Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study)

Download Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study) PDF Online Free

Author :
Publisher : DIANE Publishing
ISBN 13 : 1428988114
Total Pages : 147 pages
Book Rating : 4.4/5 (289 download)

DOWNLOAD NOW!


Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-03 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Benzene is used primarily as a solvent in the chemical & pharmaceutical industries, as a starting material & intermediate in the synthesis of numerous chemicals, & in gasoline. The major U.S. source of benzene is petroleum. Benzene has been previously evaluated in 2-year carcinogenicity studies. In this study, the carcinogenic effects of benzene were studied in the haplo-insufficient p16Ink4a/p19Arf mouse model as part of an ongoing effort to seek improved model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic information relative to understanding an agent¿s mode of action. Illustrations.

Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study)

Download Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) PDF Online Free

Author :
Publisher : DIANE Publishing
ISBN 13 : 1437902243
Total Pages : 81 pages
Book Rating : 4.4/5 (379 download)

DOWNLOAD NOW!


Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-06 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycidol is used as a chemical intermediate in the pharmaceutical industry, as a stabilizer in the manufacture of vinyl polymers, and as an intermediate in the synthesis of glycerol, Glycidol ethers, and amines. Glycidol was nominated for carcinogenecity study by the Environmental Protection Agency (EPA). Glycidol was selected for study in the haploinsufficient p16Ink4a/p19Arf mouse because it was found to be carcinogenic in rats and mice in conventional 2-year rodent studies (NTP, 1990), but was negative in a study in p53+/- mice (Tennant et al., 1999). In this study, male and female mice received Glycidol (greater than 95% pure) by gavage for 40 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP GMM.

Download NTP GMM. PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!


Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP GMM.

Download NTP GMM. PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!


Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mutagenic Impurities

Download Mutagenic Impurities PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119551218
Total Pages : 548 pages
Book Rating : 4.1/5 (195 download)

DOWNLOAD NOW!


Book Synopsis Mutagenic Impurities by : Andrew Teasdale

Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

Principles & Practice of Neuro-Oncology

Download Principles & Practice of Neuro-Oncology PDF Online Free

Author :
Publisher : Demos Medical Publishing
ISBN 13 : 1617050148
Total Pages : 967 pages
Book Rating : 4.6/5 (17 download)

DOWNLOAD NOW!


Book Synopsis Principles & Practice of Neuro-Oncology by :

Download or read book Principles & Practice of Neuro-Oncology written by and published by Demos Medical Publishing. This book was released on 2010-10-21 with total page 967 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-oncologic (brain and spine) cancers account for 19,000 new cases and 13,000 deaths per year. The early and proper diagnosis of these virulent cancers is critical to patient outcomes and diagnosis and treatment strategies are continually evolving. The multidisciplinary team that manages these patients involves medical and radiation oncology, neurosurgery, neuroimaging, nurses and therapists. Principles and Practices of Neuro-Oncology establishes a new gold standard in care through a comprehensive, multidisciplinary text covering all aspects of neuro-oncology. Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric cancers. Expert contributors from multiple disciplines provide detailed and in-depth discussions of the entire field of neuro-oncology including histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches. With contributions from over 180 authors, numerous diagrams, illustrations and tables, and a 48 page color section, Principles and Practice of Neuro-Oncology reflects the breadth and depth of this multi-faceted specialty.

Genotoxic Impurities

Download Genotoxic Impurities PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470934751
Total Pages : 455 pages
Book Rating : 4.4/5 (79 download)

DOWNLOAD NOW!


Book Synopsis Genotoxic Impurities by : Andrew Teasdale

Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981

Download Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 PDF Online Free

Author :
Publisher :
ISBN 13 : 9789283212294
Total Pages : 0 pages
Book Rating : 4.2/5 (122 download)

DOWNLOAD NOW!


Book Synopsis Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 by :

Download or read book Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Carcinogenic Potency and Genotoxicity Databases

Download Handbook of Carcinogenic Potency and Genotoxicity Databases PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Substances of Abuse

Download Substances of Abuse PDF Online Free

Author :
Publisher : Royal Society of Chemistry
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.E/5 ( download)

DOWNLOAD NOW!


