Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants

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Publisher : CreateSpace
ISBN 13 : 9781502846198
Total Pages : 128 pages
Book Rating : 4.8/5 (461 download)

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Book Synopsis Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants by : National Aeronautics and Space Administration

Download or read book Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants written by National Aeronautics and Space Administration and published by CreateSpace. This book was released on 2014-10-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) is preparing to launch a manned space station---Space Station Freedom--by the mid-1990s. Because Space Station Freedom will be a closed complex environment, some contamination of its atmosphere is inevitable. Several hundred chemicals are likely to be found in the closed atmosphere of the space station, most in very low concentrations. Important sources of atmospheric contaminants include metabolic waste products of crew members and off-gassing of cabin materials and equipment. Release of chemicals from experiments performed on board the space station is also a possible source of contamination, and the water reclamation system has the potential to introduce novel compounds into the air. NASA is concerned about the health, safety, and functional abilities of crews exposed to these contaminants. This report, prepared by the Committee on Toxicology of the National Research Council's Board on Environmental Studies and Toxicology, is in response to a request from NASA for guidelines to develop spacecraft maximum allowable concentrations (SMACs) for space-station contaminants. SMACs are used to provide guidance on allowable chemical exposures during normal operations and emergency situations. Short-term SMACs refer to concentrations of airborne substances (such as gas, vapor, or aerosol) that will not compromise the performance of specific tasks during emergency conditions lasting up to 24 hr. Exposure to 1- or 24-hr SMACs will not cause serious or permanent effects but may cause reversible effects that do not impair judgment or interfere with proper responses to emergencies such as fires or accidental releases. Long-term SMACs are intended to avoid adverse health effects (either immediate or delayed) and to avoid degradation in crew performance with continuous exposure in a closed space-station environment for as long as 180 days. Chemical accumulation, detoxification, excretion, and repair of toxic insults are thus important in determining 180-day SMACs.

Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants

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Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781723141171
Total Pages : 132 pages
Book Rating : 4.1/5 (411 download)

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Book Synopsis Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants by : National Aeronautics and Space Administration (NASA)

Download or read book Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants written by National Aeronautics and Space Administration (NASA) and published by Createspace Independent Publishing Platform. This book was released on 2018-07-18 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) is preparing to launch a manned space station by the year 1996. Because of concerns about the health, safety, and functioning abilities of the crews, NASA has requested that the National Research Council (NRC) through the Board on Environmental Studies and Toxicology (BEST) provide advice on toxicological matters for the space-station program. The Subcommittee on Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants was established by the Committee on Toxicology (COT) to address NASA's concerns. Spacecraft maximum allowable concentrations (SMAC's) are defined as the maximum concentrations of airborne substances (such as gas, vapor, or aerosol) that will not cause adverse health effects, significant discomfort, or degradation in crew performance. Unspecified Center ATMOSPHERIC COMPOSITION; HUMAN PERFORMANCE; LIFE SUPPORT SYSTEMS; SPACE STATION FREEDOM; SPACECRAFT CABIN ATMOSPHERES; SPACECRAFT CONTAMINATION; TOXICOLOGY; TRACE CONTAMINANTS; AEROSOLS; AIR PURIFICATION; AIR SAMPLING; FLIGHT CREWS; VAPORS...

Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants

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Publisher :
ISBN 13 : 9780309366465
Total Pages : 127 pages
Book Rating : 4.3/5 (664 download)

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Book Synopsis Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants by : National Research Council

Download or read book Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants written by National Research Council and published by . This book was released on 1992 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309183510
Total Pages : 385 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : National Research Council

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by National Research Council and published by National Academies Press. This book was released on 2000-03-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) is aware of the potential toxicological hazards to crew members that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council (NRC) to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants, and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the subcommittee. In response to this request, the NRC first developed criteria and methods for preparing SMACs for spacecraft contaminants, published in its 1992 report Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. Since then, the NRC's Subcommittee on Spacecraft Maximum Allowable Concentrations has been reviewing NASA's documentation of chemical-specific SMACs. This report is the fourth volume in the series Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. The first volume was published in 1994 and the second and third in 1996. Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants: Volume 4 has been reviewed in draft form by individuals chosen for their technical expertise and diverse perspectives in accordance with procedures approved by the NRC's Report Review Committee for reviewing NRC and Institute of Medicine reports. The purpose of that Independent review was to provide candid and critical comments to assist the NRC in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 9780585243818
Total Pages : 365 pages
Book Rating : 4.2/5 (438 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by :

