Essentials Of Cancer Genomic Computational Approaches And Precision Medicine

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Author : Nosheen Masood
Publisher : Springer Nature
ISBN 13 : 9811510679
Total Pages : 499 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by : Nosheen Masood

Download or read book 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine written by Nosheen Masood and published by Springer Nature. This book was released on 2020-03-20 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Author :
Publisher :
ISBN 13 : 9789811510687
Total Pages : 498 pages
Book Rating : 4.5/5 (16 download)

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Book Synopsis 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by :

Download or read book 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine written by and published by . This book was released on 2020 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Cancer Genomics

Author : Graham Dellaire
Publisher : Academic Press
ISBN 13 : 0123972744
Total Pages : 511 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Cancer Genomics by : Graham Dellaire

Download or read book Cancer Genomics written by Graham Dellaire and published by Academic Press. This book was released on 2013-11-21 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Computational Methods for Precision Oncology

Author : Alessandro Laganà
Publisher : Springer Nature
ISBN 13 : 303091836X
Total Pages : 341 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Computational Methods for Precision Oncology by : Alessandro Laganà

Download or read book Computational Methods for Precision Oncology written by Alessandro Laganà and published by Springer Nature. This book was released on 2022-03-01 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.

Computational Methods for Multi-Omics Data Analysis in Cancer Precision Medicine

Author : Ehsan Nazemalhosseini-Mojarad
Publisher : Frontiers Media SA
ISBN 13 : 2832530389
Total Pages : 433 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Computational Methods for Multi-Omics Data Analysis in Cancer Precision Medicine by : Ehsan Nazemalhosseini-Mojarad

Download or read book Computational Methods for Multi-Omics Data Analysis in Cancer Precision Medicine written by Ehsan Nazemalhosseini-Mojarad and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Author : Erika Ruiz-Garcia
Publisher : Springer Nature
ISBN 13 : 3030241009
Total Pages : 171 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics by : Erika Ruiz-Garcia

Download or read book Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics written by Erika Ruiz-Garcia and published by Springer Nature. This book was released on 2019-11-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Oncology: Genomics, Precision Medicine and Therapeutic Targets

Author : Hardeep Singh Tuli
Publisher : Springer Nature
ISBN 13 : 9819915295
Total Pages : 283 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Oncology: Genomics, Precision Medicine and Therapeutic Targets by : Hardeep Singh Tuli

Download or read book Oncology: Genomics, Precision Medicine and Therapeutic Targets written by Hardeep Singh Tuli and published by Springer Nature. This book was released on 2023-06-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Genomic and Precision Medicine

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0128006536
Total Pages : 379 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomic and Precision Medicine by : Geoffrey S. Ginsburg

Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2022-04-09 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients

Cancer Genetics and Genomics for Personalized Medicine

Author : Il-Jin Kim
Publisher : CRC Press
ISBN 13 : 1315341107
Total Pages : 230 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Cancer Genetics and Genomics for Personalized Medicine by : Il-Jin Kim

Download or read book Cancer Genetics and Genomics for Personalized Medicine written by Il-Jin Kim and published by CRC Press. This book was released on 2017-04-11 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Computational Approaches for Cancer Precision Medicine

Author : Lindsay C. Stetson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (928 download)

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Book Synopsis Computational Approaches for Cancer Precision Medicine by : Lindsay C. Stetson

Download or read book Computational Approaches for Cancer Precision Medicine written by Lindsay C. Stetson and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Many types of cancer have no proven means of prevention or effective therapies. Precision medicine is an emerging approach for disease treatment that takes into account the biology of the patient in an effort to improve therapeutic outcome. While significant advances have been made in precision medicine when it comes to select cancers such as breast and lung, precision medicine is still not used by clinicians when initiating treatment for most cancer patients. Advances in DNA sequencing and large-scale studies such as The Cancer Genome Atlas (TCGA) have led to a better understanding of the molecular initiators and drivers of cancer, but challenges remain in bringing precision medicine from the bench to the bedside. A major impediment to achieving personalized therapy is the small number of drugs developed to target the proteins encoded by potential driver genes. Additionally, the large numbers of genetic aberrations in cancer discovered through next-generation sequencing have not always translated into actionable drug targets. In this dissertation these two challenges are addressed. First, we demonstrate that data from large-scale pharmacogenomic studies can be computationally mined to create omic signatures of drug response. The benefit of this study is the ability to rapidly and cost-effectively identify drugs and research compounds that can be repositioned or repurposed for use in different cancer types. Additionally, we demonstrate that this approach can successfully identify the precise subgroup of cancer patients that will benefit from a drug treatment based on their unique tumor biology. We then show that proteomics studies completed as part of TCGA can be computationally mined to create protein models predictive of patient survival. The resulting protein signatures can be used by clinicians to identify those patients that are high-risk and should be treated more aggressively or referred to clinical trial. Additionally, proteins that are correlated to patient survival are potential actionable drug targets. Both drug development and clinical trials are expensive; computational approaches such as those described in this dissertation are critical to the cost-effective and timely development of precision medicines.

Next Generation Sequencing in Cancer Research

Author : Wei Wu
Publisher : Springer Science & Business Media
ISBN 13 : 1461476453
Total Pages : 383 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Next Generation Sequencing in Cancer Research by : Wei Wu

Download or read book Next Generation Sequencing in Cancer Research written by Wei Wu and published by Springer Science & Business Media. This book was released on 2013-08-04 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

Precision Cancer Medicine

Author : Sameek Roychowdhury
Publisher : Springer Nature
ISBN 13 : 3030236374
Total Pages : 196 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Precision Cancer Medicine by : Sameek Roychowdhury

Download or read book Precision Cancer Medicine written by Sameek Roychowdhury and published by Springer Nature. This book was released on 2020-01-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Essentials of Genomic and Personalized Medicine

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0080958117
Total Pages : 851 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Essentials of Genomic and Personalized Medicine by : Geoffrey S. Ginsburg

Download or read book Essentials of Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2009-10-02 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. Full color throughout Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practic Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Clinical Cancer Genomic Medicine

Author : Claire Morgan
Publisher : Academic Press
ISBN 13 : 9780443153211
Total Pages : 0 pages
Book Rating : 4.1/5 (532 download)

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Book Synopsis Clinical Cancer Genomic Medicine by : Claire Morgan

Download or read book Clinical Cancer Genomic Medicine written by Claire Morgan and published by Academic Press. This book was released on 2024-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomic of cancer development, diagnosis, and management and the use of them in the clinical setting. It aims to provide readers with not only the genetic basis of cancer, but the role genomics play in understanding the molecular basis of the disease along with aiding diagnosis and treatment.The content is split into three parts: the first, Fundamentals of Cancer Genetics and Genomics, discusses the basics of oncogenomic and emerging technologies; the second, Clinical Cancer Genetics and Genomics, brings information on specific cancer types, such as breast, gastrointestinal, ocular, skin and pediatric; and the third, Clinical Cancer Genomic Medicine, encompasses knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications of cancer genomic testing.It is a valuable resource for oncologists, clinicians, researchers, healthcare workers and members of biomedical field who needs to understand more about the benefits of genetics and genomics for cancer and their application in clinical setting.

Computational Approaches for Integrative Cancer Genomics

Author : Christian Pérez Llamas
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Computational Approaches for Integrative Cancer Genomics by : Christian Pérez Llamas

Download or read book Computational Approaches for Integrative Cancer Genomics written by Christian Pérez Llamas and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology and Functional Genomics for Precision Medicine

Author : Yu Jiyang
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659806438
Total Pages : 688 pages
Book Rating : 4.8/5 (64 download)

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Book Synopsis Systems Biology and Functional Genomics for Precision Medicine by : Yu Jiyang

Download or read book Systems Biology and Functional Genomics for Precision Medicine written by Yu Jiyang and published by LAP Lambert Academic Publishing. This book was released on 2015-11-17 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data-driven personalized or precision medicine is coming of age. It's increasingly easy to collect relevant "big data" from genomics to clinics. However, the interpretation of "big data" and translation into down-stream testable experimental hypotheses and patient-beneficial clinical applications or therapeutics remain difficult. This book demonstrates how to leverage and integrate computational & systems biology analysis of cancer genomics data and genome-wide functional genomics screens to identify novel driver-type therapeutic targets as well as predictive biomarkers to overcome drug-resistance and to treat aggressive human cancers. Specifically the author developed network-based systems biology framework to infer disease drivers from large volumes of cancer genomics data and sophisticated statistical algorithms to deconvolute and analyze noisy high-throughput microarray or NGS-based functional genomics screening data. Two of the discoveries from this book have successfully launched two clinical trials and one biomarker patent for specific subtypes of breast cancer.

Cancer Genomics and Proteomics

Author : Narendra Wajapeyee
Publisher : Humana Press
ISBN 13 : 9781493909919
Total Pages : 0 pages
Book Rating : 4.9/5 (99 download)

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Book Synopsis Cancer Genomics and Proteomics by : Narendra Wajapeyee

Download or read book Cancer Genomics and Proteomics written by Narendra Wajapeyee and published by Humana Press. This book was released on 2014-07-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics and Proteomics: Methods and Protocols, Second Edition includes methods for the analyses of cancer genome and proteome that have illuminated us about the changes in cancer cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Genomics and Proteomics: Methods and Protocols, Second Edition seeks to aid scientists in the further study into various aspects of tumor initiation and progression.