Gene Mapping, Discovery, and Expression

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Publisher : Springer Science & Business Media
ISBN 13 : 1597450979
Total Pages : 335 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Gene Mapping, Discovery, and Expression

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (748 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The general underlying theme of "Gene Mapping, Discovery, and Expression" is DNA-sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and analysis. This volume also provides a computational protocol for identifying and mapping recent segmental and gene duplications, as well as step-by-step procedures for identifying paralogous genes, using the genome browser at UCSC. Lastly, several chapters in this volume offer non-invasive technologies for the isolation of transcription factor complexes formed with specific DNA sequences used as bait. These methods can lead to the discovery of novel transcription factors with important roles in the control of gene expression.

Mapping and Sequencing the Human Genome

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Author :
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Gene Discovery for Disease Models

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118002172
Total Pages : 642 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Gene Discovery for Disease Models by : Weikuan Gu

Download or read book Gene Discovery for Disease Models written by Weikuan Gu and published by John Wiley & Sons. This book was released on 2011-03-03 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).

Gene Mapping, Discovery, and Expression

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Author :
Publisher : Humana Press
ISBN 13 : 9781588295750
Total Pages : 334 pages
Book Rating : 4.2/5 (957 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by Humana Press. This book was released on 2006-04-01 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Advances in Genomic Sequence Analysis and Pattern Discovery

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Author :
Publisher : World Scientific
ISBN 13 : 9814327727
Total Pages : 236 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Advances in Genomic Sequence Analysis and Pattern Discovery by : Laura Elnitski

Download or read book Advances in Genomic Sequence Analysis and Pattern Discovery written by Laura Elnitski and published by World Scientific. This book was released on 2011 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

Molecular Biology of The Cell

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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene-Mapping Techniques and Applications

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Author :
Publisher : CRC Press
ISBN 13 : 9780824785352
Total Pages : 360 pages
Book Rating : 4.7/5 (853 download)

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Book Synopsis Gene-Mapping Techniques and Applications by : Lawrence B. Schook

Download or read book Gene-Mapping Techniques and Applications written by Lawrence B. Schook and published by CRC Press. This book was released on 1991-05-15 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.

Genetic Analysis of Complex Disease

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Publisher : John Wiley & Sons
ISBN 13 : 0471781134
Total Pages : 507 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Genetic Analysis of Complex Disease by : Jonathan L. Haines

Download or read book Genetic Analysis of Complex Disease written by Jonathan L. Haines and published by John Wiley & Sons. This book was released on 2007-02-26 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.

Reproductive Biotechnology in Finfish Aquaculture

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Publisher : Elsevier
ISBN 13 : 0080929869
Total Pages : 328 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Reproductive Biotechnology in Finfish Aquaculture by : C.-S. Lee

Download or read book Reproductive Biotechnology in Finfish Aquaculture written by C.-S. Lee and published by Elsevier. This book was released on 2012-12-02 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful reproduction of cultured brood stock is essential to the sustainable aquaculture of aquatic organisms. This book describes recent advances in the field of finfish reproductive biotechnology. The chapters in this volume are written by eminent scientists who review the progress and assess the status of biotechnology research that is applicable to the reproduction of finfish species for aquaculture. A wide range of topics is included starting with broodstock technologies such as broodstock genetics, broodstock nutrition, environmental control of maturation and impacts of stress on broodstock, gametes and progeny. The volume includes technologies for induction of ovulation and spermiation using synthetic hypothalamic peptides. Gamete technologies which are described include cryopreservation, chromosome set manipulation, disease prevention and control for gametes and embryos and the development of transgenic fish with enhanced production characteristics. Genetic and endocrine technologies for the production of monosex male and female fish stocks are also described. The closing chapter summarizes the discussion of each topic at the workshop, provides recommendations to industry and describes priorities of research and development. Researchers as well as teaching faculty in the aquaculture field will find this volume of great value.

From Molecular Genetics to Genomics

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Author :
Publisher : Routledge
ISBN 13 : 1134334087
Total Pages : 241 pages
Book Rating : 4.1/5 (343 download)

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Book Synopsis From Molecular Genetics to Genomics by : Jean-Paul Gaudillière

Download or read book From Molecular Genetics to Genomics written by Jean-Paul Gaudillière and published by Routledge. This book was released on 2004-10-07 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of molecular genetics and genomics.

Transducing the Genome

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Author :
Publisher : Schaum's Outline Series
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Transducing the Genome by : Gary Zweiger

Download or read book Transducing the Genome written by Gary Zweiger and published by Schaum's Outline Series. This book was released on 2001 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this important book, a scientist gives an inside account of the historic paradigm shift underway in the life sciences as a result of The Human Genome Project, and provides a philosophical framework in which to understand biology and medicine as information sciences.

