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Frontiers In Transplantology
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Book Synopsis Frontiers in Transplantology by : Hesham Abdeldayem
Download or read book Frontiers in Transplantology written by Hesham Abdeldayem and published by BoD – Books on Demand. This book was released on 2016-09-07 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.
Book Synopsis Defying the Gods by : Scott McCartney
Download or read book Defying the Gods written by Scott McCartney and published by Scribner. This book was released on 1994 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Defying the Gods, Scott McCartney takes the reader inside the world of organ transplants, focusing on four patients at the Baylor University Medical Center in Dallas. Baylor is home to one of the top three leading transplant teams in the country - a pair of "Top Gun" cutters who have stretched the boundaries of science to save lives. Defying the Gods shows not only what goes on inside the operating room, but also details the circumstances that brought the patients and the organs to the operating table - because for every triumphant successful transplant, there is the death of the person who donated the organ. McCartney follows the four patients on this difficult journey, from the weeks or even months of anguished waiting on the list of potential recipients, to the stressful recovery period when both doctors and patients watch tensely to see if the organ will be rejected by the patient's body - which in some cases means death. McCartney also profiles the transplant surgeons, who consider themselves on the cutting edge of medicine as they constantly push back the borders of death, and explains and critiques the transplant system: Who decides who gets one of the small number of available organs, and how is that decision made? Are doctors' and hospitals' hands tied by the laws regulating the collection and allocation of organs, or do they manipulate those laws? How important is it for patients to pass what doctors call the "wallet biopsy"? What can we do to assure an adequate supply of organs in the future? Defying the Gods is the definitive account of the history, science, and ethics that make transplants possible, covering the terrible choices transplantation presents for families, themoral dilemmas facing doctors, and the ongoing debate over how best to allocate the limited organs to those who need them. It is both suspenseful and moving, addressing important medical issues on a most human level.
Book Synopsis Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives by : Caner Süsal
Download or read book Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives written by Caner Süsal and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation by : Narinder K. Mehra
Download or read book Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation written by Narinder K. Mehra and published by Frontiers Media SA. This book was released on 2017-07-25 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, in addition to serving as excellent tools for initiating pre-transplant desensitization and post- transplant antibody monitoring. Consensus is evolving on the optimal routine employment of these methods in donor selection strategies along with an understanding of the clinical relevance of antibodies detected by each of them. The immunoassays based on the Luminex platform and flow cytometric beads are however unable to discriminate complement fixing from non-complement fixing HLA antibodies. This is important because the former are considered clinically more pertinent in the peri-transplant period. The C1q assay which is a modification of the solid phase assay based on Luminex single antigen beads, which can be used effectively to monitor high dose IVIG desensitization is essentially a surrogate complement fixing assay, retaining the exquisite sensitivity and specificity of the Luminex platform. Currently, information obtained from these assays is preliminary and much needs to be done to standardize technologies and set a consensus ‘MFI cut off’ for antibody positivity. Besides the overriding influence of anti-HLA antibodies on overall solid organ graft survival, immune response to non-HLA antigens has become a topic of substantial interest in recent years. An ever expanding list of non-HLA antigens has been implicated in graft rejection for various organs, of which the most noted are the Major Histocompatibility Complex class I chain-related molecule A (MICA), Vimentin, Myosin, Angiotensin II type 1 receptor (AT1R), Tubulin and Collagen. MICA is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in renal transplantation. Although there are clear indications of MICA antibodies being associated with adverse graft outcome, to date a definitive consensus on this relationship has not been agreed. Because MICA molecules are not expressed constitutively on immunocompetent cells such as T and B lymphocytes, it is of utmost importance to address the impact of MICA donor specific antibodies (DSA) as compared to those that are non- donor specific (NDSA) on graft outcome. The soluble isoform of MICA molecule (sMICA) that is derived from the proteolytic shedding of membrane bound molecules has the potential to engage the NK-cell activating receptor NKG2D and down-regulate its expression. Consequent to the interaction of NKG2D by sMICA, the receptor ligand complex is endocytosed and degraded and thus suppresses NKG2D mediated lysis of the target by NK cells. Thus interaction between NKG2D and sMICA leads to expansion of immunosuppressive/anergic T cells thereby resulting in suppression of NKG2D mediated host innate immunity. These concept support the possible involvement of an immunosuppressive role for sMICA during allotransplantation as shown recently for heart transplantation. This research topic focusses on the clinical utility of investigating the complete antibody repertoire in solid organ transplantation.
