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Estrogen Responsive Breast Cancer Growth Regulation
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Book Synopsis Estrogen Responsive Breast Cancer Growth Regulation by :
Download or read book Estrogen Responsive Breast Cancer Growth Regulation written by and published by . This book was released on 1995 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of this program was to characterize the serum factor(s) which regulated steroid hormone dependent human breast cancer cell growth. This included an identification of the molecule(s) and studies to establish the endocrine physiology of the regulator(s) as well as partial characterization of the receptors mediating serum factor action. We have discovered that two plasma glycoproteins, SHBG Type II and CBG, are negative regulators (i. e. inhibitors) of estrogen receptor positive (ER+) and progesterone receptor positive (PR+) breast cancer cell growth, respectively, and that autonomous (ER- and PR- ) breast cancer cells are not inhibited by these glycoproteins. The new form of sex hormone binding globulin has been designated SHBG Type II. It has not previously been identified or characterized from any source. The discovery of a new regulatory role for CBG in breast cancer growth may provide our first molecular link between increased stress and an elevated risk of breast cancer.
Book Synopsis Regulatory Mechanisms in Breast Cancer by : Marc E. Lippman
Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
Book Synopsis Phytochemical Regulation of Estrogen Responsiveness and Proliferation of Human Breast Cancer Cells by : Shyam Narayan Sundar
Download or read book Phytochemical Regulation of Estrogen Responsiveness and Proliferation of Human Breast Cancer Cells written by Shyam Narayan Sundar and published by . This book was released on 2006 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of the Protein Kinase C Delta Isoform by Estrogen in the MCF-7 Human Breast Cancer Cell Line and a Role for Protein Kinase C Delta in Growth Regulation by : Malathy Shanmugam
Download or read book Regulation of the Protein Kinase C Delta Isoform by Estrogen in the MCF-7 Human Breast Cancer Cell Line and a Role for Protein Kinase C Delta in Growth Regulation written by Malathy Shanmugam and published by . This book was released on 1997 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous evidence in our laboratory demonstrated the ability of estrogen to regulate specifically the protein kinase C (PKC) $\delta$ isoform in the rat and rabbit corpus luteum. The purpose of this study was to evaluate estrogen's ability to regulate PKC, specifically the PKC $\delta$ isoform, in the estrogen responsive, MCF-7 human breast cancer cell line. With the increasingly characterized role of PKC $\delta$ in growth regulation, we were interested to also determine the ability of PKC $\delta$ to regulate growth in the MCF-7 cell line. Treatment of MCF-7 cells with 10$\sp{-10}$ through 10$\sp{-8}$ M estrogen for 7 days down-regulated specifically PKC $\delta$ mRNA and protein; expression of other PKC isoforms was unchanged. These concentrations of estrogen were maximally proliferative for the MCF-7 cells and an inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells was observed. PKC $\delta$ protein levels were found to be 10 fold higher in MCF-7 compared to the estrogen receptor-negative, MDA-MB 231 cells which grow aggressively in the absence of estrogen. In view of the inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells we wished to determine whether activation of PKC $\delta$ could signal growth inhibition. Phorbol ester treatments that lead to G1 growth arrest and induction of the cyclin-dependent kinase inhibitor p21$\rm\sp{Waf1/Cip1}$ in MCF-7 cells promoted activation of PKC $\delta$, as evidenced in immunecomplex phosphorylation assays. To show that phorbol ester stimulated G1 growth arrest could be mediated by the induction of p21$\rm\sp{Waf1/Cip1}$ by activated PKC $\delta,$ we demonstrated that constitutively active PKC $\delta$ in the absence but not in the presence of dominant negative PKC $\delta$ activated the WAF1/CIP1 promoter-luciferase construct in transient transfection assays. Activated PKC $\delta$ can therefore signal the transcriptional induction of p21$\rm\sp{WAF1/CIP1}.$ Our results are consistent with the hypothesis that modulation of PKC $\delta$ expression and activation state provides a pathway for growth regulation in breast cancer cells.
Book Synopsis Hormonal Regulation of Mammary Tumors by : Benjamin S. Leung
Download or read book Hormonal Regulation of Mammary Tumors written by Benjamin S. Leung and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Book Synopsis Oxidation Sensitive ER Transcriptional Regulation in Hormone-dependent Breast Cancer by : Hoi Sze Christina Yau
Download or read book Oxidation Sensitive ER Transcriptional Regulation in Hormone-dependent Breast Cancer written by Hoi Sze Christina Yau and published by . This book was released on 2008 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth by : Shunyuan Jiang
Download or read book Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth written by Shunyuan Jiang and published by . This book was released on 1991 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer by : Kyuri Kim
Download or read book Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer written by Kyuri Kim and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogens are associated with the development and progression of breast cancer in addition to their role in normal reproductive physiology, and estrogen receptors (ER) mediate the actions of estrogen in target tissues by regulating the expression of numerous biologically important target genes. The progression of human breast cancer and the development of resistance to endocrine therapies are thought to be associated with ER phosphorylation. We generated multiple combinations of ER phospho-mutants, at residues serine 104, 106, 118, 167, 236, and 305, and examined their impact on receptor half-life, the agonist and antagonist balance of selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs), the regulation of ER transcriptional activity, and stimulation of cell proliferation in response to estradiol and SERMs/SERD. We showed that changes in ER affecting the phosphorylation status of the receptor greatly impact receptor function and differential SERM and SERD modulated cellular responses that could contribute to resistance to endocrine therapies in breast cancer. We also studied the regulation of microRNAs (miRNAs) by estradiol and growth factors through ER and extracellular signal-regulated kinase 2 (ERK2) in order to understand their physiological impact on breast cancer. We identified nine miRNA- encoding genes harboring overlapping ER and ERK2 binding sites close to their transcription start sites, which require ER and ERK2 for transcriptional induction as well as estradiol- mediated miRNA regulation. We then identified TP63, a target of miR-101, miR-190 and miR- 196a2, and showed that TP63 plays an important role in estradiol- or growth factor-mediated cellular response in breast cancer cells (MCF-7 and MDA-MB-231) by increasing tumor cell growth and in vitro invasion mainly controlled by miR-196a2 action. These results suggest a tumor-suppressive role of miR-196a2 in regulating TP63 expression and the aggressive behavior of breast cancers.
