Functional Protein Microarrays In Drug Discovery

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Functional Protein Microarrays in Drug Discovery

Author : Paul F. Predki
Publisher : CRC Press
ISBN 13 : 1420009842
Total Pages : 482 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Functional Protein Microarrays in Drug Discovery by : Paul F. Predki

Download or read book Functional Protein Microarrays in Drug Discovery written by Paul F. Predki and published by CRC Press. This book was released on 2007-03-30 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications. The book discusses the generation of functional protein content and describes both standard and state-of-the-art fabrication methods. It reviews current and next generation approaches to assay detection and presents a wide range of applications, from biomolecular interaction discovery and characterization to immune response profiling. The book also addresses several fundamental computational issues, bioinformatics and data analysis.

Protein Microarray Technology

Author : Dev Kambhampati
Publisher : John Wiley & Sons
ISBN 13 : 3527605215
Total Pages : 276 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Protein Microarray Technology by : Dev Kambhampati

Download or read book Protein Microarray Technology written by Dev Kambhampati and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.

Functional Informatics in Drug Discovery

Author : Sergey Ilyin
Publisher : CRC Press
ISBN 13 : 1000713415
Total Pages : 125 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Functional Informatics in Drug Discovery by : Sergey Ilyin

Download or read book Functional Informatics in Drug Discovery written by Sergey Ilyin and published by CRC Press. This book was released on 2007-08-27 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical

Applying Genomic and Proteomic Microarray Technology in Drug Discovery

Author : Robert S. Matson
Publisher : CRC Press
ISBN 13 : 0203491130
Total Pages : 260 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Applying Genomic and Proteomic Microarray Technology in Drug Discovery by : Robert S. Matson

Download or read book Applying Genomic and Proteomic Microarray Technology in Drug Discovery written by Robert S. Matson and published by CRC Press. This book was released on 2004-12-28 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarrays play an increasingly significant role in drug discovery. Written by a leader in the field, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. The author addresses the drawbacks, helping

Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition

Author : Robert S. Matson
Publisher : CRC Press
ISBN 13 : 1439855633
Total Pages : 325 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition by : Robert S. Matson

Download or read book Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition written by Robert S. Matson and published by CRC Press. This book was released on 2013-03-13 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. Updated and revised to reflect recent progress in the field, the second edition discusses: Expanded omics-driven applications, including the areas of metabolomics and chemical biology The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented The development of the gene expression microarray and representative applications The development of protein microarray technology, including its history and key applications Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons. Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.

Proteomics for Biological Discovery

Author : Timothy D. Veenstra
Publisher : John Wiley & Sons
ISBN 13 : 0470007737
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Proteomics for Biological Discovery by : Timothy D. Veenstra

Download or read book Proteomics for Biological Discovery written by Timothy D. Veenstra and published by John Wiley & Sons. This book was released on 2006-06-12 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.

Rapid Test

Author : Laura Anfossi
Publisher : BoD – Books on Demand
ISBN 13 : 178923901X
Total Pages : 104 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Rapid Test by : Laura Anfossi

Download or read book Rapid Test written by Laura Anfossi and published by BoD – Books on Demand. This book was released on 2018-09-26 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid tests, also known as point-of-care tests, have been in use for decades in the clinical and medical area and have become increasingly popular as an efficient screening method for conducting on-site analysis thanks to their simplicity, speed, specificity and sensitivity. Nowadays, rapid tests are widely applied for clinical, drug, food, forensic and environmental analysis and fields of application are rapidly increasing together with advances in the technology. The growing interest in rapid tests and their expanding application in diverse fields, together with requirements of improved sensitivity, reliability, multiple detection capacity and robustness, are prompting innovation in the design of novel platforms, and in the exploitation of innovative detection strategies. The book covers advances in materials, technology and test design.

Protein Arrays, Biochips and Proteomics

Author : Joanna S. Albala
Publisher : CRC Press
ISBN 13 : 0203911121
Total Pages : 440 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Protein Arrays, Biochips and Proteomics by : Joanna S. Albala

Download or read book Protein Arrays, Biochips and Proteomics written by Joanna S. Albala and published by CRC Press. This book was released on 2003-08-20 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-prote

Protein Microarray for Disease Analysis

Author : Catherine J. Wu
Publisher : Humana Press
ISBN 13 : 9781617790447
Total Pages : 373 pages
Book Rating : 4.7/5 (94 download)

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Book Synopsis Protein Microarray for Disease Analysis by : Catherine J. Wu

Download or read book Protein Microarray for Disease Analysis written by Catherine J. Wu and published by Humana Press. This book was released on 2011-08-25 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein microarrays have been used for a wide variety of important tasks, such as identifying protein-protein interactions, discovering disease biomarkers, identifying DNA-binding specificity by protein variants, and for characterization of the humoral immune response. In Protein Microarray for Disease Analysis: Methods and Protocols, expert researchers provide concise descriptions of the methodologies currently used to fabricate microarrays for the comprehensive analysis of proteins or responses to proteins that can be used to dissect human disease. These methodologies are the toolbox for revolutionizing drug development and cell-level biochemical understanding of human disease processes. Beginning with a section on protein-detecting analytical microarrays, the volume continues with sections covering antigen microarrays for immunoprofiling, protein function microarrays, the validation of candidate targets, proteomic libraries, as well as signal detection strategies and data analysis techniques. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Protein Microarray for Disease Analysis: Methods and Protocols serves as a solid framework to aid scientists in understanding how protein microarray technology is presently developing and how it can be applied to transform our analysis of human disease.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Author : Haleem J. Issaq
Publisher : Academic Press
ISBN 13 : 0123947952
Total Pages : 489 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Proteomic and Metabolomic Approaches to Biomarker Discovery by : Haleem J. Issaq

Download or read book Proteomic and Metabolomic Approaches to Biomarker Discovery written by Haleem J. Issaq and published by Academic Press. This book was released on 2013-05-20 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions

Author : Gisa Gerold
Publisher : Elsevier
ISBN 13 : 0128230428
Total Pages : 268 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions by : Gisa Gerold

Download or read book Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions written by Gisa Gerold and published by Elsevier. This book was released on 2021-05-05 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more. Discusses the latest methodological breakthroughs in mass spectrometry-based proteomics Reviews how technology has advanced our knowledge on virus-host interactions Provides future perspectives on proteomics research in virology

Exploration and Analysis of DNA Microarray and Protein Array Data

Author : Dhammika Amaratunga
Publisher : John Wiley & Sons
ISBN 13 : 0470317965
Total Pages : 270 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Exploration and Analysis of DNA Microarray and Protein Array Data by : Dhammika Amaratunga

Download or read book Exploration and Analysis of DNA Microarray and Protein Array Data written by Dhammika Amaratunga and published by John Wiley & Sons. This book was released on 2009-09-25 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage. Highlights of the text include: A review of basic molecular biology, followed by an introduction to microarrays and their preparation Chapters on processing scanned images and preprocessing microarray data Methods for identifying differentially expressed genes in comparative microarray experiments Discussions of gene and sample clustering and class prediction Extension of analysis methods to protein array data Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors’ Web site make this important text a valuable resource for both students and professionals in the field.

Microarray Methods and Protocols

Author : Robert S. Matson
Publisher : CRC Press
ISBN 13 : 1420046667
Total Pages : 216 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Microarray Methods and Protocols by : Robert S. Matson

Download or read book Microarray Methods and Protocols written by Robert S. Matson and published by CRC Press. This book was released on 2009-01-20 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Step-by-Step Guide to Present and Future Uses of Microarray TechnologyMicroarray technology continues to evolve, taking on a variety of forms. From the spotting of cDNA and the in situ synthesis of oligonucleotide arrays now come microarrays comprising proteins, carbohydrates, drugs, tissues, and cells. With contributions from microarray experts

Protein Microarrays

Author : Mark Schena
Publisher : Jones & Bartlett Publishers
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Protein Microarrays by : Mark Schena

Download or read book Protein Microarrays written by Mark Schena and published by Jones & Bartlett Publishers. This book was released on 2005 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Microarrays is one of the first books in this exciting new technology and will be an essential reference for most biologists and biotechnology professionals.

Microarray Innovations

Author : Gary Hardiman
Publisher : CRC Press
ISBN 13 : 1420094513
Total Pages : 362 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Microarray Innovations by : Gary Hardiman

Download or read book Microarray Innovations written by Gary Hardiman and published by CRC Press. This book was released on 2009-04-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr

Small Molecule Microarrays: Methods and Protocols

Author : Mahesh Uttamchandani
Publisher : Methods in Molecular Biology
ISBN 13 : 9781493982424
Total Pages : 274 pages
Book Rating : 4.9/5 (824 download)

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Book Synopsis Small Molecule Microarrays: Methods and Protocols by : Mahesh Uttamchandani

Download or read book Small Molecule Microarrays: Methods and Protocols written by Mahesh Uttamchandani and published by Methods in Molecular Biology. This book was released on 2018-12-05 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proteomics: Biomedical and Pharmaceutical Applications

Author : Hubert Hondermarck
Publisher : Springer Science & Business Media
ISBN 13 : 1402023235
Total Pages : 396 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Proteomics: Biomedical and Pharmaceutical Applications by : Hubert Hondermarck

Download or read book Proteomics: Biomedical and Pharmaceutical Applications written by Hubert Hondermarck and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.