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Author : Josefine Gerhardt
Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.:/5 (778 download)
Download or read book Functional Characterization of Prostate Cancer Biomarkers written by Josefine Gerhardt and published by . This book was released on 2011 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yu Zhang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (17 download)
Download or read book Functional Characterization of Three Novel Candidate Biomarkers and Therapeutic Targets for Prostate Cancer written by Yu Zhang and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew Daniel Parker
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (1 download)
Download or read book Identification and Functional Characterisation of Prostate Cancer Biomarkers written by Matthew Daniel Parker and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (1 download)
Download or read book Functional Characterization of JAG1 in Prostate Cancer written by and published by . This book was released on 2016 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xing Xu
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (95 download)
Download or read book Functional Characterization of Common Prostate Cancer Risk Variants written by Xing Xu and published by . This book was released on 2014 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Julia Romic-Pickl
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (983 download)
Download or read book Functional Characterization of the Prostate Cancer Progression Marker MiR-375 written by Julia Romic-Pickl and published by . This book was released on 2016* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Md Faqrul Hasan
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (11 download)
Download or read book Identification and Functional Characterization of a Long Non-coding RNA Associated with Prostate Cancer written by Md Faqrul Hasan and published by . This book was released on 2019 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most common cancer in men in the western world. Although early stage prostate cancer is treatable late stage, more specifically, metastatic and drug resistant prostate cancers are mostly incurable. The failure of current treatments obligates the research community to explore novel areas in prostate cancer biology and find better therapeutic targets. Emerging evidences show that non-coding RNAs specifically long non-coding RNAs (lncRNAs) play regulatory roles in various cellular processes and are frequently dysregulated in cancer including prostate cancer. These aberrantly expressed lncRNAs mostly with unexplored genetic information may drive cancer progression. Previous studies done in our laboratory showed a tumor suppressor role of a cluster of small non-coding RNAs or microRNA (miRNA) miR-17-92a in PC-3 prostate cancer cells. To learn the underlying mechanism, transcriptome analysis with or without expression of miR-17-92a was conducted in our laboratory. RNA-sequencing data analysis identified reduced expression of a set of lncRNAs and oncogenes, and up regulation of several tumor suppressor genes upon expression of miR-17-92a cluster miRNAs. One of the down regulated intergenic lncRNAs, PAINT (Prostate Cancer Associated Intergenic Non-coding Transcript) (LINC00888), was selected for determining its functional role in prostate cancer. TCGA and GEO profiles analyses revealed up regulation of PAINT in prostate tumors with higher Gleason Scores, in highly aggressive metastatic prostate cancer cell lines, and upon androgen deprivation therapy of prostate cancer cells.
Author : Alexander Hermani
Publisher :
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.:/5 (181 download)
Download or read book Identification and Functional Characterization of Novel Markers for Prostate Cancer written by Alexander Hermani and published by . This book was released on 2005 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (227 download)
Download or read book Functional Characterization of Two Novel Human Prostate Cancer Metastasis Related Genes written by and published by . This book was released on 2006 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: We propose to identify the functional characterization of two novel cancer-specific, metastasis-related genes whose constitutive expression may be pivotal for prostate cancer progression. Work accomplished in the first year was performed based on the proposed statement of work. We have characterized the full-length cDNAs of the Seq1 and Seq2 genes using at least three 5 and 3 rapid amplification of cDNA ends (RACE) commercial kits (Invitrogen Carlsbad, CA, BD Bioscience (Clontech Inc), and Seegene, Rockville, MD). In the second year, we subcloned cDNAs in expression plasmids and were sequence verified for orientation and recombinant protein expression, in vitro translation, and antibody production. Our research plans of development of antibodies and validation of expression in tissue sections were disrupted by hurricane Katrina and destruction of all of our laboratory materials and supplies and experimental animals. Tulane is now working hard towards restructuring our facilities to resume our research project in the Spring/2006.
