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Functional Genomics Of Xenobiotic Detoxifying Fungal Cytochrome P450 System
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Book Synopsis Functional Genomics of Xenobiotic Detoxifying Fungal Cytochrome P450 System by : Venkataramanan Subramanian
Download or read book Functional Genomics of Xenobiotic Detoxifying Fungal Cytochrome P450 System written by Venkataramanan Subramanian and published by . This book was released on 2008 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The white rot fungus Phanerochaete chrysosporiumis primarily known for its ability to degrade a wide range of xenobiotic compounds including the highly recalcitrant polycyclic aromatic hydrocarbons. The natural substrate of this basidiomycete fungus is however, lignin, the most abundant aromatic polymer on earth. The versatililty of this fungus in breaking down a wide array of compounds arises from the presence of a highly nonspecific enzyme system (peroxidase enzyme system) in its repertoire. Most of the research involving degradation of toxic chemicals has focused on this biodegrading enzyme machinery. Cytochrome P450 monooxygenases (P450s) on the other hand, are heme-thiolate proteins that are known to be involved in metabolism of endogenous compounds as well as xenobiotic compounds in higher eukaryotes. Nearly 150 P450s are present in this organism, which is the highest number known till date among fungal species. Based on the sequence similarity criteria and our phylogenetic analysis, these P450s have been classified under 12 families and 23 sub-families. Despite indirect evidences suggesting the role of P450s in oxidation of xenobiotics, there have been hardly any reports on characterization and role of individual P450s either in regulation of physiological processes or in direct metabolism of xenobiotics in this organism. Here we characterized and investigated the role of P450 enzymes in two different mechanisms in this fungus. One, indirect involvement of P450s in peroxidase-mediated oxidation of xenobiotics, and two, direct involvement of P450s in metabolism of xenobiotics. In order to achieve the first objective, we investigated the role of PC-bphgene, the only member of the P450 CYP53 in synthesis of a secondary metabolite, veratryl alcohol, which regulates the activity of the peroxidase enzyme system of this fungus. In order to achieve the second objective, we used the functional genomic approach based on a custom-designed microarray and heterologous expression of the components of the P450 enzyme system (P450 and its associated electron transfer proteins) in this white rot fungus.
Book Synopsis Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 by : Eugene G. Hrycay
Download or read book Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 written by Eugene G. Hrycay and published by Springer. This book was released on 2015-05-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Book Synopsis Pharmacoepigenetics by : Ramón Cacabelos
Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
Book Synopsis The Biosynthesis of Mycotoxins by : Pieter Steyn
Download or read book The Biosynthesis of Mycotoxins written by Pieter Steyn and published by Elsevier. This book was released on 2012-12-02 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.
Download or read book The Fungi written by Sarah C. Watkinson and published by Academic Press. This book was released on 2015-12-08 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fungi, Third Edition, offers a comprehensive and thoroughly integrated treatment of the biology of the fungi. This modern synthesis highlights the scientific foundations that continue to inform mycologists today, as well as recent breakthroughs and the formidable challenges in current research. The Fungi combines a wide scope with the depth of inquiry and clarity offered by three leading fungal biologists. The book describes the astonishing diversity of the fungi, their complex life cycles, and intriguing mechanisms of spore release. The distinctive cell biology of the fungi is linked to their development as well as their metabolism and physiology. One of the great advances in mycology in recent decades is the recognition of the vital importance of fungi in the natural environment. Plants are supported by mycorrhizal symbioses with fungi, are attacked by other fungi that cause plant diseases, and are the major decomposers of their dead tissues. Fungi also engage in supportive and harmful interactions with animals, including humans. They are major players in global nutrient cycles. This book is written for undergraduates and graduate students, and will also be useful for professional biologists interested in familiarizing themselves with specific topics in fungal biology. - Describes the diversity of the fungi, their life cycles, and mechanisms of spore release - Highlights the study of fungal genetics and draws upon a wealth of information derived from molecular biological research - Explains the cellular and molecular interactions that underlie the key roles of fungi in plant diversity and productivity - Elucidates the interactions of fungi with other microbes and animals - Highlights fungi in a changing world - Details the expanding uses of fungi in biotechnology
Book Synopsis Bioprospecting of Microorganism-Based Industrial Molecules by : Sudhir P. Singh
Download or read book Bioprospecting of Microorganism-Based Industrial Molecules written by Sudhir P. Singh and published by John Wiley & Sons. This book was released on 2021-12-13 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover a comprehensive and current overview of microbial bioprospecting written by leading voices in the field In Bioprospecting of Microorganism-Based Industrial Molecules, distinguished researchers and authors Sudhir P. Singh and Santosh Kumar Upadhyay deliver global perspectives of bioprospecting of biodiversity. The book covers diverse aspects of bioprospecting of microorganisms demonstrating biomass value of nutraceutical, pharmaceutical, biomedical, and bioenergetic importance. The authors present an amalgamation of translational research on bioresource utilization and ecological sustainability that will further the reader’s knowledge of the applications of different microbial diversity and reveal new avenues of research investigation. Readers will also benefit from: A thorough introduction to microbial biodiversity and bioprospecting An exploration of anti-ageing and skin lightening microbial products and microbial production of anti-cancerous biomolecules A treatment of UV protective compounds from algal biodiversity and polysaccharides from marine microalgal sources Discussions of microbial sources of insect toxic proteins and the role of microbes in bio-surfactants production Perfect for academics, scientists, researchers, graduate and post-graduate students working and studying in the areas of microbiology, food biotechnology, industrial microbiology, plant biotechnology, and microbial biotechnology, Bioprospecting of Microorganism-Based Industrial Molecules is an indispensable guide for anyone looking for a comprehensive overview of the subject.
Book Synopsis Hormones and Resistance by : Hans Selye
Download or read book Hormones and Resistance written by Hans Selye and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 1158 pages. Available in PDF, EPUB and Kindle. Book excerpt: 7 If so, the individual members of each class thus identified could then be subjected to a more profound pharmacokinetic analysis. In other words, we had to determine first which hormone protects against which drug, before we could explore how it did this. We had to know first that a hormone has adaptive value before we could ask whether this is due to a syntoxic or a catatoxic mechanism. Such observations, as the fact that an indomethacin-induced intestinal ulcer can be prevented by ethylestrenol, orthat cortisol aggravates certain infections, reveal nothing about how these hormones work; but only findings of this type can tell us where further research would be rewarding. Of course, scientists can rarely identify by direct observation the tbings that they are looking for; most of the time they have to be guided by indirect indices. The ebernist often first detects a compound, or even a particular functional group in its molecule, by inference from a color reaction, a revealing X-ray diffraction pattern or the formation of a characteristic precipitate. The physician must first suspect the presence of a microbe through certain clinical signs and symptoms before he can verify his diagnosis by looking for a particular organism. It is perhaps not too daring to hope that in our first efforts to clarify the role of hormones in resistance, simple, directly visible indicators might also serve us best.
Book Synopsis Advances in Microbial Physiology by : Robert K. Poole
Download or read book Advances in Microbial Physiology written by Robert K. Poole and published by Academic Press. This book was released on 2019-10-24 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microbial Physiology, Volume 75, the latest release in this ongoing series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering, Sulfoxides in bacterial systems, RNA degradosomes and control by signals including c-di-GMP, Protein nanowires: biological function and synthetic constructs for 'Green' electronics, Bacterial nitrous oxide respiration: electron transport chains and copper transfer reactions, Multiple degrees of separation in the central pathways of the catabolism of aromatic compounds in Dikarya fungi, and more. - Contains contributions from leading authorities in microbial physiology - Informs and updates on all the latest developments in the field of microbial physiology
Book Synopsis Bioanalytical Tools in Water Quality Assessment by : Beate Escher
Download or read book Bioanalytical Tools in Water Quality Assessment written by Beate Escher and published by IWA Publishing. This book was released on 2011-12-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen
Book Synopsis Microbial Biodegradation and Bioremediation by : Surajit Das
Download or read book Microbial Biodegradation and Bioremediation written by Surajit Das and published by Elsevier. This book was released on 2014-07-01 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Biodegradation and Bioremediation brings together experts in relevant fields to describe the successful application of microbes and their derivatives for bioremediation of potentially toxic and relatively novel compounds. This single-source reference encompasses all categories of pollutants and their applications in a convenient, comprehensive package. Our natural biodiversity and environment is in danger due to the release of continuously emerging potential pollutants by anthropogenic activities. Though many attempts have been made to eradicate and remediate these noxious elements, every day thousands of xenobiotics of relatively new entities emerge, thus worsening the situation. Primitive microorganisms are highly adaptable to toxic environments, and can reduce the load of toxic elements by their successful transformation and remediation. - Describes many novel approaches of microbial bioremediation including genetic engineering, metagenomics, microbial fuel cell technology, biosurfactants and biofilm-based bioremediation - Introduces relatively new hazardous elements and their bioremediation practices including oil spills, military waste water, greenhouse gases, polythene wastes, and more - Provides the most advanced techniques in the field of bioremediation, including insilico approach, microbes as pollution indicators, use of bioreactors, techniques of pollution monitoring, and more
Book Synopsis Mycotoxins in Fruits and Vegetables by : R. Barkai-Golan
Download or read book Mycotoxins in Fruits and Vegetables written by R. Barkai-Golan and published by Elsevier. This book was released on 2011-09-02 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are toxins produced by aerobic, microscopic fungus under special conditions of moisture and temperature. They colonize in a variety of foods from harvest to the grocer. Mycotoxins have gained world wide interest in recent years with the revelation of the effect of these toxins on health. A current example is the presence of ochratoxin A, a human carcinogen and nephrotoxin, in wines. The increased concern about fruit safety has led to increased studies throughout the world and enhanced awareness for stringent regulations governing mycotoxin limits in food.Presented in three defined sections, this is the first book to provide comprehensive analysis of the main mycotoxins contaminating fruits and vegetables and their derived products. The first section provides a safety evaluation of mycotoxins in fruits and vegetables, details regarding factors affecting mycotoxin production and diffusion in the fruit tissue, and recent methods for detection of mycotoxigenic fungi and mycotoxins produced by the fungi. The second part takes a critical look at the main individual mycotoxins and the third section focuses on approaches for prevention and control. - The first book dedicated to mycotoxins in fruits and vegetables - Presents mycological, mycotoxicological and phytopathological aspects of fruits and vegetables - Includes an analysis of detection, prevention and control methods for mycotoxigenic fungi and the mycotoxins they produce - Provides a complete risk assessment and safety evaluation of mycotoxins in perishable produce
Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Author :Paul Ortiz De Monetllano Publisher :Springer Science & Business Media ISBN 13 :9780306421471 Total Pages :572 pages Book Rating :4.4/5 (214 download)
Book Synopsis Cytochrome P-450 by : Paul Ortiz De Monetllano
Download or read book Cytochrome P-450 written by Paul Ortiz De Monetllano and published by Springer Science & Business Media. This book was released on 1986-03 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.
Book Synopsis Regulation of Enzymatic Systems Detoxifying Xenobiotics in Plants by : Kriton K. Hatzios
Download or read book Regulation of Enzymatic Systems Detoxifying Xenobiotics in Plants written by Kriton K. Hatzios and published by Springer Science & Business Media. This book was released on 1997-07-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Research Workshop (ARW) on "Regulation of Enzymatic Systems Detoxifying Xenobiotics in Plants" intended to provide a forum to scientists from academia, industry, and govemment for discussing and critically assessing recent advances in the field of xenobiotic metabolism in plants and for identifying new directions for future research. Plants function in a chemical environment made up of nutrients and xenobiotics. Xenobiotics (foreign chemicals) are natural or synthetic compounds that can not be utilized by plants for energy-yielding metabolism. Plants may be exposed to xenobiotics either deliberately, due to their use as pesticides or accidentally, from industrial, agricultural, and other uses. Plants, like most other organisms, evolved a remarkable battery or metabolic reactions to defend themselves against the potentially toxic effects of xenobiotics. The main enzymatic reactions utilized by plants for xenobiotic detoxification include oxidation, reduction, hydrolysis and conjugation with glutathione, sugars (e.g., glucose), and amino acids. Eventually, xenobiotic conjugates are converted to insoluble bound residues or to secondary conjugates, which are deposited in the vacuole of plant cells.
