Handbook Of Glycosyltransferases And Related Genes

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Handbook of Glycosyltransferases and Related Genes

Author : Naoyuki Taniguchi
Publisher : Springer Science & Business Media
ISBN 13 : 4431678778
Total Pages : 668 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Handbook of Glycosyltransferases and Related Genes by : Naoyuki Taniguchi

Download or read book Handbook of Glycosyltransferases and Related Genes written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

The Molecular Immunology of Complex Carbohydrates-3

Author : Albert M. Wu
Publisher : Springer Science & Business Media
ISBN 13 : 1441978771
Total Pages : 823 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Molecular Immunology of Complex Carbohydrates-3 by : Albert M. Wu

Download or read book The Molecular Immunology of Complex Carbohydrates-3 written by Albert M. Wu and published by Springer Science & Business Media. This book was released on 2011-05-27 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Neuroglycobiology

Author : Minoru Fukuda
Publisher : Oxford University Press, USA
ISBN 13 : 9780198525387
Total Pages : 272 pages
Book Rating : 4.5/5 (253 download)

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Book Synopsis Neuroglycobiology by : Minoru Fukuda

Download or read book Neuroglycobiology written by Minoru Fukuda and published by Oxford University Press, USA. This book was released on 2005 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates play a major role in brain function. In the past decade, tremendous progress has been made in understanding their structure and function within the nervous system. This book presents a state of the art account of this rapidly expanding field.

Human Chorionic Gonadotropin (hCG)

Author : Laurence A. Cole
Publisher : Elsevier
ISBN 13 : 012384908X
Total Pages : 400 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Human Chorionic Gonadotropin (hCG) by : Laurence A. Cole

Download or read book Human Chorionic Gonadotropin (hCG) written by Laurence A. Cole and published by Elsevier. This book was released on 2010-09-21 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. It provides comprehensive information on hCG from basic science to clinical medicine Written by specialists in the field

The Glycome

Author : Adeel Malik
Publisher : CRC Press
ISBN 13 : 1000344320
Total Pages : 305 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis The Glycome by : Adeel Malik

Download or read book The Glycome written by Adeel Malik and published by CRC Press. This book was released on 2021-07-07 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.

Gangliosides in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128123427
Total Pages : 480 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Gangliosides in Health and Disease by :

Download or read book Gangliosides in Health and Disease written by and published by Academic Press. This book was released on 2018-04-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field. Contains accessible content that is ideal for students and researchers alike Written by leading authorities in the field

Polymer-Protein Conjugates

Author : Gianfranco Pasut
Publisher : Elsevier
ISBN 13 : 0444640827
Total Pages : 512 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Polymer-Protein Conjugates by : Gianfranco Pasut

Download or read book Polymer-Protein Conjugates written by Gianfranco Pasut and published by Elsevier. This book was released on 2019-10-30 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Advances in Carbohydrate Chemistry and Biochemistry

Author : David C. Baker
Publisher : Academic Press
ISBN 13 : 0323851126
Total Pages : 194 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Advances in Carbohydrate Chemistry and Biochemistry by : David C. Baker

Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by David C. Baker and published by Academic Press. This book was released on 2021-12-04 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Carbohydrate Chemistry and Biochemistry, Volume 80 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles and a Biographical Memoire for Leslie Hough. Features contributions from leading authorities and industry experts who specialize in carbohydrate chemistry, biochemistry and research Integrates the industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates Informs and updates on all the latest developments in the field

Glycomics

Author : Minoru Fukuda
Publisher : Elsevier
ISBN 13 : 0080549454
Total Pages : 461 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Glycomics by : Minoru Fukuda

Download or read book Glycomics written by Minoru Fukuda and published by Elsevier. This book was released on 2006-11-13 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the second of three in the Methods in Enzymology series, including Glycobiology (vol. 415) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.

The Role of Glycosylation in Health and Disease

Author : Gordan Lauc
Publisher : Springer Nature
ISBN 13 : 3030701158
Total Pages : 392 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis The Role of Glycosylation in Health and Disease by : Gordan Lauc

Download or read book The Role of Glycosylation in Health and Disease written by Gordan Lauc and published by Springer Nature. This book was released on 2021-09-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Experimental Glycoscience

Author : Naoyuki Taniguchi
Publisher : Springer Science & Business Media
ISBN 13 : 4431779221
Total Pages : 476 pages
Book Rating : 4.4/5 (317 download)

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Book Synopsis Experimental Glycoscience by : Naoyuki Taniguchi

Download or read book Experimental Glycoscience written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2009-03-05 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.

Biochemistry and Molecular Biology Compendium

Author : Roger L. Lundblad
Publisher : CRC Press
ISBN 13 : 1351680536
Total Pages : 551 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Biochemistry and Molecular Biology Compendium by : Roger L. Lundblad

Download or read book Biochemistry and Molecular Biology Compendium written by Roger L. Lundblad and published by CRC Press. This book was released on 2019-11-11 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Glycosylation and Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128016140
Total Pages : 418 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Glycosylation and Cancer by :

Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Understanding PTMs in Neurodegenerative Diseases

Author : Victor Corasolla Carregari
Publisher : Springer Nature
ISBN 13 : 3031054601
Total Pages : 150 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Understanding PTMs in Neurodegenerative Diseases by : Victor Corasolla Carregari

Download or read book Understanding PTMs in Neurodegenerative Diseases written by Victor Corasolla Carregari and published by Springer Nature. This book was released on 2022-08-27 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.

Multi-Step Enzyme Catalysis

Author : Eduardo Garcia-Junceda
Publisher : John Wiley & Sons
ISBN 13 : 3527623396
Total Pages : 256 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Multi-Step Enzyme Catalysis by : Eduardo Garcia-Junceda

Download or read book Multi-Step Enzyme Catalysis written by Eduardo Garcia-Junceda and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.