Book Synopsis Substances of Abuse by : John H. Duffus

Download or read book Substances of Abuse written by John H. Duffus and published by Royal Society of Chemistry. This book was released on 1997 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be an invaluable source of reference to occupational health workers, industrial health and safety professionals, toxicologists and professionals in drug metabolism.

Handbook of Carcinogen Testing

Download Handbook of Carcinogen Testing PDF Online Free

Author :
Publisher : William Andrew Inc.
ISBN 13 : 9780815513568
Total Pages : 856 pages
Book Rating : 4.5/5 (135 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Carcinogen Testing by : Harry A. Milman

Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.

Chemical Carcinogenesis

Download Chemical Carcinogenesis PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

DOWNLOAD NOW!


Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Textbook of Neuro-oncology

Download Textbook of Neuro-oncology PDF Online Free

Author :
Publisher : Saunders
ISBN 13 :
Total Pages : 884 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Textbook of Neuro-oncology by : Mitchel S. Berger

Download or read book Textbook of Neuro-oncology written by Mitchel S. Berger and published by Saunders. This book was released on 2005 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new resource presents today's most comprehensive, multidisciplinary coverage of cancers of the central and peripheral nervous system. Experts in neurosurgery, neuroradiology, neuropathology, neuro-oncology, and all other relevant fields present well-rounded, in-depth, cutting-edge information on epidemiology, diagnosis, and treatment for each type of tumor entity. This practical organization allows readers to efficiently access complete clinical knowledge on any form of neurological cancer.

Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study)

Download Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) PDF Online Free

Author :
Publisher : DIANE Publishing
ISBN 13 : 1428988815
Total Pages : 364 pages
Book Rating : 4.4/5 (289 download)

DOWNLOAD NOW!


Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-04 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenolphthalein (PH) was commonly used as a laxative for most of the 20th cent. The use of PH in laxatives has decreased since 1997 when the FDA proposed to withdraw its classification as an OTC drug. PH has been previously evaluated in carcinogenecity studies in 1996. The major route of human exposure to PH is via ingestion, dermal contact, & inhalation of contaminated air originating from process units manufacturing the compound. In this study, the carcinogenic effects of PH were studied in the haploinsufficient p16Ink4a/p19Arf mouse model as an ongoing goal to seek model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic info. relative to understanding an agent¿s model of action. Illustrations.

Chemical Carcinogenesis

Download Chemical Carcinogenesis PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468443348
Total Pages : 496 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!


Book Synopsis Chemical Carcinogenesis by : Claudio Nicolini

Download or read book Chemical Carcinogenesis written by Claudio Nicolini and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.

Principles of Neuro-Oncology

Download Principles of Neuro-Oncology PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9783030548810
Total Pages : 982 pages
Book Rating : 4.5/5 (488 download)

DOWNLOAD NOW!


Book Synopsis Principles of Neuro-Oncology by : Alejandro Monroy-Sosa

Download or read book Principles of Neuro-Oncology written by Alejandro Monroy-Sosa and published by Springer. This book was released on 2021-12-24 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the management of brain and skull base tumors. It features detailed insight into the intrinsic molecular biology, anatomical foundation, radiological planning, surgical execution, and the novel therapeutics that guide today’s treatment regimens. The first section features concepts related to the epidemiology and pathological basis of disease processes, including relevant cellular and molecular biology. In the second section, integral anatomical foundations and principles are covered including microsurgical anatomy of the cerebrum, white matter tracts, ventricles, brainstem, skull base, advancements in radiological imaging, and cognitive examinations. Surgical approaches and how to execute these procedures are then subsequently discussed in the third part of the work. Principles of Neuro-Oncology: Brain & Skull Base is a practically applicable guide to the latest treatment techniques available to treat these patients. Therefore, it is an indispensable resource for all physicians who utilize these methodologies in their day-to-day practice.

Toxicological Profile for Benzene

Download Toxicological Profile for Benzene PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Toxicological Profile for Benzene by : Oak Ridge National Laboratory

Download or read book Toxicological Profile for Benzene written by Oak Ridge National Laboratory and published by . This book was released on 1989 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: