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Author : Nabyl Merbouh
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (555 download)
Download or read book Functionalization of Carbohydrates Toward Metal Binding written by Nabyl Merbouh and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nabyl Merbouh
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.:/5 (555 download)
Download or read book Functionalization of Carbohydrates Toward Metal Binding written by Nabyl Merbouh and published by . This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiaolei Li (Ph.D.)
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Development of Transition Metal-catalyzed Site-selective Carbohydrate Functionalization Reactions and Tissue-selective Protein Degraders written by Xiaolei Li (Ph.D.) and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates are synthetically challenging molecules with vital biological roles in all living systems. To better understand the biological functions of this fundamentally important class of molecules, novel methodologies are urgently needed in two different directions: building block synthesis and selective glycosylation. During my Ph.D. study, I developed two different methodologies for building block synthesis, which could simplify the assembly of oligosaccharides.Differentiation of hydroxy groups on the carbohydrate is usually considered challenging as a result of the almost identical chemical environment. 1,2-trans diols are even more difficult to deal with compared to 1,2-cis diols. In my first project, I developed a method for regio- and stereo-selective OH carbene insertion together with my collaborator. Under very mild conditions, a series of 1,2-trans diols can be selectively functionalized. The regioselectivity originated from interactions between substrates and transition-metal catalysts, while the stereochemistry came from intramolecular proton delivery. The newly introduced moiety can work as a protection group, function group for the glycoconjugate mimic synthesis, or participate in the following glycosylation reactions and impact the anomeric selectivity. Inspired by the regio-selectivity of first projects, I developed another transition metal-catalyzed reaction, which could successfully epimerize one hydroxyl group in 1,2-trans diols, thus many rare sugars can be accessed easily starting from readily available common sugars. Compared to the traditional route, the method I developed can simplify the synthesis significantly and is more environmentally friendly. Synthesis of aminosugars through direct amination of 1,2-trans diols is also investigated. Bromodomain (BRD) is an evolutionarily conserved protein-protein interaction module that can recognize and bind acetylated lysine residues in histones and many other proteins. BRD4 protein, which is considered a transcriptional factor and epigenetic regulator, can bind to acetylated histone and recruit protein complexes to stabilize the binding of RNA polymerase II to histone. The dysregulation of BRD4 can cause cancer and other diseases such as immune and inflammatory diseases. Because of this, the BRD4 protein has been long considered an important therapeutic target. In the third project, I worked on the development of tissue-selective BRD4 degraders, aiming to provide a novel therapy for prostate cancer. By attaching tissue-selective ligands to BRD4 degraders, we successfully achieved selectivity among different cell lines, which proved our initial hypothesis. The tri-functional degraders will be tested in vivo in the future.
Author : Wei Chung Chen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (953 download)
Download or read book Functionalization of Carbohydrates on the Macro-, Nano-, and Molecular Scale written by Wei Chung Chen and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The main objective of the present thesis is to modify and to study carbohydrates in order to make use of their surface properties in bulk, on the nano and molecular scale. To achieve this goal, several strategies were explored. In the case of bulk cellulose, the silylation of wood pulp by gas-phase reaction with trichloromethylsilane (TCMS) produced a material that we call Cellufoam. In this silylation reaction, the hydroxyl (-OH) groups of cellulose are silylated, which suppresses cellulose's affinity for water. With a water drop contact angle of 150o, the surface can be described as superhydrophobic. By forcing water into Cellufoam's fibre lumen and pressing the pulp into a handsheet, the material was shown to expand upon drying. This is the result of the interplay between capillary force and the force of elastic rebound. After each cycle of use and rewetting, this dry-expansion property became less pronounced. The reduction in performance is explained by the exposure of hydroxyl (-OH) groups caused by mechanical damage after each cycle. On the nanoscale, cellulose nanocrystals (CNC) were modified to stabilize heterogeneous metal-in-water mixtures. Silver nanoparticles (AgNP) were both synthesized and stabilized by the use of cationic cellulose nanocrystals (cCNC). It was shown that chloride and silver ions in solution can only yield silver chloride in the presence of CNC. However, by using cCNC, where each particle is smaller and exposes more surface area, AgNP was produced due to the larger presence of -OH groups. In this work, it was determined that reducing ends (C=O) and -OH groups are both capable of forming AgNP. Therefore, it can be proposed that reducing sugars are not the only types of sugars with the ability to reduce metal ions. As a continuation of the AgNP study, sucrose, a non-reducing sugar, was explored as a reducing agent and stabilizer for the growth of AgNP. A stable colloidal suspension was formed without heating on the order of hours. By high-resolution TEM, a core-shell structure was observed in which the core is single crystal silver and the shell is composed of sucrose based on elemental analysis. In comparison, arabinose and galactose also formed silver colloidal suspensions, but these suspensions were less stable because their shells were much thinner. The greater stability of the sucrose AgNP suspension also causes the formation of a silver mirror on the surface of the glass vial. Under the same condition, silver colloidal suspensions stabilized by reducing sugars succumbed to sedimentation. In this thesis, it is shown that carbohydrates in their various forms possess very different properties depending on their numerous functional groups. By silylation, cationization, and the presence of aldehyde reducing ends, these materials can be made superhydrophobic, stabilize metal nanoparticles, and form silver core-shell structures." --
Author : Masoud Mozafari
Publisher : Woodhead Publishing
ISBN 13 : 0128169842
Total Pages : 584 pages
Book Rating : 4.1/5 (281 download)
Download or read book Metal-Organic Frameworks for Biomedical Applications written by Masoud Mozafari and published by Woodhead Publishing. This book was released on 2020-03-17 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-Organic Frameworks for Biomedical Applications is a comprehensive, authoritative reference that offers a substantial and complete treatment of published results that have yet to be critically reviewed. It offers a summary of current research and provides in-depth understanding of the role of metal-organic frameworks in biomedical engineering. The title consists of twenty-two chapters presented by leading international researchers in the field. Chapters are arranged by target-application in biomedical engineering, allowing medical and pharmaceutic specialists to translate current materials and engineering science on metal-organic frameworks into their work. Presents the state-of-the art in metal-organic frameworks for biomedical applications Offers comprehensive treatment of metal-organic frameworks that is useful to pharmaceutic and medical experts who are non-specialists in materials science Helps materials scientists and engineers understand the needs of biomedical engineering Critically-reviews published results and current research in the field
Author :
Publisher :
ISBN 13 :
Total Pages : 868 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vineet Kumar
Publisher : CRC Press
ISBN 13 : 1000367207
Total Pages : 603 pages
Book Rating : 4.0/5 (3 download)
Download or read book Functionalized Nanomaterials written by Vineet Kumar and published by CRC Press. This book was released on 2021-07-28 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials contain some unique properties due to their nanometric size and surface functionalization. Nanomaterial functionalization also affects their compatibility to biocompatibility and toxicity behaviors. environment and living organism. This makes functionalized nanomaterials a material with huge scope and few challenges. This book provides detailed information about the nanomaterial functionalization and their application. Recent advancements, challenges and opportunities in the preparation and applications of functionalized nanomaterials are also highlighted. This book can serve as a reference book for scientific investigators, doctoral and post-doctoral scholars; undergrad and grad. This book is very useful for multidisciplinary researchers, industry personnel’s, journalists, and policy makers. Features: Covers all aspects of Nanomaterial functionalization and its applications Describes and methods of functionalized nanomaterials synthesis for different applications Discusses the challenges, recent findings, and cutting-edge global research trends on functionalization of nanomaterials and its applications It discusses the regulatory frameworks for the safe use of functionalized nanomaterials. It contains contributions from international experts from multiple disciplines.
Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 0470592079
Total Pages : 448 pages
Book Rating : 4.4/5 (75 download)
Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Author : Devarajan Thangadurai
Publisher : Springer Nature
ISBN 13 : 3030414647
Total Pages : 497 pages
Book Rating : 4.0/5 (34 download)
Download or read book Functional Bionanomaterials written by Devarajan Thangadurai and published by Springer Nature. This book was released on 2020-07-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested each year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the global economy. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.
Author : Tim Storr
Publisher : John Wiley & Sons
ISBN 13 : 1118697898
Total Pages : 650 pages
Book Rating : 4.1/5 (186 download)
Download or read book Ligand Design in Medicinal Inorganic Chemistry written by Tim Storr and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Author : Kalim Deshmukh
Publisher : Elsevier
ISBN 13 : 0323994628
Total Pages : 984 pages
Book Rating : 4.3/5 (239 download)
Download or read book Functionalized Nanofibers written by Kalim Deshmukh and published by Elsevier. This book was released on 2023-04-19 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanofibers: Synthesis and Industrial Applications presents the latest advances in the fabrication, design, processing, and properties of functionalized nanofibers for a range of advanced applications. Sections introduce fabrication, mechanisms, and design of functionalized nanofibers, explaining electrospinning and non-electrospinning techniques, optimization of structural designs, surface functionalization techniques, and characterization methods. Subsequent sections focus on specific application areas, highlighting preparation methods and applications of functionalized nanofibers across biomedicine, surfaces and coatings, food, environment, energy, electronics, and textiles. Finally, environmental impact and safety and legal aspects related to the utilization of functionalized nanofibers are considered. This is a valuable resource for researchers and advanced students with an interest in nanomaterials and nanotechnology, and across other disciplines such as polymer science, chemistry, chemical engineering, and materials science and engineering. - Integrates discussions of physics, chemistry, biology and materials science behind functionalized nanofibers - Opens the door to a range of applications across biomedicine, surfaces and coatings, food, environment, energy, electronics and textiles - Analyzes challenges and opportunities relating to environmental, health and safety issues
Author : Chuan-Fa Chang
Publisher : BoD – Books on Demand
ISBN 13 : 9535108646
Total Pages : 574 pages
Book Rating : 4.5/5 (351 download)
Download or read book Carbohydrates written by Chuan-Fa Chang and published by BoD – Books on Demand. This book was released on 2012-11-21 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is my great honor and pleasure to introduce this comprehensive book to readers who are interested in carbohydrates. This book contains 23 excellent chapters written by experts from the fields of chemistry, glycobiology, microbiology, immunology, botany, zoology, as well as biotechnology. According to the topics, methods and targets, the 23 chapters are further divided into five independent sections. In addition to the basic research, this book also offers much in the way of experiences, tools, and technologies for readers who are interested in different fields of Glycobiology. I believe that readers can obtain more than anticipated from this meaningful and useful book.
Author : Uma Shanker
Publisher : Elsevier
ISBN 13 : 0128236159
Total Pages : 624 pages
Book Rating : 4.1/5 (282 download)
Download or read book Green Functionalized Nanomaterials for Environmental Applications written by Uma Shanker and published by Elsevier. This book was released on 2021-08-20 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green nanomaterials are classed as nanomaterials with no environmentally harmful, toxic, properties. The photocatalysis of nanomaterials involves photo-conduction value in efficient removal/degradation of noxious pollutants. Green nanotechnology has objectives for the development of products and processes which are environmentally friendly, economically sustainable, safe, energy-efficient, and produce little waste or emissions. Such products and processes are based on renewable materials and/or have a low net impact on the environment. Green functionalized nanomaterials, formed by a combination of nanomaterials with natural materials or are derived through a green source, are the new trends in the remediation of pollutants in environmental industries. This has the effect of making photoactive nanomaterials work under UV/sunlight radiation in order to produce reactive radical species that rapidly remove pollutants by redox mechanism. Green Functionalized Nanomaterials for Environmental Applications focuses on recent developments in the area of fabrication of green nanomaterials and their properties. It also looks at ways of lowering the risk of exposure of green functionalized nanomaterials. This needs to be pursued in the future for investigating and assessing health risks, which may be due to exposure to green nanomaterials. It is an important reference source for all those seeking to improve their understanding of how green functionalized nanomaterials are being used in a range of environmental applications, as well as considering potential toxicity implications. - Highlights innovative industrial technologies for green functionalized nanomaterials - Covers major fabrication techniques for sustainable functionalized nanomaterials - Shows how sustainable functionalized nanomaterials are being developed for commercial applications
Author : Hans-Jörg Schneider
Publisher : Royal Society of Chemistry
ISBN 13 : 1782620621
Total Pages : 556 pages
Book Rating : 4.7/5 (826 download)
Download or read book Chemoresponsive Materials written by Hans-Jörg Schneider and published by Royal Society of Chemistry. This book was released on 2015-07-13 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart materials stimulated by chemical or biological signals are of interest for their many applications including drug delivery, as well as in new sensors and actuators for environmental monitoring, process and food control, and medicine. In contrast to other books on responsive materials, this volume concentrates on materials which are stimulated by chemical or biological signals. Chemoresponsive Materials introduces the area with chapters covering different responsive material systems including hydrogels, organogels, membranes, thin layers, polymer brushes, chemomechanical and imprinted polymers, nanomaterials, silica particles, as well as carbohydrate- and bio-based systems. Many promising applications are highlighted, with an emphasis on drug delivery, sensors and actuators. With contributions from internationally known experts, the book will appeal to graduate students and researchers in academia, healthcare and industry interested in functional materials and their applications.
Author : Vanesa Calvino-Casilda
Publisher : CRC Press
ISBN 13 : 1351786695
Total Pages : 241 pages
Book Rating : 4.3/5 (517 download)
Download or read book Nanocatalysis written by Vanesa Calvino-Casilda and published by CRC Press. This book was released on 2019-02-14 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis and design of new nanocatalysts is an important area of research that aims to introduce multiple types of useful applications in a greener market. The necessity of nanostructuring the active sites has emerged as the key point in a successful design of the catalysts. The book covers the progress in this research area done in the last ten years. It includes the classification of catalysts and structure of active sites at the nanoscale. The book covers examples to present the concept, evolution of nanocatalysts from the perspective of chemistry of materials and their applications.
Author : Els. J. M. Van Damme
Publisher : John Wiley & Sons
ISBN 13 : 9780471964452
Total Pages : 478 pages
Book Rating : 4.9/5 (644 download)
Download or read book Handbook of Plant Lectins written by Els. J. M. Van Damme and published by John Wiley & Sons. This book was released on 1998-03-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant lectins are extensively used as tools and as bioactiveproteins in different areas of biomedical and biological research.The Handbook of Plant Lectins provides a comprehensive yet conciseoverview of the biochemical properties, carbohydrate-bindingspecificity, biological activities and applications of most of thecurrently known plant lectins. This handbook consists of two majorsections: an introductory guide and a quick reference dictionary.Part I acquaints the newcomer to the lectin field with theessential information on lectins and their importance tobiomedicine: * what are lectins? * their carbohydrate-binding specificity * effects on nutrition and immunology * use in histochemistry * application as therapeutic agents Part II lists approximately 200 lectin entries in alphabeticalorder. Each entry deals with the lectin(s) of a particular plantand provides, (where known), details of: * isolation and characterisation; * sugar binding specificity; * biological activities; * applications; * commercial availability; and, * a bibliography. Useful summary tables list lectins according to their specificity,thereby allowing the user to choose the best lectin for theirapplication. A list of suppliers is also provided. Handbook ofPlant Lectins will be of interest to biologists and biomedicalresearchers studying cell biology, cancer research, nutrition,immunology, pathology and physiology.
Author : Laura Cipolla
Publisher : World Scientific
ISBN 13 : 1783267216
Total Pages : 535 pages
Book Rating : 4.7/5 (832 download)
Download or read book Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics written by Laura Cipolla and published by World Scientific. This book was released on 2015-07-23 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.
