Examining The Effects Of Exercise Training On Tumor Response To Nithracycline Based Chemotherapy

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Examining the Effects of Exercise Training on Tumor Response to Anthracycline-Based Chemotherapy

Author :
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.:/5 (644 download)

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Book Synopsis Examining the Effects of Exercise Training on Tumor Response to Anthracycline-Based Chemotherapy by :

Download or read book Examining the Effects of Exercise Training on Tumor Response to Anthracycline-Based Chemotherapy written by and published by . This book was released on 2004 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this study is to examine the effects of exercise training on tumor response to anthracycline-based chemotherapy. Eighty athymic Fischer 344 mice will be purchased at 21 days and at 26 days of age, MDA-MB-231 carcinoma cells (3x10EXP 6 cells prepared from donor tumors) will be subcutaneously implanted into the right flank of all animals. At 40 days of age, animals will be randomly assigned to one of four groups: (i) exercise alone (n=20), (ii) doxorubicin alone (n=20), (iii) exercise plus doxorubicin (n=20), and (iv) control (n=20). Animals assigned to doxorubicin alone and exercise plus doxorubicin will receive intravenous injections of doxorubicin at 5mg/kg every 7 days. The exercise group will be progressively trained to run at 22m/min at 0% grade for 45 minutes 5 days/week for 8 weeks. Forty eight hours after the final exercise session, all experimental animals will be sacrificed via carbon dioxide anesthetization and cervical dislocation. The primary tumor will be surgically removed, weighed and histologically processed. The primary outcome will be tumor volume measured in two dimensions. Secondary outcomes will be tumor growth delay calculated as the number of days for each individual animal tumor to reach 1000 cubic mm compared with the control group.

Examining the Effects of Exercise Training on Tumor Response to Nithracycline-Based Chemotherapy

Author :
Publisher :
ISBN 13 :
Total Pages : 39 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Examining the Effects of Exercise Training on Tumor Response to Nithracycline-Based Chemotherapy by :

Download or read book Examining the Effects of Exercise Training on Tumor Response to Nithracycline-Based Chemotherapy written by and published by . This book was released on 2005 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients during adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents. Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n= 21 per group): (i) control, (ii) exercise only, (iii) doxorubicin only, or (iv) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18m/min at 0% grade for 45mins, 5 days/wk for 8 weeks. Tumor growth delay was significantly longer in the doxorubicin only and exercise + doxorubicin groups compared with the control (median 42 vs. 25 days, p=0.0082; 36 vs. 25 days, p=0.029, respectively) and exercise only groups (median 42 vs. 25 days, p=0.029; 36 vs. 25 days, p=0.080, respectively). There was no significant difference between doxorubicin only and exercise + doxorubicin groups (median 42 vs. 36 days, p=0.33) suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay.

The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study (Idea Award).

Download The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study (Idea Award). PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study (Idea Award). by :

Download or read book The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study (Idea Award). written by and published by . This book was released on 2006 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the effects of exercise training on tumor vascularity and response to neoadjuvant therapy in operable breast cancer in a phase I-II randomized design. Method: Using a two-armed, prospective, randomized design, potential participants will be identified and screened for eligibility via medical record review of patients scheduled for their primary neoadjuvant chemotherapy treatment consultation at DUMC. Following the successful completion of all baseline assessments participants will be randomly assigned to an exercise or control group. Participants assigned to combined exercise training and chemotherapy will perform an individualized exercise training program consisting of three cycle ergometry sessions per week at approximately 60-80% of VO2peak on nonconsecutive days for the duration of neoadjuvant chemotherapy (approximately 12 weeks). Most Significant Research Finding During Reporting Period: As per our statement of work, human ethnical approval was obtained (Task 1); all exercise testing / training procedures and clinical protocols were clarified (Task 2), and data collection has been initiated (Task 3). To date, all 3 patients in phase I of the study have been enrolled and no doselimiting toxicities have been identified with acceptable exercise adherence (>60%), thus phase II has been initiated.

