Forensic Dna Profiling Protocols Methods In Molecular Biology

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Forensic DNA Profiling Protocols

Author : Patrick J. Lincoln
Publisher : Springer Science & Business Media
ISBN 13 : 0896034437
Total Pages : 617 pages
Book Rating : 4.8/5 (96 download)

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Book Synopsis Forensic DNA Profiling Protocols by : Patrick J. Lincoln

Download or read book Forensic DNA Profiling Protocols written by Patrick J. Lincoln and published by Springer Science & Business Media. This book was released on 1998-01-22 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art collection of easily reproducible methods includes all of the major techniques of DNA analysis currently used in forensic identity testing. The methods include the recovery of DNA from a large range of sample types, analysis of DNA as single and multi-locus VNTR probes, PCR amplification of STR and other loci, and mitochondrial sequencing. The expert scientists writing here -- many from laboratories around the world -- also discuss how to interpret the results in cases of unknown identity and disputed parentage.-- Covers all steps from extraction of human DNA through to analysis and interpretation-- Takes advantage of new methodologies such as capillary electrophoresis-- Clear step-by-step instructions ensure unfailing reproducibility.

Forensic DNA Profiling Protocols. Methods in Molecular Biology

Author : Patrick J. Lincoln
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (748 download)

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Book Synopsis Forensic DNA Profiling Protocols. Methods in Molecular Biology by : Patrick J. Lincoln

Download or read book Forensic DNA Profiling Protocols. Methods in Molecular Biology written by Patrick J. Lincoln and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading forensic experts from around the world describe in detail their time-proven methods for identity testing through DNA analysis. Their state-of-the-art collection of easily reproducible methods includes all of the major techniques of DNA analysis currently used in forensic identity testing. The book covers PCR- based test systems the now widely used STR typing systems (complete with details of both manual and automated detection systems) repeat unit mapping (MVR) direct phase minisequencing capillary electrophoresis and direct blotting. Also fully discussed are the recovery of DNA from a wide range of sample types (blood semen skeletal remains and saliva) species testing sex determination and mitochondrial DNA testing. SMP Version: This state-of-the-art collection of easily reproducible methods includes all of the major techniques of DNA analysis currently used in forensic identity testing. The methods include the recovery of DNA from a large range of sample types analysis of DNA as single and multi-locus VNTR probes PCR amplification of STR and other loci and mitochondrial sequencing.; The expert scientists writing here-many from laboratories around the world-also discuss how to interpret the results in cases of unknown identity and disputed parentage.

Forensic DNA Typing Protocols

Author : Angel Carracedo
Publisher : Springer Science & Business Media
ISBN 13 : 1592598676
Total Pages : 282 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Forensic DNA Typing Protocols by : Angel Carracedo

Download or read book Forensic DNA Typing Protocols written by Angel Carracedo and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art collection of readily reproducible laboratory methods for DNA identity analysis, including Y chromosome haplotyping, mtDNA, and SNP typing. The book offers well-tested protocols for DNA quantification using real-time PCR on forensic samples and for the determination of the number of amelogenine gene copies. For forensic geneticists, there are readily reproducible methods for species identification, ancient DNA, and pharmacogenetics. Additional chapters address new applications in the forensic genetics lab, such a species identification or typing of CYP polymorphisms for the analysis of adverse to drugs.

Forensic DNA Analysis

Author : Catherine Cupples Connon
Publisher : Springer Nature
ISBN 13 : 1071632957
Total Pages : 423 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Forensic DNA Analysis by : Catherine Cupples Connon

Download or read book Forensic DNA Analysis written by Catherine Cupples Connon and published by Springer Nature. This book was released on 2023-08-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the latest techniques used in forensic DNA analysis. The chapters include a comprehensive collection of extraction, quantification, STR amplification, and detection methods for routine forensic samples, including manual, semi-automated, and automated procedures using both home-brew and commercial products. The chapters also discuss probabilistic modeling software and specialized start-to-finish procedures for mitochondrial DNA analysis, archived latent fingerprints, latent DNA, rapid DNA profiling, and next-generation sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Forensic DNA Analysis: Methods and Protocols is a valuable resource for researchers interested in learning more about forensic DNA analysis procedures.

DNA Technology in Forensic Science

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309045878
Total Pages : 199 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis DNA Technology in Forensic Science by : National Research Council

Download or read book DNA Technology in Forensic Science written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matching DNA samples from crime scenes and suspects is rapidly becoming a key source of evidence for use in our justice system. DNA Technology in Forensic Science offers recommendations for resolving crucial questions that are emerging as DNA typing becomes more widespread. The volume addresses key issues: Quality and reliability in DNA typing, including the introduction of new technologies, problems of standardization, and approaches to certification. DNA typing in the courtroom, including issues of population genetics, levels of understanding among judges and juries, and admissibility. Societal issues, such as privacy of DNA data, storage of samples and data, and the rights of defendants to quality testing technology. Combining this original volume with the new update-The Evaluation of Forensic DNA Evidence-provides the complete, up-to-date picture of this highly important and visible topic. This volume offers important guidance to anyone working with this emerging law enforcement tool: policymakers, specialists in criminal law, forensic scientists, geneticists, researchers, faculty, and students.

DNA Electrophoresis Protocols for Forensic Genetics

Author : Antonio Alonso
Publisher : Humana Press
ISBN 13 : 9781617794605
Total Pages : 394 pages
Book Rating : 4.7/5 (946 download)

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Book Synopsis DNA Electrophoresis Protocols for Forensic Genetics by : Antonio Alonso

Download or read book DNA Electrophoresis Protocols for Forensic Genetics written by Antonio Alonso and published by Humana Press. This book was released on 2011-12-08 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic DNA profiling procedures are mainly based on high resolution and high throughput capillary electrophoresis separation and detection systems of PCR amplicons obtained from DNA genomic markers with different inheritance patterns. In DNA Electrophoresis Protocols for Forensic Genetics, expert researchers in the field detail many of the protocols and methods which are now commonly used to perform forensic DNA profiling. It includes protocols for profiling of autosomal STRs, Y-STRs, X-STRs, autosomal SNPs, INDELS, Y-SNPs, mtDNA-SNPs, and mtDNA hypervariable regions HV1 and HV2 . Protocols for molecular identification of non-human species and mRNA profiling for body fluid identification are also included. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

DNA Typing Protocols

Author : Bruce Budowle
Publisher : Eaton Publishing Company
ISBN 13 : 9781881299233
Total Pages : 304 pages
Book Rating : 4.2/5 (992 download)

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Book Synopsis DNA Typing Protocols by : Bruce Budowle

Download or read book DNA Typing Protocols written by Bruce Budowle and published by Eaton Publishing Company. This book was released on 2000 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Fingerprinting: Advancements and Future Endeavors

Author : Hirak Ranjan Dash
Publisher : Springer
ISBN 13 : 9811315833
Total Pages : 325 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis DNA Fingerprinting: Advancements and Future Endeavors by : Hirak Ranjan Dash

Download or read book DNA Fingerprinting: Advancements and Future Endeavors written by Hirak Ranjan Dash and published by Springer. This book was released on 2018-11-01 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics and various applications of DNA fingerprinting, including in actual case studies. The book is divided in four modules; Module 1: Basics of DNA Fingerprinting, Module 2: Applications of DNA Fingerprinting, Module 3: DNA Fingerprinting: Case Studies, and Module 4: Future of DNA Fingerprinting. Each module consists of 4 to 5 chapters, written by reputed researchers, academics and forensic scientists from around the globe. The respective chapters cover e.g. related fields, the tools and techniques used, various genotyping kits, real-world case studies, ancient DNA and wild life forensics, molecular diagnosis of human diseases, legal aspects, microbial forensics and the economics of the DNA fingerprinting technique. The book offers a practical guide for professionals, graduate and post-graduate students in the fields of Forensic Science, Medicine, Genetics, Anthropology, Microbiology, and Zoology. It also serves as a useful reference resource, summarizing major technological advances in the field of DNA fingerprinting, the problems faced in this field of science and possible new solutions to these problems. Presently, DNA fingerprinting is utilized in solving the majority of criminal cases; as such, the book is also helpful for investigating agencies, as it includes representative case studies.

