Genetically Modified Model Report On Toxicology And Carcinogenesis Study Of Benzene Cas No 71 43 1 In Genetically Modified Haplo Insufficient P16ink4a P19arf Mice Gavage Study

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Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study)

Author : J. K. Dunnick
Publisher : DIANE Publishing
ISBN 13 : 1428988114
Total Pages : 147 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-03 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Benzene is used primarily as a solvent in the chemical & pharmaceutical industries, as a starting material & intermediate in the synthesis of numerous chemicals, & in gasoline. The major U.S. source of benzene is petroleum. Benzene has been previously evaluated in 2-year carcinogenicity studies. In this study, the carcinogenic effects of benzene were studied in the haplo-insufficient p16Ink4a/p19Arf mouse model as part of an ongoing effort to seek improved model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic information relative to understanding an agent¿s mode of action. Illustrations.

Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study)

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Author : J. K. Dunnick
Publisher : DIANE Publishing
ISBN 13 : 1437902243
Total Pages : 81 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-06 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycidol is used as a chemical intermediate in the pharmaceutical industry, as a stabilizer in the manufacture of vinyl polymers, and as an intermediate in the synthesis of glycerol, Glycidol ethers, and amines. Glycidol was nominated for carcinogenecity study by the Environmental Protection Agency (EPA). Glycidol was selected for study in the haploinsufficient p16Ink4a/p19Arf mouse because it was found to be carcinogenic in rats and mice in conventional 2-year rodent studies (NTP, 1990), but was negative in a study in p53+/- mice (Tennant et al., 1999). In this study, male and female mice received Glycidol (greater than 95% pure) by gavage for 40 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP GMM.

Author :
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (9 download)

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Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study)

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Author : National Toxicology Program (U.S.)
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (241 download)

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Book Synopsis NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) by : National Toxicology Program (U.S.)

Download or read book NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) written by National Toxicology Program (U.S.) and published by . This book was released on 2007 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)

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Author : G. A. Boorman
Publisher :
ISBN 13 : 9781422315224
Total Pages : 227 pages
Book Rating : 4.3/5 (152 download)

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Book Synopsis Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) by : G. A. Boorman

Download or read book Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromodichloromethane (BD) is a by-product of the chlorination of drinking water. It is formed by the halogen substitution & oxidation reactions of chlorine & naturally occurring organic matter (e.g., humic or fluvic acids) in water containing bromide. BD was nominated to the Nat. Toxicology Program for toxicology & carcinogenecity studies. Male & female Tb.AC hemizygous mice received bromodichloromethane (at least 99% pure) by dermal application for 26 or 39 weeks, in drinking water for 26 or 42 weeks, or by gavage for 26 or 41 weeks. p53 Haploinsufficient mice received BD in drinking water for 26 or 42 weeks or by gavage for 26 or 42 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP GMM.

Author :
Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.:/5 (9 download)

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Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mutagenic Impurities

Author : Andrew Teasdale
Publisher : John Wiley & Sons
ISBN 13 : 1119551218
Total Pages : 548 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Mutagenic Impurities by : Andrew Teasdale

Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

Genotoxic Impurities

Author : Andrew Teasdale
Publisher : John Wiley & Sons
ISBN 13 : 0470934751
Total Pages : 455 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Genotoxic Impurities by : Andrew Teasdale

Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Principles & Practice of Neuro-Oncology

Author :
Publisher : Demos Medical Publishing
ISBN 13 : 1617050148
Total Pages : 750 pages
Book Rating : 4.6/5 (17 download)

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Download or read book Principles & Practice of Neuro-Oncology written by and published by Demos Medical Publishing. This book was released on 2010-10-21 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-oncologic (brain and spine) cancers account for 19,000 new cases and 13,000 deaths per year. The early and proper diagnosis of these virulent cancers is critical to patient outcomes and diagnosis and treatment strategies are continually evolving. The multidisciplinary team that manages these patients involves medical and radiation oncology, neurosurgery, neuroimaging, nurses and therapists. Principles and Practices of Neuro-Oncology establishes a new gold standard in care through a comprehensive, multidisciplinary text covering all aspects of neuro-oncology. Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric cancers. Expert contributors from multiple disciplines provide detailed and in-depth discussions of the entire field of neuro-oncology including histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches. With contributions from over 180 authors, numerous diagrams, illustrations and tables, and a 48 page color section, Principles and Practice of Neuro-Oncology reflects the breadth and depth of this multi-faceted specialty.

Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981

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Author :
Publisher :
ISBN 13 : 9789283212294
Total Pages : 0 pages
Book Rating : 4.2/5 (122 download)

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Book Synopsis Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 by :

Download or read book Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Carcinogenic Potency and Genotoxicity Databases

Author : Lois Swirsky Gold
Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

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Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Substances of Abuse

Author : John H. Duffus
Publisher : Royal Society of Chemistry
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Substances of Abuse by : John H. Duffus

Download or read book Substances of Abuse written by John H. Duffus and published by Royal Society of Chemistry. This book was released on 1997 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be an invaluable source of reference to occupational health workers, industrial health and safety professionals, toxicologists and professionals in drug metabolism.

Handbook of Carcinogen Testing

Author : Harry A. Milman
Publisher : William Andrew Inc.
ISBN 13 : 9780815513568
Total Pages : 856 pages
Book Rating : 4.5/5 (135 download)

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Book Synopsis Handbook of Carcinogen Testing by : Harry A. Milman

Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.

Benzene Carcinogenicity

Author : Muzaffer Aksoy
Publisher : CRC Press
ISBN 13 : 1351368907
Total Pages : 228 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Benzene Carcinogenicity by : Muzaffer Aksoy

Download or read book Benzene Carcinogenicity written by Muzaffer Aksoy and published by CRC Press. This book was released on 2017-07-28 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth exploration of Benzene Carcinogenicity including source, measurement, analysis, and clinical conclusions.

Toxicological Profile for Benzene

Author :
Publisher :
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.3/5 (91 download)

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Download or read book Toxicological Profile for Benzene written by and published by . This book was released on 2007 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Carcinogenesis

Author : Trevor M. Penning
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

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Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Textbook of Neuro-oncology

Author : Mitchel S. Berger
Publisher : Saunders
ISBN 13 :
Total Pages : 884 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Textbook of Neuro-oncology by : Mitchel S. Berger

Download or read book Textbook of Neuro-oncology written by Mitchel S. Berger and published by Saunders. This book was released on 2005 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new resource presents today's most comprehensive, multidisciplinary coverage of cancers of the central and peripheral nervous system. Experts in neurosurgery, neuroradiology, neuropathology, neuro-oncology, and all other relevant fields present well-rounded, in-depth, cutting-edge information on epidemiology, diagnosis, and treatment for each type of tumor entity. This practical organization allows readers to efficiently access complete clinical knowledge on any form of neurological cancer.