Gene Expression And Its Discontents

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Gene Expression and Its Discontents

Author : Rodrick Wallace
Publisher : Springer
ISBN 13 : 3319480782
Total Pages : 344 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Gene Expression and Its Discontents by : Rodrick Wallace

Download or read book Gene Expression and Its Discontents written by Rodrick Wallace and published by Springer. This book was released on 2016-11-23 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Gene Expression and Its Discontents

Author : Rodrick Wallace
Publisher : Springer
ISBN 13 : 9781441914934
Total Pages : 240 pages
Book Rating : 4.9/5 (149 download)

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Book Synopsis Gene Expression and Its Discontents by : Rodrick Wallace

Download or read book Gene Expression and Its Discontents written by Rodrick Wallace and published by Springer. This book was released on 2010 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cognitive Dynamics on Clausewitz Landscapes

Author : Rodrick Wallace
Publisher : Springer Nature
ISBN 13 : 3030264246
Total Pages : 173 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Cognitive Dynamics on Clausewitz Landscapes by : Rodrick Wallace

Download or read book Cognitive Dynamics on Clausewitz Landscapes written by Rodrick Wallace and published by Springer Nature. This book was released on 2019-08-20 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress. Characterized as friction and the fog-of-war by the Prussian military theorist Carl von Clausewitz, such conditions impair institutional cognition in real-time conflict and pose a real and continuing threat to organizations, such as the US military. In a linked collection of formal essays and a mathematical appendix, the book explores different aspects of cognitive and evolutionary process as conducted under the direction of doctrine that acts as a kind of genome for retention of what is learned through Lamarckian evolutionary selection pressures: armies and corporate entities learn from conflict, and incorporate that learning into their ongoing procedures. The book proposes models and policy solutions for strategic competence. A central feature of the book is a formal description of the famous OODA loop of the US military theorist John Boyd in terms of the Data Rate Theorem that links control and information theories. That description is expanded to cover more fully the impact of stochastic fog-of-war effects on tactical and operational scales of conflict. Subsequent chapters examine in more detail the role of doctrine, and the particular effect of embedding culture on cognitive and Lamarckian evolutionary processes associated with conflict on tactical, operational, and strategic scales and levels of organization. A scientifically sophisticated exercise in applied mathematics, history, evolutionary theory, and ecosystem theory, this book will be appropriate for researchers and students interested in defense, security, and international relations, as well as non-academic career professionals in government and industry.

Computational Psychiatry

Author : Rodrick Wallace
Publisher : Springer
ISBN 13 : 3319539108
Total Pages : 243 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Computational Psychiatry by : Rodrick Wallace

Download or read book Computational Psychiatry written by Rodrick Wallace and published by Springer. This book was released on 2017-04-20 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

An Ecosystem Approach to Economic Stabilization

Author : Rodrick Wallace
Publisher : Routledge
ISBN 13 : 1317566696
Total Pages : 175 pages
Book Rating : 4.3/5 (175 download)

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Book Synopsis An Ecosystem Approach to Economic Stabilization by : Rodrick Wallace

Download or read book An Ecosystem Approach to Economic Stabilization written by Rodrick Wallace and published by Routledge. This book was released on 2015-02-11 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur. This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.

Essays on the Extended Evolutionary Synthesis

Author : Rodrick Wallace
Publisher : Springer Nature
ISBN 13 : 3031298799
Total Pages : 177 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Essays on the Extended Evolutionary Synthesis by : Rodrick Wallace

Download or read book Essays on the Extended Evolutionary Synthesis written by Rodrick Wallace and published by Springer Nature. This book was released on 2023 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the ‘punctuated equilibrium' of Eldrege and Gould, through Lewontin's ‘triple helix' and the various visions and revisions of the Extended Evolutionary Synthesis (EES) of Laland and others, both data and theory have demanded an opening-up of the 1950's Evolutionary Synthesis that so firmly wedded evolutionary theory to the mathematics of gene frequency analysis. It can, however, be argued that a single deep and comprehensive mathematical theory may simply not be possible for the almost infinite varieties of evolutionary process active at and across the full range of scales of biological, social, institutional, and cultural phenomena. Indeed, the case history of 'meme theory' should have raised a red flag that narrow gene-centered models of evolutionary process may indeed have serious limitations. What is attempted here is less grand, but still broader than a gene-centered analysis. Following the instruction of Maturana and Varela that all living systems are cognitive, in a certain sense, and that living as a process is a process of cognition, the asymptotic limit theorems of information and control theories that bound all cognition provide a basis for constructing an only modestly deep but wider-ranging series of probability models that might be converted into useful statistical tools for the analysis of observational and experimental data related to evolutionary process. The line of argument in this series of interrelated essays proves to be surprisingly direct.

The Mind and Its Discontents

Author : Grant Gillett
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Mind and Its Discontents by : Grant Gillett

Download or read book The Mind and Its Discontents written by Grant Gillett and published by Oxford University Press, USA. This book was released on 2009-04-30 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author argues that to understand mental illness fully requires more than a study of biological models of mental processes and pathologies. He stresses that the causes of human mental disorders are to be found in human interactions.

