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Author : Alfred Rayney Waller
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (593 download)
Download or read book Glutathione Conjugation in Non-human Primates written by Alfred Rayney Waller and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Titia Martine Truce Mulders
Publisher :
ISBN 13 : 9789090079325
Total Pages : 171 pages
Book Rating : 4.0/5 (793 download)
Download or read book In Vivo Characterization of Glutathione Conjugation in Humans written by Titia Martine Truce Mulders and published by . This book was released on 1995 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (321 download)
Download or read book Toxicological Profile for Naphthalene written by and published by . This book was released on 1993 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.3/5 (91 download)
Download or read book Toxicological Profile for Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene written by and published by . This book was released on 2005 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : T.E. Gram
Publisher : Elsevier
ISBN 13 : 1483287629
Total Pages : 325 pages
Book Rating : 4.4/5 (832 download)
Download or read book Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells written by T.E. Gram and published by Elsevier. This book was released on 2013-10-22 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.
Author : Patrick M. Dansette
Publisher : Springer Science & Business Media
ISBN 13 : 1461506670
Total Pages : 716 pages
Book Rating : 4.4/5 (615 download)
Download or read book Biological Reactive Intermediates Vi written by Patrick M. Dansette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Author : Francesco De Matteis
Publisher : Springer
ISBN 13 : 1349087599
Total Pages : 305 pages
Book Rating : 4.3/5 (49 download)
Download or read book Selectivity and Molecular Mechanisms of Toxicity written by Francesco De Matteis and published by Springer. This book was released on 1987-06-18 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wanda M Haschek
Publisher : Academic Press
ISBN 13 : 0124157653
Total Pages : 3055 pages
Book Rating : 4.1/5 (241 download)
Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology written by Wanda M Haschek and published by Academic Press. This book was released on 2013-05-01 with total page 3055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Author : S. Matsunaka
Publisher : Elsevier
ISBN 13 : 1483150453
Total Pages : 582 pages
Book Rating : 4.4/5 (831 download)
Download or read book Mode of Action, Metabolism and Toxicology written by S. Matsunaka and published by Elsevier. This book was released on 2013-10-22 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pesticide Chemistry: Human Welfare and the Environment, Volume 3: Mode of Action, Metabolism and Toxicology covers the proceeding of the Fifth International Congress of Pesticide Chemistry. This book is organized into three parts that tackle relevant issues regarding the use of pesticide. The opening part tackles topics relevant to the biochemistry of pests and mode of action of pesticides, such as influence of chlorinated and parathyroid insecticide on cellular calcium regulatory mechanisms; behavioral and lethal actions of amidines on invertebrates; and insect chitin synthetase as biochemical probe for insecticidal compounds. The second part encompasses metabolism and degradation of pesticides and xenobiotics and includes topics on propesticides; selective toxicity conferred by activation; and comparative biochemistry of animal, plant, and microorganism oxidases. The last part covers the toxicology of pesticides and xenobiotics, including the role of biochemical studies in modern toxicological assessment of pesticides; neurophysiological and behavioral assessment of pesticide toxicity; and genetic toxicology applied to the assessment of mutagenic, carcinogenic, and teratogenic action of pesticides and related compounds. This book will be of great interest to chemists, biologists, botanists, and entomologists or professionals whose line of work involves the use of pesticides and who are concerned with pesticide side-effects to the users and the environment.
Author : Lars I. Eriksson
Publisher : Elsevier Health Sciences
ISBN 13 : 044306959X
Total Pages : 3221 pages
Book Rating : 4.4/5 (43 download)
Download or read book Miller's Anesthesia written by Lars I. Eriksson and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 3221 pages. Available in PDF, EPUB and Kindle. Book excerpt: From fundamental principles to advanced subspecialty procedures, this text is the go-to reference on the technical, scientific, and clinical challenges professionals face. Features new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design.
Author : H.C. Grice
Publisher : Springer Science & Business Media
ISBN 13 : 3642493718
Total Pages : 200 pages
Book Rating : 4.6/5 (424 download)
Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards written by H.C. Grice and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se~arate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refinement of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have largely been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results. Publicity surrounding toxicologic issues has created chronic public apprehension about the ability of science and government to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government and industry, with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.