Adjuvant Therapy for Breast Cancer

Author : Monica Castiglione
Publisher : Springer Science & Business Media
ISBN 13 : 0387751157
Total Pages : 483 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione

Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Exercise Oncology

Author : Kathryn H. Schmitz
Publisher : Springer Nature
ISBN 13 : 3030420116
Total Pages : 438 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Exercise Oncology by : Kathryn H. Schmitz

Download or read book Exercise Oncology written by Kathryn H. Schmitz and published by Springer Nature. This book was released on 2020-05-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book presents a unique and practical approach to the evolving field of exercise oncology - the study of physical activity in the context of cancer prevention and control. Presenting the current state of the art, the book is sensibly divided into four thematic sections. Following an opening chapter presenting an overview and timeline of exercise oncology, the chapters comprising part I discuss primary cancer prevention, physical activity and survivorship, and the mechanisms by which these operate. Diagnosis and treatment considerations are discussed in part II, including prehabilitation, exercise during surgical recovery, infusion and radiation therapies, and treatment efficacy. Post-treatment and end-of-life care are covered in part III, including cardio-oncology, energetics and palliative care. Part IV presents behavioral, logistical and policy-making considerations, highlighting a multidisciplinary approach to exercise oncology as well as practical matters such as reimbursement and economics. Written and edited by experts in the field, Exercise Oncology will be a go-to practical resource for sports medicine clinicians, family and primary care physicians, oncologists, physical therapy and rehabilitation specialists, and all medical professionals who treat cancer patients.

Selected Health Conditions and Likelihood of Improvement with Treatment

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309670950
Total Pages : 319 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Selected Health Conditions and Likelihood of Improvement with Treatment by : National Academies of Sciences, Engineering, and Medicine

Download or read book Selected Health Conditions and Likelihood of Improvement with Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.

Endocrine and Metabolic Late Effects in Cancer Survivors

Author : Francesco Felicetti (Oncologist)
Publisher :
ISBN 13 : 9783318067903
Total Pages : 162 pages
Book Rating : 4.0/5 (679 download)

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Book Synopsis Endocrine and Metabolic Late Effects in Cancer Survivors by : Francesco Felicetti (Oncologist)

Download or read book Endocrine and Metabolic Late Effects in Cancer Survivors written by Francesco Felicetti (Oncologist) and published by . This book was released on 2021 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.

Systematic Reviews in Health Research

Author : Matthias Egger
Publisher : John Wiley & Sons
ISBN 13 : 1405160500
Total Pages : 612 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Systematic Reviews in Health Research by : Matthias Egger

Download or read book Systematic Reviews in Health Research written by Matthias Egger and published by John Wiley & Sons. This book was released on 2022-06-21 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematic Reviews in Health Research Explore the cutting-edge of systematic reviews in healthcare In this Third Edition of the classic Systematic Reviews textbook, now titled Systematic Reviews in Health Research, a team of distinguished researchers deliver a comprehensive and authoritative guide to the rapidly evolving area of systematic reviews and meta-analysis. The book demonstrates why systematic reviews—when conducted properly—provide the highest quality evidence on clinical and public health interventions and shows how they contribute to inference in many other contexts. The new edition reflects the broad role of systematic reviews, including: Twelve new chapters, covering additional study designs, methods and software, for example, on genetic association studies, prediction models, prevalence studies, network and dose-response meta-analysis Thorough update of 15 chapters focusing on systematic reviews of interventions Access to a companion website offering supplementary materials and practical exercises (www.systematic-reviews3.org) A key text for health researchers, Systematic Reviews in Health Research is also an indispensable resource for practitioners, students, and instructors in the health sciences needing to understand research synthesis.