Book Synopsis New Frontiers in Liver Transplantation by : Duke Todd
Download or read book New Frontiers in Liver Transplantation written by Duke Todd and published by . This book was released on 2019-06-17 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The replacement of a diseased liver with a healthy liver is known as liver transplantation. Liver transplantation is used as a treatment option for acute liver failure and end-stage liver disease. Orthotopic transplantation is a common and effective technique used for liver transplantation. The transplantation surgery usually takes 4 to 18 hours. The common requirements for a liver donor include good health, a blood type which is compatible with the recipient, having an age of 20-60 years, and being of similar or larger size than the recipient. Liver transplantation involves a few complications, such as infection, bleeding, possibility of blood clots, painful incision and prolonged recovery. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of liver transplantation. It studies, analyzes and upholds the pillars of liver transplantation and its utmost significance in modern times. The extensive content of this book provides the readers with a thorough understanding of the subject.
Book Synopsis ABO-Incompatible Kidney Transplantation, Chapter 12 by : Masayuki Tasaki
Download or read book ABO-Incompatible Kidney Transplantation, Chapter 12 written by Masayuki Tasaki and published by . This book was released on 2016 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previously, ABO-incompatible kidney transplantation (KTx) was believed to be a "taboo" for immunological reasons. In Japan, the Tokyo Women's Medical University reported the first successful case of such transplantation, performed on January 19, 1989. Since then, we have been striving to improve the outcome of ABO-incompatible transplantation for a quarter of a century.
Book Synopsis Frontiers of Combining Systems by : F. Baader
Download or read book Frontiers of Combining Systems written by F. Baader and published by Springer. This book was released on 2014-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Donation refusal is high in all the regions of Argentina. - The deficient operative structure is a negative reality that allows inadequate donor maintenance and organ procurement. - In more developed regions, there are a high number of organs which are not utilized. This is true for heart, liver and lungs. Small waiting lists for these organs probably reflect an inadequate economic coverage for these organ transplant activities. - There is a long waiting list for cadaveric kidney transplants, which reflect poor procurement and transplant activity. - Lack of awareness by many physicians leads to the denouncing of brain deaths. In spite of these factors, we can say that there has been a significant growth in organ procuration and transplantation in 1993, after the regionalization of the INCUCAI. Conclusions Is there a shortage of organs in Argentina? There may be. But the situation in Argentina differs from that in Europe, as we have a pool of organs which are not utilized (donation refusal, operational deficits, lack of denouncing of brain deaths). Perhaps, in the future, when we are able to make good use of all the organs submitted for transplantation, we will be able to say objectively whether the number of organs is sufficient or not. Acknowledgements I would like to thank the University of Lyon and the Merieux Foundation, especially Professors Traeger, Touraine and Dr. Dupuy for the honour of being invited to talk about the issue of organ procurement.
Book Synopsis Frontiers in Thoracic Transplantation: Molecular Medicine by :
Download or read book Frontiers in Thoracic Transplantation: Molecular Medicine written by and published by . This book was released on 2005 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Frontiers on Bone Marrow Transplantation by :
Download or read book Frontiers on Bone Marrow Transplantation written by and published by . This book was released on 1991 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Challenging Frontiers in Renal Transplantation by : Hessel Peters-Sengers
Download or read book Challenging Frontiers in Renal Transplantation written by Hessel Peters-Sengers and published by . This book was released on 2018 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation by : Dominik Schneidawind
Download or read book Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation written by Dominik Schneidawind and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Transplantation Immunology by : Fritz H. Bach
Download or read book Transplantation Immunology written by Fritz H. Bach and published by Wiley-Liss. This book was released on 1995-08-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided into four sections: Major and Minor Histocompatibility Antigens, Immunobiology of Graft Rejection, Clinical Transplantation, and Frontiers in Transplantation. The first two sections cover present-day understanding of the genetic controls of immunity as well as the two basic concerns of transplantation immunology, namely donor tissue antigens and the host cellular response. The third section deals with clinical aspects of transplantation, while the fourth looks toward future efforts of scientific research in this field—including advances in tolerance and xenotransplantation. A detailed appendix entitled "Molecular Biology for the Clinician" is included to help make the material accessible to readers of all backgrounds. Authored by a wide range of experts in both clinical and research fields, individual chapters cover such topics as: T cell immunity Antigen presentation Alloreactivity Pancreas and islet cell transplantation Allogeneic bone marrow transplantation Models of tolerance induction Xenotransplantation The swine leukocyte antigen (SLA) complex Transplantation Immunology is an ideal teaching text for the fundamental concepts, latest findings, and future directions in this increasingly important field. This volume will appeal to a wide range of clinicians including surgeons and primary-care physicians, as well as scientists in molecular biology and immunology.
