate HAT. The recent approval of a new medicine (fexinidazole) for the treatment of gambiense HAT has opened new possibilities for the management of cases and thus warrants the new WHO recommendations contained herein. While studies of fexinidazole and other therapies are ongoing, these guidelines are considered interim guidelines until new information becomes available. This document focuses on the management of patients affected by gambiense HAT and constitutes an update to the WHO therapeutic guidance issued in 2013.

Human African Trypanosomiasis (Sleeping Sickness)

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Author : Christian Burri
Publisher : MDPI
ISBN 13 : 3039289632
Total Pages : 280 pages
Book Rating : 4.0/5 (392 download)

Book Synopsis Human African Trypanosomiasis (Sleeping Sickness) by : Christian Burri

Download or read book Human African Trypanosomiasis (Sleeping Sickness) written by Christian Burri and published by MDPI. This book was released on 2020-06-17 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.

Control and Surveillance of Human African Trypanosomiasis

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Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241209844
Total Pages : 249 pages
Book Rating : 4.2/5 (412 download)

Book Synopsis Control and Surveillance of Human African Trypanosomiasis by : World Health Organization

Download or read book Control and Surveillance of Human African Trypanosomiasis written by World Health Organization and published by World Health Organization. This book was released on 2013 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides information about new diagnostic approaches, new therapeutic regimens and better understanding of the distribution of the disease with high-quality mapping. The roles of human and animal reservoirs and the tsetse fly vectors that transmit the parasites are emphasized. The new information has formed the basis for an integrated strategy with which it is hoped that elimination of HAT will be achieved. The report also contains recommendations on the approaches that will lead to elimination of the disease. Human African Tryponosomiasis (HAT) is a disease that afflicts populations in rural Africa, where the tsetse fly vector that transmits the causative trypanosome parasites thrives. There are two forms of HAT: one, known as gambiense HAT, is endemic in West and Central Africa and causes over 95% of current cases; the other, known as rhodesiense HAT, is endemic in East and southern Africa and accounts for the remainder of cases. The presence of parasites in the brain leads to progressive neurological breakdown. Changes to sleep-wake patterns are among the symptoms that characterize the disease, also known as "sleeping sickness". Eventually, patients fall into a coma and die if not treated. Different treatments are available against parasites present in the haemolymphatic system (first stage) and those that have entered the brain (second stage). Currently, lumbar puncture is required to select the appropriate drug.

African Trypanosomiasis

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Author : Gerald T. Hughes
Publisher : Nova Science Publishers
ISBN 13 : 9781634847124
Total Pages : 0 pages
Book Rating : 4.8/5 (471 download)

Book Synopsis African Trypanosomiasis by : Gerald T. Hughes

Download or read book African Trypanosomiasis written by Gerald T. Hughes and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African trypanosomiasis or sleeping sickness is caused by infection with the morphologically indistinguishable subspecies Trypanosoma brucei rhodesiense (in East and Southern Africa) and Trypanosoma brucei gambiense (in West and Central Africa). The disease is presently almost under control and less than 4000 cases are currently reported. In both, T. b. rhodesiense and T. b. gambiense infection, after the injection of infective metacyclic trypanosomes with tsetse fly vector saliva, the parasites establish in the skin, differentiate to the bloodstream stage and spread via the local draining lymph node into the vascular system. In this book, Chapter One presents an overview of the current epidemiology, clinical features, diagnosis and treatment options. Chapter Two provides an in-depth review of diagnostic methods for African trypanosomiasis. Chapter Three discusses the use of aminoadamantane derivatives against Trypanosoma brucei.

The Colonial Disease

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Author : Maryinez Lyons
Publisher : Cambridge University Press
ISBN 13 : 9780521524520
Total Pages : 356 pages
Book Rating : 4.5/5 (245 download)

Book Synopsis The Colonial Disease by : Maryinez Lyons

Download or read book The Colonial Disease written by Maryinez Lyons and published by Cambridge University Press. This book was released on 2002-06-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: A case-study in the history of sleeping sickness, relating it to the western 'civilising mission'.

The Trypanosomiases

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Author : Ian Maudlin
Publisher : CABI
ISBN 13 : 9780851990347
Total Pages : 644 pages
Book Rating : 4.9/5 (93 download)

Book Synopsis The Trypanosomiases by : Ian Maudlin

Download or read book The Trypanosomiases written by Ian Maudlin and published by CABI. This book was released on 2004-07-09 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.

Uveitis

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Author : C. Stephen Foster
Publisher : Springer Nature
ISBN 13 : 3030529746
Total Pages : 347 pages
Book Rating : 4.0/5 (35 download)

Book Synopsis Uveitis by : C. Stephen Foster

Download or read book Uveitis written by C. Stephen Foster and published by Springer Nature. This book was released on 2020-12-03 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing solely on uveitis care, this quick reference guide will provide a compiled and easy to navigate differential diagnosis – making an often daunting task for clinicians easier, quicker, and more accurate by using a concise outline format to list the most critical aspects of a disease entity. Uveitis: A Quick Guide to Essential Diagnosis opens with a Diagnosis Flowchart, so that the reader can select the most probable diagnoses based on patient’s history and exam. From there the reader can then quickly turn to the corresponding chapter to learn about the most critical aspects of the disease entity: epidemiology, characteristic exam and imaging findings, prognostic factors, and treatment options. This book is written for ophthalmic care providers including general ophthalmologists, subspecialists, fellows, residents and optometrists and features research and contributions from institutions that are global leaders in uveitis care.

