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Author :
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.3/5 (91 download)
Download or read book Global Assessment of the State-of-the-science of Endocrine Disruptors written by and published by . This book was released on 2002 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse
Publisher :
ISBN 13 : 9780309297547
Total Pages : 0 pages
Book Rating : 4.2/5 (975 download)
Download or read book Review of the Environmental Protection Agency's State-of-the-science Evaluation of Nonmonotonic Dose-response Relationships as They Apply to Endocrine Disruptors written by National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.
Author : Heather B. Patisaul
Publisher : Oxford University Press
ISBN 13 : 0199935734
Total Pages : 273 pages
Book Rating : 4.1/5 (999 download)
Download or read book Endocrine Disruptors, Brain, and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. This work focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. It provides an overall synthesis of the EDC field including its historical roots, major hypotheses, key findings, public health policy implications, and research gaps.
Author : Alexandra Fucic
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017412
Total Pages : 539 pages
Book Rating : 4.7/5 (88 download)
Download or read book Challenges in Endocrine Disruptor Toxicology and Risk Assessment written by Alexandra Fucic and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
Author : Germaine Buck Louis
Publisher : World Health Organization
ISBN 13 : 924157237X
Total Pages : 352 pages
Book Rating : 4.2/5 (415 download)
Download or read book Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals written by Germaine Buck Louis and published by World Health Organization. This book was released on 2006 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conclusions, and recommendations -- Introduction and background -- Unique biological characteristics of children -- Developmental stage-specific susceptibilities and outcomes in children -- Exposure assessment of children -- Methodologies to assess health outcomes in children -- Implications and strategies for risk assessment for children.
Author : Jean-Francois Férard
Publisher : Springer
ISBN 13 : 9789400750401
Total Pages : 0 pages
Book Rating : 4.7/5 (54 download)
Download or read book Encyclopedia of Aquatic Ecotoxicology written by Jean-Francois Férard and published by Springer. This book was released on 2013-06-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its 104 chapters, this Encyclopedia of aquatic ecotoxicology reveals the diversity of issues, problems and challenges that have faced, and are facing today, receiving environments. It also indicates ways by which tools, strategies and future investigations can contribute to correct, minimize, solve and prevent water quality degradation. Structured homogeneously, the chapters convey salient information on historical background, features, characteristics, uses and/or applications of treated topics, often complemented by illustrations and case studies, as well as by conclusions and prospects. This work is most suitable for teaching purposes. Academics, for example, could literally deliver comprehensive lectures to students simply based on chapter outlines and contents. Meet the Authors of the Encyclopedia! Check out 'Meet the Authors' under ADDITIONAL INFORMATION (Right menu).
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309174260
Total Pages : 452 pages
Book Rating : 4.3/5 (91 download)
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-01-03 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Author : Susan Buckingham
Publisher : Routledge
ISBN 13 : 1134703953
Total Pages : 164 pages
Book Rating : 4.1/5 (347 download)
Download or read book Gender and Environment written by Susan Buckingham and published by Routledge. This book was released on 2005-08-18 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accessible and lively, this is the first introductory level text to introduce the key issues in the rapidly growing area of gender and environment. This text provides an analysis of how gender relations affect the natural environment and of how environmental issues have a differential impact on women and men. Using case studies from the developed and developing worlds, this text covers · gendered roles in the family · community and international connections · conception · giving birth · western practices · the body and the self.
Author : Sushil K. Khetan
Publisher : John Wiley & Sons
ISBN 13 : 1118891155
Total Pages : 410 pages
Book Rating : 4.1/5 (188 download)
Download or read book Endocrine Disruptors in the Environment written by Sushil K. Khetan and published by John Wiley & Sons. This book was released on 2014-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.
Author : Suzanne H. Reuben
Publisher : DIANE Publishing
ISBN 13 : 1437934218
Total Pages : 240 pages
Book Rating : 4.4/5 (379 download)
Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.
Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Author : Jones B. Graceli
Publisher : Frontiers Media SA
ISBN 13 : 2889633438
Total Pages : 75 pages
Book Rating : 4.8/5 (896 download)
Download or read book Organotins as a Complete Physiologic and Endocrine Disruptor: Role of Disease Development written by Jones B. Graceli and published by Frontiers Media SA. This book was released on 2020-01-17 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marcelo Larramendy
Publisher : BoD – Books on Demand
ISBN 13 : 953512160X
Total Pages : 242 pages
Book Rating : 4.5/5 (351 download)
Download or read book Emerging Pollutants in the Environment written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2015-09-02 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, Emerging Pollutants in the Environment Current and Further Implications, includes overviews by significant researchers on the topic of emerging pollutants toxicology, which covers the hazardous effects of common emerging xenobiotics employed in our every day anthropogenic activities. We hope that this book will meet the expectations and needs of all those who are interested in the negative implications of several emerging pollutants on living species.
Author : John E. Elliott
Publisher : Springer Science & Business Media
ISBN 13 : 0387894322
Total Pages : 476 pages
Book Rating : 4.3/5 (878 download)
Download or read book Wildlife Ecotoxicology written by John E. Elliott and published by Springer Science & Business Media. This book was released on 2011-08-27 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many books have now been published in the broad field of environmental toxicology. However, to date, none of have presented the often fascinating stories of the wildlife science, and the steps along the way from discovery of problems caused by environmental pollutants to the regulatory and non-regulatory efforts to address the problems. This book provides case by case examinations of how toxic chemical effects on wildlife have brought about policy and regulatory decisions, and positive changes in environmental conditions. Wild animal stories, whether they are about the disappearance of charismatic top predators, or of grossly deformed embryos or frogs, provide powerful symbols that can and have captured the public's imagination and have resulted in increased awareness by decision makers. It is the intent of this book to present factual and balanced overviews and summaries of the science and the subsequent regulatory processes that followed to effect change (or not). We cover a variety of chemicals and topics beginning with an update of the classic California coastal DDT story of eggshell thinning and avian reproduction to more recent cases, such as the veterinarian pharmaceutical that has brought three species of Asian vultures to the brink of extinction. Researchers, regulators, educators, NGOs and the general public will find valuable insights into the processes and mechanisms involved both in environmental scientific investigation and in efforts to effect positive change.
Author : Aristidis M. Tsatsakis
Publisher : Elsevier
ISBN 13 : 0323853587
Total Pages : 684 pages
Book Rating : 4.3/5 (238 download)
Download or read book Toxicological Risk Assessment and Multi-System Health Impacts from Exposure written by Aristidis M. Tsatsakis and published by Elsevier. This book was released on 2021-08-01 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Author : Elsa Nielsen
Publisher : CRC Press
ISBN 13 : 1420006940
Total Pages : 450 pages
Book Rating : 4.4/5 (2 download)
Download or read book Toxicological Risk Assessment of Chemicals written by Elsa Nielsen and published by CRC Press. This book was released on 2008-02-21 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128011203
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