Book Synopsis Transplantation Surgery by : Nadey Hakim
Download or read book Transplantation Surgery written by Nadey Hakim and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.
Book Synopsis Contemporary Bioethics by : Mohammed Ali Al-Bar
Download or read book Contemporary Bioethics written by Mohammed Ali Al-Bar and published by Springer. This book was released on 2015-05-27 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved.
Book Synopsis Split liver transplantation by : X. Rogiers
Download or read book Split liver transplantation written by X. Rogiers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aimed at the trainee surgeon and experienced transplant surgeon, this compendium on split-liver grafting contains articles written by faculty members of the first International Course on Split-Liver Transplantation. It covers the main aspects of the field and is geared towards helping surgeons select the best surgical techniques as well as identifying the pitfalls. The text features detailed instructions on the various procedures as well as an overview of the area.
Book Synopsis ABO-incompatible Kidney Transplantation by : Kōta Takahashi
Download or read book ABO-incompatible Kidney Transplantation written by Kōta Takahashi and published by . This book was released on 2001 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABO incompatible kidney transplantation is indicated for patients for whom no ABO-identical or minor mismatch donor is available. Since the author and his colleagues performed the first ABO-incompatible kidney transplantation in Japan in 1989, 400 such transplantations have been performed in 41 hospitals in Japan and this practice has contributed to a number of new developments. One is a clearer and more suitable model for conceptualising the mechanism of humoral immune response which enables identification of antigens and antibodies and a therapeutic strategy against rejection. The rejection mechanisms are discussed not only from the perspective of immunology but also viewed from different angles, including anatomy, microscopic and macroscopic pathology, molecular biology and haematology. Immunosuppressive therapy is discussed, divided in four categories: extracorporeal immunomodulation with removal of humoral antibodies; drug therapy to suppress cellular immunity; splenectomy; and anticoagulation therapy. Surgical procedures for kidney transplantation and splenectomy are treated, including discussion of the best timing for the latter. The book gives an overview of the current status with statistics and results of questionnaires and ends with discussions of 17 case histories.
Book Synopsis The New Frontiers of Fashion Law by : Rossella Esther Cerchia
Download or read book The New Frontiers of Fashion Law written by Rossella Esther Cerchia and published by MDPI. This book was released on 2021-01-13 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fashion law encompasses a wide variety of issues that concern an article of clothing or a fashion accessory, starting from the moment they are designed and following them through distribution and marketing phases, all the way until they reach the end-user. Contract law, intellectual property, company law, tax law, international trade, and customs law are of fundamental importance in defining this new field of law that is gradually taking shape. This volume focuses on the new frontiers of fashion law, taking into account the various fields that have recently emerged as being of great interest for the entire fashion world: from sustainable fashion to wearable technologies, from new remedies to cultural appropriation to the regulation of model weight, from advertising law on the digital market to the impact of new technologies on product distribution. The purpose is to stimulate discussion on contemporary problems that have the potential to define new boundaries of fashion law, such as the impact of the heightened ethical sensitivity of consumers (who increasingly require effective solutions), that a comparative law perspective renders more interesting. The volume seeks to sketch out the new legal fields in which the fashion industry is getting involved, identifying the new boundaries of fashion law that existing literature has not dealt with in a comprehensive manner.
