Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Hemopoietic Growth Factors Oncogenes And Cytokines In Clinical Hematology full books in PDF, epub, and Kindle. Read online Hemopoietic Growth Factors Oncogenes And Cytokines In Clinical Hematology ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Elio Cacciola
Publisher :
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.3/5 (91 download)
Download or read book Hemopoietic Growth Factors, Oncogenes, and Cytokines in Clinical Hematology written by Elio Cacciola and published by . This book was released on 1994 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John R. Wingard
Publisher : Springer Science & Business Media
ISBN 13 : 1461550130
Total Pages : 424 pages
Book Rating : 4.4/5 (615 download)
Download or read book Clinical Applications of Cytokines and Growth Factors written by John R. Wingard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.
Author : George Morstyn
Publisher : Springer Science & Business Media
ISBN 13 : 1592597475
Total Pages : 470 pages
Book Rating : 4.5/5 (925 download)
Download or read book Hematopoietic Growth Factors in Oncology written by George Morstyn and published by Springer Science & Business Media. This book was released on 2004-02-05 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whether to promote platelet recovery or to ameliorate the complications of cancer and the side effects of chemotherapy, hematopoietic growth factors (HGFs) now account for more than $5 billion per year of the US health care budget. In Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics, leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and non-Hodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem-cell factor and its receptor, c-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology. Comprehensive and up-to-date, Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Practice offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombocytopenia in patients with malignant and nonmalignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit.
Author : Enrique Pimentel
Publisher : CRC Press
ISBN 13 : 9780849325076
Total Pages : 392 pages
Book Rating : 4.3/5 (25 download)
Download or read book Handbook of Growth Factors written by Enrique Pimentel and published by CRC Press. This book was released on 1994-06-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Growth Factors, Volume III is devoted to hematopoiesis and its regulation by endogenous factors with growth stimulatory and growth inhibitory properties. The book provides detailed discussions on signaling agents related to the regulation of hematopoiesis, including the interleukins, the colony-stimulating factors, the interferons, the tumor necrosis factors, the erythropoietic growth factors, the platelet-derived growth factor, the leukemia inhibitory factor, and the transferrins. The structure and function of each factor is covered in detail, as well as its receptor and postreceptor mechanism of action and its possible role in neoplastic processes. The book also explores the present state of the knowledge about megakaryocyte growth factors and macrophage-derived growth factors.
Author : Andreas Habenicht
Publisher : Springer Science & Business Media
ISBN 13 : 3642748562
Total Pages : 484 pages
Book Rating : 4.6/5 (427 download)
Download or read book Growth Factors, Differentiation Factors, and Cytokines written by Andreas Habenicht and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading international experts contribute to this selection of reviews covering the merging fields of growth factors, differentiation factors, and cytokines. These appear to play fundamental roles in a wide variety of physiological and pathophysiological processes that include the regulation of growth in normal and malignant cells, embryogenesis, the immune response, wound healing, inflammation, and atherogenesis. The major aspects of recent research and development are discussed, providing an important update in this pioneering field.
Author : Gary Lyman
Publisher : Springer Science & Business Media
ISBN 13 : 1441970738
Total Pages : 431 pages
Book Rating : 4.4/5 (419 download)
Download or read book Hematopoietic Growth Factors in Oncology written by Gary Lyman and published by Springer Science & Business Media. This book was released on 2010-11-05 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in the treatment of cancer over the past two decades has been rapid with many new and novel therapeutic modalities arriving at an unprecedented pace. Overall cancer mortality rates have actually begun to fall in parallel with progress in the diagnosis and treatment of malignant disease. Despite our advances in the understanding of the biology and molecular genetics of cancer, as well as the availability of an increasing array of effective therapies, cancer treatment today and for the foreseeable future will include the traditional modalities of surgery, radiation therapy and chemotherapy. Myelosuppressive agents with their potential hematopoietic toxicities remain the mainstay of systemic treatment for both metastatic and early stage cancer. The complications of cancer chemotherapy have serious impact on a patient’s well being and overall quality of life. Fortunately, advances in cancer treatment have been accompanied by equally impressive progress in the availability of a wide array of supportive care modalities which have greatly enhanced the ability of oncologists to minimize the impact of cancer and its treatment on patient quality of life as well improve delivery of potentially curative cancer treatment. Despite the increasing complexity of modern cancer treatment, it is the obligation of the oncologist as well as the entire cancer care team to be certain that cancer patients receive the optimal supportive care available for their disease and its treatment. Among the most serious and potentially life threatening toxicities of cancer treatment are the hematologic toxicities accompanying myelosuppression including anemia and associated asthenia and fatigue, neutropenia and fever associated with infection in the immunocompromised patient and thrombocytopenia and accompanying risk of bleeding. Special supportive care needs arise in the very elderly care patient that may tax the ability of even the most skilled clinician. Despite the considerable progress that has been made with more effective and safer treatment strategies, myelosuppressive chemotherapy will remain the mainstay of systemic treatment for cancer for the foreseeable future. While considerable progress has occurred, better methods and broader application of supportive care measures are needed to reduce the symptomatic effects of cancer and the associated toxicities associated with cancer treatment. No area of cancer supportive care better illustrates the progress that has resulted from advances in our understanding of cellular and molecular biology, genetic engineering and the development of more effective yet often more toxic cancer treatments than that of the hematopoietic growth factors. This volume will review and integrate the major advances in our understanding of the underlying molecular biology and pharmacology of these agents along with the results of well designed and executed randomized controlled trials of the erythroid stimulating agents, the myeloid growth factors and the new thrombopoietic agents each addressing a major threat associated with bone marrow suppression accompanying cancer treatment. The current clinical utilization of these agents is based on numerous randomized controlled trials and meta-analyses along with evidence-based clinical practice guidelines developed by professional societies guiding their appropriate and cost-effective use in clinical care.
Author : Anthony D. Whetton
Publisher : Springer Science & Business Media
ISBN 13 : 0585317283
Total Pages : 727 pages
Book Rating : 4.5/5 (853 download)
Download or read book Blood Cell Biochemistry written by Anthony D. Whetton and published by Springer Science & Business Media. This book was released on 1996-08-31 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below).
Author : Roland Mertelsmann
Publisher :
ISBN 13 : 9780824794002
Total Pages : pages
Book Rating : 4.7/5 (94 download)
Download or read book Hematopoietic Growth Factors in Clinical Applications written by Roland Mertelsmann and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition contains a wealth of new information on cytokines and the self-renewal, proliferation, maturation, and state of activity of hematopoietic and immunological progenitor cells and their progeny-demonstrating their efficacy in treating disease states associated with hematopoietic failure or impaired blood cell function. Discusses the demonstrated and potential clinical benefits of hematopoietic growth factors, the economic consequences of using these agents, and various practical usage concerns!
Author : Roland Mertelsmann
Publisher :
ISBN 13 :
Total Pages : 534 pages
Book Rating : 4.3/5 (91 download)
Download or read book Hematopoietic Growth Factors in Clinical Applications written by Roland Mertelsmann and published by . This book was released on 1990 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition contains a wealth of new information on cytokines and the self-renewal, proliferation, maturation, and state of activity of hematopoietic and immunological progenitor cells and their progeny-demonstrating their efficacy in treating disease states associated with hematopoietic failure or impaired blood cell function. Discusses the demonstrated and potential clinical benefits of hematopoietic growth factors, the economic consequences of using these agents, and various practical usage concerns!
Author : Roland Mertelsmann
Publisher : CRC Press
ISBN 13 : 9780824792688
Total Pages : 424 pages
Book Rating : 4.7/5 (926 download)
Download or read book Hematopoietic Growth Factors in Clinical Applications, Second Edition, written by Roland Mertelsmann and published by CRC Press. This book was released on 1994-09-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition contains a wealth of new information on cytokines and the self-renewal, proliferation, maturation, and state of activity of hematopoietic and immunological progenitor cells and their progeny-demonstrating their efficacy in treating disease states associated with hematopoietic failure or impaired blood cell function. Discusses the demonstrated and potential clinical benefits of hematopoietic growth factors, the economic consequences of using these agents, and various practical usage concerns!
