Host Targeting Antivirals For Treatment Of Hepatitis C

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Host-Targeting Antivirals for Treatment of Hepatitis C

Author : Kyoko Tsukiyama-Kohara
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Host-Targeting Antivirals for Treatment of Hepatitis C by : Kyoko Tsukiyama-Kohara

Download or read book Host-Targeting Antivirals for Treatment of Hepatitis C written by Kyoko Tsukiyama-Kohara and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of chronic hepatitis C virus (HCV) infection has been revolutionized during last years with the development of highly potent direct-acting antivirals (DAAs) specifically targeting HCV proteins. DAAs are the current standard of care for patients with chronic hepatitis C, leading to high cure rates. However, some hurdles exist including the high cost of these therapies restricting access to patients, their inability to protect against the risk of developing hepatocellular carcinoma in patients with advanced fibrosis, and emergence of resistant variants resulting in treatment failure. New therapeutic options should be essential to overcome DAAs limitations and improve survival. By targeting host-cell factors involved in HCV life cycle, host-targeting antivirals (HTAs) offer opportunity for promising anti-HCV therapy with low mutational rate and may act in a synergistic manner with DAAs to prevent viral resistance and reduce viral replication. Moreover, HTAs could be effective in difficult-to-cure patients by acting through complementary mechanisms. In this chapter, we will focus on the latest and most relevant studies regarding the host-cell factors required in HCV infection and explored as targets of antiviral therapy, we will also discuss the HTAs evaluated in preclinical and clinical development and their potential role as alternative or complementary therapeutic strategies.

Advances in Hepatology

Author : Luis Rodrigo
Publisher : BoD – Books on Demand
ISBN 13 : 1839686235
Total Pages : 260 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Advances in Hepatology by : Luis Rodrigo

Download or read book Advances in Hepatology written by Luis Rodrigo and published by BoD – Books on Demand. This book was released on 2021-07-28 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses clinical advances in hepatology, with a focus on metabolic diseases and chronic hepatitis C. The development of direct-acting antiviral (DAA) agents for the treatment of hepatitis C virus (HCV) infection in 2010 has completely transformed the management of this disease. This transformative nature of DAA therapy underpins the goal of the World Health Organization (WHO) to eliminate HCV infection as a public health threat by 2030. The advantages of using these therapies include high efficacy (sustained virological response rate >95%) with minimal side effects, good tolerability, easy drug administration (once-daily oral dosing) and short duration of treatment (8-12 weeks). The commercialization of second-generation DAA agents due to their high effectiveness, few side-effects and pangenotypic action. This transformative nature of DAA therapy underpins the goal of the WHO to eliminate HCV infection as a public health threat by 2030.

Mechanisms of Action and Efficacy of HCV Direct-acting Antiviral Agents and the Host-targeting Agent Cyclosporin A

Author : Dandan Liu
Publisher :
ISBN 13 :
Total Pages : 159 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Mechanisms of Action and Efficacy of HCV Direct-acting Antiviral Agents and the Host-targeting Agent Cyclosporin A by : Dandan Liu

Download or read book Mechanisms of Action and Efficacy of HCV Direct-acting Antiviral Agents and the Host-targeting Agent Cyclosporin A written by Dandan Liu and published by . This book was released on 2016 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antiviral Chemotherapy

Author : D. J. Jeffries
Publisher :
ISBN 13 :
Total Pages : 614 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Antiviral Chemotherapy by : D. J. Jeffries

Download or read book Antiviral Chemotherapy written by D. J. Jeffries and published by . This book was released on 1995-07-11 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.

Hepatitis Prevention and Treatment

Author : Joseph M. Colacino
Publisher : Birkhäuser
ISBN 13 : 3034879032
Total Pages : 250 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Hepatitis Prevention and Treatment by : Joseph M. Colacino

Download or read book Hepatitis Prevention and Treatment written by Joseph M. Colacino and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Successful Strategies for the Discovery of Antiviral Drugs

Author : Manoj C. Desai
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737819
Total Pages : 551 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Successful Strategies for the Discovery of Antiviral Drugs by : Manoj C. Desai

Download or read book Successful Strategies for the Discovery of Antiviral Drugs written by Manoj C. Desai and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Viral Pathogenesis

Author : Michael G. Katze
Publisher : Academic Press
ISBN 13 : 0128011742
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Pathogenesis by : Michael G. Katze

Download or read book Viral Pathogenesis written by Michael G. Katze and published by Academic Press. This book was released on 2015-12-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Antiviral Strategies

Author : Hans-Georg Kräusslich
Publisher : Springer Science & Business Media
ISBN 13 : 3540790861
Total Pages : 386 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Antiviral Strategies by : Hans-Georg Kräusslich

Download or read book Antiviral Strategies written by Hans-Georg Kräusslich and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

Eliminating the Public Health Problem of Hepatitis B and C in the United States

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309438020
Total Pages : 187 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Eliminating the Public Health Problem of Hepatitis B and C in the United States by : National Academies of Sciences, Engineering, and Medicine

Download or read book Eliminating the Public Health Problem of Hepatitis B and C in the United States written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-06-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Investigating Hepatitis C Virus Interactions with Host Lipid Pathways that are Critical for Viral Propagation Using Small Molecule Inhibitors and Chemical Biology Methods

Download Investigating Hepatitis C Virus Interactions with Host Lipid Pathways that are Critical for Viral Propagation Using Small Molecule Inhibitors and Chemical Biology Methods PDF Online Free

Author : Rodney Lyn
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis Investigating Hepatitis C Virus Interactions with Host Lipid Pathways that are Critical for Viral Propagation Using Small Molecule Inhibitors and Chemical Biology Methods by : Rodney Lyn

