Functionalized Mesoporous Silica Nanoparticles and Their Applications in Drug Delivery and Magnetic Resonance Imaging Contrast Enhancement

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ISBN 13 :
Total Pages : 187 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Functionalized Mesoporous Silica Nanoparticles and Their Applications in Drug Delivery and Magnetic Resonance Imaging Contrast Enhancement by : Tian Deng

Download or read book Functionalized Mesoporous Silica Nanoparticles and Their Applications in Drug Delivery and Magnetic Resonance Imaging Contrast Enhancement written by Tian Deng and published by . This book was released on 2021 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation makes contributions to the fields of functionalized mesoporous silica nanoparticles (MSNs) designed for magnetic resonance imaging (MRI) contrast enhancement and high-intensity focused ultrasound (HIFU) triggered cargo release. MRI-guided HIFU (MRIgHIFU) has been applied as a therapeutic tool in the clinic, and enhanced MRI contrast will improve the precision and applicability of HIFU therapy. In Chapter 2, the ultrasound responsive MSNs carriers are reviewed. In Chapter 3, the proof-of-concept spotlight technique based on MRIgHIFU and MSNs is introduced. With periodic HIFU modulation, the functionalized MSNs generated reversible MRI T1 relaxivity changes at the 1.5 mm3 focal point. Fourier analysis was used to extract signal changes at the modulation frequency, and a modulation enhancement map spotlights the precise region of interest by increasing contrast almost 100-fold. In Chapter 4, another functionalized MSNs were designed for the spotlight technique, and the spectral analysis was further studied to maximize the contrast enhancement. In particular, a framework was presented to analyze the trade-offs between different parameter choices for the signal processing method. In Chapter 5, the application of the spotlight technique was demonstrated at human body temperature. The MSNs were functionalized with the tailored poly(2-oxazoline)s with a lower critical solution temperature (LCST) at 40 °C, so that it could generate reversible MRI contrast change at human body temperature. The temperature oscillation range was small (3 °C), and the data acquisition was relatively fast (in 100 s), which made it a step closer to the biomedical applications in the clinic. The HIFU-responsive cargo delivery was studied in Chapters 6 and 7. The large pore MSNs (LPMSNs) were studied as the nanocarriers to load a large drug molecule, Docetaxel. With the loading procedure and HIFU parameters tuned, the HIFU-responsive release was demonstrated in a biologically relevant solvent. HIFU-responsive MRI contrast agent delivery was studied using MSNs capped with thermo-responsive polymer. The cargo loading and release conditions were optimized, and the HIFU-responsive cargo release can be monitored by MRI contrast change. The spotlight technique in this dissertation is promising for biomedical applications of precision therapy. The framework on parameter choice and demonstrated MRI contrast enhancement at human body temperature provides the foundation for further clinical translation.

Mesoporous Materials for Drug Delivery and Theranostics

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Publisher : MDPI
ISBN 13 : 3039439391
Total Pages : 204 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Mesoporous Materials for Drug Delivery and Theranostics by : Valentina Cauda

Download or read book Mesoporous Materials for Drug Delivery and Theranostics written by Valentina Cauda and published by MDPI. This book was released on 2020-12-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.

Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems

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Publisher : Springer
ISBN 13 : 3662486229
Total Pages : 100 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems by : Yu Chen

Download or read book Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems written by Yu Chen and published by Springer. This book was released on 2015-10-14 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.

Development and Application of Multi-functionalized Mesoporous Silica Nanomaterials in Intracellular Drug Delivery and Heterogeneous Catalysis

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ISBN 13 :
Total Pages : 165 pages
Book Rating : 4.:/5 (86 download)

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Book Synopsis Development and Application of Multi-functionalized Mesoporous Silica Nanomaterials in Intracellular Drug Delivery and Heterogeneous Catalysis by : Chih-Hsiang Tsai

Download or read book Development and Application of Multi-functionalized Mesoporous Silica Nanomaterials in Intracellular Drug Delivery and Heterogeneous Catalysis written by Chih-Hsiang Tsai and published by . This book was released on 2012 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Smart Tools for Smart Applications

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Publisher : MDPI
ISBN 13 : 3036502343
Total Pages : 206 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Smart Tools for Smart Applications by : Francesca Garello

Download or read book Smart Tools for Smart Applications written by Francesca Garello and published by MDPI. This book was released on 2021-03-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, micro- and nanosystems with magnetic properties have been extensively investigated in many fields, ranging from physics to medicine. The research in these areas has lately shown that if the magnetic compounds are opportunely functionalized and modified with moieties and specific functional groups, a plethora of challenging multidisciplinary applications is available, including the development of magnetically controlled particles, stimuli-responsive materials, magnetically guided chemical/drug-delivery systems, sensors, spintronics, separation and purification of contaminated groundwater and soils, ferrofluids and magnetorheological fluids, contrast agents for MRI, and internal sources of heat for the thermoablation of cancer. Magnetic compounds have been found to be highly selective and effective in all these application fields, from the molecular level to the microscale. This book aims at underlining the latest advances in the field of magnetic compounds, nanosystems, and materials, covering a large variety of topics related to novel synthesis and functionalization methods and the properties, applications, and use of magnetic systems in chemistry, materials science, diagnostics, and medical therapy.

Silica-coated Magnetic Nanoparticles

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Publisher : Springer
ISBN 13 : 3319501585
Total Pages : 93 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Silica-coated Magnetic Nanoparticles by : Mariela A. Agotegaray

Download or read book Silica-coated Magnetic Nanoparticles written by Mariela A. Agotegaray and published by Springer. This book was released on 2017-01-04 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.

Functionalized Mesoporous Silica Nanoparticles (MSNs) for Applications in Drug Delivery and Catalysis

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ISBN 13 :
Total Pages : 109 pages
Book Rating : 4.:/5 (79 download)

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Book Synopsis Functionalized Mesoporous Silica Nanoparticles (MSNs) for Applications in Drug Delivery and Catalysis by : Wei Huang

Download or read book Functionalized Mesoporous Silica Nanoparticles (MSNs) for Applications in Drug Delivery and Catalysis written by Wei Huang and published by . This book was released on 2010 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mesoporous Silica Nanoparticles

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ISBN 13 : 9783111338446
Total Pages : 0 pages
Book Rating : 4.3/5 (384 download)

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Book Synopsis Mesoporous Silica Nanoparticles by : Sachin Namdeo Kothawade

Download or read book Mesoporous Silica Nanoparticles written by Sachin Namdeo Kothawade and published by . This book was released on 2024-11-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.

FASTtrack Pharmaceutics

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Publisher : Pharmaceutical Press
ISBN 13 : 0857110594
Total Pages : 257 pages
Book Rating : 4.8/5 (571 download)

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Book Synopsis FASTtrack Pharmaceutics by : Yvonne Perrie

Download or read book FASTtrack Pharmaceutics written by Yvonne Perrie and published by Pharmaceutical Press. This book was released on 2012 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.

Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery and Bioimaging

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Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (114 download)

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Book Synopsis Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery and Bioimaging by : Chi-An Cheng

Download or read book Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery and Bioimaging written by Chi-An Cheng and published by . This book was released on 2020 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation makes contributions to the fields of formulation and delivery of anticancer drugs, antibiotics, and imaging agents, primarily focused on engineering mesoporous silica nanoparticles (MSNs) for stimuli-responsive drug delivery. The strategies and techniques developed in this dissertation will be especially useful for achieving precision medicine or personalized medicine, which is defined as the "right drug, right dosage at right timing to right patient". Although various emerging approaches for personalized disease treatment that take individual variability into account have been developed, the necessity of delivering the desired therapeutics at the desired time to the specific site of the disease and with accurate dosage remains a challenge. Here we first review the previously reported stimuli-responsive MSNs controlled by supramolecular nanomachines for antibiotic and drug delivery. In the second part of the dissertation, we report novel MSNs-based nanoparticles engineered to be responsive to noninvasive stimuli, such as alternating magnetic field (AMF) or high-intensity focused ultrasound (HIFU). AMF-responsive drug delivery demonstrates the controlled therapeutic efficacy for pancreatic cancer cells in vitro by adjusting different lengths of AMF exposure time. The HIFUresponsive MSNs provide a promising platform for magnetic resonance imaging (MRI)-guided HIFU (MRgHIFU)-stimulated cargo delivery. The change of T1 reports on the amount of released cargo which is imageable by MRI ex vivo. Both AMF-and MRgHIFU-stimulation strategies offer the potential for the spatial, temporal, and dosage control of drug delivery. In the last part, we develop an approach to achieve both high loading and high release amount of a water-insoluble antibiotic clofazimine (CFZ) carried by MSNs by using acetophenone (AP) as a chaperone molecule, solving the water insolubility problem faced when treating multidrug-resistant tuberculosis. The treatment of Mycobacterium tuberculosis infected macrophages with optimized CFZ-loaded MSNs shows good therapeutic efficacy in vitro. Finally, we develop a hollow mesoporous silica nanoparticle (HMSN) formulated near infrared (NIR) fluorophore IR-140, to realize a novel biocompatible shortwave infrared (SWIR) optical imaging contrast agent for bioimaging with a higher tissue penetration depth. The J-aggregates of IR-140 stabilized inside HMSNs showed the potential to overcome the stability, toxicity, and brightness challenges faced by common SWIR contrast agents.

Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications

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Publisher :
ISBN 13 :
Total Pages : 263 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications by : Wei Chen

Download or read book Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications written by Wei Chen and published by . This book was released on 2019 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.

Functionalized Nanomaterials

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Publisher : CRC Press
ISBN 13 : 1000367207
Total Pages : 603 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Functionalized Nanomaterials by : Vineet Kumar

Download or read book Functionalized Nanomaterials written by Vineet Kumar and published by CRC Press. This book was released on 2021-07-28 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials contain some unique properties due to their nanometric size and surface functionalization. Nanomaterial functionalization also affects their compatibility to biocompatibility and toxicity behaviors. environment and living organism. This makes functionalized nanomaterials a material with huge scope and few challenges. This book provides detailed information about the nanomaterial functionalization and their application. Recent advancements, challenges and opportunities in the preparation and applications of functionalized nanomaterials are also highlighted. This book can serve as a reference book for scientific investigators, doctoral and post-doctoral scholars; undergrad and grad. This book is very useful for multidisciplinary researchers, industry personnel’s, journalists, and policy makers. Features: Covers all aspects of Nanomaterial functionalization and its applications Describes and methods of functionalized nanomaterials synthesis for different applications Discusses the challenges, recent findings, and cutting-edge global research trends on functionalization of nanomaterials and its applications It discusses the regulatory frameworks for the safe use of functionalized nanomaterials. It contains contributions from international experts from multiple disciplines.

Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery

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Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (664 download)

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Book Synopsis Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery by : Nikola Knežević

Download or read book Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery written by Nikola Knežević and published by . This book was released on 2009 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Functionalization of Mesoporous Silica Nanoparticles and Their Applications in Organo-, Metallic and Organometallic Catalysis

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ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 (656 download)

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Book Synopsis Functionalization of Mesoporous Silica Nanoparticles and Their Applications in Organo-, Metallic and Organometallic Catalysis by : Yulin Huang

Download or read book Functionalization of Mesoporous Silica Nanoparticles and Their Applications in Organo-, Metallic and Organometallic Catalysis written by Yulin Huang and published by . This book was released on 2009 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices

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Publisher : Elsevier
ISBN 13 : 0443190119
Total Pages : 796 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices by : Kalim Deshmukh

Download or read book Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices written by Kalim Deshmukh and published by Elsevier. This book was released on 2024-01-22 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices: Current and Emerging Research Trends explores the various aspects of functionalization of magnetic nanosystems in great detail, providing a thorough review of the associated benefits and challenges. The book begins with an overview of each key pillar for the design and application of functionalized magnetic nanosystems, from the synthesis, processing methods, and characterization techniques, to biocompatibility and toxicity considerations. Later chapters focus on specific nanomaterials and targeted biomedical applications, including point-of-care diagnosis, cancer therapy, medical imaging, biosensing and more. Importance is given to the safety considerations; environmental, legal and ethical implications, and commercial aspects of functionalized magnetic nanosystems - providing guidance relevant for advancing research into clinical practice. Provides an overview of fundamentals in the design and application of magnetic nanosystems, from synthesis and processing to functionalization and toxicity assessment Explores research in industry and clinical practice, providing insights into ethical, environmental, legal, and commercial aspects Covers a wide range of diagnostic applications for functionalized magnetic nanosystems, such as in medical imaging, drug detection, tissue engineering, and more

Advances in Nanotheranostics II

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Publisher : Springer
ISBN 13 : 9811000638
Total Pages : 386 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Advances in Nanotheranostics II by : Zhifei Dai

Download or read book Advances in Nanotheranostics II written by Zhifei Dai and published by Springer. This book was released on 2016-01-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery

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ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery by : Nikola Knezevic

Download or read book Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery written by Nikola Knezevic and published by . This book was released on 2009 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: