Functionalized Porous Silicon For Applications In Chemical Sensing Tumor Imaging And Drug Delivery

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Functionalized Porous Silicon for Applications in Chemical Sensing, Tumor Imaging and Drug Delivery

Author : Sanahan Vijayakumar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis Functionalized Porous Silicon for Applications in Chemical Sensing, Tumor Imaging and Drug Delivery by : Sanahan Vijayakumar

Download or read book Functionalized Porous Silicon for Applications in Chemical Sensing, Tumor Imaging and Drug Delivery written by Sanahan Vijayakumar and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 30 years, porous silicon as a material has been leveraged for its usefulness in biomedical and sensing applications. Its tunable structural features, low toxicity profile and readily modifiable surface render this material extremely useful for a wide variety of applications. By chemically modifying surface species, such as silicon hydrides and silicon oxides with silanes, the properties of porous silicon can be enhanced for its use for chemical sensing, biomedical imaging, and drug delivery. After a brief introduction to porous silicon materials, the first part of this dissertation details surface-modified porous silicon photonic crystals for the chemical sensing of toxic vapors and nerve agents. Chapter 2 utilizes a dual-peak porous silicon photonic crystal embedded with specific for the selective detection of hydrogen fluoride (HF), hydrogen cyanide (HCN), and the chemical nerve agent diisopropyl fluorophosphate (DFP). The pore walls are rendered hydrophobic with octadecylsilane to aid with the loading of the colorimetric molecules while being insensitive to humidity fluctuations. This provides a robust means to develop a remote detection system for chemical agents. Chapter 3 employs the same photonic crystal, modified, however, with a specialized protein-based gatekeeper that is rendered semi-permeable only in the presence of HCN. This is one of the first novel designs of a bio-inorganic sensor capable of detecting chemical agents with high specificity and precision. The second portion of the dissertation describes how surface-modified porous silicon nanoparticles can be applied in biomedical applications. The first project details the use of Anti-KIT protein DNA-aptamers decorated onto a fluorescently labelled porous silicon nanoparticle for the in vitro and in vivo imaging of gastrointestinal stromal tumors. This work provides an effective platform in which aptamer-conjugated porous silicon nanoparticle constructs can be used for the targeted imaging of KIT-expressing cancers. The final project utilizes hydrophobic porous silicon nanoparticles for the delivery of erucamide, a highly hydrophobic fatty acid amide, within the retina. By harnessing the versatility of porous silicon, erucamide's target cells and mechanism of neurotrophic action can be identified.

Porous Silicon for Biomedical Applications

Author : Hélder A. Santos
Publisher : Woodhead Publishing
ISBN 13 : 0128225246
Total Pages : 646 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Porous Silicon for Biomedical Applications by : Hélder A. Santos

Download or read book Porous Silicon for Biomedical Applications written by Hélder A. Santos and published by Woodhead Publishing. This book was released on 2021-10-23 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy. Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field. Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material. Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings. Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.

Porous Silicon: From Formation to Application: Biomedical and Sensor Applications, Volume Two

Author : Ghenadii Korotcenkov
Publisher : CRC Press
ISBN 13 : 1482264579
Total Pages : 418 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Porous Silicon: From Formation to Application: Biomedical and Sensor Applications, Volume Two by : Ghenadii Korotcenkov

Download or read book Porous Silicon: From Formation to Application: Biomedical and Sensor Applications, Volume Two written by Ghenadii Korotcenkov and published by CRC Press. This book was released on 2016-01-05 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous silicon is rapidly attracting increasing interest from various fields, including optoelectronics, microelectronics, photonics, medicine, chemistry, and biosensing. This nanostructured and biodegradable material has a range of unique properties that make it ideal for many applications. For example, the pores and surface chemistry of the mater

Porous Silicon in Practice

Author : M. J. Sailor
Publisher : John Wiley & Sons
ISBN 13 : 3527641912
Total Pages : 214 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Porous Silicon in Practice by : M. J. Sailor

Download or read book Porous Silicon in Practice written by M. J. Sailor and published by John Wiley & Sons. This book was released on 2012-01-09 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: By means of electrochemical treatment, crystalline silicon can be permeated with tiny, nanostructured pores that entirely change the characteristics and properties of the material. One prominent example of this can be seen in the interaction of porous silicon with living cells, which can be totally unwilling to settle on smooth silicon surfaces but readily adhere to porous silicon, giving rise to great hopes for such future applications as programmable drug delivery or advanced, braincontrolled prosthetics. Porous silicon research is active in the fields of sensors, tissue engineering, medical therapeutics and diagnostics, photovoltaics, rechargeable batteries, energetic materials, photonics, and MEMS (Micro Electro Mechanical Systems). Written by an outstanding, well-recognized expert in the field, this book provides detailed, step-by-step instructions to prepare and characterize the major types of porous silicon. It is intended for those new to the fi eld. Sampling of topics covered: * Principles of Etching Porous Silicon * Etch Cell Construction and Considerations * Photonic Crystals, Microcavities, and Bragg Stacks Etched in Silicon * Preparation of Free-standing Films and Particles of Porous Silicon * Preparation of Photoluminescent Nanoparticles from Porous Silicon * Preparation of Silicon Nanowires by Electrochemical Etch of Silicon * Surface Modifi cation Chemistry and Biochemistry * Measurement of Optical Properties * Measurement of Pore Size, Porosity, Thickness, Surface Area The whole is backed by a generous use of color photographs to illustrate the described procedures in detail, plus a bibliography of further literature pertinent to a wide range of application fi elds. For materials scientists, chemists, physicists, optical physicists, biomaterials scientists, neurobiologists, bioengineers, and graduate students in those fields, as well as those working in the semiconductor industry.

Advances in Chemical Sensors

Author : Wen Wang
Publisher : IntechOpen
ISBN 13 : 9789533077925
Total Pages : 360 pages
Book Rating : 4.0/5 (779 download)

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Book Synopsis Advances in Chemical Sensors by : Wen Wang

Download or read book Advances in Chemical Sensors written by Wen Wang and published by IntechOpen. This book was released on 2012-01-20 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical sensor plays an essential role in the fields of environmental conservation and monitoring, disaster and disease prevention, and industrial analysis. A typical chemical sensor is a device that transforms chemical information in a selective and reversible way, ranging from the concentration of a specific sample component to total composition analysis, into an analytically useful signal. Much research work has been performed to achieve a chemical sensor with such excellent qualities as quick response, low cost, small size, superior sensitivity, good reversibility and selectivity, and excellent detection limit. This book introduces the latest advances on chemical sensors. It consists of 15 chapters composed by the researchers active in the field of chemical sensors, and is divided into 5 sections according to the classification following the principles of signal transducer. This collection of up-to-date information and the latest research progress on chemical sensor will provide valuable references and learning materials for all those working in the field of chemical sensors.

Silicon Nano-biotechnology

Author : Yao He
Publisher : Springer Science & Business Media
ISBN 13 : 3642546684
Total Pages : 113 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Silicon Nano-biotechnology by : Yao He

Download or read book Silicon Nano-biotechnology written by Yao He and published by Springer Science & Business Media. This book was released on 2014-04-02 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest advances in the development of silicon nano-biotechnology for biological and biomedical applications, which include biosensing, bioimaging, and cancer therapy. In this book, newly developed silicon nano-biotechnology and its biomedical applications are systematically introduced. For instance, fluorescent silicon nanoparticles, serving as novel high-performance biological nanoprobes, are superbly suited to real-time and long-term bioimaging. Silicon nanowire-based sensing platform is especially capable of sensitive, specific, and multiplexed detection of various biological species. Silicon-based nanocarriers with ultra-high drug-loading capacity are highly efficacious for in vitro and in vivo cancer therapies. This book is intended for readers who are interested in the design of functional silicon nanostructures and their biological and biomedical applications. It uses silicon nanoparticles and silicon nanowires as models and discusses topics ranging from their synthesis to their biological applications, the goal being to highlight these exciting achievements as starting points in the field of silicon nano-biotechnology. Yao He is a Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China. Yuanyuan Su is an Associate Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China.

Biodegradable Porous Silicon Nanomaterials for Imaging and Treatment of Cancer

Author : Luo Gu
Publisher :
ISBN 13 : 9781267415622
Total Pages : 173 pages
Book Rating : 4.4/5 (156 download)

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Book Synopsis Biodegradable Porous Silicon Nanomaterials for Imaging and Treatment of Cancer by : Luo Gu

Download or read book Biodegradable Porous Silicon Nanomaterials for Imaging and Treatment of Cancer written by Luo Gu and published by . This book was released on 2012 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the second leading cause of death, claiming ~0.56 million lives in the U.S. every year following heart diseases (~0.62 million). From 1991 to 2007, mortality associated with heart diseases decreased 39%; by contrast, the death rate of cancer only decreased by 17% in spite of intensive research and improved therapeutics. The stagnation of conventional medicine and the complexity of cancer demand new therapeutic strategies. As an emerging approach, the use of nanomaterials as cancer diagnostic and therapeutic agents has shown promising results due to their unique physical and chemical properties. To date, more than two dozen nanoparticle-based products have been approved for clinical use and they show advantages over conventional therapeutics. However, translation of many other nanomaterials has been impeded due to concerns over toxicity and biodegradability. This dissertation presents the development of biodegradable luminescent porous silicon nanomaterials and their potential applications for imaging and treatment of cancer. Chapter 3 presents a diagnostic application of LPSiNPs. Time-gated fluorescence imaging of tumors using LPSiNPs with long emission lifetime is developed. This technique can effectively eliminate interference from short-lived tissue autofluorescence and improve the detection sensitivity. Chapter 4-6 demonstrate the therapeutic applications of porous silicon nanomaterials. In Chapter 4, magnetically-guided delivery of anticancer drug to cancer cells in vitro is achieved using magnetic, luminescent porous Si microparticles. Chapter 5 demonstrates that porous silicon nanoparticles can be used as photosensitizer and generate cytotoxic singlet oxygen when irradiated by light. The phototoxicity of the nanoparticles against cancer cells is also studied. Finally, the use of LPSiNPs for immune activation is investigated in Chapter 6.

Advances in Chemical Sensors

Author : Wen Wang
Publisher : IntechOpen
ISBN 13 : 9789533077925
Total Pages : 360 pages
Book Rating : 4.0/5 (779 download)

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Book Synopsis Advances in Chemical Sensors by : Wen Wang

Bionanomaterials for Biosensors, Drug Delivery, and Medical Applications

Author : Won-Chun Oh
Publisher : CRC Press
ISBN 13 : 1003822975
Total Pages : 287 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Bionanomaterials for Biosensors, Drug Delivery, and Medical Applications by : Won-Chun Oh

Download or read book Bionanomaterials for Biosensors, Drug Delivery, and Medical Applications written by Won-Chun Oh and published by CRC Press. This book was released on 2023-12-13 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers advances in nanostructured materials across a variety of biomedical applications as the field evolves from development of prototype devices to real-world implementation. It provides an in-depth look at the current state of the art in oxide nanostructures, carbon nanostructures, and 2D material fabrication and highlights the most important biomedical applications and devices of nanomaterials, including drug delivery, medical imaging, gene therapy, biosensors, and diagnostics. FEATURES Presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications Details finished and ongoing toxicity evaluations of emerging nanomaterials Offers a multidisciplinary perspective This book is recommended for senior undergraduate and graduate students, professionals, and researchers working in the fields of bioengineering, materials science and engineering, and biotechnology.

Electrochemically Engineered Nanoporous Materials

Author : Dusan Losic
Publisher : Springer
ISBN 13 : 3319203460
Total Pages : 377 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Electrochemically Engineered Nanoporous Materials by : Dusan Losic

Download or read book Electrochemically Engineered Nanoporous Materials written by Dusan Losic and published by Springer. This book was released on 2015-07-18 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth knowledge about the fabrications, structures, properties and applications of three outstanding electrochemically engineered nanoporous materials including porous silicon, nanoporous alumina and nanotubular titania. The book integrates three major themes describing these materials. The first theme is on porous silicon reviewing the methods for preparation by electrochemical etching, properties and methods for surface functionalization relevant for biosensing applications. Biomedical applications of porous silicon are major focus, described in several chapters reviewing recent developments on bioanalysis, emerging capture probes and drug delivery. The second theme on nanoporous alumina starts with describing the concept of self-organized electrochemical process used for synthesis nanopore and nanotube structures of valve metal oxides and reviewing recent development and progress on this field. The following chapters are focused mainly on optical properties and biosensing application of nanoporous alumina providing the reader with the depth of understanding of the structure controlled optical and photonic properties and design of optical biosensing devices using different detection principles such as photoluminescence, surface plasmon resonance, reflective spectrometry, wave guiding, Raman scattering etc. The third theme is focused on nanotubular titania reviewing three key applications including photocatalysis, solar cells and drug delivery. The book represents an important resource for academics, researchers, industry professionals, post-graduate and high-level undergraduate students providing them with both an overview of the current state-of-the-art on these materials and their future developments.

Nanooncology

Author : Gil Gonçalves
Publisher : Springer
ISBN 13 : 3319898787
Total Pages : 457 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Nanooncology by : Gil Gonçalves

Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-01 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.

NanoBiosensing

Author : Huangxian Ju
Publisher : Springer Science & Business Media
ISBN 13 : 1441996222
Total Pages : 596 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis NanoBiosensing by : Huangxian Ju

Download or read book NanoBiosensing written by Huangxian Ju and published by Springer Science & Business Media. This book was released on 2011-08-18 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover the full scope of nanobiosensing, which combines the newest research results in the cross-disciplines of chemistry, biology, and materials science with biosensing and bioanalysis to develop novel detection principles, sensing mechanisms, and device engineering methods. It not only covers the important types of nanomaterials for biosensing applications, including carbon nanotubes, carbon nanofiber, quantum dots, fullerenes, fluorescent and biological molecules, etc., but also illustrates a wide range of sensing principles, including electrochemical detection, fluorescence, chemiluminesence, antibody-antigen interactions, and magnetic detection. The book details novel developments in the methodology and devices of biosensing and bioanalysis combined with nanoscience and nanotechnology, as well as their applications in biomedicine and environmental monitoring. Furthermore, the reported works on the application and biofunction of nanoparticles have attracted extensive attention and interest, thus they are of particular interest to readers. The reader will obtain a rich survey of nanobiosensing technology, including the principles and application of biosensing, the design and biofunctionalization of bionanomaterials, as well as the methodology to develop biosensing devices and bioanalytical systems.

Biopolymer-Based Composites

Author : Sougata Jana
Publisher : Woodhead Publishing
ISBN 13 : 0081019157
Total Pages : 424 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Biopolymer-Based Composites by : Sougata Jana

Download or read book Biopolymer-Based Composites written by Sougata Jana and published by Woodhead Publishing. This book was released on 2017-06-15 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer-Based Composites: Drug Delivery and Biomedical Applications presents a comprehensive review on recent developments in biopolymer-based composites and their use in drug delivery and biomedical applications. The information contained in this book is critical for the more efficient use of composites, as detailed up-to-date information is a pre-requirement. The information provided brings cutting-edge developments to the attention of young investigators to encourage further advances in the field of bio-composite research. Currently, biopolymers are being investigated for the design of various drug delivery and biomedical devices due to their non-toxic, biodegradable and biocompatible nature. Mostly, biopolymer-based solid orals, gels, hydrogel beads, and transdermal matrices have been designed in order to control drug/protein release in simulated bio-fluids. Presents the most updated information in the field of pharmaceutical and biological sciences Contains color figures and illustrations to help users understand key topics Useful guide for young researchers working towards new innovations Includes chapters covered by eminent scientists in the field

Modern Sensors, Transducers and Sensor Networks

Author : Sergey Yurish
Publisher : Lulu.com
ISBN 13 : 8461596137
Total Pages : 423 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Modern Sensors, Transducers and Sensor Networks by : Sergey Yurish

Download or read book Modern Sensors, Transducers and Sensor Networks written by Sergey Yurish and published by Lulu.com. This book was released on 2012 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Modern Sensors, Transducers and Sensor Networks is the first book from the Advances in Sensors: Reviews book Series contains dozen collected sensor related, advanced state-of-the-art reviews written by 31 internationaly recognized experts from academia and industry. Built upon the series Advances in Sensors: Reviews - a premier sensor review source, it presents an overview of highlights in the field. Coverage includes current developments in sensing nanomaterials, technologies, MEMS sensor design, synthesis, modeling and applications of sensors, transducers and wireless sensor networks, signal detection and advanced signal processing, as well as new sensing principles and methods of measurements. This volume is divided into three main sections: physical sensors, chemical sensors and biosensors, and sensor networks including sensor technology, sensor market reviews and applications." -- Back cover.

Targeted Drug Delivery : Concepts and Design

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 788 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan

Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Silicon-Based Hybrid Nanoparticles

Author : Sabu Thomas
Publisher : Elsevier
ISBN 13 : 012824254X
Total Pages : 391 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Silicon-Based Hybrid Nanoparticles by : Sabu Thomas

Download or read book Silicon-Based Hybrid Nanoparticles written by Sabu Thomas and published by Elsevier. This book was released on 2021-09-24 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silicon-Based Hybrid Nanoparticles: Fundamentals, Properties, and Applications focuses on the fundamental principles and promising applications of silicon-based hybrid nanoparticles in nanoelectronics, energy storage/conversion, catalysis, sensors, biomedicine, environment and imaging. This book is an important reference source for materials scientists and engineers who are seeking to understand more about the major properties and applications of silicon-based hybrid nanoparticles. As the hybridization of silicon nanoparticles with other semiconductors or metal oxides nanoparticles may exhibit superior features, when compared to lone, individual nanoparticles, this book provides the latest insights. In addition, the silicon/iron oxide hybrid nanoparticles also possess excellent fluorescence, super-paramagnetism, and biocompatibility that can be effectively used for the diagnostic imaging system in vivo. Similarly, gold-silicon nanohybrids could be used as highly efficient near-infrared hyperthermia agents for cancer cell destruction. Outlines the major thermal, electrical, optical, magnetic and toxic properties of silicon-based hybrid nanoparticles Describes major applications in energy, environmental science and catalysis Assesses the major challenges to manufacturing silicon-based nanostructured materials on an industrial scale

Semiconducting Silicon Nanowires for Biomedical Applications

Author : Jeffery L. Coffer
Publisher : Woodhead Publishing
ISBN 13 : 0323851312
Total Pages : 442 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Semiconducting Silicon Nanowires for Biomedical Applications by : Jeffery L. Coffer

Download or read book Semiconducting Silicon Nanowires for Biomedical Applications written by Jeffery L. Coffer and published by Woodhead Publishing. This book was released on 2021-09-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material. The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Attention then turns to use of these structures for tissue engineering and delivery applications, followed by detection and sensing. Reflecting the evolution of this multidisciplinary subject, several new key topics are highlighted, including our understanding of the cell-nanowire interface, latest advances in associated morphologies (including silicon nanoneedles and nanotubes for therapeutic delivery), and significantly, the status of silicon nanowire commercialization in biotechnology. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and the next generation of nano-biotech platforms that require a detailed understanding of the cell-nanowire interface, along with researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive structures. Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding & internalization, tissue engineering scaffolds, mediated differentiation of stem cells, and silicon nanoneedles & nanotubes for delivery of small molecule / biologic-based therapeutics Highlights the use of silicon nanowires for detection and sensing Presents a detailed description of our current understanding of the cell-nanowire interface Covers the current status of commercial development of silicon nanowire-based platforms