Book Synopsis Growth Regulation of Human Breast Cancer Cells by Estrogens and Antiestrogens by : Anne E. Lykkesfeldt
Download or read book Growth Regulation of Human Breast Cancer Cells by Estrogens and Antiestrogens written by Anne E. Lykkesfeldt and published by . This book was released on 1997 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Estrogen Independence and Antiestrogen Resistance in Breast Cancer Cells in Culture by : Ethel M. Cormier
Download or read book Development of Estrogen Independence and Antiestrogen Resistance in Breast Cancer Cells in Culture written by Ethel M. Cormier and published by . This book was released on 1988 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Elucidating MicroRNA-mediated Regulation of Estrogen Signaling and Response in Human Breast Cancer Cells by : Brian Daniel Adams
Download or read book Elucidating MicroRNA-mediated Regulation of Estrogen Signaling and Response in Human Breast Cancer Cells written by Brian Daniel Adams and published by . This book was released on 2009 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Breast Cancer Lymphatic Dissemination - Influence of Estrogen and Progesterone by :
Download or read book Breast Cancer Lymphatic Dissemination - Influence of Estrogen and Progesterone written by and published by . This book was released on 2008 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancers commonly spread to lymph nodes (LNs). If the primary tumors are estrogen receptor (ER) and/or progesterone receptor (PR) positive, then the likelihood that LN metastases express receptors exceeds 80%. We developed metastasis models using ZsGreen labeled MCF-7 and T47D human breast cancer cells. Tumors were tracked in living mice by whole-body imaging, and macrometastases or micrometastases were detected by intravital imaging or fluorescence microscopy. Tumor growth was estrogen dependent. To determine if the LN microenvironment alters estrogen-dependent gene expression, we developed a unique model to identify estradiol regulated genes in ER+ breast tumors and LN metastases. Fluorescent ER+ MCF-7 tumors were grown in ovariectomized nude mice supplemented with estradiol. Once axillary LN metastasis arose, estradiol was withdrawn (EWD), for 1 or 4 weeks, or continued, to assess estradiol responsiveness. On EWD, proliferation rates fell similarly in tumors and LN metastases. However, estradiol-dependent ER down-regulation and PR induction were deficient in LN metastases, indicating that ER transcriptional activity was altered in the LN. Cancer cells from estradiol treated and EWD primary tumors and matched LN metastases were isolated by laser capture microdissection. Global gene expression profiling identified transcripts that were regulated by the tissue microenvironment, by hormones, or by both. Interestingly, numerous genes that were estradiol regulated in tumors lost estradiol sensitivity or were regulated in the opposite direction by estradiol in LN metastases. We propose that the LN microenvironment alters estradiol signaling and contributes to antiestrogen resistance.
Book Synopsis Hormones and Cancer by : Wendell W. Leavitt
Download or read book Hormones and Cancer written by Wendell W. Leavitt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.
Book Synopsis Endocrine Therapy and Growth Regulation of Breast Cancer by : Urs Eppenberger
Download or read book Endocrine Therapy and Growth Regulation of Breast Cancer written by Urs Eppenberger and published by Springer. This book was released on 1989-03-03 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key questions involved in the treatment of disseminated breast cancer are discussed in this well-presented overview. It is the result of an initiative taken by the Swiss Group for Clinical Cancer Research to reveal the most recent developments in experimental and clinical research. The topics discussed include: the comparison of in vitro cultures of epithelial cells with breast cancer cells, the effect of steroids and their antagonists, the involvement of suppressor genes in tumour progression, the modulation of transforming growth factors by estrogen, and prognostic factors such as cERB-2 and EGF-R in breast cancer.
Book Synopsis Effects of Estrogen Deprivations on Hormone Responsive Breast Cancer Cell Lines by : John J. Pink
Download or read book Effects of Estrogen Deprivations on Hormone Responsive Breast Cancer Cell Lines written by John J. Pink and published by . This book was released on 1995 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hormone Action by : Bert W. O'Malley
Download or read book Hormone Action written by Bert W. O'Malley and published by . This book was released on 1974 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone assays; Hormone receptors; Evaluation of biological effects of hormones; Purification and synthesis of hormones.
Book Synopsis Estrogen and Breast Cancer by : W. R. Miller
Download or read book Estrogen and Breast Cancer written by W. R. Miller and published by Landes Bioscience. This book was released on 1996 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
