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Author : Tobias Bollenbach
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (18 download)
Download or read book Formation of Morphogen Gradients written by Tobias Bollenbach and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James Briscoe
Publisher :
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.F/5 ( download)
Download or read book Generation and Interpretation of Morphogen Gradients written by James Briscoe and published by . This book was released on 2010 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signalling by morphogens such as the Hedgehog family, Notch, Wingless/Wnt and various growth factors is essential during embryogenesis. The establishment of concentration gradients of these morphogens plays a key role during developmental patterning in all multicellular organisms, assuring that distinct cell/tissue types and organs appear at the right place in the right time during embryogenesis. Regulation of morphogen synthesis, trafficking and diffusion are all known to play a part in setting up these gradients, and a complex web of signaling mechanisms ensures that specific responses occur at the correct threshold concentration in the recipient cells whose fate depends on these morphogens.
Author : James Briscoe
Publisher : Academic Press
ISBN 13 : 0128127902
Total Pages : 498 pages
Book Rating : 4.1/5 (281 download)
Download or read book Morphogenetic Gradients and Development written by James Briscoe and published by Academic Press. This book was released on 2020-03 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gradients and Tissue Patterning, Volume 137 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.
Download or read book Formation of Morphogen Gradients written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphogens are signaling molecules that play a key role in animal development. They spread from a restricted source into an adjacent target tissue forming a concentration gradient. The fate of cells in the target tissue is determined by the local concentration of such morphogens. Morphogen transport through the tissue has been studied in experiments which lead to the suggestion of several transport mechanisms. While diffusion in the extracellular space contributes to transport, recent experiments on the morphogen Decapentaplegic (Dpp) in the fruit fly Drosophila provide evidence for the importance of a cellular transport mechanism that was termed "planar transcytosis". In this mechanism, morphogens are transported through cells by repeated rounds of internalization and externalization. Starting from a microscopic theoretical description of these processes, we derive systems of nonlinear transport equations which describe the interplay of transcytosis and passive diffusion. We compare the results of numerical calculations based on this theoretical description of morphogen transport to recent experimental data on the morphogen Dpp in the Drosophila wing disk. Agreement with the experimental data is only achieved if the parameters entering the theoretical description are chosen such that transcytosis contributes strongly to transport. Analyzing the derived transport equations, we find that transcytosis leads to an increased robustness of the created gradients with respect to morphogen over-expression. Indications for this kind of robustness have been found in experiments. Furthermore, we theoretically investigate morphogen gradient formation in disordered systems. Here, an important question is how the position of concentration thresholds can be defined with high precision in the noisy environment present in typical developing tissues. Among other things, we find that the dimensionality of the system in which the gradient is formed plays an important.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0123973481
Total Pages : 993 pages
Book Rating : 4.1/5 (239 download)
Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
Author : Benjamin Vargas
Publisher :
ISBN 13 : 9780549411222
Total Pages : 134 pages
Book Rating : 4.4/5 (112 download)
Download or read book Mixed End Conditions and Morphogen Gradient Formation written by Benjamin Vargas and published by . This book was released on 2007 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation is concerned with ligands (such as Decapentaplegic or Dpp for short) that are produced along the anterior-posterior border of the Drosophila wing imaginal disc and then transported away toward the disc edge. They bind with cell surface receptors and possibly non-receptors to form concentration gradients of both ligand receptor complexes and ligand non-receptor complexes respectively. Recent articles such as [13], [15], [16], [17], have already focused on systems of diffusion and reversible binding involving ligand, ligand receptor complexes and receptors with and without non-receptors including aggregated source end models ([13] and [17]). We will focus our attention on one of the compartments (posterior or anterior) of the wing imaginal disc in a one dimensional model. We will then extend this model by including non-receptors in the system. Finally, we consider a two dimensional ligand and receptor model by considering the apical-basal extent of the disc as well. It is in this model where we analyze and determine why the wing imaginal disc size changes with environmental temperature changes.
Author : Johanna Dickmann
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)
Download or read book Formation of Long-ranged Morphogen Gradients by Cell-to-cell Relay written by Johanna Dickmann and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Howard C. Berg
Publisher : Springer Science & Business Media
ISBN 13 : 0387216383
Total Pages : 136 pages
Book Rating : 4.3/5 (872 download)
Download or read book E. coli in Motion written by Howard C. Berg and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Escherichia coli, commonly referred to as E. coli, has been the organism of choice for molecular genetics for decades. Its machinery and mobile behavior is one of the most fascinating topics for cell scientists. Scientists and engineers, not trained in microbiology, and who would like to learn more about living machines, can see it as a unique example. This cross-disciplinary monograph covers more than thirty years of research and is accessible to graduate students and scientists alike.
Author : Julien Dubrulle
Publisher : Humana
ISBN 13 : 9781493993888
Total Pages : 306 pages
Book Rating : 4.9/5 (938 download)
Download or read book Morphogen Gradients written by Julien Dubrulle and published by Humana. This book was released on 2019-12-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book presents methods focusing on the visualization of morphogen gradients, the analysis of their biophysical and biological properties, and the theoretical aspects underlying their functions. The study of morphogen gradients combines biophysics, cell and developmental biology, and applied mathematics approaches to understand their formation, their biological functions, and the prediction of their behavior in space and time, and this volume serves as a practical, hands-on guide to the field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and helpful, Morphogen Gradients: Methods and Protocols is an ideal collection for researchers in this vital area of study.
Author : Hans Driesch
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Science and Philosophy of the Organism written by Hans Driesch and published by . This book was released on 1908 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. M. W. Slack
Publisher : CUP Archive
ISBN 13 : 9780521273299
Total Pages : 260 pages
Book Rating : 4.2/5 (732 download)
Download or read book From Egg to Embryo written by J. M. W. Slack and published by CUP Archive. This book was released on 1983 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the development of the animal embryo starting from the fertilised egg. The emphasis is on the problem of pattern formation: how cells in different regions of the embryo become programmed to form the various structures of the body in the correct relative positions.
Author : Hans Spemann
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.:/5 (318 download)
Download or read book Embryonic Development and Induction written by Hans Spemann and published by . This book was released on 1962 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jamie Davies
Publisher : Springer Science & Business Media
ISBN 13 : 0387308733
Total Pages : 255 pages
Book Rating : 4.3/5 (873 download)
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Author : Douglas W Houston
Publisher : Academic Press
ISBN 13 : 0128125918
Total Pages : 238 pages
Book Rating : 4.1/5 (281 download)
Download or read book Cell Polarity in Development and Disease written by Douglas W Houston and published by Academic Press. This book was released on 2017-11-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs
Author : Kaan Certel
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (148 download)
Download or read book Cell-specific Interpretation of Morphogen Gradients Regulating Cell Proliferation and Pattern Formation written by Kaan Certel and published by . This book was released on 1999 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peng Cheng Zhang
Publisher :
ISBN 13 : 9781339125497
Total Pages : 145 pages
Book Rating : 4.1/5 (254 download)
Download or read book Precision and Robustness in the Interpretation of Morphogen Gradients written by Peng Cheng Zhang and published by . This book was released on 2015 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental pattern formation is orchestrated by diffusible signaling molecules, termed morphogens, that form gradients from which cells can determine positionally appropriate fates. Stochasticity in morphogen binding, signal transduction, and gene expression create local cell-to-cell variability in the readout of morphogen gradients. However, little is known about the actual levels of noise in morphogen gradient responses, or the mechanisms that might control it. To investigate this, I quantified the transcriptional activity noise, protein expression noise, and protein half-life of optomotor blind (omb), one of the downstream targets of the morphogen Dpp in the Drosophila larval wing imaginal disc. Using combined fluorescence in situ hybridization (FISH) with intronic probes, immunofluorescence, image segmentation and image analysis, I observed a very high level of transcriptional variability characterized by coefficients of variation (CV) as high as ~110%, in the cells in which omb plays a central role in specifying the location of wing vein primordium L5. However, the half-life of the Omb protein was found to be very long, ~ 6 hours, which would be expected to provide significant temporal filtering of the transcriptional noise. I showed that the reduction in noise from transcript to protein is sufficient to account for the precision of the positional information that patterns vein L5. I also investigated why the positioning of vein L5 is remarkably robust to genetic manipulation that change the shape of the Dpp morphogen gradient. I observed that patters of Dpp signaling and Omb expression are not constant during larval development, but change continuously, and not always in concert with each other. By taking into account the long half-life of Omb it was possible to build a model that explains both these movements and the remarkable robustness of L5 patterning to changes in Dpp gradient shape.