The New Mind-Body Science of Depression

Author : Vladimir Maletic
Publisher : W. W. Norton & Company
ISBN 13 : 0393708608
Total Pages : 461 pages
Book Rating : 4.3/5 (937 download)

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Book Synopsis The New Mind-Body Science of Depression by : Vladimir Maletic

Download or read book The New Mind-Body Science of Depression written by Vladimir Maletic and published by W. W. Norton & Company. This book was released on 2017-06-13 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific and therapeutic implications of a new way of understanding a common disease. Depression has often been studied, but this multifaceted disease remains far from understood. Here, leading researchers present a major new view of the disorder that synthesizes multiple lines of scientific evidence from neurobiology, mindfulness, and genetics. A comprehensive mind-body approach to understanding, evaluating, and treating this disease.

The Philosophy of Biology

Author : Marjorie Grene
Publisher : Cambridge University Press
ISBN 13 : 9780521643801
Total Pages : 446 pages
Book Rating : 4.6/5 (438 download)

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Book Synopsis The Philosophy of Biology by : Marjorie Grene

Download or read book The Philosophy of Biology written by Marjorie Grene and published by Cambridge University Press. This book was released on 2004-08-02 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines how the philosophy of biology has evolved to our current understanding.

The Aging Brain

Author : Timothy R. MD Jennings
Publisher : Baker Books
ISBN 13 : 1493409441
Total Pages : 199 pages
Book Rating : 4.4/5 (934 download)

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Book Synopsis The Aging Brain by : Timothy R. MD Jennings

Download or read book The Aging Brain written by Timothy R. MD Jennings and published by Baker Books. This book was released on 2018-06-19 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: While growing older is inevitable, many of the troubles we associate with aging--including dementia, disability, and an increased dependence on others--are not. The choices we make now can help us to maintain our vitality, a sharp mind, and our independence as we age. Filled with simple, everyday actions we can take to avoid disease, promote vitality, and prevent dementia and late onset Alzheimer's, The Aging Brain is an easy-to-use guide to maintaining brain and body health throughout our lives. Based on solid, up-to-date scientific research, the interventions explained in this book not only prevent progression toward dementia even in those who have already shown mild cognitive impairment, they also reduce disability and depression and keep people living independently longer than those who do not practice these methods. For anyone hoping to slow the aging process, as well as anyone who acts as a caregiver to someone at risk of or already beginning to suffer from dementia and other age-related diseases, this book offers a hopeful, healthy way forward.

The Archaeology of Mind

Author : Jaak Panksepp
Publisher : W. W. Norton & Company
ISBN 13 : 0393705315
Total Pages : 593 pages
Book Rating : 4.3/5 (937 download)

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Book Synopsis The Archaeology of Mind by : Jaak Panksepp

Download or read book The Archaeology of Mind written by Jaak Panksepp and published by W. W. Norton & Company. This book was released on 2012-09-11 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Care: sources of maternal nurturance --

Transactions on Computational Systems Biology XI

Author : Ralph-Johan Back
Publisher : Springer
ISBN 13 : 3642041868
Total Pages : 343 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Transactions on Computational Systems Biology XI by : Ralph-Johan Back

Download or read book Transactions on Computational Systems Biology XI written by Ralph-Johan Back and published by Springer. This book was released on 2009-10-01 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue on Computational Models for Cell Processes is based on a workshop that took place in Turku, Finland, May 2008. The papers span a mix of approaches to systems biology, ranging from quantitative techniques to computing paradigms inspired by biology.

Globalization and Its Discontents

Author : Joseph E. Stiglitz
Publisher : W. W. Norton & Company
ISBN 13 : 0393071073
Total Pages : 305 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Globalization and Its Discontents by : Joseph E. Stiglitz

Download or read book Globalization and Its Discontents written by Joseph E. Stiglitz and published by W. W. Norton & Company. This book was released on 2003-04-17 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This powerful, unsettling book gives us a rare glimpse behind the closed doors of global financial institutions by the winner of the 2001 Nobel Prize in Economics. When it was first published, this national bestseller quickly became a touchstone in the globalization debate. Renowned economist and Nobel Prize winner Joseph E. Stiglitz had a ringside seat for most of the major economic events of the last decade, including stints as chairman of the Council of Economic Advisers and chief economist at the World Bank. Particularly concerned with the plight of the developing nations, he became increasingly disillusioned as he saw the International Monetary Fund and other major institutions put the interests of Wall Street and the financial community ahead of the poorer nations. Those seeking to understand why globalization has engendered the hostility of protesters in Seattle and Genoa will find the reasons here. While this book includes no simple formula on how to make globalization work, Stiglitz provides a reform agenda that will provoke debate for years to come. Rarely do we get such an insider's analysis of the major institutions of globalization as in this penetrating book. With a new foreword for this paperback edition.