Exercise for Cardiovascular Disease Prevention and Treatment

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811043043
Total Pages : 382 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Exercise for Cardiovascular Disease Prevention and Treatment by : Junjie Xiao

Download or read book Exercise for Cardiovascular Disease Prevention and Treatment written by Junjie Xiao and published by Springer. This book was released on 2017-11-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an intensive overview on exercise for cardiovascular disease prevention and treatment, from basic research to clinical practice. The volume firstly summarizes the acute and chronic response to exercise. Secondly, evidence for exercise as medicine for the heart based on clinical studies and basic research is summarized. Thirdly, molecular mechanisms mediating the beneficial effects of exercise including IGF-1-PI3K-AKT signalling, NO signalling, C/EBPB-Cited4 signalling, Non-coding RNAs, epigenetic regulators, mitochondria adaption and exosomes are presented. Finally, exercise dosing, prescription and future prospects are provided. This book will provide valuable reference for researchers in cell biology, physiology, as well as physician, physical therapist in cardiology, sport medicine, etc.

Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs

Author : American Association of Cardiovascular & Pulmonary Rehabilitation
Publisher : Human Kinetics
ISBN 13 : 9780736048644
Total Pages : 294 pages
Book Rating : 4.0/5 (486 download)

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Book Synopsis Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs by : American Association of Cardiovascular & Pulmonary Rehabilitation

Download or read book Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs written by American Association of Cardiovascular & Pulmonary Rehabilitation and published by Human Kinetics. This book was released on 2004 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition addresses the cost effectiveness of interventions that educate and motivate patients to assume personal responsibility for long-term disease prevention.

Clinical Gynecology

Author : Eric J. Bieber
Publisher : Cambridge University Press
ISBN 13 : 1107040396
Total Pages : 1127 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Clinical Gynecology by : Eric J. Bieber

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Immunosenescence and Clinical Consequences

Author : Valquiria Bueno
Publisher : Frontiers Media SA
ISBN 13 : 2889711714
Total Pages : 159 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Immunosenescence and Clinical Consequences by : Valquiria Bueno

Download or read book Immunosenescence and Clinical Consequences written by Valquiria Bueno and published by Frontiers Media SA. This book was released on 2021-08-10 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ovarian Cancers

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309380499
Total Pages : 397 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Ovarian Cancers by : National Academies of Sciences, Engineering, and Medicine

Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Geriatric Gastroenterology

Author : C. S. Pitchumoni
Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Geriatric Gastroenterology by : C. S. Pitchumoni

Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Chaperokine Activity of Heat Shock Proteins

Author : Alexzander A. A. Asea
Publisher : Springer
ISBN 13 : 3030022544
Total Pages : 320 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Chaperokine Activity of Heat Shock Proteins by : Alexzander A. A. Asea

Download or read book Chaperokine Activity of Heat Shock Proteins written by Alexzander A. A. Asea and published by Springer. This book was released on 2019-02-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. The book Chaperokine Activity of Heat Shock Proteins provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Childhood Cancer and Functional Impacts Across the Care Continuum

Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309683494
Total Pages : pages
Book Rating : 4.6/5 (834 download)

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Book Synopsis Childhood Cancer and Functional Impacts Across the Care Continuum by : National Academies of Sciences Engineering and Medicine

Download or read book Childhood Cancer and Functional Impacts Across the Care Continuum written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2021-09-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

The Oxford Handbook of Music Therapy

Author : Jane Edwards
Publisher : Oxford University Press
ISBN 13 : 0198817142
Total Pages : 1009 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis The Oxford Handbook of Music Therapy by : Jane Edwards

Download or read book The Oxford Handbook of Music Therapy written by Jane Edwards and published by Oxford University Press. This book was released on 2017 with total page 1009 pages. Available in PDF, EPUB and Kindle. Book excerpt: Music therapy is growing internationally to be one of the leading evidence-based psychosocial allied health professions to meet needs across the lifespan.The Oxford Handbook of Music Therapy is the most comprehensive text on this topic in its history. It presents exhaustive coverage of the topic from international leaders in the field.