Author : Mehdi Razzaghi-Abyaneh
Publisher : BoD – Books on Demand
ISBN 13 : 9535109049
Total Pages : 410 pages
Book Rating : 4.5/5 (351 download)
Download or read book Aflatoxins written by Mehdi Razzaghi-Abyaneh and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is broadly divided into five sections and 17 chapters, highlighting recent advances in aflatoxin research from epidemiology to molecular genomics and control measures, biocontrol approaches, modern analytical techniques, economic concerns and underlying mechanisms of contamination processes. This book will update readers on several cutting-edge aspects of aflatoxins research with useful up-to-date information for mycologists, toxicologists, microbiologists, agriculture scientists, plant pathologists and pharmacologists, who may be interest to understanding of the impact, significance and recent advances within the field of of aflatoxins with a focus on control strategy.
Author : Eula Bingham
Publisher : John Wiley & Sons
ISBN 13 : 0470410817
Total Pages : 5872 pages
Book Rating : 4.4/5 (74 download)
Download or read book Patty's Toxicology, 6 Volume Set written by Eula Bingham and published by John Wiley & Sons. This book was released on 2012-07-31 with total page 5872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring the improved format used in the 5th edition, this updated set presents, in logical groupings, comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures, making it essential for toxicologists and industrial hygienists. This edition has about 40% new authors who have brought a new and international perspective to interpreting industrial toxicology, and discusses new subjects such as nanotechnology, flavorings and the food industry, reactive chemical control to comprehensive chemical policy, metalworking fluids, and pharmaceuticals.
Author : Marja Sorsa
Publisher :
ISBN 13 : 9789283221272
Total Pages : 438 pages
Book Rating : 4.2/5 (212 download)
Download or read book Butadiene and Styrene written by Marja Sorsa and published by . This book was released on 1993 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both butadiene and styrene are produced in high volumes; their combined annual production is 20 million tons. They occur together in many industrial and commercial products, including latexes, polymers, adhesives, and particularly in styrene-butadiene rubber tires. Styrene was classified in 1987 within IARC criteria as 2B (possibly carcinogenic to humans); 1,3-butadiene was placed in class 2A (probably carcinogenic to humans) at the meeting of a working group convened by IARC in 1991. This volume brings together the latest information about the toxic hazards of the two compounds. The focus of research on styrene seems to be its neurotoxicological effects and its potential carcinogenicity. Interest in 1,3-butadiene is much more recent and appears to be directed primarily towards species-specific differences in its carcinogenicity. Papers included in this volume were selected so that current data obtained by ambient and biological monitoring and on genetic toxicity and carcinogenicity are amply covered for both compounds. Seven main areas of research are covered: exposures to butadiene and styrene; estimation of internal doses received by exposed people; measurements of metabolites and of adducts with DNA and protein as markers of exposure; neurotoxicity and reproductive effects; genetic toxicity; carcinogenicity; and implications for public health. New results from epidemiological studies of subjects occupationally exposed to butadiene and to styrene are reported. Special consideration is given to the need for developing and validating biological markers of exposure to butadiene and to styrene in order to measure biological effects and susceptibility in human populations, so that adverse effects can be detected earlier and action taken to reduce public health risks. Information on the mechanisms of carcinogenic action is reviewed, since differences between species with respect to such mechanisms can have a major bearing on the extrapolation to human of findings of carcinogenicity in animals. These topics, representing the 'state of the art' with respect to scientific knowledge about the toxic manifestations and mechanisms of 1,3-butadiene and styrene are all covered in this volume.
Author : Shayne C. Gad
Publisher : CRC Press
ISBN 13 : 142001420X
Total Pages : 950 pages
Book Rating : 4.4/5 (2 download)
Download or read book Animal Models in Toxicology written by Shayne C. Gad and published by CRC Press. This book was released on 2006-10-30 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
Author : Ross Cameron
Publisher : Springer Science & Business Media
ISBN 13 : 3642610137
Total Pages : 701 pages
Book Rating : 4.6/5 (426 download)
Download or read book Drug-Induced Hepatotoxicity written by Ross Cameron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances in science and medicine we are now experiencing are unprec edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.
Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
