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Guidance On Information Requirements And Chemical Safety Assessment
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Book Synopsis The MAK-Collection for Occupational Health and Safety by : Harun Parlar
Download or read book The MAK-Collection for Occupational Health and Safety written by Harun Parlar and published by John Wiley & Sons. This book was released on 2009-04-07 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides detailed, ready-to-use protocols for air monitoring methods, developed to monitor concentrations of occupational toxicants at the workplace, while they can also be used for environmental monitoring. All the methods are reliable, reproducible, adhere to quality assurance standards and cover all the required steps from sampling to the interpretation of results. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors. In addition, the advantages and disadvantages of each method are clearly outlined.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309392209 Total Pages :117 pages Book Rating :4.3/5 (93 download)
Book Synopsis Chemical Laboratory Safety and Security by : National Academies of Sciences, Engineering, and Medicine
Download or read book Chemical Laboratory Safety and Security written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-07 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Department of State charged the Academies with the task of producing a protocol for development of standard operating procedures (SOPs) that would serve as a complement to the Chemical Laboratory Safety and Security: A Guide to Prudent Chemical Management and be included with the other materials in the 2010 toolkit. To accomplish this task, a committee with experience and knowledge in good chemical safety and security practices in academic and industrial laboratories with awareness of international standards and regulations was formed. The hope is that this toolkit expansion product will enhance the use of the previous reference book and the accompanying toolkit, especially in developing countries where safety resources are scarce and experience of operators and end-users may be limited.
Book Synopsis Test No. 421: Reproduction/Developmental Toxicity Screening Test by : OECD
Download or read book Test No. 421: Reproduction/Developmental Toxicity Screening Test written by OECD and published by OECD Publishing. This book was released on 1995-07-27 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Book Synopsis Chemical Risk Assessment by : Peter Fisk
Download or read book Chemical Risk Assessment written by Peter Fisk and published by John Wiley & Sons. This book was released on 2013-10-28 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential guide and support to understanding of the science and policy, procedure and practice that underpins the REACH risk assessments required for the use and placing on the market of chemicals in the European Union. A clear understanding of information provision and how this affects the assessment of chemical safety is fundamentally important to the success of policy on chemicals and ultimately to the sustainability of the chemicals industry. Within the book, the scientific processes that underpin the policy are explained in a practical way. Importantly, it includes coverage of techniques to help solve the problems of using potentially risky and hazardous chemicals through the use of less hazardous alternatives and ‘green chemistry’, and also the analysis of the risks of the use of the most hazardous substances against the social and economic benefits of use. Chemical Risk Assessment: A Manual for REACH covers the following main themes: i) Assessment of chemical risk; ii) Risk management; iii) Hazard reduction, substitution and green chemistry; iv) Risk versus benefit – socio-economic analysis. The book acts as a practical guide and overview to chemicals risk assessment and risk management (in the EU context), as well as a support text for planning for the challenges of the future, which will see ever-increasing pressure to withdraw hazardous substances from the EU (and global) market, balanced against opportunities for innovation in the development of less hazardous chemicals.
Book Synopsis The History of Alternative Test Methods in Toxicology by :
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Book Synopsis Mixture Toxicity by : Cornelis A. M. van Gestel
Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Book Synopsis Modeling of Indoor Air Quality and Exposure by : Niren Laxmichand Nagda
Download or read book Modeling of Indoor Air Quality and Exposure written by Niren Laxmichand Nagda and published by ASTM International. This book was released on 1993 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Science and Decisions by : National Research Council
Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
Book Synopsis Environmental Pollutant Exposures and Public Health by : R M Harrison
Download or read book Environmental Pollutant Exposures and Public Health written by R M Harrison and published by Royal Society of Chemistry. This book was released on 2020-10-27 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both genes and environment have profound effects upon our health. While some environmental factors such as polluted air are high in the public consciousness, there are many other pathways for people’s exposure to toxic chemicals, such as through food, water and contaminated land. It is not only chemicals that can affect health; environmental radioactivity, pathogenic organisms and our changing climate also have implications for public health, and all contribute to the global burden of disease, leading to both disability and deaths of millions of people annually across the world. An understanding of the pathways of environmental exposure, and its effects upon health is key to developing regulations and behaviours that reduce or prevent exposure, and the consequent impacts upon health. Covering topics from dietary exposure to chemicals through to the health effects of climate change, this book brings together contributors from around the world to highlight the latest science on the impacts of environmental pollutant exposure upon public health.
