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Author : Anwen Shao
Publisher : Frontiers Media SA
ISBN 13 : 2889746356
Total Pages : 224 pages
Book Rating : 4.8/5 (897 download)
Download or read book Ferroptosis in Stroke, Neurotrauma and Neurodegeneration written by Anwen Shao and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anwen Shao
Publisher : Frontiers Media SA
ISBN 13 : 2832530397
Total Pages : 130 pages
Book Rating : 4.8/5 (325 download)
Download or read book Ferroptosis in Stroke, Neurotrauma and Neurodegeneration, Volume II written by Anwen Shao and published by Frontiers Media SA. This book was released on 2023-07-31 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Ferroptosis in Stroke, Neurotrauma and Neurodegeneration series: Ferroptosis in Stroke, Neurotrauma and Neurodegeneration Ferroptosis is a recently defined iron-dependent non-apoptotic form of cell death. Diverse stressors can destabilize metabolic processes in the cell, leading to excessive intracellular accumulation of reactive oxygen species that culminate in the collapse and rupture of the membrane structure of cellular organelles, such as mitochondria, endoplasmic reticulum, and lysosome. Ferroptosis is a form of cell death characterized by the accumulation of intracellular iron and lipid ROS. The primary morphologic manifestations of ferroptosis include cell volume shrinkage and increased mitochondrial membrane density. These are different from apoptotic types of cell death such as necroptosis (early destruction of membrane integrity, cell and organelle swelling, cytoplasmic granulation and chromatin fragmentation, and cellular lysis), and pyroptosis (necrosis-like cell-membrane pore formation and rupture, cellular swelling, pro-inflammatory intracellular content release, as well as apoptosis-like nuclear condensation and DNA fragmentation). Emerging evidence shows that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury (TBI), Alzheimer's disease and Parkinson's disease. Additionally, ferroptosis inhibition has been shown to protect neurons and ameliorate cognitive impairment in various disease animal models. To date, several ferroptosis inhibitors have been found. As Ferroptosis is characterized by the accumulation of intracellular iron and lipid ROS, these inhibitors are primarily categorized as either antioxidants or iron chelators. For example in hemorrhagic stroke, it was found that the neuronal death and iron deposition, induced by hemoglobin in organotypic hippocampal slice cultures and primary cortical neurons, can be attenuated by administration of ferrostatin-1, or other ferroptosis inhibitors. In this Research Topic researchers are welcome to submit original research and review articles. We are interested in all topics associated with ferroptosis and neurological diseases, from underlying mechanisms to clinical transformation including potential targeting and treatment and others. We also welcome original articles analyzing similarities and differences among ferroptosis and other kinds of cell death, such as apoptosis and pyroptosis, in neurological diseases and hope to find key insights for future drug-development.
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
ISBN 13 : 1441966528
Total Pages : 414 pages
Book Rating : 4.4/5 (419 download)
Download or read book Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases written by Akhlaq A. Farooqui and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.
Author : Fawaz Alzaid
Publisher : Frontiers Media SA
ISBN 13 : 2832554091
Total Pages : 146 pages
Book Rating : 4.8/5 (325 download)
Download or read book Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation written by Fawaz Alzaid and published by Frontiers Media SA. This book was released on 2024-09-05 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening insulin resistance and a further loss of metabolic function and homeostasis in innervated peripheral tissues (e.g., liver, adipose tissue). Persistent metabolic stress predisposes patients to peripheral neuropathies, cognitive dysfunction, and development of neurodegenerative diseases (e.g., Alzheimer’s disease). Multiple associations link metabolic disease to neuropathology, targeting neuroinflammation to preserve neuronal integrity holds promise for managing metabolic diseases and associated neurological complications. Research on "Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation" is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology. Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions.
Author : Yuanjian Fang
Publisher : Frontiers Media SA
ISBN 13 : 2832545750
Total Pages : 147 pages
Book Rating : 4.8/5 (325 download)
Download or read book Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases, Volume II written by Yuanjian Fang and published by Frontiers Media SA. This book was released on 2024-03-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accumulating evidence reveals both local and peripheral immune systems participated in the pathophysiology changes of acute and chronic neurological diseases. Immune cell activation facilitates inflammatory response in neurological diseases such as stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. The immune response initiated by brain local cells (microglia and astrocytes) and peripheral blood cells (monocytes/macrophages, neutrophil, T cells, B cells), are now commonly thought to contribute “double-edged sword” effects to the progression of neurological diseases, which not only promoting repair and recovery, but also accelerating brain injury. Meanwhile, local and peripheral immune responses have complex crosstalk in the development of post-stroke injury and neurodegeneration disease.
Author : Isabella Zanella
Publisher : Frontiers Media SA
ISBN 13 : 2889634515
Total Pages : 369 pages
Book Rating : 4.8/5 (896 download)
Download or read book Iron and Neurodegeneration written by Isabella Zanella and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Daolin Tang
Publisher : Springer Nature
ISBN 13 : 3030267806
Total Pages : 320 pages
Book Rating : 4.0/5 (32 download)
Download or read book Ferroptosis in Health and Disease written by Daolin Tang and published by Springer Nature. This book was released on 2019-10-10 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research.
Author : Arianna Bellucci
Publisher : Frontiers Media SA
ISBN 13 : 2832541054
Total Pages : 316 pages
Book Rating : 4.8/5 (325 download)
Download or read book Advances in brain disorders: From mechanisms to therapeutic targets written by Arianna Bellucci and published by Frontiers Media SA. This book was released on 2023-12-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ulrich Dirnagl
Publisher : Springer Science & Business Media
ISBN 13 : 3662054264
Total Pages : 248 pages
Book Rating : 4.6/5 (62 download)
Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Author : Mirna Lechpammer
Publisher :
ISBN 13 : 9781316671863
Total Pages : pages
Book Rating : 4.6/5 (718 download)
Download or read book Perinatal Neuropathology written by Mirna Lechpammer and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "1 Clinical history, clinical correlations with placental pathology and prematurity The initial steps in the process of perinatal nervous system evaluation, namely the planning of the optimal approach and choice of samples to be obtained, are driven by the clinical context. Of key importance are the following data: a. Gestational age at time of demise (if stillborn); or gestational age and postnatal age (if liveborn), for comparison with normative standards of development (see Appendix); b. State of maternal health (age, parity, pre-existing medical conditions or ones appearing during gestation or around the time of delivery, exposure to medications/toxins/infections), and of health of siblings or other family members: - Concerns for inherited (i.e., genetic) conditions, metabolic disorders, congenital infections, etc., may indicate the need for special testing; c. Details of prenatal course, including any imaging, amniocentesis, or monitoring: - Prenatal imaging modalities most commonly consist of transabdominal ultrasonography, generally done at the time of the first prenatal visit (to confirm pregnancy) or more usually in the mid-second-trimester for detection of fetal or placental anomalies"--
Author : Michael Brainin
Publisher : Cambridge University Press
ISBN 13 : 1107047498
Total Pages : 425 pages
Book Rating : 4.1/5 (7 download)
Download or read book Textbook of Stroke Medicine written by Michael Brainin and published by Cambridge University Press. This book was released on 2014-09-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.
Author : John Zhang
Publisher : Springer Science & Business Media
ISBN 13 : 3709106931
Total Pages : 420 pages
Book Rating : 4.7/5 (91 download)
Download or read book Intracerebral Hemorrhage Research written by John Zhang and published by Springer Science & Business Media. This book was released on 2011-07-05 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.
Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author : Florian Lang
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cell Volume Regulation written by Florian Lang and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
Author : Bernhard Schaller
Publisher : Nova Publishers
ISBN 13 : 9781604562286
Total Pages : 116 pages
Book Rating : 4.5/5 (622 download)
Download or read book Endogenous Neuroprotection written by Bernhard Schaller and published by Nova Publishers. This book was released on 2008 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.
Author : Abel Lajtha
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (82 download)
Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Nasir Khan
Publisher : Springer Nature
ISBN 13 : 3030736784
Total Pages : 238 pages
Book Rating : 4.0/5 (37 download)
Download or read book Hydrogen Sulfide and Plant Acclimation to Abiotic Stresses written by M. Nasir Khan and published by Springer Nature. This book was released on 2021-08-30 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the role of hydrogen sulfide in the protection of plants against abiotic stresses and abiotic stress-induced complications by the way of converging advanced key methods of proteomics, genomics, and metabolomics. It provides an update on the biosynthesis, signaling, and mechanism of action of hydrogen sulfide in combating abiotic stresses in plants. Also, special emphasis is given to the interaction of hydrogen sulfide with other signaling molecules (such as nitric oxide, carbon monoxide, hydrogen peroxide etc.), phytohormones, mineral nutrients, ions, and ion channels in plants. This work, uniquely, covers key aspects of hydrogen sulfide signaling in relation to abiotic stresses in plants, including programmed cell death, stomatal movement, and fruit ripening.
