Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

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Publisher : National Academies Press
ISBN 13 : 0309212219
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Intracranial Pressure and Neuromonitoring in Brain Injury

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Publisher : Springer Science & Business Media
ISBN 13 : 9783211830949
Total Pages : 472 pages
Book Rating : 4.8/5 (39 download)

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Book Synopsis Intracranial Pressure and Neuromonitoring in Brain Injury by : Anthony Marmarou

Download or read book Intracranial Pressure and Neuromonitoring in Brain Injury written by Anthony Marmarou and published by Springer Science & Business Media. This book was released on 1998-08-24 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the most recent works on intracranial pressure and neuromonitoring in brain injury selected from 300 abstracts submitted to the 10th International Symposium on Intracranial Pressure. It includes state of the art monitoring of the brain injured patient in intensive care as well as the current state of knowledge in neurochemical and oxygen monitoring of the injured brain. Recent advances in molecular mechanisms of injury and the pathophysiology of ischemia and trauma are also included. "... this publication presents a comprehensive survey of the present state of art in the field and thus gives directions for further research to those engaged in ICP measurement and neuromonitoring”. Intensive Care Med

Veterinary Psychopharmacology

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Publisher : John Wiley & Sons
ISBN 13 : 0470344148
Total Pages : 288 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Veterinary Psychopharmacology by : Sharon L. Crowell-Davis

Download or read book Veterinary Psychopharmacology written by Sharon L. Crowell-Davis and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day veterinarians in practice are asked to treat petsexhibiting problem behaviors. In the last several yearspharmacologic treatments of behavior have made significant advancesand can serve as a critical part of therapy. Veterinary Pscyhopharmacology is a complete source of currentknowledge on the subject of pharmacologic behavior modificationthat veterinarians can turn to for the answers they need. Classification of disorders is eschewed in favor of in-depthexplanations of pharmacologic options in inducing behavior changes.Special emphasis is given to explaining the underlying mechanism ofpharmacologic agents used in therapy; thus, veterinarians will knownot only which drugs to prescribe but why they should be prescribedand how they work. Veterinary behaviorists, their students and residents, veterinarypractitioners of all levels, and veterinary students will find thisbook invaluable in providing information about their patients'behavior problems and the psychoactive medications that might helpthem.

Kainic Acid as a Tool in Neurobiology

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Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Kainic Acid as a Tool in Neurobiology by : Edith G. McGeer

Download or read book Kainic Acid as a Tool in Neurobiology written by Edith G. McGeer and published by Lippincott Williams & Wilkins. This book was released on 1978 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Astrocytes and Epilepsy

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Publisher : Academic Press
ISBN 13 : 0128026243
Total Pages : 395 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Astrocytes and Epilepsy by : Jacqueline A. Hubbard

Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. - Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume - Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions - Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Neurobiology of the Locus Coeruleus

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Author :
Publisher : Elsevier
ISBN 13 : 0080862136
Total Pages : 657 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Neurobiology of the Locus Coeruleus by :

Download or read book Neurobiology of the Locus Coeruleus written by and published by Elsevier. This book was released on 1991-11-21 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of the Locus Coeruleus

Biology of the NMDA Receptor

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Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

The Glutamate/GABA-Glutamine Cycle

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Publisher : Springer
ISBN 13 : 3319450964
Total Pages : 420 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Glutamate/GABA-Glutamine Cycle by : Arne Schousboe

Download or read book The Glutamate/GABA-Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Ageing and Dementia

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Publisher : Springer Science & Business Media
ISBN 13 : 9783211837979
Total Pages : 400 pages
Book Rating : 4.8/5 (379 download)

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Book Synopsis Ageing and Dementia by : Kurt Jellinger

Download or read book Ageing and Dementia written by Kurt Jellinger and published by Springer Science & Business Media. This book was released on 2002-08-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.

Introduction to Neuropsychopharmacology

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Publisher : Oxford University Press
ISBN 13 : 0195380533
Total Pages : 568 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Introduction to Neuropsychopharmacology by : Leslie Iversen

Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.

Factors Affecting Neurological Aging

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Publisher : Academic Press
ISBN 13 : 0128179910
Total Pages : 688 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Factors Affecting Neurological Aging by : Colin R Martin

Download or read book Factors Affecting Neurological Aging written by Colin R Martin and published by Academic Press. This book was released on 2021-06-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. - Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging - Features sections on the genetic components that influence aging and diseases of aging - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables

Consciousness Transitions

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Publisher : Elsevier
ISBN 13 : 0080554636
Total Pages : 349 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Consciousness Transitions by : Hans Liljenström

Download or read book Consciousness Transitions written by Hans Liljenström and published by Elsevier. This book was released on 2011-10-13 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was not long ago when the consciousness was not considered a problem for science. However, this has now changed and the problem of consciousness is considered the greatest challenge to science. In the last decade, a great number of books and articles have been published in the field, but very few have focused on the how consciousness evolves and develops, and what characterizes the transitions between different conscious states, in animals and humans. This book addresses these questions. Renowned researchers from different fields of science (including neurobiology, evolutionary biology, ethology, cognitive science, computational neuroscience and philosophy) contribute with their results and theories in this book, making it a unique collection of the state-of-the-art of this young field of consciousness studies. First book on the topic Focus on different levels of consciousness, including: Evolutionary, developmental, and functional Highly interdisciplinary

Pharmacology of Pain

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331915
Total Pages : 978 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Pharmacology of Pain by : Pierre Beaulieu

Download or read book Pharmacology of Pain written by Pierre Beaulieu and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees

Webvision

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (53 download)

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Book Synopsis Webvision by : Helga Kolb

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The NMDA Receptors

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Publisher : Springer
ISBN 13 : 3319497952
Total Pages : 153 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The NMDA Receptors by : Kenji Hashimoto

Download or read book The NMDA Receptors written by Kenji Hashimoto and published by Springer. This book was released on 2017-02-08 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochemical, and behavioral aspects, to highlight their distinctive regulatory properties, their functional significance, and their therapeutic potential in a number of diseases. A group of international experts discuss the development of NMDA receptors, their basic functions, and how they are implicated in a wide range of diseases including depression, psychosis, and pain.

Rapid Acting Antidepressants

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Publisher : Academic Press
ISBN 13 : 0128201908
Total Pages : 404 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Rapid Acting Antidepressants by :

Download or read book Rapid Acting Antidepressants written by and published by Academic Press. This book was released on 2020-06-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Fundamental Neuroscience

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Publisher :
ISBN 13 :
Total Pages : 1666 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Fundamental Neuroscience by : Michael J. Zigmond

Download or read book Fundamental Neuroscience written by Michael J. Zigmond and published by . This book was released on 1999 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience is a comprehensive textbook that seeks to define the full scope of neuroscience. Developed in accordance with results of extensive reviews by neuroscience instructors, this premier textbook is divided into seven integrated sections. Each section may be used for a specific course, or the full text may be adopted to provide a broad-based curriculum that will carry the student from molecular to cognittive neuroscience.