Download or read book Investigating Hepatitis C Virus Interactions with Host Lipid Pathways that are Critical for Viral Propagation Using Small Molecule Inhibitors and Chemical Biology Methods written by Rodney Lyn and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C virus (HCV) is remarkably capable of efficiently hijacking host cell pathways including lipid metabolism in the liver in order to create pro-viral environments for pathogenesis. It is becoming increasingly clear that identifying small molecule inhibitors that target host factors exploited by the virus will expand available HCV treatment options. As such, a thorough understanding of host-virus interactions is critical to the development of alternative therapeutic strategies. Hepatic lipid droplets (LDs) are recruited by HCV to play essential roles in the viral lifecycle. The intracellular location of LDs is modified upon interacting with viral structural core protein. This enables formation of platforms that support viral particle assembly. Because these interactions are non-static, capturing its dynamic processes in order to better understand viral assembly can be achieved with label-free molecular imaging enhanced with live-cell capabilities. Chemical biology approaches that includes CARS microscopy employed in a multi-modal imaging system was used to probe interactions between HCV and host LDs. By successfully tracking LD trajectories, we identified core protein's ability to alter LD speed and control for LD directionality. Using protein expression model systems that allowed for simultaneous tracking of core protein and LDs, our data revealed that mutations in the core protein region that vary in hydrophobicity and LD binding strengths, are factors that control for differential modulation of LD kinetics. Furthermore, we measured bidirectional LD travels runs and velocities, and observed critical properties by which core protein induces LD migration towards regions of viral particle assembly. Given that many steps in the HCV lifecycle are directly linked to host lipid metabolism, it is not surprising that disrupting lipid biosynthetic pathways would negatively affect viral replication. From this outlook, we explored small molecule inhibitors that targeted several lipid metabolic pathways to study its antiviral properties. Using fluorescent probes covalently labeled to viral RNA, we captured the visualization of disrupted replication complexes upon antagonizing nuclear hormone receptors that are linked to regulating lipid homeostasis. Correspondingly, biochemistry and molecular imaging techniques were also employed to identify novel antiviral mechanisms of small molecule inhibitors that target additional HCV-dependent lipid metabolic pathways.

Chronic Hepatitis C Virus

Author : Mitchell L. Shiffman
Publisher : Springer Science & Business Media
ISBN 13 : 1461411920
Total Pages : 333 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Chronic Hepatitis C Virus by : Mitchell L. Shiffman

Download or read book Chronic Hepatitis C Virus written by Mitchell L. Shiffman and published by Springer Science & Business Media. This book was released on 2011-11-17 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Hepatitis C Virus-host Interactions

Author : Vanessa Fontanes
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Hepatitis C Virus-host Interactions by : Vanessa Fontanes

Download or read book Hepatitis C Virus-host Interactions written by Vanessa Fontanes and published by . This book was released on 2008 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hepatitis C

Author : Imran Shahid
Publisher : BoD – Books on Demand
ISBN 13 : 1789842077
Total Pages : 214 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Hepatitis C by : Imran Shahid

Download or read book Hepatitis C written by Imran Shahid and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527810706
Total Pages : 530 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

New Concepts of Antiviral Therapy

Author : Elke Bogner
Publisher : Springer Science & Business Media
ISBN 13 : 0387310479
Total Pages : 543 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis New Concepts of Antiviral Therapy by : Elke Bogner

Download or read book New Concepts of Antiviral Therapy written by Elke Bogner and published by Springer Science & Business Media. This book was released on 2007-01-31 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.

Examining Serine Hydrolase Small Molecule Inhibitors as Regulators of Hepatitis C Virus Life Cycle

Author : David Lefebvre
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Examining Serine Hydrolase Small Molecule Inhibitors as Regulators of Hepatitis C Virus Life Cycle by : David Lefebvre

Download or read book Examining Serine Hydrolase Small Molecule Inhibitors as Regulators of Hepatitis C Virus Life Cycle written by David Lefebvre and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C virus (HCV) is a hepatotropic positive-sense RNA virus of the Flaviviridae virus family and is a major cause of chronic liver disease worldwide. Like all obligate parasites, HCV relies on host pathways to enable its pathogenesis. HCV, in particular, has a clear link with hepatic lipid metabolism, promoting a lipid-rich environment for its proliferation. This manifests as liver steatosis in many patients harboring chronic HCV infection. Based on our recent findings regarding an immunometabolic and HCV antiviral microRNA (miRNA), miRNA-185 targeting and down regulating serine hydrolases (SH) involved in lipid and endocannabinoid metabolism, here we investigate HCV and its dependency on certain metabolic serine hydrolases involved in lipid and endocannabinoid metabolism. Serine hydrolases are one of the largest and most diverse enzyme families. This enzyme family has emerged as a center of therapeutic potential due to its implications in many metabolic roles. Here, we demonstrate that pharmacological inhibition of metabolic serine hydrolases alpha-beta hydrolyzing domain 6 (ABHD6), carboxylesterase 1 (CES1), and monoacylglycerol lipase (MGLL), enzymes involved in the hydrolysis of the endogenous cannabinoid receptor 1 (CB1) agonist 2-arachidonoyl glycerol (2-AG) are potently antiviral against HCV. Serine hydrolase inhibition with the MGLL inhibitor MJN110 paired with endocannabinoid signaling antagonization led to additive antiviral effects against HCV and has revealed modulation of the viral pathogenic phenotype to be its key course of action. MGLL inhibitor MJN110 transcriptomic characterization revealed modulations in humoral immunity and phagocytosis and acts antiviraly against HCV independent of CB1 antagonization. This provides an avenue for future investigation, assessing the viability of CB1 antagonization, and MGLL as a key host targeted antiviral factor in affecting HCV viral life cycle.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.