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Author : Vivian Kahl
Publisher : Frontiers Media SA
ISBN 13 : 2889746917
Total Pages : 168 pages
Book Rating : 4.8/5 (897 download)
Download or read book Genome Instability: Old Problem, New Solutions written by Vivian Kahl and published by Frontiers Media SA. This book was released on 2022-03-15 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erich A. Nigg
Publisher : Springer Science & Business Media
ISBN 13 : 1402037643
Total Pages : 509 pages
Book Rating : 4.4/5 (2 download)
Download or read book Genome Instability in Cancer Development written by Erich A. Nigg and published by Springer Science & Business Media. This book was released on 2006-01-14 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.
Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)
Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Author : Leon P. Bignold
Publisher : Springer Science & Business Media
ISBN 13 : 3764373784
Total Pages : 377 pages
Book Rating : 4.7/5 (643 download)
Download or read book Cancer: Cell Structures, Carcinogens and Genomic Instability written by Leon P. Bignold and published by Springer Science & Business Media. This book was released on 2006-01-27 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genetic instability. The invitation came while I was working with Herrn Dr. med. Hubertus Jersmann (MD Düsseldorf, PhD, now Senior Lecturer in Medicine of the University of Adelaide) and Professor Brian Coghlan (Emeritus Professor of German, the University of Adelaide), on the work of the nineteenth century cancer pathologists, especially David Paul von Hansemann (1858–1920). With the delivery of the manuscripts from the authors of the chapters, it became obvious that a background chapter for the volume could include some of the material which we had “uncovered” together. Because of this, chapter 1 is authored by the three of us, and the “new” material figures prominently.
Author : Günter Obe
Publisher : Springer Science & Business Media
ISBN 13 : 3540714146
Total Pages : 526 pages
Book Rating : 4.5/5 (47 download)
Download or read book Chromosomal Alterations written by Günter Obe and published by Springer Science & Business Media. This book was released on 2007-06-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.
Author : Nicholas E. Geacintov
Publisher : John Wiley & Sons
ISBN 13 : 3527642110
Total Pages : 446 pages
Book Rating : 4.5/5 (276 download)
Download or read book The Chemical Biology of DNA Damage written by Nicholas E. Geacintov and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.
Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)
Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Author :
Publisher :
ISBN 13 :
Total Pages : 1620 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Debasis Bagchi
Publisher : CRC Press
ISBN 13 : 0203506707
Total Pages : 693 pages
Book Rating : 4.2/5 (35 download)
Download or read book Phytopharmaceuticals in Cancer Chemoprevention written by Debasis Bagchi and published by CRC Press. This book was released on 2004-10-28 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, a significant amount of research has been conducted on phytopharmaceuticals. Today, a growing body of evidence demonstrates the efficacy of a wide variety of natural products and affirms their potential in the treatment of cancer. Phytopharmaceuticals in Cancer Chemoprevention focuses on the role of natural supplemen
Author : William E. Luttrell
Publisher : AIHA
ISBN 13 : 1931504881
Total Pages : 468 pages
Book Rating : 4.9/5 (315 download)
Download or read book Toxicology Principles for the Industrial Hygienist written by William E. Luttrell and published by AIHA. This book was released on 2008 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the applications of toxicology principles to the practice of industrial hygiene, using case studies as examples.
Author : Charles Levenstein
Publisher : Guilford Press
ISBN 13 : 9781572302341
Total Pages : 558 pages
Book Rating : 4.3/5 (23 download)
Download or read book Work, Health, and Environment written by Charles Levenstein and published by Guilford Press. This book was released on 1997-07-19 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an indispensable collection on the crisis of worker health and safety in the United States. This collection offers an all-important lesson for the labor movement: that problems of occupational health and safety are not merely technical problems but rather problems relating to workers' lack of control over the organization of capitalist production.
Author :
Publisher : Elsevier
ISBN 13 : 0080463444
Total Pages : 618 pages
Book Rating : 4.0/5 (84 download)
Download or read book DNA Repair, Part A written by and published by Elsevier. This book was released on 2006-06-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair, Part A provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. - A laboratory standard for more than 40 years - Over 400 volumes strong - Also available on ScienceDirect - Part A of a 2-part series
Author : Andreas Luch
Publisher : World Scientific
ISBN 13 : 1783260874
Total Pages : 514 pages
Book Rating : 4.7/5 (832 download)
Download or read book The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons written by Andreas Luch and published by World Scientific. This book was released on 2005-08-22 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.