Author :Organisation for Economic Co-operation and Development Publisher :Organisation for Economic Co-operation and Development ; [Montréal : Renouf] ISBN 13 :9789264122215 Total Pages : pages Book Rating :4.1/5 (222 download)
Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development
Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prudent Practices in the Laboratory by : National Research Council
Download or read book Prudent Practices in the Laboratory written by National Research Council and published by National Academies Press. This book was released on 2011-03-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prudent Practices in the Laboratory-the book that has served for decades as the standard for chemical laboratory safety practice-now features updates and new topics. This revised edition has an expanded chapter on chemical management and delves into new areas, such as nanotechnology, laboratory security, and emergency planning. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices in the Laboratory provides guidance on planning procedures for the handling, storage, and disposal of chemicals. The book offers prudent practices designed to promote safety and includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices in the Laboratory will continue to serve as the leading source of chemical safety guidelines for people working with laboratory chemicals: research chemists, technicians, safety officers, educators, and students.
Book Synopsis Niosh Pocket Guide to Chemical Hazards by : Niosh
Download or read book Niosh Pocket Guide to Chemical Hazards written by Niosh and published by www.Militarybookshop.CompanyUK. This book was released on 2012-06-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NIOSH Pocket Guide to Chemical Hazards presents information taken from the NIOSH/OSHA Occupational Health Guidelines for Chemical Hazards, from National Institute for Occupational Safety and Health (NIOSH) criteria documents and Current Intelligence Bulletins, and from recognized references in the fields of industrial hygiene, occupational medicine, toxicology, and analytical chemistry. The information is presented in tabular form to provide a quick, convenient source of information on general industrial hygiene practices. The information in the Pocket Guide includes chemical structures or formulas, identification codes, synonyms, exposure limits, chemical and physical properties, incompatibilities and reactivities, measurement methods, respirator selections, signs and symptoms of exposure, and procedures for emergency treatment.
Author :CCPS (Center for Chemical Process Safety) Publisher :John Wiley & Sons ISBN 13 :111820963X Total Pages :759 pages Book Rating :4.1/5 (182 download)
Book Synopsis Guidelines for Risk Based Process Safety by : CCPS (Center for Chemical Process Safety)
Download or read book Guidelines for Risk Based Process Safety written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guidelines for Risk Based Process Safety provides guidelines for industries that manufacture, consume, or handle chemicals, by focusing on new ways to design, correct, or improve process safety management practices. This new framework for thinking about process safety builds upon the original process safety management ideas published in the early 1990s, integrates industry lessons learned over the intervening years, utilizes applicable "total quality" principles (i.e., plan, do, check, act), and organizes it in a way that will be useful to all organizations - even those with relatively lower hazard activities - throughout the life-cycle of a company.
Book Synopsis Guidelines for Setting Specific Concentration Limits for Carcinogens in Annex I of Directive 67/548/EEC by :
Download or read book Guidelines for Setting Specific Concentration Limits for Carcinogens in Annex I of Directive 67/548/EEC written by and published by . This book was released on 1999 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Science and Judgment in Risk Assessment by : National Research Council
Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.
Book Synopsis Risk Assessment in the Federal Government by : National Research Council
Download or read book Risk Assessment in the Federal Government written by National Research Council and published by National Academies Press. This book was released on 1983-02-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of potentially hazardous substances has become a controversial issue. This volume evaluates past efforts to develop and use risk assessment guidelines, reviews the experience of regulatory agencies with different administrative arrangements for risk assessment, and evaluates various proposals to modify procedures. The book's conclusions and recommendations can be applied across the entire field of environmental health.
Author :CCPS (Center for Chemical Process Safety) Publisher :John Wiley & Sons ISBN 13 :0470935413 Total Pages :784 pages Book Rating :4.4/5 (79 download)
Book Synopsis Guidelines for Chemical Process Quantitative Risk Analysis by : CCPS (Center for Chemical Process Safety)
Download or read book Guidelines for Chemical Process Quantitative Risk Analysis written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2010-08-27 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical process quantitative risk analysis (CPQRA) as applied to the CPI was first fully described in the first edition of this CCPS Guidelines book. This second edition is packed with information reflecting advances in this evolving methodology, and includes worked examples on a CD-ROM. CPQRA is used to identify incident scenarios and evaluate their risk by defining the probability of failure, the various consequences and the potential impact of those consequences. It is an invaluable methodology to evaluate these when qualitative analysis cannot provide adequate understanding and when more information is needed for risk management. This technique provides a means to evaluate acute hazards and alternative risk reduction strategies, and identify areas for cost-effective risk reduction. There are no simple answers when complex issues are concerned, but CPQRA2 offers a cogent, well-illustrated guide to applying these risk-analysis techniques, particularly to risk control studies. Special Details: Includes CD-ROM with example problems worked using Excel and Quattro Pro. For use with Windows 95, 98, and NT.