Genetics of Complex Traits & Diseases from Under-Represented Populations

Author : Segun Fatumo
Publisher : Frontiers Media SA
ISBN 13 : 2889744647
Total Pages : 123 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Genetics of Complex Traits & Diseases from Under-Represented Populations by : Segun Fatumo

Download or read book Genetics of Complex Traits & Diseases from Under-Represented Populations written by Segun Fatumo and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mapping the Future of Biology

Author : Anouk Barberousse
Publisher : Springer Science & Business Media
ISBN 13 : 1402096364
Total Pages : 178 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mapping the Future of Biology by : Anouk Barberousse

Download or read book Mapping the Future of Biology written by Anouk Barberousse and published by Springer Science & Business Media. This book was released on 2009-02-26 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carving Nature at its Joints? In order to map the future of biology we need to understand where we are and how we got there. Present day biology is the realization of the famous metaphor of the organism as a bete ˆ machine elaborated by Descartes in Part V of the Discours,a realization far beyond what anyone in the seventeenth century could have im- ined. Until the middle of the nineteenth century that machine was an articulated collection of macroscopic parts, a system of gears and levers moving gasses, solids, and liquids, and causing some parts of the machine to move in response to the force produced by others. Then, in the nineteenth century, two divergent changes occurred in the level at which the living machine came to be investigated. First, with the rise of chemistry and the particulate view of the composition of matter, the forces on macroscopic machine came to be understood as the ma- festation of molecular events, and functional biology became a study of molecular interactions. That is, the machine ceased to be a clock or a water pump and became an articulated network of chemical reactions. Until the ?rst third of the twentieth century this chemical view of life, as re?ected in the development of classical b- chemistry treated the chemistry of biological molecules in much the same way as for any organic chemical reaction, with reaction rates and side products that were the consequence of statistical properties of the concentrations of reactants.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1452 pages
Book Rating : 4.3/5 (243 download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Caste

Author : Isabel Wilkerson
Publisher : Random House Trade Paperbacks
ISBN 13 : 0593230272
Total Pages : 545 pages
Book Rating : 4.5/5 (932 download)

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Book Synopsis Caste by : Isabel Wilkerson

Download or read book Caste written by Isabel Wilkerson and published by Random House Trade Paperbacks. This book was released on 2023-02-14 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • “An instant American classic and almost certainly the keynote nonfiction book of the American century thus far.”—Dwight Garner, The New York Times The Pulitzer Prize–winning, bestselling author of The Warmth of Other Suns examines the unspoken caste system that has shaped America and shows how our lives today are still defined by a hierarchy of human divisions—now with a new Afterword by the author. #1 NONFICTION BOOK OF THE YEAR: Time ONE OF THE BEST BOOKS OF THE YEAR: The Washington Post, The New York Times, Los Angeles Times, The Boston Globe, O: The Oprah Magazine, NPR, Bloomberg, The Christian Science Monitor, New York Post, The New York Public Library, Fortune, Smithsonian Magazine, Marie Claire, Slate, Library Journal, Kirkus Reviews Winner of the Carl Sandberg Literary Award • Winner of the Los Angeles Times Book Prize • National Book Award Longlist • National Book Critics Circle Award Finalist • Dayton Literary Peace Prize Finalist • PEN/John Kenneth Galbraith Award for Nonfiction Finalist • PEN/Jean Stein Book Award Longlist • Kirkus Prize Finalist “As we go about our daily lives, caste is the wordless usher in a darkened theater, flashlight cast down in the aisles, guiding us to our assigned seats for a performance. The hierarchy of caste is not about feelings or morality. It is about power—which groups have it and which do not.” In this brilliant book, Isabel Wilkerson gives us a masterful portrait of an unseen phenomenon in America as she explores, through an immersive, deeply researched, and beautifully written narrative and stories about real people, how America today and throughout its history has been shaped by a hidden caste system, a rigid hierarchy of human rankings. Beyond race, class, or other factors, there is a powerful caste system that influences people’s lives and behavior and the nation’s fate. Linking the caste systems of America, India, and Nazi Germany, Wilkerson explores eight pillars that underlie caste systems across civilizations, including divine will, bloodlines, stigma, and more. Using riveting stories about people—including Martin Luther King, Jr., baseball’s Satchel Paige, a single father and his toddler son, Wilkerson herself, and many others—she shows the ways that the insidious undertow of caste is experienced every day. She documents how the Nazis studied the racial systems in America to plan their outcasting of the Jews; she discusses why the cruel logic of caste requires that there be a bottom rung for those in the middle to measure themselves against; she writes about the surprising health costs of caste, in depression and life expectancy, and the effects of this hierarchy on our culture and politics. Finally, she points forward to ways America can move beyond the artificial and destructive separations of human divisions, toward hope in our common humanity. Original and revealing, Caste: The Origins of Our Discontents is an eye-opening story of people and history, and a reexamination of what lies under the surface of ordinary lives and of American life today.