Tropical Dermatology E-Book

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Author : Steven K Tyring
Publisher : Elsevier Health Sciences
ISBN 13 : 032333914X
Total Pages : 421 pages
Book Rating : 4.3/5 (233 download)

Book Synopsis Tropical Dermatology E-Book by : Steven K Tyring

Download or read book Tropical Dermatology E-Book written by Steven K Tyring and published by Elsevier Health Sciences. This book was released on 2016-10-17 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an increasingly global community, the rapid adaptation of microorganisms has facilitated the return of old communicable diseases and the emergence of new ones. Tropical Dermatology, 2nd Edition, provides a practical, highly illustrated approach to the diagnosis and treatment of a wide range of tropical skin diseases. In a concise and user-friendly format, it offers authoritative coverage of epidemiology, diagnosis, differential diagnosis, pathology, laboratory tests, management, and prevention for both common and rare conditions. Examines the full range of tropical skin diseases in an easy-to-reference format, with consistently organized, templated chapters. Structures clinical guidance by disease rather than by microbe or "bug." Covers the key issues for travelers, important considerations for people working in the tropics, and non-infectious conditions. Provides authoritative guidance for dermatologists, infectious disease specialists, and travel medicine physicians. Includes new chapters on Tungiasis, Ebola and Zika virus. Features updates on emerging diseases and new therapies throughout. Includes brand-new, "hard-to-find" clinical images, for a total of more than 650 full-color illustrations throughout. Integrates the knowledge and experience of new international contributors, including recognized experts in dermatology from the United States, Europe, South America, Africa, and Asia.

The African Trypanosomes

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Author : Samuel J. Black
Publisher : Springer Science & Business Media
ISBN 13 : 0306468948
Total Pages : 185 pages
Book Rating : 4.3/5 (64 download)

Book Synopsis The African Trypanosomes by : Samuel J. Black

Download or read book The African Trypanosomes written by Samuel J. Black and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

Trypanosomes and Trypanosomiasis

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Author : Stefan Magez
Publisher : Springer Science & Business Media
ISBN 13 : 3709115566
Total Pages : 300 pages
Book Rating : 4.7/5 (91 download)

Book Synopsis Trypanosomes and Trypanosomiasis by : Stefan Magez

Download or read book Trypanosomes and Trypanosomiasis written by Stefan Magez and published by Springer Science & Business Media. This book was released on 2013-09-24 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume written by experts in the field of trypanosome research covers every aspect of trypanosome-vector-host biology. It is a must read for basic researchers working with trypanosomes and related organisms, infection and drug development as well as parasitology in a broader sense.

Trypanosomiasis

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Author : Donald Kruel
Publisher : Infobase Publishing
ISBN 13 : 1438101740
Total Pages : 135 pages
Book Rating : 4.4/5 (381 download)

Book Synopsis Trypanosomiasis by : Donald Kruel

Download or read book Trypanosomiasis written by Donald Kruel and published by Infobase Publishing. This book was released on 2007 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the two main types of trypanosomiasis, how and where it is spread, as well as its treatment.

Human African Trypanosomiasis (Sleeping Sickness)

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Author : Christian Burri
Publisher :
ISBN 13 : 9783039289646
Total Pages : 280 pages
Book Rating : 4.2/5 (896 download)

Book Synopsis Human African Trypanosomiasis (Sleeping Sickness) by : Christian Burri

Download or read book Human African Trypanosomiasis (Sleeping Sickness) written by Christian Burri and published by . This book was released on 2020 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.

Sleeping Sickness Bulletin

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Author : Great Britain. Bureau of Hygiene and Tropical Diseases
Publisher :
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.:/5 (31 download)

Book Synopsis Sleeping Sickness Bulletin by : Great Britain. Bureau of Hygiene and Tropical Diseases

Download or read book Sleeping Sickness Bulletin written by Great Britain. Bureau of Hygiene and Tropical Diseases and published by . This book was released on 1909 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reports of the Sleeping Sickness Commission

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Author : Royal Society (Great Britain). Sleeping Sickness Commission
Publisher :
ISBN 13 :
Total Pages : 420 pages
Book Rating : 4.:/5 (29 download)

Book Synopsis Reports of the Sleeping Sickness Commission by : Royal Society (Great Britain). Sleeping Sickness Commission

Download or read book Reports of the Sleeping Sickness Commission written by Royal Society (Great Britain). Sleeping Sickness Commission and published by . This book was released on 1903 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reports of the Sleeping Sickness Commission of the Royal Society

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Author : Royal Society (Great Britain). Sleeping Sickness Commission
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Reports of the Sleeping Sickness Commission of the Royal Society by : Royal Society (Great Britain). Sleeping Sickness Commission

Download or read book Reports of the Sleeping Sickness Commission of the Royal Society written by Royal Society (Great Britain). Sleeping Sickness Commission and published by . This book was released on 1903 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: