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Handbook Of Microdialysis
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Download or read book Handbook of Microdialysis written by and published by Elsevier. This book was released on 2007-02-02 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience.* Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods* Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology* Includes clinical applications of microdialysis
Book Synopsis Applications of Microdialysis in Pharmaceutical Science by : Tung-Hu Tsai
Download or read book Applications of Microdialysis in Pharmaceutical Science written by Tung-Hu Tsai and published by John Wiley & Sons. This book was released on 2011-07-13 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research. Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include: Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases Continuous measurement of glucose concentrations in diabetics Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.
Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Glen Baker
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Glen Baker and published by Springer Science & Business Media. This book was released on 2007-03-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition
Book Synopsis Handbook of Non-Invasive Methods and the Skin by : Jorgen Serup
Download or read book Handbook of Non-Invasive Methods and the Skin written by Jorgen Serup and published by CRC Press. This book was released on 2006-02-23 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from prominent experts, this comprehensive handbook covers the field of non-invasive biophysical measurement methods in clinical and experimental dermatology. Structured to provide both educational and practical information, the book has proven to be of value to both young researchers and senior scientists. All coverage of major evaluation and measurement methods share a consistent format, covering scope, sources of error, application, and validity. The second edition incorporates 69 revised chapters and 95 new chapters covering topics such as computer technique, imaging techniques, skin friction, barrier functions, and more.
Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : Michelle A. Rudek
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Book Synopsis In Vivo Glucose Sensing by : David D. Cunningham
Download or read book In Vivo Glucose Sensing written by David D. Cunningham and published by John Wiley & Sons. This book was released on 2009-11-19 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vivo Glucose Sensing is a key reference for scientists and engineers working on the development of glucose sensing technologies for the management of diabetes and other medical conditions. It discusses the analytical chemistry behind the strategies currently used for measuring glucose in vivo. It focuses on analyzing samples in the real world and discusses the biological complexities that make glucose sensing difficult. Covering current implantable devices, next-generation implantable sensing methods, and non-invasive methods for measuring glucose, this book concludes with an overview of possible applications other than diabetes.
Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : William D. Figg
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William D. Figg and published by Springer Science & Business Media. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Book Synopsis Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 2: Microdialysis And Sensing Of Neural Tissues by : George S Wilson
Download or read book Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 2: Microdialysis And Sensing Of Neural Tissues written by George S Wilson and published by World Scientific. This book was released on 2017-06-28 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.
Book Synopsis Comprehensive Sampling and Sample Preparation by : Josep M. Bayona
Download or read book Comprehensive Sampling and Sample Preparation written by Josep M. Bayona and published by Academic Press. This book was released on 2012-12-31 with total page 2998 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Sampling and Sample Preparation is a complete treatment of the theory and methodology of sampling in all physical phases and the theory of sample preparation for all major extraction techniques. It is the perfect starting point for researchers and students to design and implement their experiments and support those experiments with quality-reviewed background information. In its four volumes, fundamentals of sampling and sample preparation are reinforced through broad and detailed sections dealing with Biological and Medical, Environmental and Forensic, and Food and Beverage applications. The contributions are organized to reflect the way in which analytical chemists approach a problem. It is intended for a broad audience of analytical chemists, both educators and practitioners of the art and can assist in the preparation of courses as well in the selection of sampling and sample preparation techniques to address the challenges at hand. Above all, it is designed to be helpful in learning more about these topics, as well as to encourage an interest in sampling and sample preparation by outlining the present practice of the technology and by indicating research opportunities. Sampling and Sample preparation is a large and well-defined field in Analytical Chemistry, relevant for many application areas such as medicine, environmental science, biochemistry, pharmacology, geology, and food science. This work covers all these aspects and will be extremely useful to researchers and students, who can use it as a starting point to design and implement their experiments and for quality-reviewed background information There are limited resources that Educators can use to effectively teach the fundamental aspects of modern sample preparation technology. Comprehensive Sampling and Sample Preparation addresses this need, but focuses on the common principles of new developments in extraction technologies rather than the differences between techniques thus facilitating a more thorough understanding Provides a complete overview of the field. Not only will help to save time, it will also help to make correct assessments and avoid costly mistakes in sampling in the process Sample and sample preparation are integral parts of the analytical process but are often less considered and sometimes even completely disregarded in the available literature. To fill this gap, leading scientists have contributed 130 chapters, organized in 4 volumes, covering all modern aspects of sampling and liquid, solid phase and membrane extractions, as well as the challenges associated with different types of matrices in relevant application areas
Book Synopsis Handbook of Sample Preparation by : Janusz Pawliszyn
Download or read book Handbook of Sample Preparation written by Janusz Pawliszyn and published by Wiley-Blackwell. This book was released on 2011-03-17 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover new keys to solving analytical problems using the Latest sample preparation methods Commonly viewed of as a routine task rather than as an integral component in the analytical process, sample preparation has long been undervalued as a science and underdeveloped as a technology. In an effort to reverse this trend, Handbook of Sample Preparation shows why sample preparation deserves closer scientific scrutiny, and makes a compelling case for colleges and professional laboratories to devote more resources to promote the benefits of its correct application. Handbook of Sample Preparation includes: A solid overview of standard sampling methodologies and their analytical capabilities An introduction of non-traditional sampling technologies, which address the need for solvent-free alternatives, automation, and miniaturization A discussion of the analytical shift toward performing sampling on-site, rather than in the laboratory An examination of various extraction technologies and their applications for different types of matrices A look at how to take advantage of new sampling strategies to streamline laboratory procedures, reduce research costs, and increase overall productivity An excellent primer on the fundamentals of extraction as well as a sound guide on the latest technological upgrades influencing current sampling techniques, this versatile text serves as an important and accessible tool for both students and seasoned practitioners as they seek new avenues for improving the accuracy of their analyses.
Book Synopsis Handbook of Neurosurgery by : Mark S. Greenberg
Download or read book Handbook of Neurosurgery written by Mark S. Greenberg and published by Thieme. This book was released on 2010-02-01 with total page 1356 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have...[a] low-cost, highly portable, and extremely useful reference volume, which will undoubtedly enjoy continued longevity into the foreseeable future.--Journal of NeurosurgeryA vital resource...For rapid access to the diagnosis and management of all neurosurgical things, there is no substitute.--The Journal of TRAUMA Injury, Infection, and Critical CareFor two decades, Handbook of Neurosurgery -- now in a fully updated seventh edition -- has been an invaluable companion for every neurosurgery resident and nurse, as well as neurologists and others involved in the care of patients with brain and spine disorders. Dr. Greenberg's classic text covers the breadth of neurosurgery and its allied specialties and provides the latest information on anatomy and physiology, differential diagnosis, and currently accepted principles of clinical management. Renowned for its scope and accessibility, this portable, single-volume guide is packed with more than 1,300 pages of practical information, including thousands of literature citations, handy cross-references, and a thorough index.Features: New to the seventh edition: detailed coverage of blunt cervical arterial injuries; awake craniotomies; brain mapping; new grading systems for cervical and thoracolumbar fractures; radiation safety for neurosurgeons; organ donation after cardiac death; and expanded discussion of endovascular techniques Numerous updates, including information on dural arteriovenous malformations; tumors and molecular biology; and new neuromonitoring modalities such as brain oxygen tension, cerebral microdialysis, and regional cerebral blood flow The return of basic surgical material to acquaint readers with the operating room A practical new feature called Booking the Case supplies helpful information about scheduling surgery and obtaining informed consent Highly valuable section on hot topics in neurocritical care Color highlights and full-color inserts to enhance readability Comprehensive and conveniently compact, this book is a must-have reference for neurosurgery residents and a useful tool for anyone working in the clinical neurosciences.
Book Synopsis Handbook of Cannabis and Related Pathologies by : Victor R Preedy
Download or read book Handbook of Cannabis and Related Pathologies written by Victor R Preedy and published by Academic Press. This book was released on 2016-12-31 with total page 1382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug's effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. - Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points - Presents illustrations with at least six figures, tables, and diagrams per chapter - Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment - Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse
Book Synopsis Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques by : James P. Landers
Download or read book Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques written by James P. Landers and published by CRC Press. This book was released on 2007-12-18 with total page 1598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this bestselling work continues to offer state-of-the-art information on the development and employment of capillary electrophoresis. With special emphasis on microseparations and microfluidics, it features new chapters describing the use of microchip electrophoresis and associated microtechniques, with a focus on the extraordinary breadth of work undertaken to expand CE methodologies in recent years. Enhanced by contributions from leading international experts, the Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition remains a seminal reference for the chemistry, biology, and engineering fields.
Book Synopsis Encyclopedia of Psychopharmacology by : Ian Stolerman
Download or read book Encyclopedia of Psychopharmacology written by Ian Stolerman and published by Springer Science & Business Media. This book was released on 2010-07-31 with total page 1433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Book Synopsis Endocannabinoids and Related Lipids in Chronic Pain by : Niclas Stensson
Download or read book Endocannabinoids and Related Lipids in Chronic Pain written by Niclas Stensson and published by Linköping University Electronic Press. This book was released on 2018-05-03 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Europe, approximately one in five adults experience chronic pain, pain that lasts more than three months. Chronic pain is a significant problem not only for those people suffering from chronic pain but also for society. The prevalence of chronic pain is higher in women and lower socioeconomic groups. Although chronic pain often originates in a specific site, it may eventually spread to several sites, transforming into chronic widespread pain (CWP), a condition evident in about 10% of the adult population. Approximately 1.2-5.4% are classified with fibromyalgia (FM). In addition to CWP, common symptoms of FM include, stiffness, fatigue, sleep disturbances, and cognitive dysfunction and common co-morbidities include depression and anxiety. Although FM/CWP has been reported to alter both central and peripheral nociceptive mechanisms, no objective biomarkers have been found that correlate with CWP/FM and no standard examinations such as blood test, X-ray or computed tomography can provide support for a diagnosis. Because there are no objective biomarkers that correlate with the pathophysiological processes associated with CWP/FM, this debilitating disease is difficult to diagnose and ultimately treat. However, there are some promising therapeutic targets for chronic pain with inter alia analgesic, anti-inflammatory, and stress modulating properties: the endocannabinoids (ECs) arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG) and their related lipids oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and stearoylethanolamide (SEA). This thesis investigates whether ECs and the related N-acylethanolamines (NAEs) can be used as potential biomarkers for CWP/FM. Specifically, the studies compared the peripheral and systemic levels of ECs and NAEs in 121 women with CWP/FM and in 137 healthy controls in two different cohorts. In addition, the correlation between lipid levels and common pain characteristics such as intensity, sensitivity, and duration were investigated. The EC and related lipid levels were measured using liquid chromatography in combination with tandem mass spectrometry. Multivariate data analysis was used for biomarker evaluation. Compared to the healthy controls, the CWP/FM patients had significantly higher concentrations of OEA, PEA, and SEA in muscle and plasma (p ? 0.05) and significantly higher 2-AG in plasma (p ? 0.01). These results may indicate that NAEs, are mobilized differently in painful muscles compared with pain free muscles. Moreover, increased systemic levels of NAEs and 2-AG in patients might be signs of ongoing low-grade inflammation in CWP/FM. These findings contribute to a better understanding of how peripheral and systemic factors maintain and activate chronic pain. Although the investigated lipids have statistically significant effects but biologically uncertain role in the clinical manifestations of CWP/FM. Thus plasma lipids are not a good biomarker for CWP/FM. Nevertheless, increased lipid levels indicate a metabolic asymmetry in CWP/FM, a finding that could serve as a basis for more research on pain management.
Book Synopsis Next Generation Antidepressants by : Chad E. Beyer
Download or read book Next Generation Antidepressants written by Chad E. Beyer and published by Cambridge University Press. This book was released on 2010-05-20 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.
Book Synopsis Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 1: Fundamentals And Applications by : George S Wilson
Download or read book Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 1: Fundamentals And Applications written by George S Wilson and published by World Scientific. This book was released on 2014-11-27 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume documents the transition from the development of electrochemical monitoring of brain function, now more than 40 years old, to fundamental neuroscience. This includes the links of molecular neuroscience to biobehavior, to a molecular understanding of neurologically-linked diseases and to the investigation of neuroactive molecules made possible by new detection methodology. This work should be of interest to a broad audience, especially those who are engaged in neuroscience research, for example in drug discovery, but are not familiar with electrochemical methodology.