Forensic DNA Profiling

Author : Jo-Anne Bright
Publisher : CRC Press
ISBN 13 : 0429672918
Total Pages : 242 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Forensic DNA Profiling by : Jo-Anne Bright

Download or read book Forensic DNA Profiling written by Jo-Anne Bright and published by CRC Press. This book was released on 2019-12-09 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA testing and its forensic analysis are recognized as the “gold standard” in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods, the polymerase chain reaction (PCR), capillary electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models—including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES: • The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results • Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel • New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence • Includes a chapter on assigning LRs for close relatives (i.e., “It’s not me, it was my brother”), and discusses strategies for the validation of probabilistic genotyping software Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

Forensic DNA Analysis

Author : J. Thomas McClintock
Publisher : CRC Press
ISBN 13 : 1420063308
Total Pages : 178 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Forensic DNA Analysis by : J. Thomas McClintock

Download or read book Forensic DNA Analysis written by J. Thomas McClintock and published by CRC Press. This book was released on 2008-02-19 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its short but active history, the use of DNA typing has revolutionized criminal investigations. It is almost inconceivable to bring a case to trial without positive identification through what is now our most accurate means. Proficiency with the methodology, principles, and interpretation of DNA evidence is crucial for today‘s criminalist.

Forensic DNA Applications

Author : Dragan Primorac
Publisher : CRC Press
ISBN 13 : 1466580224
Total Pages : 652 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Forensic DNA Applications by : Dragan Primorac

Download or read book Forensic DNA Applications written by Dragan Primorac and published by CRC Press. This book was released on 2014-01-29 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic DNA Applications: An Interdisciplinary Perspective was developed as an outgrowth of a conference held by the International Society of Applied Biological Sciences. The topic was human genome–based applications in forensic science, anthropology, and individualized medicine. Assembling the contributions of contributors from numerous regions around the world, this volume is designed as both a textbook for forensic molecular biology students and a reference for practitioners and those in the legal system. The book begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control. The second section examines the collection and preservation of biological evidence under a variety of different circumstances and the identification of human remains—including in mass disaster settings. It discusses applications to bioterrorism investigations, animal DNA testing in criminal cases, pedigree questions and wildlife forensic problems, applications in forensic entomology, and forensic botany. The third section explores recent developments and new technologies, including the rigorous identification of tissue of origin, mtDNA profiling using immobilized probe strips, chips and next-generation sequencing, the use of SNPs to ascertain phenotypic characteristics, and the "molecular autopsy" that looks at aspects of toxicogenetics and pharmacogenetics. The book concludes with a discussion on law, ethics, and policy. It examines the use of DNA evidence in the criminal justice system in both the United States and Europe, ethical issues in forensic laboratory practices, familial searches, DNA databases, ancestry searches, physical phenotyping, and report writing. The contributors also examine DNA applications in immigration and human trafficking cases and international perspectives on DNA databases.

Principles and Practices of DNA Analysis: A Laboratory Manual for Forensic DNA Typing

Author : Hirak Ranjan Dash
Publisher : Humana
ISBN 13 : 9781071602768
Total Pages : 344 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Principles and Practices of DNA Analysis: A Laboratory Manual for Forensic DNA Typing by : Hirak Ranjan Dash

Download or read book Principles and Practices of DNA Analysis: A Laboratory Manual for Forensic DNA Typing written by Hirak Ranjan Dash and published by Humana. This book was released on 2021-02-21 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents hands-on protocols for conventional and advanced forensic DNA fingerprinting experiments. It includes manual, semi-automatic, and advanced automatic techniques for DNA extraction from different biological samples. It also discusses various qualitative and quantitative approaches for the assessment of extracted forensic DNA. It contains protocols for the amplification of short tandem repeat markers (STRs) for the amplification-based target enrichment of the forensic samples. Further, it examines genotyping of the STR loci through capillary electrophoresis and includes real-world case studies where forensic DNA analysis has been used in the criminal and civil disputes. The book concludes by presenting technological developments in the field of DNA forensic analysis. Suitable for beginners, it is a key reference resource on a wide variety of DNA profiling techniques and applications.

The Evaluation of Forensic DNA Evidence

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309121949
Total Pages : 271 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Evaluation of Forensic DNA Evidence by : National Research Council

Download or read book The Evaluation of Forensic DNA Evidence written by National Research Council and published by National Academies Press. This book was released on 1997-01-12 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.

Forensic Biology

Author : Richard Li
Publisher : CRC Press
ISBN 13 : 1420043447
Total Pages : 435 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Forensic Biology by : Richard Li

Download or read book Forensic Biology written by Richard Li and published by CRC Press. This book was released on 2008-04-24 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed as an accessible introduction to basic scientific principles and their application in professional practice, Forensic Biology provides a concise overview of the field. Focusing solely on the science behind the forensic analysis of biological evidence, this book highlights the principles, methods, and techniques used in forensic sero

Forensic Analysis of Biological Evidence

Author : J. Thomas McClintock
Publisher : CRC Press
ISBN 13 : 1466504587
Total Pages : 176 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Forensic Analysis of Biological Evidence by : J. Thomas McClintock

Download or read book Forensic Analysis of Biological Evidence written by J. Thomas McClintock and published by CRC Press. This book was released on 2017-08-02 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: A powerful tool in the identification of individuals, DNA typing has revolutionized criminal and paternity investigations. Widespread analysis is now conducted by public and private laboratories in the United States and abroad. Focusing on the basic techniques used in forensic DNA laboratories, Forensic Analysis of Biological Evidence: A Laboratory

A Guide to Forensic DNA Profiling

Author : Scott Bader
Publisher : John Wiley & Sons
ISBN 13 : 1118751523
Total Pages : 453 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis A Guide to Forensic DNA Profiling by : Scott Bader

Download or read book A Guide to Forensic DNA Profiling written by Scott Bader and published by John Wiley & Sons. This book was released on 2016-03-21 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court - report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.

An Introduction to Forensic DNA Analysis, Second Edition

Author : Norah Rudin
Publisher : CRC Press
ISBN 13 : 9781420058505
Total Pages : 332 pages
Book Rating : 4.0/5 (585 download)

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Book Synopsis An Introduction to Forensic DNA Analysis, Second Edition by : Norah Rudin

Download or read book An Introduction to Forensic DNA Analysis, Second Edition written by Norah Rudin and published by CRC Press. This book was released on 2001-12-21 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in DNA analysis techniques have surfaced since the 1997 publication of the bestselling An Introduction to Forensic DNA Analysis. DNA typing has become increasingly automated and miniaturized. Also, with the advent of Short Tandem Repeat (STR) technology, even the most minute sample of degraded DNA can yield a profile, providing valuable case information. However, just as the judicial system slowly and reluctantly accepted RFLP and AmpliType® PM+DQA1 typing, it is now scrutinizing the admissibility of STRs. Acknowledging STR typing as the current system of choice, An Introduction to Forensic DNA Analysis, Second Edition translates new and established concepts into plain English so that laypeople can gain insight into how DNA analysis works, from sample collection to interpretation of results. In response to the shift toward more efficient techniques, the authors cover the legal admissibility of STR typing, expand the chapter on DNA databases, and revise the section on automated analysis. They also present key decisions and appellate or supreme court rulings that provide precedent at the state and federal levels. Discussing forensic DNA issues from both a scientific and a legal perspective, the authors of An Introduction to Forensic DNA Analysis, Second Edition present the material in a manner understandable by professionals in the legal system, law enforcement, and forensic science. They cover general principles in a clear fashion and include a glossary of terms and other useful appendices for easy reference.