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Author : Wei Xiong
Publisher : Frontiers Media SA
ISBN 13 : 2889630692
Total Pages : 135 pages
Book Rating : 4.8/5 (896 download)
Download or read book Fluxomics and Metabolic Analysis in Systems Microbiology written by Wei Xiong and published by Frontiers Media SA. This book was released on 2019-10-21 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jens Nielsen
Publisher : Springer Science & Business Media
ISBN 13 : 3540747192
Total Pages : 292 pages
Book Rating : 4.5/5 (47 download)
Download or read book Metabolomics written by Jens Nielsen and published by Springer Science & Business Media. This book was released on 2007-09-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giving a fresh, substantial and in-depth overview of the topic, this book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it helps to significantly broaden our perspective on the principles and strategies underpinning this emerging field.
Author : Xueyang Feng
Publisher :
ISBN 13 :
Total Pages : 495 pages
Book Rating : 4.:/5 (795 download)
Download or read book Development and Application of Fluxomics Tools for Analyzing Metabolisms in Non-model Microorganisms written by Xueyang Feng and published by . This book was released on 2012 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decoding microbial metabolism is of great importance in revealing the mechanisms governing the physiology of microbes and rewiring the cellular functions in metabolic engineering. Complementing the genomics, transcriptomics, proteinomics and metabolomics analysis of microbial metabolism, fluxomics tools can measure and simulate the in vivo enzymatic reactions as direct readouts of microbial metabolism. This dissertation develops and applies broad-scope tools in metabolic flux analysis to investigate metabolic insights of non-model environmental microorganisms. 13C-based pathway analysis has been applied to analyze specific carbon metabolic routes by tracing and analyzing isotopomer labeling patterns of different metabolites after growing cells with 13C-labeled substrates. Novel pathways, including Re-type citrate synthase in tricarboxylic acid cycle and citramalate pathways as an alternate route for isoleucine biosynthesis, have been identified in Thermoanaerobacter X514 and other environmental microorganisms. Via the same approach, the utilizations of diverse carbon/nitrogen substrates and productions of hydrogen during mixotrophic metabolism in Cyanothece 51142 have been characterized, and the medium for a slow-growing bacterium, Dehalococcoides ethenogenes 195, has been optimized. In addition, 13C-based metabolic flux analysis has been developed to quantitatively profile flux distributions in central metabolisms in a green sulfur bacterium, Chlorobaculum tepidum, and thermophilic ethanol-producing Thermoanaerobacter X514. The impact of isotope discrimination on 13C-based metabolic flux analysis has also been estimated. A constraint-based flux analysis approach was newly developed to integrate the bioprocess model into genome-scale flux balance analysis to decipher the dynamic metabolisms of Shewanella oneidensis MR-1. The sub-optimal metabolism and the time-dependent metabolic fluxes were profiled in a genome-scale metabolic network. A web-based platform was constructed for high-throughput metabolic model drafting to bridge the gap between fast-paced genome-sequencing and slow-paced metabolic model reconstruction. The platform provides over 1,000 sequenced genomes for model drafting and diverse customized tools for model reconstruction. The in silico simulation of flux distributions in both metabolic steady state and dynamic state can be achieved via flux balance analysis and dynamic flux balance analysis embedded in this platform. Cutting-edge fluxomics tools for functional characterization and metabolic prediction continue to be developed in the future. Broad-scope systems biology tools with integration of transcriptomics, proteinomics and fluxomics can reveal cell-wide regulations and speed up the metabolic engineering of non-model microorganisms for diverse bioenergy and environmental applications.
Author : M. Tomita
Publisher : Springer Science & Business Media
ISBN 13 : 4431280553
Total Pages : 267 pages
Book Rating : 4.4/5 (312 download)
Download or read book Metabolomics written by M. Tomita and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Author : Xiaoyuan Wang
Publisher : Springer Science & Business Media
ISBN 13 : 9400750552
Total Pages : 445 pages
Book Rating : 4.4/5 (7 download)
Download or read book Reprogramming Microbial Metabolic Pathways written by Xiaoyuan Wang and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
Author : K. Shimizu
Publisher : Woodhead Publishing
ISBN 13 : 9781907568015
Total Pages : 0 pages
Book Rating : 4.5/5 (68 download)
Download or read book Bacterial Cellular Metabolic Systems written by K. Shimizu and published by Woodhead Publishing. This book was released on 2013-03-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism.
