Author : Amit K. Singh
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (755 download)
Book Synopsis Engineered Near-infrared Nanomaterials for Cancer Theranostics by : Amit K. Singh
Download or read book Engineered Near-infrared Nanomaterials for Cancer Theranostics written by Amit K. Singh and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Subsequently, these NIRF nanoparticles were modified to exhibit photothermal properties by integration of either photothermal materials within the NIRF particulate structure. Conventionally used plasmonic photothermal materials due to their size and shape restrictions could not be incorporated in the NIRF nanoparticles. A novel strategy based on interplasmon coupling between sub 4nm gold nanoparticles was developed to overcome this limitation. Surface of NIRF NPs was decorated either externally or internally with small gold nanoparticles in a controlled fashion (surface coverage 6-14%, size 0.7, 1.2, and 3.8nm). The gold speckled silica nanoparticles thus formed exhibited both optical luminescence and photothermal properties. Another strategy to incorporate photothemal properties in NIRF NPs was based on mixed micelles mediated synthesis of organic-inorganic hybrid structures. Molecular photothermal agents such as metal-naphthalocyanine dyes were incorporated inside the pores of NIRF NPs (photothermal: fluorescence dye 4:1). The high optical absorbance cross-section and optical imaging properties of MNPs were utilized for image guided photothermal ablation (tumor necrosis> 90%) of a human breast cancer tumor inside mice.