Author : Arnold Ganser
Publisher : CRC Press
ISBN 13 : 9780824701932
Total Pages : 416 pages
Book Rating : 4.7/5 (19 download)
Download or read book Cytokines in the Treatment of Hematopoietic Failure written by Arnold Ganser and published by CRC Press. This book was released on 1998-09-03 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world experts in the field, this book presents up-to-date, in-depth coverage of hematopoietic growth factors and related cytokines that are currently being developed or used for managing congenital and acquired forms of chronic cytopenias. Summarizes important clinical trial data in a convenient tabulated format and provides fundamental knowledge on hematopoiesis physiology and regulation! Facilitating rational decision making and cost-effective treatment strategies, this clinically and disease-oriented work describes as well as assesses the benefits and limitations of hematopoietic growth factor and cytokine use in graft failure peripheral-blood progenitor cell transplantation chemotherapy- and radiotherapy-induced cytopenias in patients with solid tumors and hematological malignancies, including leukemias and myelodysplastic syndromes cytopenic states related to infectious conditions such as AIDS ex vivo expansion of hematopoietic progenitor cells post-operative procedures for bone marrow transplantation renal failure the neonate transfusion medicine and more! Supplemented with literature citations and drawings, Cytokines in the Treatment of Hematopoietic Failure is an essential resource for hematologists, oncologists, internists, radiotherapists, pediatricians, neonatologists, infectious disease specialists, nephrologists, immunologists, transfusion medicine specialists, researchers in pharmaceutical companies, and graduate and medical school students in these disciplines.
Author : Cees Smit Sibinga
Publisher : Springer
ISBN 13 : 9781461311386
Total Pages : 206 pages
Book Rating : 4.3/5 (113 download)
Download or read book Cytokines and Growth Factors in Blood Transfusion written by Cees Smit Sibinga and published by Springer. This book was released on 2011-11-25 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis – laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine – clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine – erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
Author : Ralph van Furth
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)
Download or read book Hemopoietic Growth Factors and Mononuclear Phagocytes written by Ralph van Furth and published by S. Karger AG (Switzerland). This book was released on 1993 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen J. Withrow
Publisher : Elsevier Health Sciences
ISBN 13 : 1437723624
Total Pages : 775 pages
Book Rating : 4.4/5 (377 download)
Download or read book Withrow and MacEwen's Small Animal Clinical Oncology written by Stephen J. Withrow and published by Elsevier Health Sciences. This book was released on 2012-11-13 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.
Author : Rolf Neth
Publisher : Springer
ISBN 13 :
Total Pages : 484 pages
Book Rating : 4.3/5 (91 download)
Download or read book Modern Trends in Human Leukemia IX written by Rolf Neth and published by Springer. This book was released on 1992 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Author : Eliane Gluckman
Publisher : John Libbey Eurotext
ISBN 13 : 9782742001033
Total Pages : 410 pages
Book Rating : 4.0/5 (1 download)
Download or read book Ontogeny of Hematopoiesis, Aplastic Anemia written by Eliane Gluckman and published by John Libbey Eurotext. This book was released on 1995 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many questions were raised during this multidisciplinary meeting during which geneticists, haematologists, embryologists, immunologists, transplant surgeons and physicians exchanged views on these questions. The second part of the meeting was devoted to an examination of the mechanisms of medullary deficiency. A more clinical approach was taken to the epidemiological, molecular and genetic aspects of medullary deficiency. There was also discussion of various therapeutic methods, including transplants, the use of haematopoietic growth factors, immunosuppressive treatments and gene therapy. Proceedings of the joint international workshop on "Foetal and neonatal hematopoiesis and mechanisms of bone marrow failure", Paris, April 1995.
Author : National Cancer Institute (U.S.). Division of Cancer Biology, Diagnosis, and Centers
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.E/5 ( download)
Download or read book Annual Report written by National Cancer Institute (U.S.). Division of Cancer Biology, Diagnosis, and Centers and published by . This book was released on 1995 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
