Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Framework For The Use Of Systematic Review In Chemical Risk Assessment full books in PDF, epub, and Kindle. Read online Framework For The Use Of Systematic Review In Chemical Risk Assessment ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author :
Publisher : World Health Organization
ISBN 13 : 924003448X
Total Pages : 77 pages
Book Rating : 4.2/5 (4 download)
Download or read book Framework for the use of systematic review in chemical risk assessment written by and published by World Health Organization. This book was released on 2021-11-03 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Academies Of Sciences Engineeri
Publisher : National Academies Press
ISBN 13 : 9780309683869
Total Pages : pages
Book Rating : 4.6/5 (838 download)
Download or read book The Use of Systematic Review in Epa's Toxic Substances Control ACT Risk Evaluations written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2021-11-16 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematic review - a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies - has become the foundation for assessing evidence to be used for decision making in a variety of health contexts, including health care and public health. At the request of the Environmental Protection Agency (EPA), this publication reviews EPA's 2018 guidance document Application of Systematic Review in TSCA (Toxic Substances and Control Act) Risk Evaluations and associated materials to determine whether the process is comprehensive, workable, objective, and transparent.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309164257
Total Pages : 267 pages
Book Rating : 4.3/5 (91 download)
Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)
Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264070826
Total Pages : 14 pages
Book Rating : 4.2/5 (64 download)
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Author : R M Harrison
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737231
Total Pages : 323 pages
Book Rating : 4.8/5 (497 download)
Download or read book Chemical Alternatives Assessments written by R M Harrison and published by Royal Society of Chemistry. This book was released on 2013-04-30 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemicals are an essential part of everyday life and all too-often taken for granted, yet often portrayed negatively in the media. Concern over the deleterious effects of chemicals to the environment and human health have prompted governments in the developed world to establish screening programmes such as REACH and HPV Challenge to identify chemicals presenting the greatest degree of risk to health and the environment. While such programmes identify chemicals with the greatest risk, there is no ranking system for alternative chemicals, which while being potentially less harmful, still carry a degree of risk. This volume of the Issues in Environmental Science and Technology series investigates how the alternatives can be assessed and their risk determined. With contributions from experts across the globe, this volume addresses some of the key concepts behind risk assessment of alternative chemicals. Some of the current protocols adopted are discussed, and several chapters explore the topic in the context of industry, making this book essential reading for industrialists as well as academics, postgraduate students and policy makers.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309167949
Total Pages : 180 pages
Book Rating : 4.3/5 (91 download)
Download or read book Occupational Health and Safety in the Care and Use of Nonhuman Primates written by National Research Council and published by National Academies Press. This book was released on 2003-06-13 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.
Author : United States Government Accountability Office
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781984159397
Total Pages : 90 pages
Book Rating : 4.1/5 (593 download)
Download or read book Chemical Assessments written by United States Government Accountability Office and published by Createspace Independent Publishing Platform. This book was released on 2018-01-24 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Information System
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309033497
Total Pages : 206 pages
Book Rating : 4.3/5 (9 download)
Download or read book Risk Assessment in the Federal Government written by National Research Council and published by National Academies Press. This book was released on 1983-02-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of potentially hazardous substances has become a controversial issue. This volume evaluates past efforts to develop and use risk assessment guidelines, reviews the experience of regulatory agencies with different administrative arrangements for risk assessment, and evaluates various proposals to modify procedures. The book's conclusions and recommendations can be applied across the entire field of environmental health.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030904894X
Total Pages : 668 pages
Book Rating : 4.3/5 (9 download)
Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309458625
Total Pages : 423 pages
Book Rating : 4.3/5 (94 download)
Download or read book Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Author : United States. Presidential/Congressional Commission on Risk Assessment and Risk Management
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (6 download)
Download or read book Framework for environmental health risk management written by United States. Presidential/Congressional Commission on Risk Assessment and Risk Management and published by . This book was released on 1997 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309068762
Total Pages : 388 pages
Book Rating : 4.3/5 (9 download)
Download or read book Strategies to Protect the Health of Deployed U.S. Forces written by National Research Council and published by National Academies Press. This book was released on 2000-04-17 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk management is especially important for military forces deployed in hostile and/or chemically contaminated environments, and on-line or rapid turn-around capabilities for assessing exposures can create viable options for preventing or minimizing incapaciting exposures or latent disease or disability in the years after the deployment. With military support for the development, testing, and validation of state-of-the-art personal and area sensors, telecommunications, and data management resources, the DOD can enhance its capabilities for meeting its novel and challenging tasks and create technologies that will find widespread civilian uses. Strategies to Protect the Health of Deployed U.S. Forces assesses currently available options and technologies for productive pre-deployment environmental surveillance, exposure surveillance during deployments, and retrospective exposure surveillance post-deployment. This report also considers some opportunities for technological and operational advancements in technology for more effective exposure surveillance and effects management options for force deployments in future years.
Download or read book Guidelines for Setting Specific Concentration Limits for Carcinogens in Annex I of Directive 67/548/EEC written by and published by . This book was released on 1999 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeanne X. Kasperson
Publisher :
ISBN 13 : 9781844070725
Total Pages : 0 pages
Book Rating : 4.0/5 (77 download)
Download or read book The Social Contours of Risk: Publics, risk communication and the social. amplificiation of risk written by Jeanne X. Kasperson and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jeanne and Roger Kasperson are two of the world's leading and most influential analysts of the social dimensions of risk. This book brings together their most important contributions to this fundamental and wide-ranging field.
Author : Ali S. Faqi
Publisher : Humana Press
ISBN 13 : 9781493972067
Total Pages : 314 pages
Book Rating : 4.9/5 (72 download)
Download or read book Developmental and Reproductive Toxicology written by Ali S. Faqi and published by Humana Press. This book was released on 2017-08-18 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div
Author : Susanne Hempel
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (13 download)
Download or read book Systematic Reviews for Occupational Safety and Health Questions written by Susanne Hempel and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This report introduces systematic reviews of the literature as a research methodology to summarize the existing evidence with a transparent, reliable, and valid approach. It covers the systematic review steps: (1) define the question, (2) create a protocol, (3) conduct a literature search and screen for inclusion, (4) document and assess included studies, and (5) evaluate and interpret the body of evidence. The report also provides resources for drawing conclusions and developing recommendations based on the systematic review. We performed a literature review and consulted with producers and consumers of systematic reviews over the course of the project to identify available resources. National Institute for Occupational Safety and Health (NIOSH) staff provided a draft systematic review framework and continuous input to ensure relevance and applicability to occupational safety and health questions. The report draws on key general existing guidance for systematic reviews as well as identified resources specific to occupational safety and health evidence synthesis. Occupational safety and health is an extensive multidisciplinary field and encompasses a broad spectrum of issues that affect the health and safety of individuals in the workplace. Standard systematic review tools and methods may need to be adapted to fit the unique requirements of evidence synthesis for occupational safety and health questions. The report provides practical guidance to execute a systematic review as well as considerations specific to evidence synthesis for occupational safety and health questions"--Publisher's description.