Genome Mapping and Genomics in Domestic Animals

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Publisher : Springer Science & Business Media
ISBN 13 : 3540738355
Total Pages : 289 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Genome Mapping and Genomics in Domestic Animals by : Noelle E. Cockett

Download or read book Genome Mapping and Genomics in Domestic Animals written by Noelle E. Cockett and published by Springer Science & Business Media. This book was released on 2008-10-31 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics research on animals has generated huge databases and several new concepts and strategies, which are used to elucidate origin, evolution and phylogeny of species. Genetic and physical maps of genomes give details on chromosomal location, function, expression and regulation of genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on selected animal systems contributed by leading scientists from around the world. This volume offers information on gene mapping and genomics research in domesticated and farmed animals including cattle, water buffalo, sheep, deer, poultry, turkeys, rabbits, dogs and pigs. While the genome maps for some species are very limited, full genome sequences are available for cattle, chickens and dogs. Genomic research contributes to the identification of genetic regions that control the functionality and well-being of animals. Several farmed species are also used as models for biomedical studies.

New Technologies in Aquaculture

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Publisher : Elsevier
ISBN 13 : 1845696476
Total Pages : 1224 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis New Technologies in Aquaculture by : Gavin Burnell

Download or read book New Technologies in Aquaculture written by Gavin Burnell and published by Elsevier. This book was released on 2009-07-30 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt: With wild stocks declining due to over-fishing, aquaculture will have a more significant role to play in meeting future demand for fresh fish. Developments in research continue to lead to improvements in aquaculture production systems, resulting in increased production efficiency, higher product quality for consumers and a more sustainable industry. New technologies in aquaculture reviews essential advances in these areas. Part one focuses on the genetic improvement of farmed species and control of reproduction, with chapters on genome-based technologies in aquaculture research, selective breeding and the production of single sex and sterile populations, among other topics. Parts two and three review key issues in health, diet and husbandry, such as the control of viral and parasitic diseases, diet and husbandry techniques to improve disease resistance, advances in diets for particular fish species and the impact of harmful algal bloom on shellfisheries aquaculture. Chapters in Parts three and four then examine the design of different aquaculture production systems, including offshore technologies, tank-based recirculating systems and ponds, and key environmental issues, such as the prediction and assessment of the impact of aquaculture. Concluding chapters focus on farming new species. With its well-known editors and distinguished international team of contributors, New technologies in aquaculture is an essential purchase for professionals and researchers in the aquaculture industry. Reviews recent advances in improvements in aquaculture production Focuses on the genetic improvement and reproduction of farmed species, including genome-based technologies Discusses key health issues, including advances in disease diagnosis, vaccine development and other emerging methods to control pathogens in aquaculture

Multiple Testing Procedures with Applications to Genomics

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Publisher : Springer Science & Business Media
ISBN 13 : 0387493174
Total Pages : 611 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Multiple Testing Procedures with Applications to Genomics by : Sandrine Dudoit

Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Principles of Biology

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Publisher :
ISBN 13 : 9781636350417
Total Pages : pages
Book Rating : 4.3/5 (54 download)

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Book Synopsis Principles of Biology by : Lisa Bartee

Download or read book Principles of Biology written by Lisa Bartee and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.

Self-Incompatibility in Flowering Plants

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Publisher : Springer Science & Business Media
ISBN 13 : 3540684867
Total Pages : 341 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Self-Incompatibility in Flowering Plants by : Vernonica E. Franklin-Tong

Download or read book Self-Incompatibility in Flowering Plants written by Vernonica E. Franklin-Tong and published by Springer Science & Business Media. This book was released on 2008-07-30 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Great progress has been made in our understanding of pollen-pistil interactions and self-incompatibility (SI) in flowering plants in the last few decades. This book covers a broad spectrum of research into SI, with accounts by internationally renowned scientists. It comprises two sections: Evolution and Population Genetics of SI, Molecular and Cell Biology of SI Systems. The reader will gain an insight into the diversity and complexity of these polymorphic cell-cell recognition and rejection systems. Heteromorphic and homomorphic SI systems and our current understanding of the evolution and phylogeny of these systems, based on the most recent molecular sequence data, are covered. Further, the book presents major advances in our knowledge of the pistil and pollen S-determinants and other unlinked components involved in SI, as well as the apparently diverse cellular regulatory mechanisms utilised to ensure inhibition of “self” pollen.