Epitope Based Re Matching Of Donor Recipient Pairs For Kidney Graft Allocation

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Epitope-based Re-matching of Donor-recipient Pairs for Kidney Graft Allocation

Author : Morgan M. Mastrocinque
Publisher :
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Epitope-based Re-matching of Donor-recipient Pairs for Kidney Graft Allocation by : Morgan M. Mastrocinque

Download or read book Epitope-based Re-matching of Donor-recipient Pairs for Kidney Graft Allocation written by Morgan M. Mastrocinque and published by . This book was released on 2021 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: When considering the matching of donor and recipient pairs for kidney transplantation, there are many aspects that must be compared and evaluated in order to ensure the best outcomes for recipients. Historically, a focus has been placed on evaluating the number of mismatches in various loci of Human Leukocyte Antigens (HLAs) in addition to other clinical factors including blood type, history of disease, etc. While HLA is still a standard technique for determining the histocompatibility of donor-recipient pairs, recent research has shown that other methods such as immunogenicity scores and eplet load may provide a more nuanced approach to donor-recipient matching, resulting in the ability to increase both quantity and quality of kidney transplants that occur. Based on evidence that eplet-based matching may provide improved outcomes for kidney transplant recipients, this thesis develops computational tools, namely a small Python-based library, to aid in the evaluation of this matching methodology and explores data in order to demonstrate computationally the potential impacts of eplet load-based matching when considering race. A secondary evaluation is also made to see how introducing an additional HLA (HLA-DQ) potentially affects re-matching success. Results demonstrate that matching on eplet load yielded an average 8x increase in matches than when using HLA mismatches.

Core Concepts in Renal Transplantation

Author : Anil Chandraker
Publisher : Springer Science & Business Media
ISBN 13 : 1461400082
Total Pages : 250 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Core Concepts in Renal Transplantation by : Anil Chandraker

Download or read book Core Concepts in Renal Transplantation written by Anil Chandraker and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management. Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplantation. This comprehensive, state-of-the-art reference summarizes the recent changes in the field of transplantation, offering the complete range of up-to-date information on all the various aspects of basic immunobiology and the medical care of the transplant recipient. Written by a team of renowned authorities in renal transplantation, this concise resource is intended for both the nephrologist and the non-specialist with an interest in kidney transplantation.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1796 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Primer on Transplantation

Author : American Society of Transplantation
Publisher : John Wiley & Sons
ISBN 13 : 1405142677
Total Pages : 320 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Primer on Transplantation by : American Society of Transplantation

Download or read book Primer on Transplantation written by American Society of Transplantation and published by John Wiley & Sons. This book was released on 2011-03-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online

Chronic Graft Versus Host Disease

Author : Georgia B. Vogelsang
Publisher : Cambridge University Press
ISBN 13 : 1139478893
Total Pages : 427 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Chronic Graft Versus Host Disease by : Georgia B. Vogelsang

Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Current Issues and Future Direction in Kidney Transplantation

Author : Thomas Rath
Publisher : BoD – Books on Demand
ISBN 13 : 9535109855
Total Pages : 494 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Current Issues and Future Direction in Kidney Transplantation by : Thomas Rath

Download or read book Current Issues and Future Direction in Kidney Transplantation written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2013-02-13 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.

Living Kidney Donation

Author : Krista L. Lentine
Publisher : Springer Nature
ISBN 13 : 3030536181
Total Pages : 390 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Living Kidney Donation by : Krista L. Lentine

Download or read book Living Kidney Donation written by Krista L. Lentine and published by Springer Nature. This book was released on 2021-03-05 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete guide to the evaluation, care, and follow-up of living kidney donors. Living donor kidney transplantation is established as the best treatment option for kidney failure. However, despite the tremendous benefits of living donation to recipients and society, the outcomes and optimal care of donors themselves have received relatively less attention. Fortunately, things are changing – including recent landmark developments in living donor risk assessment, policy and guidance. This volume offers authoritative, evidence-based guidance on the full range of clinical scenarios encountered in the evaluation and care of living kidney donors. The approach to key elements of risk assessment, ethical considerations and informed consent is accompanied by recommendations for patient-centered care before, during, and after donation. Advocacy initiatives and policies to remove disincentives to donation and advance a defensible system of practice are also discussed. General and transplant nephrologists, as well as related allied health professionals, can look to this book as a comprehensive resource addressing contemporary clinical topics in the practice of living kidney donation.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Transplantation Surgery

Author : Nadey Hakim
Publisher : Springer Science & Business Media
ISBN 13 : 1447136896
Total Pages : 452 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Transplantation Surgery by : Nadey Hakim

Download or read book Transplantation Surgery written by Nadey Hakim and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.

Long-Term Care of Kidney Transplant Patients

Author : Sundaram Hariharan
Publisher : Oxford University Press
ISBN 13 : 0197697321
Total Pages : 361 pages
Book Rating : 4.1/5 (976 download)

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Book Synopsis Long-Term Care of Kidney Transplant Patients by : Sundaram Hariharan

Download or read book Long-Term Care of Kidney Transplant Patients written by Sundaram Hariharan and published by Oxford University Press. This book was released on 2024 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-term Care of Kidney Transplant Patients provides all aspects of long-term care of kidney transplant patients. Many of the chapters highlight unmet needs relevant to certain post-transplant events that influence survival. Chapters provide clinicians and researchers with opportunities to investigate and advance the science by performing studies than can alter the trajectory of specific post-transplant diseases which will improve long-term kidney survival further until we achieve "Transplant Tolerance."

HLA Typing

Author : Sebastian Boegel
Publisher : Springer Nature
ISBN 13 : 1071638742
Total Pages : 300 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis HLA Typing by : Sebastian Boegel

Download or read book HLA Typing written by Sebastian Boegel and published by Springer Nature. This book was released on with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The EBMT Handbook

Author : Nicolaus Kröger
Publisher :
ISBN 13 : 9781013273674
Total Pages : 688 pages
Book Rating : 4.2/5 (736 download)

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Book Synopsis The EBMT Handbook by : Nicolaus Kröger

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

HLA in Health and Disease

Author : Robert Lechler
Publisher : Academic Press
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis HLA in Health and Disease by : Robert Lechler

Download or read book HLA in Health and Disease written by Robert Lechler and published by Academic Press. This book was released on 2000-05-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field

Immunology for Surgeons

Author : Andrew P. Zbar
Publisher : Springer Science & Business Media
ISBN 13 : 9781852334826
Total Pages : 486 pages
Book Rating : 4.3/5 (348 download)

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Book Synopsis Immunology for Surgeons by : Andrew P. Zbar

Download or read book Immunology for Surgeons written by Andrew P. Zbar and published by Springer Science & Business Media. This book was released on 2002-02-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the complex workings of the immune system is essential for all surgeons. Immune responses play a crucial part in the way human body reacts to infection and trauma. Immunology for Surgeons contains a high-level discussion of this difficult clinical area. The text looks at tumor immunobiology and immunotherapy as well as the worldwide results of various clinical trials. The topics discussed focus on relevant immunological and molecular biological trends for future treatment of complex surgical disease. The main objective of the text is to render a difficult area accessible for the postgraduate surgical trainee and established surgeon who is interested in immunology.

Challenges in Pediatric Kidney Transplantation

Author : Katherine E. Twombley
Publisher : Springer Nature
ISBN 13 : 3030747832
Total Pages : 429 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Challenges in Pediatric Kidney Transplantation by : Katherine E. Twombley

Download or read book Challenges in Pediatric Kidney Transplantation written by Katherine E. Twombley and published by Springer Nature. This book was released on 2021-06-26 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the unique challenges inherent in pediatric kidney transplantation. The text reviews the problems faced during each stage of the kidney transplantation process, including the occurrence of infections during the pre-transplant stage, surgical challenges during the actual transplantation, and medication issues during the post-transplant stage. The book also features high-yield case presentations of typical pediatric transplant scenarios, from the pre-transplant management of a child with CAKUT to the evaluation and treatment of antibody mediated rejection in children. Written by experts in the field, Challenges in Pediatric Kidney Transplantation: A Practical Guide is a valuable resource for clinicians, practitioners, and trainees who manage or are interested in this challenging group of patients.

Practical Atlas of Transplant Pathology

Author : W. Dean Wallace
Publisher : Springer
ISBN 13 : 3319230549
Total Pages : 208 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Practical Atlas of Transplant Pathology by : W. Dean Wallace

Download or read book Practical Atlas of Transplant Pathology written by W. Dean Wallace and published by Springer. This book was released on 2015-11-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas describes and illustrates the pathology of solid organ transplants and includes chapters covering transplant pathology of the kidney, lung, heart, liver, pancreas, small bowel and limbs. Each of these chapters briefly reviews the latest rejection classifications for each organ system with explanatory notes highlighting diagnostic criteria, and tables listing entities in the differential diagnosis. Included with each chapter are images demonstrating the pathology of the most common and important diseases, especially patterns of organ rejection and related entities or mimickers. Examples of classic disease processes are provided, as well as atypical presentations that may highlight and prevent diagnostic pitfalls. A comprehensive explanation of the immunogenetics of transplant rejection is included, enabling the general pathologist to become familiar with the most important aspects of serologic testing in this patient population. A review of post-transplant lymphoproliferative diseases is also provided. Practical Atlas of Transplant Pathology is aimed at both general and expert pathologists who encounter transplant pathology specimens in their practice.

Pediatric Hepatology and Liver Transplantation

Author : Lorenzo D'Antiga
Publisher : Springer
ISBN 13 : 3319964003
Total Pages : 829 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Pediatric Hepatology and Liver Transplantation by : Lorenzo D'Antiga

Download or read book Pediatric Hepatology and Liver Transplantation written by Lorenzo D'Antiga and published by Springer. This book was released on 2019-04-29 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.