Author : Alyssa Kathryn Dispennette
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)
Book Synopsis Feasibility and Preliminary Efficacy of Implementing a Group-mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoing Chemoradiation Treatment by : Alyssa Kathryn Dispennette
Download or read book Feasibility and Preliminary Efficacy of Implementing a Group-mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoing Chemoradiation Treatment written by Alyssa Kathryn Dispennette and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck cancer (HNCa) is diagnosed in over 63,000 patients and accounts for approximately 13,000 deaths each year in the United States. HNCa patients report some of the lowest quality of life (QOL) compared to other cancer populations, due to the clinically meaningful deficits that are associated with the established standard of care. The established standard of care for locally advanced HNCa patients includes Chemoradiation therapy (CRT), which causes acute toxicity and contributes to declines in body mass index, muscle mass, and physical function due to treatment-induced sarcopenia, also known as cancer cachexia. Strategies to manage these treatment-related side effects are necessary to preserve muscle mass, physical function, and therefore QOL in patients with HNCa. Emerging evidence supports the utility of exercise, specifically RE, interventions in offsetting the adverse treatment effects on body composition and physical function as a result of CRT in HNCa patients. Despite the potential therapeutic benefits of RE for HNCa patients undergoing treatment: (a) RE is not currently integrated as part of routine cancer care for HNCa patients and (b) few studies have examined the feasibility and preliminary efficacy of integrating RE in the supportive care of HNCa patients undergoing active CRT; and (c) the limited extant research addressing RE interventions during HNCa treatment has yielded poor adherence rates which may undermine the utility of RE as a supportive care approach. Based on this evidence, the overarching research goal is to conduct studies that inform the importance of integrating exercise interventions as an integral component of routine cancer care. The primary aims of this pilot study were to: 1) determine the feasibility of implementing a group-mediated cognitive behavioral (GMCB) RE intervention in HNCa patients undergoing CRT and 2) examine the preliminary efficacy of the personalized, GMCB RE intervention for attenuating and/or reversing the adverse effects of CRT upon relevant clinical and patient reported outcomes in HNCa patients during and following standard of care treatment. Results Feasibility measures and calculations of effect size calculations and percent change were used to examine the feasibility and preliminary efficacy of the GMCB RE intervention in HNCa patient across the 6 month pilot trial. The Cohen’s d effect sizes were calculated by taking the mean difference and diving by the pooled standard deviation to determine the magnitude. Percent change was determined by calculating the mean difference from baseline at each assessment and dividing by the baseline value. Collectively, findings from the initial cohort of the HNCaRE pilot trial (n=9) provide evidence suggesting that the GMCB RE intervention was a feasible, safe, and well-tolerated intervention for HNCa patients undergoing CRT. Evaluation of the effect sizes and percent change in key clinical and patient-reported outcomes indicate the RE intervention attenuated the deleterious effects that have been observed upon body composition, physical function, and QOL previously among HNCa patients undergoing CRT. Additionally, findings revealed that patients who demonstrated the greatest adherence to the intervention sessions yielded the most favorable changes in these outcomes underscoring the integral importance of successfully promoting adoption and adherence to the exercise prescription. Conclusion In summary, findings from the HNCaRE pilot trial provide evidence of the feasibility, safety, and preliminary efficacy of implementing a GMBC-based RE intervention among HNCa patients undergoing CRT. Consequently, the RE intervention show promise for countering the well-established deleterious effects upon body composition, physical function, and QOL accompanying CRT. Although select challenges to integrating RE during CRT remain, the present results suggest the utility of implementing this approach in the supportive care of HNCa patients should be evaluated in future large-scale efficacy studies.