Author : Tian Ding
Publisher : Springer Nature
ISBN 13 : 9811618275
Total Pages : 357 pages
Book Rating : 4.8/5 (116 download)
Download or read book Applications of Cold Plasma in Food Safety written by Tian Ding and published by Springer Nature. This book was released on 2021-11-08 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with a comprehensive overview of cold plasma technology for tackling the various food-related hazards in a wide range of food sectors. The principles and characteristics of cold plasma generation in gas and its interaction with liquids, as well as its combating modes of action for common hazards (e.g., bacteria, spores, biofilms, fungi, and fungal toxins) are emphasized in this book. It also presents the applications of cold plasma or its hurdles with other techniques to assure the microbiological safety of the key food classifications, including fruits, vegetables, cereals, grains, meat, aquatic products, liquid food products (e.g., juices, milk), nuts, spices, herbs, and food packaging. This book is useful for researchers to grasp the comprehensive understandings of how food safety can be controlled with cold plasma technology. This book also provides adequate information for engineers in food industry for better development and optimization of the plasma-generating systems. Government institutions that are responsible for food safety regulations can understand more knowledge about the intricacies and influencing factors, which should be considered for regulating the applications of cold plasma technology in food.
Author : NN Misra
Publisher : Academic Press
ISBN 13 : 012801489X
Total Pages : 382 pages
Book Rating : 4.1/5 (28 download)
Download or read book Cold Plasma in Food and Agriculture written by NN Misra and published by Academic Press. This book was released on 2016-07-15 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold Plasma in Food and Agriculture: Fundamentals and Applications is an essential reference offering a broad perspective on a new, exciting, and growing field for the food industry. Written for researchers, industry personnel, and students interested in nonthermal food technology, this reference will lay the groundwork of plasma physics, chemistry, and technology, and their biological applications. Food scientists and food engineers interested in understanding the theory and application of nonthermal plasma for food will find this book valuable because it provides a roadmap for future developments in this emerging field. This reference is also useful for biologists, chemists, and physicists who wish to understand the fundamentals of plasma physics, chemistry, and technology and their biological interactions through applying novel plasma sources to food and other sensitive biomaterials. - Examines the topic of cold plasma technology for food applications - Demonstrates state-of-the-art developments in plasma technology and potential solutions to improve food safety and quality - Presents a solid introduction for readers on the topics of plasma physics and chemistry that are required to understand biological applications for foods - Serves as a roadmap for future developments for food scientists, food engineers, and biologists, chemists, and physicists working in this emerging field
Author : Katharina Richter
Publisher : Springer Nature
ISBN 13 : 3031109929
Total Pages : 569 pages
Book Rating : 4.0/5 (311 download)
Download or read book Antibiofilm Strategies written by Katharina Richter and published by Springer Nature. This book was released on 2022-09-28 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteria and fungi are able to aggregate together or on surfaces in densely packed microcolonies, facilitated by extracellular polymeric substances for cell protection and stability. These biofilms have proven to be extremely hard to eradicate and remove once established. In chronic infections, this condition can result in a high degree of morbidity and mortality as regular antibiotic treatments are ineffective against biofilms. In industrial facilities, the formation of biofilms can ruin production and result in enormous financial losses. In this book, the current state of antibiofilm research is presented by experts from around the world. Novel, cutting-edge techniques and new optimized strategies based on established methods are discussed in chapters focused on biofilm prevention, treatment and control for the application in clinical, industrial and veterinary settings. Antibiofilm strategies, such as chemical and enzymatic treatments, surface modification and coatings, quorum sensing inhibition and dispersal induction, phage therapy, cold plasma treatment, hyperbaric oxygen treatment, and metal-based nanomedicine are covered, among many others. This book contributes to the UN’s Sustainable Development Goal 3: Good Health and Well-Being and is a valuable resource for healthcare professionals, microbiologists, academics and for educators to inform curricula of universities and colleges.
Author :
Publisher :
ISBN 13 :
Total Pages : 2036 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt:
