Extracellular Matrix Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 3642168612
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Extracellular Matrix Degradation

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Publisher : Springer
ISBN 13 : 9783642168628
Total Pages : 255 pages
Book Rating : 4.1/5 (686 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer. This book was released on 2011-04-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Extracellular Matrix: an Overview

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Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix Remodeling

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Publisher : MDPI
ISBN 13 : 3039216287
Total Pages : 428 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Extracellular Matrix Remodeling by : Nicoletta Gagliano

Download or read book Extracellular Matrix Remodeling written by Nicoletta Gagliano and published by MDPI. This book was released on 2019-11-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is where cells live. It is composed of collagen and elastic fibers, glycosaminoglycans and proteoglycans, and several glycoproteins. In most tissues, fibril-forming collagen type I is the major constituent of ECM.The function of the ECM goes beyond providing mechanical support to cells and tissues. As cells are embedded into the ECM and interact with its components through their surface receptors, cell–ECM interaction plays a key role in influencing different cell activities, such as cell proliferation and migration. The ECM also sequesters and releases growth factors affecting important cellular pathways. Overall, the ECM strongly influences and affects cell behavior and tissue homeostasis. ECM is a highly dynamic structural network that continuously undergoes controlled remodeling mediated by matrix-degrading enzymes, the matrix metalloproteinases (MMPs), under normal conditions. Quantitative and qualitative deregulation of ECM remodeling and, especially, of collagen turnover, is responsible for the alteration of ECM composition and structure, associated with the development and progression of several pathological conditions, such as organ fibrosis (determined by the abnormal accumulation of ECM components) and tumor invasion. The understanding of the diverse biological roles and properties of the ECM components is pivotal to the development of new therapeutic tools for disease treatment.

Acellular Mechanisms of Extracellular Matrix Degradation

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Acellular Mechanisms of Extracellular Matrix Degradation by : Sarah Thurstan

Download or read book Acellular Mechanisms of Extracellular Matrix Degradation written by Sarah Thurstan and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Biology of Extracellular Matrix

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Publisher : Springer Science & Business Media
ISBN 13 : 1461537703
Total Pages : 478 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Cell Biology of Extracellular Matrix by : E.D. Hay

Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The Role of Extracellular Matrix Degradation in the Control of Vascular Tone

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Author :
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.:/5 (478 download)

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Book Synopsis The Role of Extracellular Matrix Degradation in the Control of Vascular Tone by : Kelli Rae Waitkus

Download or read book The Role of Extracellular Matrix Degradation in the Control of Vascular Tone written by Kelli Rae Waitkus and published by . This book was released on 2000 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix

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Publisher : CRC Press
ISBN 13 : 9783718658428
Total Pages : 494 pages
Book Rating : 4.6/5 (584 download)

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Book Synopsis Extracellular Matrix by : W.D. Comper

Download or read book Extracellular Matrix written by W.D. Comper and published by CRC Press. This book was released on 1996-06-30 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looking at the area of the extracellular matrix of connective tissue, including the results and concepts which have recently been generated, this text describes the structural characteristics of extracellular molecules and discusses the interaction between the cell and the extracellular matrix.

Methods in Extracellular Matrix Biology

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Publisher : Academic Press
ISBN 13 : 0128122986
Total Pages : 470 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Methods in Extracellular Matrix Biology by :

Download or read book Methods in Extracellular Matrix Biology written by and published by Academic Press. This book was released on 2018-01-05 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM. Contains contributions from experts in the field from across the world Covers a wide array of topics on the extracellular matrix, including an understanding crucial proteins and the glycoproteins components of ECM Includes analysis based topics, such as quantification of collagen and elastin, mulit-photon analysis of ECM and ECM crosslink analysis

Extracellular Matrix in Development

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Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone

Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

The Extracellular Matrix

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Publisher :
ISBN 13 :
Total Pages : 191 pages
Book Rating : 4.:/5 (924 download)

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Book Synopsis The Extracellular Matrix by :

Download or read book The Extracellular Matrix written by and published by . This book was released on 1996 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix in Development and Disease

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Author :
Publisher : MDPI
ISBN 13 : 3038975702
Total Pages : 357 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Extracellular Matrix in Development and Disease by : Julia Thom Oxford

Download or read book Extracellular Matrix in Development and Disease written by Julia Thom Oxford and published by MDPI. This book was released on 2019-02-21 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS

The Role of Metalloproteinases in Extracellular Matrix Degradation

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (597 download)

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Book Synopsis The Role of Metalloproteinases in Extracellular Matrix Degradation by : J. Gavrilovic

Download or read book The Role of Metalloproteinases in Extracellular Matrix Degradation written by J. Gavrilovic and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of PAK4 in Extracellular Matrix Degradation

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Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (94 download)

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Book Synopsis The Role of PAK4 in Extracellular Matrix Degradation by : 關冠麒

Download or read book The Role of PAK4 in Extracellular Matrix Degradation written by 關冠麒 and published by . This book was released on 2014 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix in Development and Disease

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Author :
Publisher : Elsevier
ISBN 13 : 9780444518460
Total Pages : 268 pages
Book Rating : 4.5/5 (184 download)

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Book Synopsis Extracellular Matrix in Development and Disease by : Jeffrey H. Miner

Download or read book Extracellular Matrix in Development and Disease written by Jeffrey H. Miner and published by Elsevier. This book was released on 2005-11-18 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more

Identification of a Novel Regulator of Extracellular Matrix Degradation in Chondrocytes

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (127 download)

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Book Synopsis Identification of a Novel Regulator of Extracellular Matrix Degradation in Chondrocytes by : Isabella Collins

Download or read book Identification of a Novel Regulator of Extracellular Matrix Degradation in Chondrocytes written by Isabella Collins and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: