Author : Tobias Warnken
Publisher :
ISBN 13 : 9783736998063
Total Pages : 118 pages
Book Rating : 4.9/5 (98 download)
Book Synopsis Equine Metabolic Syndrome by : Tobias Warnken
Download or read book Equine Metabolic Syndrome written by Tobias Warnken and published by . This book was released on 2018-06-04 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Variations in insulin regulation reflect either as tissue insulin resistance or insulin dysregulation result in moderate to severe hyperinsulinemia in horses and ponies suffering from the Equine Metabolic Syndrome (EMS). Several pathomechanisms provoking equine insulin resistance have been suggested, but insulin signaling in healthy horses has not been studied in detail so far. Thus the objective of this PhD project was to investigate equine insulin sensitivity, glucose homeostasis and lipid metabolism by combining examinations of insulin signaling on a protein level in different main metabolic tissues and analyses of dynamic hormone and metabolite changes during acute stimulations by either oral glucose application or IV insulin and glucose injection. Furthermore, systemic markers of insulin resistance were analyzed by an innovative targeted metabolomics approach to provide better understanding of potential pathomechanisms involved in impaired insulin regulation in horses. In conclusion, equine-specific insulin signaling, the marginal relationship of insulin sensitivity to obesity and strong associations of high plasma insulin concentration to cellular oxidative stress depicted not only a special physiological condition but also indicate novel pathophysiological conditions underlying EMS.