Author : Ramesh Ummanni
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (31 download)
Download or read book Differentially Expressed Proteins in Prostate Cancer and Functional Characterization of Proteins with Altered Expression written by Ramesh Ummanni and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Annika Fendler
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (794 download)
Download or read book MiRNAs and Prostate Cancer written by Annika Fendler and published by . This book was released on 2011 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.:/5 (227 download)
Download or read book Identification and Characterization of Prostate Cancer Associated Protein Biomarkers Using High-Throughput Mass Spectrometry written by and published by . This book was released on 2006 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer (PCa) remains to be the most common non-skin cancer in the US. Currently available screening tests for PCa including prostate specific antigen (PSA) test, digital rectal examination (DRE) and prostate biopsy, call for more accurate and non-invasive techniques to detect, diagnose, and stratify the disease based on molecular markers present in the body fluids. Using MALDI-TOF mass spectrometry protein fingerprint profiling, we generated decision tree algorithms to classify cancer from non-cancer. We have also devised strategies to isolate and identify protein biomarkers from the fingerprint profiles of PCa patients in the clinical gray-area where PSA fails to detect cancer. Identification of such cancer biomarkers will assist in development of better non-invasive diagnostic tools for prostate cancer and may also lead to better therapeutic targets.
Author : Abdulrahman Mohammed Alwhaibi
Publisher :
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4.:/5 (112 download)
Download or read book The Unconventional Role of Akt1 in Advanced Prostate Cancer written by Abdulrahman Mohammed Alwhaibi and published by . This book was released on 2019 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jun Jie Hua
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book Functional Analysis of Risk Single Nucleotide Polymorphism and Long Noncoding RNA in Prostate Cancer written by Jun Jie Hua and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most commonly diagnosed non-cutaneous cancer in men worldwide. While most low-risk prostate cancer patients have a favourable clinical outcome, intermediate- and high-risk patients with aggressive forms of the disease often relapse despite the initially effective local and conventional androgen-deprivation therapies. Therefore, two main challenges in the field of prostate cancer are patient stratification into appropriate risk groups through prognostic biomarkers and novel therapeutic options for patients with aggressive prostate cancer. Prostate cancer has a strong genetic component, with Genome-wide Association Studies (GWAS) identifying over 150 risk single nucleotide polymorphisms (SNPs). While these risk SNPs are associated with prostate cancer predisposition and a few also associated with disease progression, their functional mechanisms remain elusive. Here, I evaluated the association of the risk SNP rs11672691 with prostate cancer progression and its clinical relevance, and uncovered its regulatory mechanisms at a novel bifunctional enhancer-promoter element to dysregulate two gene isoforms of a long noncoding RNA (lncRNA) PCAT19. Furthermore, I validated the oncogenic properties of the lncRNA PCAT19, and revealed its function in prostate cancer progression through the upregulation of a subset of cell cycle genes with the RNA binding protein HNRNPAB. My work signifies the clinical importance in understanding the functional mechanisms of prostate cancer risk SNPs and lncRNAs in prostate cancer. Additionally, my work also shed light on the function and molecular mechanisms of a novel class of regulatory elements in the human genome, and its role in cancer aggressiveness.
Author : Richard J. Ablin
Publisher : Macmillan
ISBN 13 : 1137278749
Total Pages : 274 pages
Book Rating : 4.1/5 (372 download)
Download or read book The Great Prostate Hoax written by Richard J. Ablin and published by Macmillan. This book was released on 2014-03-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals how fear-based and inaccurate testing is resulting in unnecessary high-risk surgeries, arguing that the PSA test was never intended for prostate cancer screening.
Author : Manfred Wirth
Publisher : Walter de Gruyter
ISBN 13 : 3110807270
Total Pages : 220 pages
Book Rating : 4.1/5 (18 download)
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jacqueline Boultwood
Publisher : Springer Science & Business Media
ISBN 13 : 1592591353
Total Pages : 302 pages
Book Rating : 4.5/5 (925 download)
Download or read book Molecular Analysis of Cancer written by Jacqueline Boultwood and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chapters describing techniques for the identification of chromosomal abnormalities and comprising: fluor- cent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), and microsatellite analysis. FISH has a pro- nent role in the molecular analysis of cancer and can be used for the detection of numerical and structural chromosomal abnormalities. The recently described SKY, in which all human metaphase chromosomes are visualized in specific colors, allows for the definition of all chromosomal rearrangements and marker chromosomes in a tumor cell. Protocols for the detection of chromosomal re- rangements by PCR and RT-PCR are described, as well as the technique of DNA fingerprinting, a powerful tool for studying somatic genetic alterations in tumorigenesis.
