Experimental Hepatocarcinogenesis

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Experimental Hepatocarcinogenesis

Author : M.B. Roberfroid
Publisher : Springer Science & Business Media
ISBN 13 : 1461309573
Total Pages : 305 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Experimental Hepatocarcinogenesis by : M.B. Roberfroid

Download or read book Experimental Hepatocarcinogenesis written by M.B. Roberfroid and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The meeting on experimental hepatocarcinogenesis which took place in Spa, Belgium at the end of May 1987 was the Second European Meeting. About 100 scientists, mostly from Europe but also from the United States, met there for three days in a very friendly atmosphere to exchange knowledge and ideas on experimental and human liver carcinogenesis. The main topics discussed during the meeting included general reviews on hepatocarcinogenesis, experimental models of hepa tocarcinogenesis, biology of hepatocarcinogenesis, and in vitro studies in hepatocarcinogenesis. They are all covered by the various chapters of this proceedings volume, which reflects the present state of knowledge in this important field of cancer research. The final aim of that research is to understand the basic mechanisms of carcinogenesis. The liver offers a parti cularly interesting tool to reach such a goal. Indeed, its biochemistry, its morphology, and its physiology are very diverse, but relatively well known. Various protocols have been developed to produce hepatocellular carcinomas or other malignant tumors. Their appearance is most often preceded by phenotypically altered foci and nodules which have been isolated and characterized. The major cell populations of normal, neoplastic, and malignant livers have been cultivated.

Hepatocellular Carcinoma

Author : Yujin Hoshida
Publisher : Springer
ISBN 13 : 3030215407
Total Pages : 366 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Liver Cell Cancer

Author : H.M. Cameron
Publisher : Elsevier
ISBN 13 : 1483163881
Total Pages : 309 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Liver Cell Cancer by : H.M. Cameron

Download or read book Liver Cell Cancer written by H.M. Cameron and published by Elsevier. This book was released on 2013-10-22 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Cell Cancer focuses on liver cell cancer, which is considered one of the most aggressive malignant tumors, and in turn, one of the most intensively studied tumors in man and experimental animals. This book discusses the geographic pathology, alpha-fetoprotein, diagnosis, treatment, and background of liver cell cancer. The clinical problem of liver cell cancer in a high incidence area; primary hepatocellular carcinoma; induction of liver cell cancer by chemicals; cell proliferation and experimental liver cancer; and immunology and pathology of experimental liver cell cancer are also discussed in the chapters. This book aims to provide a ready reference for clinicians for research, present a clear and unambiguous picture to research workers of the problems inherent in the clinical situation, and introduce a reasoned assessment of the findings, both clinical and experimental.

The Role of Cell Types in Hepatocarcinogenesis

Author : Alphonse E. Sirica
Publisher : CRC Press
ISBN 13 : 9780849347467
Total Pages : 380 pages
Book Rating : 4.3/5 (474 download)

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Book Synopsis The Role of Cell Types in Hepatocarcinogenesis by : Alphonse E. Sirica

Download or read book The Role of Cell Types in Hepatocarcinogenesis written by Alphonse E. Sirica and published by CRC Press. This book was released on 1992-09-11 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Role of Cell Types in Hepatocarcinogenesis provides the first comprehensive, review and analysis of cell precursor relationships believed to be important in the development of hepatocellular carcinoma and other types of nonmesenchymal liver tumors. The book focuses on cell lineages in liver development and neoplastic formation in both experimental animal models and humans. It also critically reviews current information supporting the existence of a "facultative liver stem cell" and its potential role as an alternative cell of origin in the genesis of various hepatic neoplasms, including hepatocellular carcinoma. Other significant topics covered include cellular and viral oncogenes, p53 gene and growth factors in hepatocarcinogenesis, and the use of newly developed transgenic animal and cell culture models designed for investigating the pathogenesis of hepatocellular carcinoma. Numerous figures and tables illustrate difficult concepts, and an extensive listing of references is included. The Role of Cell Types in Hepatocarcinogenesis is a practical reference volume that basic and clinical researchers in liver carcinogenesis, development, and differentiation will find useful in their day-to-day work.

Markers in Experimental Hepatocarcinogenesis and the Hepatic Effects of Tamoxifen and Toremifene

Author : Stefan Karlsson
Publisher :
ISBN 13 :
Total Pages : 51 pages
Book Rating : 4.:/5 (36 download)

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Book Synopsis Markers in Experimental Hepatocarcinogenesis and the Hepatic Effects of Tamoxifen and Toremifene by : Stefan Karlsson

Download or read book Markers in Experimental Hepatocarcinogenesis and the Hepatic Effects of Tamoxifen and Toremifene written by Stefan Karlsson and published by . This book was released on 1995 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular fluctuations, alpha-fetoprotein expression, and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis

Download Cellular fluctuations, alpha-fetoprotein expression, and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis PDF Online Free

Author : Wolf-Dieter Kuhlmann
Publisher : Cuvillier Verlag
ISBN 13 : 3736967756
Total Pages : 94 pages
Book Rating : 4.7/5 (369 download)

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Book Synopsis Cellular fluctuations, alpha-fetoprotein expression, and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis by : Wolf-Dieter Kuhlmann

Download or read book Cellular fluctuations, alpha-fetoprotein expression, and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis written by Wolf-Dieter Kuhlmann and published by Cuvillier Verlag. This book was released on 2023-05-25 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocytes and bile ductular cells possess stem-like potential in restoring liver tissue. This was derived from rat and mouse injury models such as (a) partial hepatectomy by surgery; (b) acute carbon tetrachloride intoxication; © injuries by D-galactosamine (GalN) or by N-nitrosomorpholine (NNM); (d) experimental hepatocarcinogenesis with NNM using different doses. Liver parenchyma was restored by adult hepatocytes after partial hepatectomy as well as after carbon tetrachloride intoxication. Concurrently, hepatocytes resumed synthesis of alpha-1-fetoprotein (AFP) which depended to a high degree on the animal species and strains used in that studies. In contrast to this way of regeneration, liver repair after heavy injuries by agents such as GalN and NNM was initiated by oval cell proliferation deriving from ductular epithelial cells of the canaliculi of HERING (canals of Hering, intrahepatic bile ductules) as sources of endogenous progenitors. Progenitor populations reach levels of differentiation with fetal gene reactivation and significant AFP expression. Proliferating oval cells operated as transit and amplification compartment during liver regeneration. Oval cell proliferation and concurrent AFP synthesis occurred also in the early stages of hepatocarcinogenesis when the carcinogen NNM was applied in toxic doses. The histologic features compared to those seen in GalN intoxication. NNM carcinogenicity was of concern for both oval cells and adult hepatocytes with risks of transformation and malignant development. At the cancer stage, carcinomas either synthesizing AFP or not can be found side by side in the same liver. AFP expression by cancer cells seems to be a special attribute to differentiation stages in carcinogenesis. Clonality, maturation arrest and retro-differentiation feature cells with high autonomy.

Experimental Model of Races, Sexes and Environmental Factors on Hepatocarcinogenesis in Rats

Author : Subhkij Angsubhakorn
Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.:/5 (397 download)

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Book Synopsis Experimental Model of Races, Sexes and Environmental Factors on Hepatocarcinogenesis in Rats by : Subhkij Angsubhakorn

Download or read book Experimental Model of Races, Sexes and Environmental Factors on Hepatocarcinogenesis in Rats written by Subhkij Angsubhakorn and published by . This book was released on 1972 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Carcinogenesis

Author :
Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Liver Carcinogenesis by :

Download or read book Liver Carcinogenesis written by and published by . This book was released on 1979 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polyploidization and Cancer

Author : Randy Y.C. Poon
Publisher : Springer Science & Business Media
ISBN 13 : 1441961992
Total Pages : 157 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Polyploidization and Cancer by : Randy Y.C. Poon

Download or read book Polyploidization and Cancer written by Randy Y.C. Poon and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Effect of Selective COX-2 Inhibitors on Hepatic Progenitor Cells and the Pathologies of Experimental Hepatocarcinogenesis

Author : Richard Davies
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (816 download)

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Book Synopsis Effect of Selective COX-2 Inhibitors on Hepatic Progenitor Cells and the Pathologies of Experimental Hepatocarcinogenesis by : Richard Davies

Download or read book Effect of Selective COX-2 Inhibitors on Hepatic Progenitor Cells and the Pathologies of Experimental Hepatocarcinogenesis written by Richard Davies and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: [Truncated abstract] Hepatocellular carcinoma (HCC) is the major malignancy complicating chronic liver disease. New therapies for the prevention of HCC are required due to the limited success and high tumour recurrence rates of existing treatments. Emerging evidence suggests that HCC arise from the transformation of adult liver progenitor cells (LPCs), which have the capacity to differentiate into hepatocytes and biliary cells during liver regeneration. LPC activation precedes neoplasia in experimental hepatocarcinogenesis. LPCs share antigenic epitopes with HCCs, including α-fetoprotein (AFP) and M2- pyruvate kinase (M2PK). In animal models of hepatocarcinogenesis, attenuation of the LPC response reduces the incidence of HCC following prolonged liver injury via a tumour necrosis factor (TNF) dependent mechanism. As TNF is a pro-inflammatory cytokine, these data suggest that anti-inflammatory agents may be effective in inhibiting LPC activation and hepatocarcinogenesis. Cyclo-oxygenase-2 (COX-2) is an inducible enzyme that mediates the production of many prostaglandins during inflammation and carcinogenesis. Recent investigations show that the administration of selective COX-2 inhibitors (SC2Is) may reduce the incidence of a variety of tumours including breast, colon and skin. The broad aim of this thesis was to conduct a series of detailed studies on the effects of a SC2I on LPC activation and the hepatic pathologies associated with hepatocarcinogenesis in order to test the hypothesis that S2CIs may be a beneficial therapy that can reduce liver injury and pre-neoplastic changes in the choline-deficient, ethionine supplemented (CDE) murine model of hepatocarcinogenesis. Administration of a SC2I (SC-236) significantly inhibited a variety of hepatic cell populations that expand during the first month of the CDE mouse model of hepatocarcinogenesis (a choline deficient, ethionine supplemented diet). Numbers of M2PK-positive LPCs (which are more hepatocytic in morphology and are also COX-2 positive) and inflammatory cells were all significantly reduced by SC-236. In contrast, numbers of A6-positive LPCs (which are more biliary cell-like in morphology and do not express COX-2) were unchanged. ... In summary, these data suggest that COX-2 inhibitors such as SC-236 inhibit LPC activation and a variety of pre-neoplastic liver pathologies as a result of COX-2 dependent and independent mechanisms that may be mediated through inhibition of Akt phosphorylation and induction of apoptosis. Moreover, SC2Is may be useful as preventative treatment strategies for HCC in patients with chronic liver disease.

Hepatic Tumor Growth

Author : Göran Carlsson
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hepatic Tumor Growth by : Göran Carlsson

Download or read book Hepatic Tumor Growth written by Göran Carlsson and published by . This book was released on 1982 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Investigations of the Specificity of Ultrastructural Markers of Experimental Hepatocarcinogenesis Induced by Chlorinated Azodyes in the Rat

Download Investigations of the Specificity of Ultrastructural Markers of Experimental Hepatocarcinogenesis Induced by Chlorinated Azodyes in the Rat PDF Online Free

Author : Chitraporn Dai Karnasuta
Publisher :
ISBN 13 :
Total Pages : 856 pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Investigations of the Specificity of Ultrastructural Markers of Experimental Hepatocarcinogenesis Induced by Chlorinated Azodyes in the Rat by : Chitraporn Dai Karnasuta

Download or read book Investigations of the Specificity of Ultrastructural Markers of Experimental Hepatocarcinogenesis Induced by Chlorinated Azodyes in the Rat written by Chitraporn Dai Karnasuta and published by . This book was released on 1985 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicity Bibliography

Author :
Publisher :
ISBN 13 :
Total Pages : 922 pages
Book Rating : 4.3/5 (126 download)

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Book Synopsis Toxicity Bibliography by :

Download or read book Toxicity Bibliography written by and published by . This book was released on 1977-04 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver and Environmental Xenobiotics

Author : S.V.S. Rana
Publisher : Springer Science & Business Media
ISBN 13 : 3662123851
Total Pages : 243 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Liver and Environmental Xenobiotics by : S.V.S. Rana

Download or read book Liver and Environmental Xenobiotics written by S.V.S. Rana and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made.

Third European Meeting on Experimental Hepatocarcinogenesis

Author :
Publisher :
ISBN 13 :
Total Pages : 49 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Third European Meeting on Experimental Hepatocarcinogenesis by :

Download or read book Third European Meeting on Experimental Hepatocarcinogenesis written by and published by . This book was released on 1990 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Pathology and Alcohol

Author : Roland R. Watson
Publisher : Springer Science & Business Media
ISBN 13 : 1461204216
Total Pages : 622 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Liver Pathology and Alcohol by : Roland R. Watson

Download or read book Liver Pathology and Alcohol written by Roland R. Watson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and other drugs of abuse are major contributing factors to liver disease and its pathology. Alcoholic cirrhosis causes thousands of deaths each year in the United States, and encourages liver replacement. A better understanding of the mechanisms of liver pathology will significantly aid basic researchers and physicians in treating and preventing liver damage. This book is designed especially for those researchers wishing to understand alcoholic liver disease. Therefore the role of alcohol in changing nutrition and its nutritional effects on liver disease are reviewed. The generation of free radicals during alcohol use has been found to be an important cause of membrane changes, of cancer development, and of lipid alterations-and thus of liver pathology. In addition to alcohol, other drugs of abuse, including morphine, cocaine, marijuana, and caffeine have also been shown to be significant contributors to liver pathology. The prevalence of drug and alcohol use and abuse today means that liver disease will continue as a major social and medical problem. The explanation of its biological origins cannot fail to help us better understand and treat the disease in the years to come.