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by and published by National Academies Press. This book was released on 2000 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) is aware of the potential toxicological hazards to crew members that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council (NRC) to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants, and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the subcommittee. In response to this request, the NRC first developed criteria and methods for preparing SMACs for spacecraft contaminants, published in its 1992 report Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. Since then, the NRC's Subcommittee on Spacecraft Maximum Allowable Concentrations has been reviewing NASA's documentation of chemical-specific SMACs. This report is the fourth volume in the series Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. The first volume was published in 1994 and the second and third in 1996. Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants: Volume 4 has been reviewed in draft form by individuals chosen for their technical expertise and diverse perspectives in accordance with procedures approved by the NRC's Report Review Committee for reviewing NRC and Institute of Medicine reports. The purpose of that Independent review was to provide candid and critical comments to assist the NRC in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309175127
Total Pages : 362 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : National Research Council

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by National Research Council and published by National Academies Press. This book was released on 1997-01-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) has measured numerous airborne contaminants in spacecraft during space missions because of the potential toxicological hazards to humans that might be associated with prolonged spacecraft missions. This volume reviews the spacecraft maximum allowable concentrations (SMACs) for various contaminants to determine whether NASA's recommended exposure limits are consistent with recommendations in the National Research Council's 1992 volume Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Publisher :
ISBN 13 : 9780309593854
Total Pages : 386 pages
Book Rating : 4.5/5 (938 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : National Research Council Staff

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by National Research Council Staff and published by . This book was released on 2000 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) is aware of the potential toxicological hazards to crew members that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council (NRC) to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants, and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the subcommittee. In response to this request, the NRC first developed criteria and methods for preparing SMACs for spacecraft contaminants, published in its 1992 report Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. Since then, the NRC's Subcommittee on Spacecraft Maximum Allowable Concentrations has been reviewing NASA's documentation of chemical-specific SMACs. This report is the fourth volume in the series Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. The first volume was published in 1994 and the second and third in 1996. Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants: Volume 4 has been reviewed in draft form by individuals chosen for their technical expertise and diverse perspectives in accordance with procedures approved by the NRC's Report Review Committee for reviewing NRC and Institute of Medicine reports. The purpose of that Independent review was to provide candid and critical comments to assist the NRC in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309556740
Total Pages : 408 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : Subcommittee on Spacecraft Maximum Allowable Concentration

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by Subcommittee on Spacecraft Maximum Allowable Concentration and published by National Academies Press. This book was released on 1996-02-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) has developed spacecraft maximum allowable concentrations (SMACs) for contaminants that might be found in the atmosphere within spacecraft during space missions to ensure the health and well-being of astronauts traveling and working in this unique environment. In volume 1 of this series, NASA developed SMACs for 11 compounds: acetaldehyde, ammonia, carbon monoxide, formaldehyde, Freon 113, hydrogen, methane, methanol, octamethyltrisiloxane, trimethylsilanol, and vinyl chloride. Volume 2 includes SMACs for 12 more airborne contaminants: acrolein, benzene, carbon dioxide, 2-ethoxyethanol, hydrazine, indole, mercury, methylene chloride, methyl ethyl ketone, nitromethane, 2-propoanol, and toluene. In developing SMACs from the toxicological literature, NASA followed the Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants published in 1992 by the National Research Council.

Refinements to the Methods for Developing Spacecraft Exposure Guidelines

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Publisher : National Academies Press
ISBN 13 : 0309390818
Total Pages : 65 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Refinements to the Methods for Developing Spacecraft Exposure Guidelines by : National Academies of Sciences, Engineering, and Medicine

Download or read book Refinements to the Methods for Developing Spacecraft Exposure Guidelines written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-07 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human spaceflight is inherently risky, with numerous potential hazards posed at each phase of a mission. Potential health risks during spaceflights include short-term health consequences from being in microgravity, as well as long-term health consequences that arise, or continue, months or years after a flight. Additional health considerations are risks posed by exposure to environmental contaminants onboard spacecraft. Because the International Space Station and spacecraft are closed environments that require recirculation of air and water supplies, some contamination of the air and water will occur. Even with onboard air and water purification systems, chemicals will accumulate in the air and water as they recirculate or are recycled onboard. Therefore, it is necessary for the National Aeronautics and Space Administration (NASA) to identify hazardous contaminants and determine exposure levels that are not expected to pose a health risk to astronauts. NASA uses spacecraft maximum allowance concentrations (SMACs) and spacecraft water exposure guidelines (SWEGs) to provide guidance on acceptable exposures to air and water contaminants during normal operations and emergency situations. Refinements to the Methods for Developing Spacecraft Exposure Guidelines updates the methods for establishing SMACs and SWEGs and assists NASA with identifying chemicals that need updated SMACs or SWEGs and new chemicals for which these guidelines should be developed.

Methods for Developing Spacecraft Water Exposure Guidelines

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Publisher : National Academies Press
ISBN 13 : 0309171741
Total Pages : 173 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Methods for Developing Spacecraft Water Exposure Guidelines by : National Research Council

Download or read book Methods for Developing Spacecraft Water Exposure Guidelines written by National Research Council and published by National Academies Press. This book was released on 2000-10-18 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) maintains an active interest in the environmental conditions associated with living and working in spacecraft and identifying hazards that might adversely affect the health and well-being of crew members. Despite major engineering advances in controlling the spacecraft environment, some water and air contamination appears to be inevitable. Several hundred chemical species are likely to be found in the closed environment of the spacecraft, and as the frequency, complexity, and duration of human space flight increase, identifying and understanding significant health hazards will become more complicated and more critical for the success of the missions. NASA asked the National Research Council (NRC) Committee on Toxicology to develop guidelines, similar to those developed by the NRC in 1992 for airborne substances, for examining the likelihood of adverse effects from water contaminants on the health and performance of spacecraft crews. In this report, the Subcommittee on Spacecraft Water Exposure Guidelines (SWEGs) examines what is known about water contaminants in spacecraft, the adequacy of current risk assessment methods, and the toxicologic issues of greatest concern.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309054788
Total Pages : 408 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : National Research Council

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by National Research Council and published by National Academies Press. This book was released on 1996-02-25 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) has developed spacecraft maximum allowable concentrations (SMACs) for contaminants that might be found in the atmosphere within spacecraft during space missions to ensure the health and well-being of astronauts traveling and working in this unique environment. In volume 1 of this series, NASA developed SMACs for 11 compounds: acetaldehyde, ammonia, carbon monoxide, formaldehyde, Freon 113, hydrogen, methane, methanol, octamethyltrisiloxane, trimethylsilanol, and vinyl chloride. Volume 2 includes SMACs for 12 more airborne contaminants: acrolein, benzene, carbon dioxide, 2-ethoxyethanol, hydrazine, indole, mercury, methylene chloride, methyl ethyl ketone, nitromethane, 2-propoanol, and toluene. In developing SMACs from the toxicological literature, NASA followed the Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants published in 1992 by the National Research Council.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Publisher : National Academies Press
ISBN 13 : 0309128447
Total Pages : 406 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : National Research Council

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by National Research Council and published by National Academies Press. This book was released on 2008-12-24 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: NASA is aware of the potential toxicologic hazards to crew that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the committee. This book is the fifth volume in the series Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants, and presents SMACs for acrolein, C3 to C8 aliphatic saturated aldehydes, C2 to C9 alkanes, ammonia, benzene, carbon dioxide, carbon monoxide, 1,2-dichloroethane, dimethylhydrazine, ethanol, formaldehyde, limonene, methanol, methylene dichloride, n-butanol, propylene glycol, toluene, trimethylsilanol, and xylenes.

Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants

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Author :
Publisher : National Academies
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.1/5 (594 download)

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Book Synopsis Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants by : National Research Council (U.S.). Subcommittee on Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants

Download or read book Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants written by National Research Council (U.S.). Subcommittee on Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants and published by National Academies. This book was released on 1992 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309589894
Total Pages : 363 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by : Subcommittee on Spacecraft Maximum Allowable Concentrations

Download or read book Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants written by Subcommittee on Spacecraft Maximum Allowable Concentrations and published by National Academies Press. This book was released on 1997-01-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) has measured numerous airborne contaminants in spacecraft during space missions because of the potential toxicological hazards to humans that might be associated with prolonged spacecraft missions. This volume reviews the spacecraft maximum allowable concentrations (SMACs) for various contaminants to determine whether NASA's recommended exposure limits are consistent with recommendations in the National Research Council's 1992 volume Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants.

Spacecraft Water Exposure Guidelines for Selected Contaminants

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Author :
Publisher : National Academies Press
ISBN 13 : 0309180074
Total Pages : 534 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Spacecraft Water Exposure Guidelines for Selected Contaminants by : National Research Council

Download or read book Spacecraft Water Exposure Guidelines for Selected Contaminants written by National Research Council and published by National Academies Press. This book was released on 2007-04-02 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Space Station is a closed and complex environment, so some contamination of its internal atmosphere and water system is expected. To protect space crews from contaminants in potable and hygiene water, the National Aeronautics and Space Administration (NASA) requested that the National Research Council (NRC) provide guidance on how to develop water exposure guidelines and review NASA's development of the exposure guidelines for specific chemicals. NASA selects water contaminants for which spacecraft water exposure guidelines (SWEGs) will be established; this involves identifying toxicity effects relevant to astronauts and calculating exposure concentrations on the basis of those end points. SWEGs are established for exposures of 1, 10, 100, and 1,000 days. This report is the second volume in the series, Spacecraft Water Exposure Guidelines for Selected Chemicals. SWEG reports for acetone, alkylamines, ammonia, barium, cadmium, caprolactam, formate, formaldehyde, manganese, total organic carbon, and zinc are included in this report. The committee concludes that the SWEGs developed for these chemicals are scientifically valid based on the data reviewed by NASA and are consistent with the NRC (2000) report, Methods for Developing Spacecraft Water Exposure Guidelines. SWEG reports for additional chemicals will be presented in a subsequent volume.

Methods for Developing Spacecraft Water Exposure Guidelines

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Publisher : National Academies Press
ISBN 13 : 0309071348
Total Pages : 173 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Methods for Developing Spacecraft Water Exposure Guidelines by : National Research Council

Download or read book Methods for Developing Spacecraft Water Exposure Guidelines written by National Research Council and published by National Academies Press. This book was released on 2000-11-18 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Aeronautics and Space Administration (NASA) maintains an active interest in the environmental conditions associated with living and working in spacecraft and identifying hazards that might adversely affect the health and well-being of crew members. Despite major engineering advances in controlling the spacecraft environment, some water and air contamination appears to be inevitable. Several hundred chemical species are likely to be found in the closed environment of the spacecraft, and as the frequency, complexity, and duration of human space flight increase, identifying and understanding significant health hazards will become more complicated and more critical for the success of the missions. NASA asked the National Research Council (NRC) Committee on Toxicology to develop guidelines, similar to those developed by the NRC in 1992 for airborne substances, for examining the likelihood of adverse effects from water contaminants on the health and performance of spacecraft crews. In this report, the Subcommittee on Spacecraft Water Exposure Guidelines (SWEGs) examines what is known about water contaminants in spacecraft, the adequacy of current risk assessment methods, and the toxicologic issues of greatest concern.

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

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Author :
Publisher : National Academies Press
ISBN 13 : 030907553X
Total Pages : 225 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals by : National Research Council

Download or read book Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals written by National Research Council and published by National Academies Press. This book was released on 2001-06-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.