Book Synopsis Plant Responses to Xenobiotics by : Anita Singh
Download or read book Plant Responses to Xenobiotics written by Anita Singh and published by Springer. This book was released on 2016-12-28 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is compilation of studies related with the xenobiotics i.e. chemical or other substance that is not normally found in the ecosystems and get accumulated at higher concentration in the biological system due to rampant industrialisation and urbanisation activities. This book has tried to give information on various issues to give comprehensive and concise knowledge of the recent advancement in the field of environmental xenobiotics and how it disturbs the plants metabolism. Other key features of the book are related to xenobiotic toxicity and detoxification mechanism, biochemical tools toward its remediation processes, molecular mechanism for xenobiotics detoxification and effect on metallomics. It also focuses on recent development in the field of waste water remediation concerned with the xenobiotics involvement. This book is different in such a way that it includes all the initial information along with the new researches. It includes the description of problem along with its solution. This volume describe the effects of xenobiotics at different levels i.e. biochemical, physiological and molecular, giving the details on signaling pathways to modify the responses of xenobiotics in plant system. Thus, it gives confirming crosstalk between xenobiotic effects and signalling pathways. This book includes description about both the organic contaminants such as pesticides, solvents and petroleum products as well as inorganic xenobiotics that include heavy metals, non-metals, metalloids, and simple soluble salts. Here the plant is main objective and that have to deal with these kinds of compounds either by avoiding accumulation of these compounds or by exhibiting several enzymatic reactions for detoxification including oxidation, reduction, and conjugation reactions. Affected plants exhibit several enzymatic and non-enzymatic antioxidant and other reactions for detoxification of ROS including oxidation, reduction, hydrolysis and conjugation reactions. The book focuses on different forms and sources of xenobiotics including organic and inorganic xenobiotics. The matter of this book will definitely increase the knowledge about the impacts of xenobiotics on plants system. There must be potentially broad readership who could find this fruitful for their study as well as for their research. As this book has balance between basic plant physiology and toxicity caused by the xenobiotics so it can be widely used in several disciplines. Overall, the book will bring deep knowledge in the field of xenobiotics toxicity in plants during recent years and it is definitely a compilation of interesting information which isn't fully covered elsewhere in the current market.
Book Synopsis Recent Advances in Cancer Research and Therapy by : Xin-Yuan Liu
Download or read book Recent Advances in Cancer Research and Therapy written by Xin-Yuan Liu and published by Elsevier. This book was released on 2012-05-18 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. - Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. - Formatted for a broad audience including all working in researching cancer treatments and therapies. - Discusses special traits and results of Chinese cancer research.
Book Synopsis Freshwater Fungi by : E. B. Gareth Jones
Download or read book Freshwater Fungi written by E. B. Gareth Jones and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-08-27 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The available literature on freshwater fungi is limited. Over the subsequent years a considerable volume of scientific papers have appeared scattered throughout numerous journals. There is therefore no recent synthesis of the subject and this is the objective of the proposed book. Freshwater habitats are rich in fungi with some 3,000 described species, most of papers focussing on their identification, substrata they grow on and world distribution. However, these fungi play an important role in the freshwater ecosystem, and are primarily involved in the breakdown of leaf litter contributing food for detritus feeders. Our book will bring together a wide range of acclaimed mycologists to review recent developments on the biology and ecology of freshwater fungi, particularly their molecular phylogeny, biodiversity, causative diseases of freshwater amphibians, fishes and invertebrate animals, decomposition of leaf litter, stream pollution and their potential role in bioremediation.
