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Fabrication Of A Surface Plasmon Resonance Platform For The Development Of An Electrokintic Surface Plasmon Resonance Ek Spr Biosensor
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Book Synopsis Fabrication of a Surface Plasmon Resonance Platform for the Development of an Electrokintic Surface Plasmon Resonance (EK-SPR) Biosensor by : Ornella Sathoud
Download or read book Fabrication of a Surface Plasmon Resonance Platform for the Development of an Electrokintic Surface Plasmon Resonance (EK-SPR) Biosensor written by Ornella Sathoud and published by . This book was released on 2019 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Point-of-Care Testing (POCT) is a clinical analysis performed near the patient, rather than in a remote, dedicated laboratory. POCT is typically performed by non-laboratory personnel and the results are used for clinical decision-making. Acute Coronary syndrome (ACS) is a group of conditions that considerably decreases or stops blood flow to the heart muscle, causing the heart to be damaged or stressed. Such events cause the release of biomarkers into the blood stream. Myocardial Infarction (MI), commonly called "heart attack", is a well-known ACS that is diagnosed by measuring the change in the level of cardiac biomarkers (preferably troponin) in the blood. This dissertation presents the fabrication of a platform to be adapted as a point-of care sensor with surface plasmon resonance as the detection method. 4-aminophenylalanine is electrografted on the gold sensing surface as the linker to allow receptors immobilization on the sensing surface. Electrokinetic method is to be combined with surface plasmon resonance, to enhance the sensitivity and selectivity of a cardiac protein biosensor. Surface Plasmon Resonance (SPR) is a real time, label free optical method that measures the refractive index change when the analyte binds receptors immobilized at the surface of a metal, here gold. In this report details on how electrografting of 4-aminophenylalanine on gold thin film permits the fabrication of an SPR biosensor platform that could possibly be as a troponin biosensor. An overview on the sensing surface characterization to confirm surface modification is offered as well as the sensor performance using bovine serum albumin bovine serum albumin antibodies.
Book Synopsis 2D Materials for Surface Plasmon Resonance-based Sensors by : Sanjeev Kumar Raghuwanshi
Download or read book 2D Materials for Surface Plasmon Resonance-based Sensors written by Sanjeev Kumar Raghuwanshi and published by CRC Press. This book was released on 2021-12-12 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2D Materials for Surface Plasmon Resonance-based Sensors offers comprehensive coverage of recent design and development (including processing and fabrication) of 2D materials in the context of plasmonic-based devices. It provides a thorough overview of the basic principles and techniques used in the analysis and design of 2D material-based optical sensor systems. Beginning with the basic concepts of plasmon/plasmonic sensors and mathematical modelling, the authors explain the fundamental properties of 2D materials, including Black Phosphorus (BP), Phosphorene, Graphene, Transition metal dichalcogenides (TMDCs), MXene's and SW-CNT. It also details the applications of these emerging materials in clinical diagnosis and their future trends. This text will be useful for practising engineers, undergraduate and postgraduate students. Key Features Presents the fundamental concepts of 2D material assisted fibre optic and prism based SPR sensor in a student-friendly manner. Includes the recent synthesis and characterization techniques of 2D materials. Provides computational results of recently discovered electronic and optical properties of the 2D materials along with their effectiveness in the field of plasmonic sensors. Presents emerging applications of novel 2D material-based plasmonic sensors in the field of chemical, bio-chemical and biosensing.
Book Synopsis Surface Plasmon Resonance Based Sensors by : Jiri Homola
Download or read book Surface Plasmon Resonance Based Sensors written by Jiri Homola and published by Springer Science & Business Media. This book was released on 2006-08-18 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive treatment of the field of SPR sensors, in three parts. Part I introduces principles of surface plasmon resonance bio-sensors, electromagnetic theory of surface plasmons, theory of SPR sensors and molecular interactions at sensor surfaces. Part II examines the development of SPR sensor instrumentation and functionalization methods. Part III reviews applications of SPR biosensors in the study of molecules, and in environmental monitoring, food safety and medical diagnostics.
Book Synopsis Handbook of Surface Plasmon Resonance by : Richard B. M. Schasfoort
Download or read book Handbook of Surface Plasmon Resonance written by Richard B. M. Schasfoort and published by Royal Society of Chemistry. This book was released on 2008 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events. This book focuses on a total system description including optics, fluidics and sensor surfaces. It covers all commercial SPR systems in the market. It is the first of its kind and fills a gap in the technical literature as no other handbook on SPR is currently available. The final chapter discussed new trends and a vision is given for future developments and needs of the SPR market. This excellent handbook provides comprehensive information with easy to use, stand-alone chapte.
Book Synopsis Surface Plasmon Resonance Sensors by : Leiva Casemiro Oliveira
Download or read book Surface Plasmon Resonance Sensors written by Leiva Casemiro Oliveira and published by Springer. This book was released on 2019-06-13 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This significantly extended second edition addresses the important physical phenomenon of Surface Plasmon Resonance (SPR) or Surface Plasmon Polaritons (SPP) in thin metal films, a phenomenon which is exploited in the design of a large variety of physico-chemical optical sensors. In this treatment, crucial materials aspects for design and optimization of SPR sensors are investigated and described in detail. The text covers a selection of nanometer thin metal films, ranging from free-electron to the platinum-type conductors, along with their combination with a large variety of dielectric substrate materials, and associated individual layer and opto-geometric arrangements. Whereas the first edition treated solely the metal-liquid interface, the SP-resonance conditions considered here are expanded to cover the metal-gas interface in the angular and wavelength interrogation modes, localized and long-range SP's and the influence of native oxidic ad-layers in the case of non-noble metals. Furthermore, a selection of metal grating structures that allow SP excitation is presented, as are features of radiative SP's. Finally, this treatise includes as-yet hardly explored SPR features of selected metal–metal and metal–dielectric superlattices. An in-depth multilayer Fresnel evaluation provides the mathematical tool for this optical analysis, which otherwise relies solely on experimentally determined electro-optical materials parameters.
Book Synopsis Surface Plasmon Resonance Sensors by : Leiva Casemiro Oliveira
Download or read book Surface Plasmon Resonance Sensors written by Leiva Casemiro Oliveira and published by Springer. This book was released on 2015-02-23 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the important physical phenomenon of Surface Plasmon Resonance or Surface Plasmon Polaritons in thin metal films, a phenomenon which is exploited in the design of a large variety of physico-chemical optical sensors. In this treatment, crucial materials aspects for design and optimization of SPR sensors are investigated and outlined in detail. The text covers the selection of nanometer thin metal films, ranging from free-electron to the platinum type conductors, along with their combination with a large variety of dielectric substrate materials, and associated individual layer and opto-geometric arrangements. Furthermore, as-yet hardly explored SPR features of selected metal–metal and metal–dielectric super lattices are included in this report. An in-depth multilayer Fresnel evaluation provides the mathematical tool for this optical analysis, which otherwise relies solely on experimentally determined electro-optical materials parameters.
Book Synopsis Surface Plasmon Resonance Imaging by : Yi Chen
Download or read book Surface Plasmon Resonance Imaging written by Yi Chen and published by Springer Nature. This book was released on 2023-07-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the fundamentals, instruments, methodology, and applications of surface plasmon resonance imaging (SPRi) and related techniques. It provides an overview of SPRi development and an easy-to-understand interpretation of theory and operation principles. Some unique ideas proposed by the authors to design and set up SPRi devices and methods are disclosed for the first time. Crucial manipulation experiences are also summarized here, including chip surface functionalization, sensitivity enhancement and coupling of SPRi with other analytical techniques. The application of SPRi for molecular interaction study, featuring high throughput, label-freeness, and physiologically compatible analysis, is discussed in detail. This book is of interest and useful to a wide readership in bioanalytical chemistry, molecular biology, and many related interdisciplinary fields.
Book Synopsis Surface Plasmon Resonance by : Pranveer Singh
Download or read book Surface Plasmon Resonance written by Pranveer Singh and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: SPR is real-time, label-free measurements of binding kinetics and affinity. This has distinct advantage over radioactive or fluorescent labelling methods, in terms of: 1) ligand-analyte binding kinetics, that can be probed without the costly and time-consuming labeling process that may interfere with molecular binding interactions; 2) binding rates and affinity can be measured directly and 3) low affinity interactions in high protein concentrations for can be characterized with less reagent consumption than other equilibrium measurement techniques; 4) Label-free detection of molecular interactions presents an attractive alternative. This is particularly true for protein targets where labels can compromise protein function. Label-free methods are also desirable because they are typically compatible with real-time detection, enabling the determination of rates of association. The success of SPR biosensors was indicated by the growing number of commercially available instruments. Since Biacore AB (originally Pharmacia Biosensor AB) launched the first commercial SPR biosensor on market in 1990, there have been many more competing SPR instruments including IASys (Affinity Sensors), SPR-670 (Nippon Laser Electronics), IBIS (IBIS Technology BV), TISPR (Texas Instruments), etc.
Book Synopsis Fabtrication of Surface Plasmon Biosensors in CYTOP. by : Hamoudi Asiri
Download or read book Fabtrication of Surface Plasmon Biosensors in CYTOP. written by Hamoudi Asiri and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Surface Plasmon Resonance by : Nico J. de Mol
Download or read book Surface Plasmon Resonance written by Nico J. de Mol and published by Humana. This book was released on 2016-08-23 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, experts in the field present a wide variety of applications involving commercially available SPR instruments. The book fills a need for well-described, hands-on SPR experimental protocols, and it highlights the backgrounds of vital issues.
Book Synopsis Characterization of Surface Plasmon Resonance (SPR) Active Nanohole Array Sensing Platforms by : Laurel L. Kegel
Download or read book Characterization of Surface Plasmon Resonance (SPR) Active Nanohole Array Sensing Platforms written by Laurel L. Kegel and published by . This book was released on 2015 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmon resonance (SPR) active nanohole array substrates offer a diverse biosensing platform with high sensitivity and unique characteristics. This dissertation investigates the sensitivity and fundamental SP features of various nanohole array substrates and demonstrates higher sensitivity than conventional continuous gold platforms, tunability to specific analytes, and great enhancement of the local field intensity. Novel instrumentation and analytical techniques are developed and utilized to assess the nanohole array SPR sensing substrates in the near infrared as well as with interaction of other nanostructures. The nanohole array substrates are evaluated throughout the near-infrared (NIR) region by novel SPR instrumentation and methodology that extends the working SPR wavelength range and measurement reliability. Development of a robust NIR-SPR instrument allows access to higher wavelength ranges where sensitivity is improved and novel SP modes and plasmonic materials may be investigated. Different aspects of the NIR-SPR instrument, including temporal stability, mechanical resilience and sensitivity, are evaluated and presented. Furthermore, a method is developed for improving precision and accuracy of empirically determined SP penetration depth, a merit of SPR spectroscopy sensitivity. The technique incorporates an adsorbate-metal bonding effect which improves the consistency in the penetration depth value calculated at different adsorbate thicknesses from 41-1089% relative deviation (without bonding effect) to 2-11% relative deviation (with bonding effect). It also improves the experimental agreement with theory, increases the accuracy of assessing novel plasmonic materials and nanostructures, and increases the precision in adsorbate parameters calculated from the penetration depth value, such as thickness, binding affinity, and surface coverage. Utilizing this NIR-SPR instrument and improved technique for calculation of penetration depth, the sensitivity and various SP modes of the nanohole arrays throughout the NIR range are evaluated, and an improvement in sensitivity compared to conventional continuous gold is observed. Both the Bragg SPs arising from diffraction by the periodic holes and the traditional propagating SPs are characterized with emphasis on sensing capability of the propagating SPs. There are numerous studies on the transmission spectroscopy of nanohole arrays; however this dissertation presents one of the few studies in Kretschmann mode, and the first in the near infrared, where greater surface sensitivity is observed. The sensitivity profile of various nanohole array parameters (periodicity, diameter, excitation wavelength) and SP modes is also presented. Further control and enhancement of the SP field is pursued by interaction between nanohole array substrate and nanoparticles to exploit field intensification between plasmonic structures, i.e. gap mode enhancement. Under specific conditions, the SPs couple together and the electric field between the structures is amplified and localized, which may be exploited for sensing purposes and surface enhanced techniques, including tip enhanced Raman spectroscopy (TERS) or surface enhanced Raman spectroscopy (SERS). A technique for observing nanohole array-nanoparticle distance dependent SP interaction is developed and utilized to demonstrate SP interaction. Scanning probe microscopy controls the position of a single nanoparticle (SNP) affixed to an atomic force microscope probe, and the location specific interaction of the SNP-nanohole array surface plasmons is measured by darkfield surface plasmon resonance spectroscopy. Coupling of the nanoparticle to the nanohole array exhibits a maximum when the SNP resides within a nanohole, which resulted in a maximum SPR wavelength shift of 17 nm and an increase in scatter intensity. This dissertation presents the first empirical observations of SPM controlled gap mode enhancement of more complex nanostructures and allows for optimization of positioning prior to use in sensing.
Book Synopsis Localized Surface Plasmon Resonance Based Nanobiosensors by : Yi-Tao Long
Download or read book Localized Surface Plasmon Resonance Based Nanobiosensors written by Yi-Tao Long and published by . This book was released on 2014-04-30 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fabrication and Testing of Gold Cylinder Fiber Based Bio-sensor Using Surface Plasmon Resonance (SPR) ... by : Siddharth Kalra
Download or read book Fabrication and Testing of Gold Cylinder Fiber Based Bio-sensor Using Surface Plasmon Resonance (SPR) ... written by Siddharth Kalra and published by . This book was released on 2011 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Submitted in partial fulfillment of the requirements for the degree of Masters of Science in Electrical Engineering in the Graduate School of Syracuse University.
Book Synopsis Development of a Surface Plasmon Resonance Biosensor Using a Plasma Deposited Functionalization Film by : Mimi N. Mar
Download or read book Development of a Surface Plasmon Resonance Biosensor Using a Plasma Deposited Functionalization Film written by Mimi N. Mar and published by . This book was released on 1995 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Surface Plasmon Resonance Biosensor for the Measurement of Complex Refractive Indices and the Monitoring of Bacterial Cell Growth by : Sandrine Filion Côté
Download or read book Surface Plasmon Resonance Biosensor for the Measurement of Complex Refractive Indices and the Monitoring of Bacterial Cell Growth written by Sandrine Filion Côté and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Surface plasmon resonance (SPR) is one of the most widely used techniques to implement biosensors due to its high sensitivity, its low limit of detection and its capacity for label-free detection. It is used extensively in a broad range of applications such as analyte detection, thin film characterisation, affinity measurements, design of probes, design of amplification techniques and drug screening. This optical technique involves the measurement of the intensity of light reflecting from a thin metal film through a glass prism as a function of the incident angle. Its success lies on the fact that the resonance conditions, at which the reflection is minimised, is highly dependent on the refractive index of the sample adjacent to the metal. By tracking the changes in resonance conditions in real-time, small changes in the surface or bulk refractive index can be measured accurately.Whilst most commercial SPR sensors are intensity-based, it has been shown that an increase in sensitivity and a greater robustness against noise can be achieved by analysing full reflection spectra through a projection method. In this thesis, this technique is further developed and improved and its advantages are demonstrated with two different SPR biosensors and for multiple applications. The first instrument is a spectro-angular SPR biosensor where the reflectivity is measured by varying both the incident angle and wavelength simultaneously. This system has been previously evaluated in the infrared; a lower limit of detection is demonstrated here when the system operates in the visible spectrum due to the improved spatial resolution and numerical precision of the image sensor. This instrument is validated as a biosensor with a proof-of-concept experiment: the detection of synthetic RNA from pathogenic Legionella pneumophila.The second instrument is a biosensor developed to measure reflection intensity with respect to an angular spectrum. The data processing method is shown to work very well with this instrument and it is improved to measure complex refractive indices. Samples with biological entities are inhomogeneous and therefore exhibit a non-negligible extinction coefficient. The ability to measure both components of the refractive index is demonstrated in this thesis through a thorough calibration and the kinetic measurement of the adsorption of liposomes on gold.Finally, an application is presented with the angular-based SPR biosensor: the monitoring of bacterial cell growth. Bacterial biofilms are a leading cause of infections in health-care settings and by taking full advantage of the angular spectrum displayed on the SPR curve, the instrument is able to monitor the formation of biofilms. The outputs of the instrument vary as the surface coverage changes and as the number of layers of bacteria increases during the growth. Once the monitoring of bacterial cell growth is demonstrated, it is also shown that this biosensor could be used as a platform to test the efficiency of disinfectants." --
Book Synopsis Electro-wetting-on-dielectric Digital Microfluidic Platform with Integrated Nanostructured Biosensor Interface for Enhanced Two-dimensional Surface Plasmon Resonance Imaging Detection by : Lidija Malic
Download or read book Electro-wetting-on-dielectric Digital Microfluidic Platform with Integrated Nanostructured Biosensor Interface for Enhanced Two-dimensional Surface Plasmon Resonance Imaging Detection written by Lidija Malic and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Surface Plasmon Resonance (SPR) Sensor with Liquid Crystal Chemical Transduction Layer by : Fran E. Taylor
Download or read book Development of a Surface Plasmon Resonance (SPR) Sensor with Liquid Crystal Chemical Transduction Layer written by Fran E. Taylor and published by . This book was released on 2003 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:
