Establishing 18f Naf Pet Quantitative Imaging Biomarkers For Treatment Response Assessment

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Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment

Author : Christie Lin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment by : Christie Lin

Download or read book Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment written by Christie Lin and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of functional imaging with positron emission tomography (PET) has increased in clinical oncology to assess response to therapy. Response assessment with PET scans is largely interpreted qualitatively, which results in subjective clinical evaluation. Alternatively, quantitative imaging can enable objective evaluation; however, the path to establish standardized response criteria of candidate quantitative imaging biomarkers (QIBs) is extremely challenging. This dissertation focused on establishing quantitative 18F-NaF PET-based treatment response assessment. Using 18F-NaF PET/CT scans of bone tumors (osseous lesions) in metastatic castration-resistant prostate cancer patients imaged in a multi-center clinical trial, we characterized test-retest repeatability of standardized uptake values (SUVs) measured from both lesions and patients, and reproducibility across imaging sites. From these studies we derived the limits of agreement, which can be interpreted as objective response criteria. To assess the generalizability of response criteria, we investigated sources of variability that may influence response assessment. Linear mixed effects models identified both differences in injected dose between scans and anatomical location of the lesion may influence repeatability. To address the need to mitigate potential variability in longitudinal imaging, we evaluated the utility of reference region normalization but found that SUVs were similarly robust without. In order to advance criteria for QIBs of response, we introduced the response-to-repeatability metric and discovered that not all candidate QIBs were able to discern statistically measurable changes at treatment follow-up. In our last study, we introduced a bootstrapping method to estimate sample size requirements needed to achieve a desired level of repeatability, a critical component in clinical trial design. Finally, we outlined statistical limitations to the generalizability of response criteria, which will guide appropriate implementation of imaging-based response assessment in the clinical routine. In summary, we present a statistical basis to enable quantitative imaging-based response criteria and methods to iteratively advance needs in both research and the clinic.

Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment

Author : Christie Lin
Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment by : Christie Lin

Download or read book Establishing 18F-NaF PET Quantitative Imaging Biomarkers for Treatment Response Assessment written by Christie Lin and published by . This book was released on 2018 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of functional imaging with positron emission tomography (PET) has increased in clinical oncology to assess response to therapy. Response assessment with PET scans is largely interpreted qualitatively, which results in subjective clinical evaluation. Alternatively, quantitative imaging can enable objective evaluation; however, the path to establish standardized response criteria of candidate quantitative imaging biomarkers (QIBs) is extremely challenging. This dissertation focused on establishing quantitative 18F-NaF PET-based treatment response assessment. Using 18F-NaF PET/CT scans of bone tumors (osseous lesions) in metastatic castration-resistant prostate cancer patients imaged in a multi-center clinical trial, we characterized test-retest repeatability of standardized uptake values (SUVs) measured from both lesions and patients, and reproducibility across imaging sites. From these studies we derived the limits of agreement, which can be interpreted as objective response criteria. To assess the generalizability of response criteria, we investigated sources of variability that may influence response assessment. Linear mixed effects models identified both differences in injected dose between scans and anatomical location of the lesion may influence repeatability. To address the need to mitigate potential variability in longitudinal imaging, we evaluated the utility of reference region normalization but found that SUVs were similarly robust without. In order to advance criteria for QIBs of response, we introduced the response-to-repeatability metric and discovered that not all candidate QIBs were able to discern statistically measurable changes at treatment follow-up. In our last study, we introduced a bootstrapping method to estimate sample size requirements needed to achieve a desired level of repeatability, a critical component in clinical trial design. Finally, we outlined statistical limitations to the generalizability of response criteria, which will guide appropriate implementation of imaging-based response assessment in the clinical routine. In summary, we present a statistical basis to enable quantitative imaging-based response criteria and methods to iteratively advance needs in both research and the clinic.

Comprehensive Assessment of Uncertainties and Errors in [18F]NaF PET Imaging

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (893 download)

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Book Synopsis Comprehensive Assessment of Uncertainties and Errors in [18F]NaF PET Imaging by :

Download or read book Comprehensive Assessment of Uncertainties and Errors in [18F]NaF PET Imaging written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative PET imaging is increasingly being used as a tool for treatment response assessment of various types of cancers, supplementing the conventional qualitative anatomical imaging. [18F]NaF is a radiotracer used for imaging of metastatic bone lesions and provides a means of visualizing and quantifying metabolic activity. [18F]NaF PET images provide better sensitivity and quantitative response assessment of the bone lesions compared to the 99mTc which is currently the clinical standard. Nevertheless, for accurate and reliable use of [18F]NaF PET for response assessment of metastatic bone lesions, many factors need to be thoroughly understood. These include the understanding of the uncertainties and errors associated with quantitative [18F]NaF PET imaging and how these uncertainties and errors impact treatment response assessment. Additionally, the reproducibility of [18F]NaF PET imaging metrics need to be assessed to determine their value as quantitative biomarkers for response assessment. This thesis work comprehensively characterized the uncertainties and errors in quantitative [18F]NaF PET imaging and investigated the impact of these uncertainties and errors on absolute and relative quantitative PET measures used in treatment response assessment. The lesions within the patients were evaluated globally and individually to understand both inter-patient and intra-patient variations. Additionally, the reproducibility of [18F]NaF PET imaging metrics such as SUV and textural features was evaluated. All these studies were performed on a multi-center clinical trial data set that used [18F]NaF PET/CT to assess treatment efficacy of metastatic bone lesions. We found that [18F]NaF PET imaging is highly reproducible; however it is affected by many uncertainties which translate to uncertainties and errors in response assessment and these need to be taken into consideration in clinical practice. We also developed and tested a methodology to quantitatively harmonize the data from the different PET/CT scanners used in the trial to increase accuracy of [18F]NaF PET/CT data. The methodology included both phantom-based and patient-based harmonization of the PET data.

Evolution of Translational Omics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Evolution of Translational Omics by : Institute of Medicine

Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Molecular Imaging in Multiple Myeloma

Author : Cristina Nanni
Publisher : Springer
ISBN 13 : 9783030190217
Total Pages : 0 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Molecular Imaging in Multiple Myeloma by : Cristina Nanni

Download or read book Molecular Imaging in Multiple Myeloma written by Cristina Nanni and published by Springer. This book was released on 2020-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the importance of molecular imaging in multiple myeloma, with detailed explanation of its clinical impact. Other important features are the definition of criteria that will aid PET/CT interpretation; identification and explanation of the most frequent pitfalls; a brief overview of the advantages and limitations of DWI MR imaging, still an experimental technique in multiple myeloma; and examination of the possible role of emerging PET tracers. When appropriate, clinical cases are used to illustrate key teaching points. All physicians involved in oncological imaging should regularly reassess and update their routine practice in the evaluation of multiple myeloma patients. This is especially true now, given the recent clarification by the International Myeloma Working Group (IMWG) of the criteria for bone damage requiring therapy and the emerging data supporting the role of the newer functional imaging techniques in predicting outcome and/or evaluating response to therapy. In this challenging context, Molecular Imaging in Multiple Myeloma will be of high value for nuclear medicine physicians, radiologists, and hematologists.

Radiomics and Radiogenomics

Author : Ruijiang Li
Publisher : CRC Press
ISBN 13 : 1351208268
Total Pages : 420 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Radiomics and Radiogenomics by : Ruijiang Li

Download or read book Radiomics and Radiogenomics written by Ruijiang Li and published by CRC Press. This book was released on 2019-07-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

Atlas of Clinical PET-CT in Treatment Response Evaluation in Oncology

Author : Stefano Fanti
Publisher : Springer Nature
ISBN 13 : 3030688585
Total Pages : 488 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Atlas of Clinical PET-CT in Treatment Response Evaluation in Oncology by : Stefano Fanti

Download or read book Atlas of Clinical PET-CT in Treatment Response Evaluation in Oncology written by Stefano Fanti and published by Springer Nature. This book was released on 2021-07-07 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas is a superb guide to the use of PET-CT for the evaluation of treatment response in oncology patients based on its ability to assess tumor metabolic status. The first part of the book explains the role of PET-CT in response evaluation in different treatment settings. For comparison, overviews of the value and limitations of CT alone, PET alone, and anatomical and functional MRI are included. Guidance is also provided on the reporting of PET-CT scans in post-therapy scenarios. The second part of the book describes and illustrates the use of PET-CT with FDG and other tracers to assess the treatment response of malignancies at different anatomic sites. Featuring a wealth of images, informative case-based discussion, and evidence-based teaching points, these disease-specific chapters clearly demonstrate the key role that PET-CT can play in distinguishing early responders from patients who are non-responders or are resistant to treatment. Prompt and accurate evaluation of treatment response is vital as we enter the era of individualized medicine, and this atlas will persuade readers of the considerable advantages of PET-CT over conventional radiological and clinical methods.

Basic Science of PET Imaging

Author : Magdy M. Khalil
Publisher : Springer
ISBN 13 : 3319400703
Total Pages : 621 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Basic Science of PET Imaging by : Magdy M. Khalil

Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

Sodium Fluoride PET/CT in Clinical Use

Author : Kalevi Kairemo
Publisher : Springer Nature
ISBN 13 : 3030235777
Total Pages : 97 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Sodium Fluoride PET/CT in Clinical Use by : Kalevi Kairemo

Download or read book Sodium Fluoride PET/CT in Clinical Use written by Kalevi Kairemo and published by Springer Nature. This book was released on 2019-11-04 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocket book is the first of its kind on sodium fluoride (18F-NaF)-PET and addresses skeletal as well as cardiovascular applications. In malignant metastatic diseases 18F-NaF-PET has already demonstrated its benefits in cancer staging, re-staging, follow-up and response evaluation. It also has an emerging diagnostic role in the calcified soft-tissue metastases of primary bone tumours, and can be applied to evaluate cardiovascular diseases, such as calcifications in heart valves and peripheral vascular disease. The book is divided into 11 chapters: five on oncology, four addressing the general aspects of skeletal conditions, and two on cardiovascular diseases. It offers a valuable guide for referring colleagues, nuclear medicine physicians/radiologists and aid clinicians, and highlights the main applications and limitations of 18F-NaF-PET hybrid imaging (PET/CT).

PET/CT in Prostate Cancer

Author : Gary Cook
Publisher : Springer
ISBN 13 : 3319576240
Total Pages : 73 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis PET/CT in Prostate Cancer by : Gary Cook

Download or read book PET/CT in Prostate Cancer written by Gary Cook and published by Springer. This book was released on 2017-07-24 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Up-to-date information is supplied on the relevance of PET/CT to diagnosis, treatment planning, and therapy, including the emerging role of PET/CT with PSMA. Readers will also find clear explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, which presents contributions from professionals worldwide who share a common purpose in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.

Bone Metastases from Prostate Cancer

Author : Francesco Bertoldo
Publisher : Springer
ISBN 13 : 3319423274
Total Pages : 293 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Bone Metastases from Prostate Cancer by : Francesco Bertoldo

Download or read book Bone Metastases from Prostate Cancer written by Francesco Bertoldo and published by Springer. This book was released on 2016-11-07 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Total Body PET Imaging, An Issue of PET Clinics, E-Book

Author : Ramsey Badawi
Publisher : Elsevier Health Sciences
ISBN 13 : 032376147X
Total Pages : 320 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Total Body PET Imaging, An Issue of PET Clinics, E-Book by : Ramsey Badawi

Download or read book Total Body PET Imaging, An Issue of PET Clinics, E-Book written by Ramsey Badawi and published by Elsevier Health Sciences. This book was released on 2020-12-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of PET Clinics focuses on Total Body PET Imaging, and is edited by Drs. Lorenzo Nardo, Ramsey Badawi, Joel S. Karp and Austin Pantel. Articles will include: UC Davis update on the uEXPLORER; Zhongshan update on the uEXPLORER; UPenn update on the PennPET Explorer; Total body imaging instrumentation design considerations; 3D/4D reconstruction and quantitative total body imaging; Analysis of 4D data for total body imaging; Total body imaging and cancer; Total body imaging and metabolic disease; Total body imaging and infection; Total body imaging and musculoskeletal disease; Total body imaging and cardiovascular disease; Total body imaging and cardiac applications; Total body imaging and neuroimaging; and more!

Basic Sciences of Nuclear Medicine

Author : Magdy M. Khalil
Publisher : Springer Nature
ISBN 13 : 3030652459
Total Pages : 571 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Basic Sciences of Nuclear Medicine by : Magdy M. Khalil

Download or read book Basic Sciences of Nuclear Medicine written by Magdy M. Khalil and published by Springer Nature. This book was released on 2021-05-26 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.

Withrow and MacEwen's Small Animal Clinical Oncology

Author : Stephen J. Withrow
Publisher : Elsevier Health Sciences
ISBN 13 : 1437723624
Total Pages : 775 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Withrow and MacEwen's Small Animal Clinical Oncology by : Stephen J. Withrow

Download or read book Withrow and MacEwen's Small Animal Clinical Oncology written by Stephen J. Withrow and published by Elsevier Health Sciences. This book was released on 2012-11-13 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.

Targeted Molecular Imaging in Oncology

Author : E. Edmund Kim
Publisher : Springer Science & Business Media
ISBN 13 : 1475735057
Total Pages : 302 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Targeted Molecular Imaging in Oncology by : E. Edmund Kim

Download or read book Targeted Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Molecular Imaging

Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
ISBN 13 : 3540767355
Total Pages : 379 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Molecular Imaging by : Shankar Vallabhajosula

Download or read book Molecular Imaging written by Shankar Vallabhajosula and published by Springer Science & Business Media. This book was released on 2009-07-13 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Therapy Response Imaging in Oncology

Author : Mizuki Nishino
Publisher : Springer Nature
ISBN 13 : 3030311716
Total Pages : 266 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Therapy Response Imaging in Oncology by : Mizuki Nishino

Download or read book Therapy Response Imaging in Oncology written by Mizuki Nishino and published by Springer Nature. This book was released on 2020-01-07 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a detailed guide to therapy response imaging in cancer patients that fully takes into account the revolutionary progress and paradigm shift in treatment approaches for advanced disease. The opening chapters describe the role of imaging as a “common language” for tumor response evaluation in oncology and address challenges and strategies in the era of precision cancer therapy and cancer immunotherapy. Practical pitfalls are discussed, with emphasis on the importance of approaching cancer as a systemic disease and the need for increased awareness of drug toxicity due to novel therapies. Therapy response imaging in a wide range of cancer types is then comprehensively described and illustrated, using a disease-specific approach. A concluding section focuses on emerging approaches and future directions, including radiomics/radiogenomics, co-clinical imaging, and molecular and functional imaging. Therapy Response Imaging in Oncology will be of high value for radiologists, nuclear medicine physicians, and oncologists. It will also be of interest to cancer care providers and oncology trial investigators.