Helicases From All Domains Of Life

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Helicases from All Domains of Life

Author : Renu Tuteja
Publisher : Academic Press
ISBN 13 : 0128146869
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Helicases from All Domains of Life by : Renu Tuteja

Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-09-21 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps. Presents updates on the functions and features of helicases across the different kingdoms Begins with a chapter on the evolutionary history of helicases Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view

RNA Helicases

Author :
Publisher : Academic Press
ISBN 13 : 0123972299
Total Pages : 584 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis RNA Helicases by :

Download or read book RNA Helicases written by and published by Academic Press. This book was released on 2012-11-13 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

DNA Helicases and DNA Motor Proteins

Author : Maria Spies
Publisher : Springer Science & Business Media
ISBN 13 : 1461450373
Total Pages : 308 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis DNA Helicases and DNA Motor Proteins by : Maria Spies

Download or read book DNA Helicases and DNA Motor Proteins written by Maria Spies and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genome Stability

Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

The DNA Replication Machinery as Therapeutic Targets

Author : Andrew F. Gardner
Publisher : Frontiers Media SA
ISBN 13 : 2889459276
Total Pages : 144 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The DNA Replication Machinery as Therapeutic Targets by : Andrew F. Gardner

Download or read book The DNA Replication Machinery as Therapeutic Targets written by Andrew F. Gardner and published by Frontiers Media SA. This book was released on 2019-09-19 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

Metagenomic Systems Biology

Author : Shailza Singh
Publisher : Springer Nature
ISBN 13 : 9811585628
Total Pages : 207 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Metagenomic Systems Biology by : Shailza Singh

Download or read book Metagenomic Systems Biology written by Shailza Singh and published by Springer Nature. This book was released on 2020-12-07 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book serves as an amalgamation of knowledge and principles used in the area of systems and synthetic biology, and targets inter-disciplinary research groups. The readers from diversified areas would be benefited by the valuable resources and information available in one book. Microbiome projects with efficient data handling can fuel progress in the area of microbial synthetic biology by providing a ready to use plug and play chassis. Advances in gene editing technology such as the use of tailor made synthetic transcription factors will further enhance the availability of synthetic devices to be applied in the fields of environment, agriculture and health. The different chapters of the book reviews a broad range of topics, including food microbiome in ecology, use of microbiome in personalized medicine, machine learning in biomedicine. The book also describes ways to harness and exploit the incredible amounts of genomic data. The book is not only limited to medicine but also caters to the needs of environmentalists, biochemical engineers etc. It will be of interest to advanced students and researchers in life sciences, computational biology, microbiology and other inter-disciplinary areas.

Molecular Life Sciences

Author : Robert D. Wells
Publisher : Springer
ISBN 13 : 9781461415299
Total Pages : 0 pages
Book Rating : 4.4/5 (152 download)

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Book Synopsis Molecular Life Sciences by : Robert D. Wells

Download or read book Molecular Life Sciences written by Robert D. Wells and published by Springer. This book was released on 2018-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. The work will include articles on genes and genomes, protein structure and function, systems biology using genomics and proteomics as the focus, molecular aspects of cell structure and function, unifying concepts and theories from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences (including teaching perspectives and assessment tools), and basic aspects of the various experimental approaches that are used in the Molecular Life Sciences.

Helicase Enzymes Part B

Author :
Publisher : Academic Press
ISBN 13 : 0323997740
Total Pages : 538 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Helicase Enzymes Part B by :

Download or read book Helicase Enzymes Part B written by and published by Academic Press. This book was released on 2022-08-12 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Helicase Enzymes

Advances in Aquatic Invertebrate Stem Cell Research

Author : Loriano Ballarin
Publisher : MDPI
ISBN 13 : 3036516360
Total Pages : 398 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Advances in Aquatic Invertebrate Stem Cell Research by : Loriano Ballarin

