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Exploring The Breast Tumor Microenvironment Association To Metastasis Novel Risk Factors And Novel Treatments And Immunotherapies
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Book Synopsis Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies by : Jorge Morales-Montor
Download or read book Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies written by Jorge Morales-Montor and published by Frontiers Media SA. This book was released on 2023-01-10 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Breast Cancer: From Bench to Personalized Medicine by : Saima Shakil Malik
Download or read book Breast Cancer: From Bench to Personalized Medicine written by Saima Shakil Malik and published by Springer Nature. This book was released on 2022-05-14 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
Book Synopsis Reconstituting the 3D Breast Cancer Microenvironment for Chemo and Immunotherapy by : Madhuri Dey
Download or read book Reconstituting the 3D Breast Cancer Microenvironment for Chemo and Immunotherapy written by Madhuri Dey and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic breast cancer is one of the deadliest forms of malignancy, primarily driven by its characteristic microenvironment comprising of cancer cells interacting with immune and stromal components. These interactions induce genetic and metabolic alterations creating a conducive environment for tumor growth. Immune-cancer interactions resulting in an immunosuppressive microenvironment further reduces the anti-tumor efficacy of immune-therapeutics. Thus, despite several advancements in cancer treatment, it still remains elusive with only a 5% success rate of new therapeutics entering clinical trials. This necessitates the development of an in vitro tumor model which would not only help us disseminate the steps in cancer progression but also aid in rapid pre-clinical screening of therapeutics. Traditionally, two-dimensional (2D) tumor models or animal models have been widely used for studying cancer growth; however, these models lack the essential cell-cell and cell-matrix interactions of a native three-dimensional (3D) tissue. A tumor in human body grows in 3D and is surrounded by a dynamic microenvironment, which marks the different stages of tumor progression. Thus, it is essential to fabricate 3D in vitro platforms which are capable of incorporating intricacies of the tumor interaction with its microenvironment. To this end, we have developed a 3D vascularized breast cancer microenvironment comprising of metastatic MDA-MB-231 breast cancer cells and human umbilical vein endothelial cells (HUVECs) loaded in human dermal fibroblast (HDF)-laden fibrin, representing the tumor stroma. Employing these cell types enabled us to study the impact of matrix as well as stromal cell density on tumor angiogenesis and cancer invasion, two of the major hallmarks of cancer. Specifically, presence of fibroblasts impacted the transcriptional profile of genes involved in tumor angiogenesis and cancer invasion, which further led to the identification of cancer-specific canonical pathways and activated upstream regulators in these complex 3D cultures. Additionally, immune-cancer crosstalk was explored employing different 3D tumor models to assess the efficiency of a novel T cell receptor- (TCR) modified primary human T cells in identifying and killing MR1 expressing MDA-MB-231 cells. TCR-modified T cells were effective in eradicating ~90% cancer cells in MDA-MB-231-only spheroids and ~70% cancer cells in MDA-MB-231/HDF spheroids, over three days of in vitro culture. The effect of T cell localization on tumor growth was also studied using a hybrid bioprinting approach. MDA-MB-231/HDF spheroids bioprinted proximal to T cells exhibited higher expression of IFN-gamma, granzymes, CCL2 and other cytokines, all indicative of T cell activation. Immune-cancer crosstalk was also explored in a dynamic-flow based 3D bioprinted vascularized tumor model. Heterotypic tumor spheroids, comprising metastatic breast cancer cells (MDA-MB-231), human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) were precisely bioprinted in a collagen/fibrin biomimetic matrix. Spheroids were bioprinted at proximal (~100 micrometer) and distal (~500 micrometer) locations from a perfused vasculature which revealed enhanced capillary sprouting, angiogenesis and anastomosis for the proximally bioprinted spheroids. Proximally bioprinted spheroids also exhibited higher invasion of cancer cells compared to the distal groups. Doxorubicin, a commonly used chemotherapy drug was perfused through the vasculature at varying dosages. A dose dependent drug response behavior with gradual reduction in tumor growth was observed after 72 h of doxorubicin perfusion. Furthermore, overexpression of several cancer biomarkers was observed for doxorubicin treated groups. Immune-cancer interaction in this complex dynamic microenvironment was studied by perfusing anti HER2-Chimeric Antigen Receptor (CAR) T cells through the central vasculature. Perfusing CAR-T cells for 24 h resulted in extensive T cell recruitment to the endothelium as well as T cell infiltration to the tumor site resulting in decreased in tumor volume. This physiologically-relevant 3D platform paves the way for a robust, high throughput and clinically relevant 3D tumor microenvironment platform for future translation of anti-cancer therapies to personalized medicine for cancer patients.
Book Synopsis Central Nervous System Metastases by : Manmeet Ahluwalia
Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Book Synopsis Novel Immune Markers and Predictive Models for Immunotherapy and Prognosis in Breast and Gynecological Cancers by : Chao Liu
Download or read book Novel Immune Markers and Predictive Models for Immunotherapy and Prognosis in Breast and Gynecological Cancers written by Chao Liu and published by Frontiers Media SA. This book was released on 2024-06-05 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine is an emerging practice by which clinicians aim to deliver a personalized treatment program to affected patients based on information gained from their individual clinical and biological profiles. In the context of precise cancer immunotherapy, multi-omics, high-throughput sequencing, big data, and other approaches serve to screen new predictive factors for immunotherapy response and prognosis in cancer patients.
Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge
Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
Book Synopsis Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy by : Noha Mousaad Elemam
Download or read book Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy written by Noha Mousaad Elemam and published by Frontiers Media SA. This book was released on 2023-09-13 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.
Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia
Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Book Synopsis Pulmonary Metastasis by : Leonard Weiss
Download or read book Pulmonary Metastasis written by Leonard Weiss and published by Macmillan Reference USA. This book was released on 1978 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Exploring the Impact of Genetics on New Drugs and Potential Drug Targets: A Multi-Omics Approach to Improve Personalized Therapeutics. by : Shaoqiu Chen
Download or read book Exploring the Impact of Genetics on New Drugs and Potential Drug Targets: A Multi-Omics Approach to Improve Personalized Therapeutics. written by Shaoqiu Chen and published by Frontiers Media SA. This book was released on 2024-07-08 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, significant advancements have been made in the field of new drug development. With the advent of high-throughput sequencing technologies, the identification of new drug targets has become more efficient and precise. In addition, multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have emerged as a powerful tool for understanding the complexity of diseases and identifying new therapeutic targets.
Book Synopsis Cancer diagnostics in solid tumors - from pathology to precision oncology by : Pedro Borralho
Download or read book Cancer diagnostics in solid tumors - from pathology to precision oncology written by Pedro Borralho and published by Frontiers Media SA. This book was released on 2023-04-05 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Soft Tissue and Bone Sarcoma by : Edwin Choy
Download or read book Soft Tissue and Bone Sarcoma written by Edwin Choy and published by MDPI. This book was released on 2018-10-08 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Soft Tissue and Bone Sarcoma" that was published in Cancers
Book Synopsis Diagnostic, Prognostic and Predictive Factors of Response in the Era of Precision Oncology in Breast Cancer by : Francesco Schettini
Download or read book Diagnostic, Prognostic and Predictive Factors of Response in the Era of Precision Oncology in Breast Cancer written by Francesco Schettini and published by Frontiers Media SA. This book was released on 2023-12-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.
Book Synopsis The tumor and microenvironment crosstalk in breast cancer: From biology to therapeutic opportunity by : Marta Truffi
Download or read book The tumor and microenvironment crosstalk in breast cancer: From biology to therapeutic opportunity written by Marta Truffi and published by Frontiers Media SA. This book was released on 2024-01-19 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multi-Omics Approaches for Decoding Heterogeneity in Cancer Immunotherapy by : Lin Qi
Download or read book Multi-Omics Approaches for Decoding Heterogeneity in Cancer Immunotherapy written by Lin Qi and published by Frontiers Media SA. This book was released on 2023-11-22 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in mathematical and computational oncology, volume III by : George Bebis
Download or read book Advances in mathematical and computational oncology, volume III written by George Bebis and published by Frontiers Media SA. This book was released on 2023-10-25 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Personalized Medicine in Oncology by : Ari VanderWalde
Download or read book Personalized Medicine in Oncology written by Ari VanderWalde and published by . This book was released on 2022 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