Author : Jens O. Krömer
Publisher :
ISBN 13 : 9781493911707
Total Pages : 316 pages
Book Rating : 4.9/5 (117 download)
Download or read book Metabolic Flux Analysis written by Jens O. Krömer and published by . This book was released on 2014 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is dedicated to Metabolic Flux Analysis in systems that can be studied under metabolic steady-state or pseudo-steady-state conditions, also called stationary approaches. Under these conditions the change of intracellular metabolite concentrations ( CMET ) as a function of the stoichiometric matrix S and the flux vector v can be approximated to zero. This approximation converts the equations system from a differential to a linear one and greatly simplifies its solution. We hope that this book will open the field of metabolic flux analysis to a wider scientific community by providing helpful tricks to those who want to start a new flux analysis project but are overwhelmed by the complexity of the approach. We tried to break it up into manageable bits of information that can be implemented step by step following the methods chapters provided. The overview chapters are there to explain the necessary basics to get started and also to review what has been achieved within a few model organisms."--Preface, page vi.
Author : Christoph Wittmann
Publisher : Springer Science & Business Media
ISBN 13 : 9400745346
Total Pages : 391 pages
Book Rating : 4.4/5 (7 download)
Download or read book Systems Metabolic Engineering written by Christoph Wittmann and published by Springer Science & Business Media. This book was released on 2012-06-15 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Author : Edward E.K. Baidoo
Publisher : Humana
ISBN 13 : 9781493987566
Total Pages : 0 pages
Book Rating : 4.9/5 (875 download)
Download or read book Microbial Metabolomics written by Edward E.K. Baidoo and published by Humana. This book was released on 2018-11-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume includes protocols that represent the breadth of microbial metabolomics approaches to both large-scale and small-scale experiments with intention of highlighting techniques that can be used for applications ranging from environmental microbiology to human disease. Utilizing mass spectrometry as their primary measurement tool, the chapters explore microbial metabolomics, metabolism and microbial physiology, metabolite sample preparation, current analytical techniques used to profile primary and secondary metabolites and lipids, as well as establishing data analysis workflows for targeted metabolomics, untargeted metabolomics, analysis of metabolic fluxes, and genome-scale models. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Metabolomics: Methods and Protocols serves as an ideal reference for both novice and advanced users and can be adapted to similar analytical platforms or customized to suit the needs of the researcher.
Author : Boris N. Kholodenko
Publisher : Garland Science
ISBN 13 : 9780954523220
Total Pages : 472 pages
Book Rating : 4.5/5 (232 download)
Download or read book Metabolic Engineering in the Post Genomic Era written by Boris N. Kholodenko and published by Garland Science. This book was released on 2004 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, titles in this series comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Engineering living cells continues to pose immense challenges to the researcher. In fact many bioengineers have only just started to appreciate the full extent of the hierarchical control used by living systems: upon attempts to increase the activity of a "rate-limiting" step, the multiple feedbacks at the metabolic, signaling and genetic levels result in the rate limiting step shifting to elsewhere in that pathway or even to elsewhere in the whole organism. The advent of full-force genomics should enable preventing this response, however, it has been difficult for researchers to know where to turn for guidance. This book aims to help the reader understand and deal with the plasticity of living cell factories and to turn the plasticity into the desired rather than the adverse direction. The book brings together all the recent, most important breakthroughs in this exciting field: Internationally renowned key scientists have reviewed each topic in detail. In the Introduction, the editors give an overview of new approaches and spell out what the engineer and the industry may now really begin to aim for; they even adapt the definition of metabolic engineering to befit the post-genomics era. Other topics included are: the experimental approaches necessary to understand cellular regulation at all of its hierarchical levels, including proteomics [Chapter 2], metabolomics [Chapter 3] and fluxomics [Chapter 4]; new tools that help metabolic engineering [Chapters 5-7]; modeling of living cells, e.g. finding metabolic pathways [Chapter 8] and comparing the actual and predicted use of these in living organisms such as E. coli and Corynebacteria [Chapters 9, 10]; the optimization of cell factories as production organisms (e.g., use of whole cell models, silicon cells, and coordinate manipulation of multiple genes [Chapters 12-15]). A chapter on future perspectives directs further developments of the field in the near future. Metabolic Engineering in the Post Genomic Erais an essential reading for everyone with an interest in engineering living cells including: Metabolic egnineers, bioengineers, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.
Author : Claude Amiard-Triquet
Publisher : Academic Press
ISBN 13 : 0128011769
Total Pages : 519 pages
Book Rating : 4.1/5 (28 download)
Download or read book Aquatic Ecotoxicology written by Claude Amiard-Triquet and published by Academic Press. This book was released on 2015-06-11 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments. Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess
Author : Paul Hudson
Publisher : John Wiley & Sons
ISBN 13 : 3527824928
Total Pages : 560 pages
Book Rating : 4.5/5 (278 download)
Download or read book Cyanobacteria Biotechnology written by Paul Hudson and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unites a biological and a biotechnological perspective on cyanobacteria, and includes the industrial aspects and applications of cyanobacteria Cyanobacteria Biotechnology offers a guide to the interesting and useful features of cyanobacteria metabolism that keeps true to a biotechnology vision. In one volume the book brings together both biology and biotechnology to illuminate the core acpects and principles of cyanobacteria metabolism. Designed to offer a practical approach to the metabolic engineering of cyanobacteria, the book contains relevant examples of how this metabolic "module" is currently being engineered and how it could be engineered in the future. The author includes information on the requirements and real-world experiences of the industrial applications of cyanobacteria. This important book: Brings together biology and biotechnology in order to gain insight into the industrial relevant topic of cyanobacteria Introduces the key aspects of the metabolism of cyanobacteria Presents a grounded, practical approach to the metabolic engineering of cyanobacteria Offers an analysis of the requirements and experiences for industrial cyanobacteria Provides a framework for readers to design their own processes Written for biotechnologists, microbiologists, biologists, biochemists, Cyanobacteria Biotechnology provides a systematic and clear volume that brings together the biological and biotechnological perspective on cyanobacteria.
Author : Vineet Kumar
Publisher : CRC Press
ISBN 13 : 1000737241
Total Pages : 630 pages
Book Rating : 4.0/5 (7 download)
Download or read book Omics for Environmental Engineering and Microbiology Systems written by Vineet Kumar and published by CRC Press. This book was released on 2022-11-07 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioremediation using microbes is a sustainable technology for biodegradation of target compounds, and an omics approach gives more clarity on these microbial communities. This book provides insights into the complex behavior of microbial communities and identifies enzymes/metabolites and their degradation pathways. It describes the application of microbes and their derivatives for the bioremediation of potentially toxic and novel compounds. It highlights the existing technologies along with industrial practices and real-life case studies. Features: Includes recent research and development in the areas of omics and microbial bioremediation. Covers the broad environmental pollution control approaches such as metagenomics, metabolomics, fluxomics, bioremediation, and biodegradation of industrial wastes. Reviews metagenomics and waste management, and recycling for environmental cleanup. Describes the metagenomic methodologies and best practices, from sample collection to data analysis for taxonomies. Explores various microbial degradation pathways and detoxification mechanisms for organic and inorganic contaminants of wastewater with their gene expression. This book is aimed at graduate students and researchers in environmental engineering, soil remediation, hazardous waste management, environmental modeling, and wastewater treatment.
Author : Bernhard Sonnleitner
Publisher : Springer
ISBN 13 : 3540487735
Total Pages : 257 pages
Book Rating : 4.5/5 (44 download)
Download or read book Bioanalysis and Biosensors for Bioprocess Monitoring written by Bernhard Sonnleitner and published by Springer. This book was released on 2003-06-30 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : Maulin P Shah
Publisher : Elsevier
ISBN 13 : 0128218959
Total Pages : 597 pages
Book Rating : 4.1/5 (282 download)
Download or read book Wastewater Treatment written by Maulin P Shah and published by Elsevier. This book was released on 2021-01-30 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wastewater Treatment: Cutting-Edge Molecular Tools, Techniques and Applied Aspects reports new findings in existing molecular biology strategies, including their limitations, challenges and potential application to remove environmental pollutants through advancements made in cutting edge tools. In addition, the book introduces new trends and advances in environmental bioremediation with thorough discussions on recent developments in this field. Describes the application of different omics tools in wastewater treatment plants (WWTPs) Describes the role of microorganisms in WWTPs Points out the reuse of treated wastewater through emerging technologies Includes the recovery of resources from wastewater Emphasizes the need for the use of cutting-edge molecular tools
Author : Maulin Shah
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110727390
Total Pages : 377 pages
Book Rating : 4.1/5 (17 download)
Download or read book Environmental Microbiology written by Maulin Shah and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-09-06 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of various emerging technologies that are used to clean up the environment from pollution caused by human activities. It assesses several existing applied and environmental microbiological techniques and introduces new technologies through applied aspects. Select topics covered include municipal wastewater treatment, environmental microorganisms, metal pollutants in the environment, and biogeochemical cycling.
Author : Ricardo Silvestre
Publisher : Springer
ISBN 13 : 3319749323
Total Pages : 478 pages
Book Rating : 4.3/5 (197 download)
Download or read book Metabolic Interaction in Infection written by Ricardo Silvestre and published by Springer. This book was released on 2018-04-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.