Download or read book Advances in Aquatic Invertebrate Stem Cell Research written by Loriano Ballarin and published by MDPI. This book was released on 2022-01-28 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is based upon work from COST Action ’16203 MARISTEM Stem cells of marine/aquatic invertebrates: from basic research to innovative applications’, supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu Aquatic invertebrates represent the largest biodiversity and the widest phylogenetic radiation on Earth, with more than 2 million known species. Up until a few years ago, their use as model organisms in biological research was limited by the paucity of omics data. Recently, the situation has rapidly changed and is still changing. Today, the genomes and various transcriptomes of many aquatic invertebrate species, as well as many recombinant proteins of invertebrate origin, are available. New technologies have revolutionized the available toolbox of research methodologies. This explains the rising interest of researchers in the use of aquatic invertebrates as reliable model organisms. In contrast to the prevalence of diverse oligopotent and unipotent stem cells in vertebrates, aquatic invertebrates (especially non-ecdysozoan invertebrates) exhibit multiple adult cell types with stem cell attributes characterized by multipotency and pluripotency; furthermore, these give rise to cell lineages characteristic of more than a single germ layer, sometimes with somatic and germ line potentials. In addition, unlike vertebrates, aquatic invertebrate adult stem cells are disseminated and widespread inside the animal body, are not associated with a regulatory microenvironment (niche) and do participate in aging and regeneration phenomena. These properties can help us to better understand the processes and phenomena in mammalian stem cell biology, such as natural chimerism and cancer, aging and senescence, immunity and autoimmune responses, which are all difficult to explain or understand in the human context. The COST Action 16203 MARISTEM "Stem cells of marine/aquatic invertebrates: from basic research to innovative applications" started in 2017 with the aim to foster the knowledge of the biology of aquatic invertebrates stem cells and strengthen the European community of researchers on aquatic invertebrate stem cells in order to build innovative ideas relevant to various biomedical disciplines. This book represents one of the deliverables of the Action and collects part of the materials produced during the past 3 years within the network as a tool to disseminate and render available what has been achieved up to now. We hope that this book will be useful to scientists interested in stem cells of non-model organisms, with particular reference to aquatic invertebrates.

Genome Stability and Human Diseases

Author : Heinz-Peter Nasheuer
Publisher : Springer Science & Business Media
ISBN 13 : 9048134714
Total Pages : 346 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Genome Stability and Human Diseases by : Heinz-Peter Nasheuer

Download or read book Genome Stability and Human Diseases written by Heinz-Peter Nasheuer and published by Springer Science & Business Media. This book was released on 2009-12-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Translation Initiation: Reconstituted Systems and Biophysical Methods

Author :
Publisher : Elsevier
ISBN 13 : 9780080553184
Total Pages : 512 pages
Book Rating : 4.5/5 (531 download)

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Book Synopsis Translation Initiation: Reconstituted Systems and Biophysical Methods by :

Download or read book Translation Initiation: Reconstituted Systems and Biophysical Methods written by and published by Elsevier. This book was released on 2007-10-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

DNA Replication

Author : Hisao Masai
Publisher : Springer
ISBN 13 : 9811069557
Total Pages : 581 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis DNA Replication by : Hisao Masai

Download or read book DNA Replication written by Hisao Masai and published by Springer. This book was released on 2018-01-22 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Salinity Responses and Tolerance in Plants, Volume 2

Author : Vinay Kumar
Publisher : Springer
ISBN 13 : 3319903187
Total Pages : 326 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Salinity Responses and Tolerance in Plants, Volume 2 by : Vinay Kumar

Download or read book Salinity Responses and Tolerance in Plants, Volume 2 written by Vinay Kumar and published by Springer. This book was released on 2018-06-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soil salinity is a key abiotic-stress and poses serious threats to crop yields and quality of produce. Owing to the underlying complexity, conventional breeding programs have met with limited success. Even genetic engineering approaches, via transferring/overexpressing a single ‘direct action gene’ per event did not yield optimal results. Nevertheless, the biotechnological advents in last decade coupled with the availability of genomic sequences of major crops and model plants have opened new vistas for understanding salinity-responses and improving salinity tolerance in important glycophytic crops. Our goal is to summarize these findings for those who wish to understand and target the molecular mechanisms for producing salt-tolerant and high-yielding crops. Through this 2-volume book series, we critically assess the potential venues for imparting salt stress tolerance to major crops in the post-genomic era. Accordingly, perspectives on improving crop salinity tolerance by targeting the sensory, ion-transport and signaling mechanisms were presented in Volume 1. Volume 2 now focuses on the potency of post-genomic era tools that include RNAi, genomic intervention, genome editing and systems biology approaches for producing salt tolerant crops.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Author : Monte Willis
Publisher : Academic Press
ISBN 13 : 0124055257
Total Pages : 338 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Cellular and Molecular Pathobiology of Cardiovascular Disease by : Monte Willis

Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Molecular Themes in DNA Replication

Author : Lynne S Cox
Publisher : Royal Society of Chemistry
ISBN 13 : 1847559859
Total Pages : 315 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Molecular Themes in DNA Replication by : Lynne S Cox

Download or read book Molecular Themes in DNA Replication written by Lynne S Cox and published by Royal Society of Chemistry. This book was released on 2009-10-31 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer.

Viruses: Essential Agents of Life

Author : Günther Witzany
Publisher : Springer Science & Business Media
ISBN 13 : 940074899X
Total Pages : 432 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Viruses: Essential Agents of Life by : Günther Witzany

Download or read book Viruses: Essential Agents of Life written by Günther Witzany and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.