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Author : Gemma Kate Lyall
Publisher :
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (879 download)
Download or read book Endothelial Function in Post-menopausal Women written by Gemma Kate Lyall and published by . This book was released on 2013 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Laura Loehr
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (419 download)
Download or read book Black-white Differences in Endothelial Function in Postmenopausal Women written by Laura Loehr and published by . This book was released on 2002 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Melissa E. Fuchs
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.:/5 (567 download)
Download or read book Raloxifene Enhances Endothelial Function in Health Postmenopausal Women written by Melissa E. Fuchs and published by . This book was released on 2001 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rodolfo Paoletti
Publisher : Springer Science & Business Media
ISBN 13 : 0585379734
Total Pages : 292 pages
Book Rating : 4.5/5 (853 download)
Download or read book Women’s Health and Menopause written by Rodolfo Paoletti and published by Springer Science & Business Media. This book was released on 2007-07-11 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The population structure in the world is rapidly changing, to the extent that in 75 years we will face a tripling of the elderly population. Although women are favored in terms of life expectancy, they also live with a longer period of disability (approximately twice that of aging men), as well as with the enemies of all the elderly, cardiovascular disease, cancer, and dementia. Menopause is the endocrine event that overlaps with aging, potentially worsening both the quality of life and the risks of disease in women.While the effect of hormone replacement therapy (HRT) on menopausal symptoms is generally viewed as rapid and consistent, and is thereby accepted by the scientific community, its relationship to the other aforementioned chronic conditions associated with menopause is considered variable and controversial.In analyzing these complex issues, this volume yields new and significant insights into both the study of menopause-related disorders and their treatment, by illustrating the most recent information on mechanisms of actions of new estrogen receptors and on the use of sophisticated techniques of statistical analysis for population-based studies.
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Vinood B. Patel
Publisher : Humana Press
ISBN 13 : 331926009X
Total Pages : 652 pages
Book Rating : 4.3/5 (192 download)
Download or read book L-Arginine in Clinical Nutrition written by Vinood B. Patel and published by Humana Press. This book was released on 2016-08-23 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. It contains seven major sections. Section 1: Basic Processes at the Cellular Levels, Section 2: Arginine Metabolism and Functions, Section 3: Arginine Status in Cells Related to Organ Damage and Disease, Section 4: Arginine Status and Use in Healthy Individuals, Section 5: Arginine and Diseases of the Gastrointestinal Tract, Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases and Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease. Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists.
Author : Andrew Vincent Kuczmarski
Publisher :
ISBN 13 :
Total Pages : 229 pages
Book Rating : 4.4/5 (711 download)
Download or read book Role of the Endothelin System in Vascular Dysfunction in Women written by Andrew Vincent Kuczmarski and published by . This book was released on 2021 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Postmenopausal women have increased rates of cardiovascular disease compared to age-matched men and premenopausal women. Vascular dysfunction precedes the development of cardiovascular disease and is characterized by a pro-constrictor state of the blood vessel. Changes in vascular function can be due to phenotypic changes in the vascular endothelium and smooth muscle. Endothelin-1 (ET-1) is a potent vasoconstrictor that contributes to the development of vascular dysfunction. ET-1 is primarily produced by vascular endothelial cells and acts on endothelin A (ETAR) and endothelin B receptors (ETBR) on the vascular smooth muscle cells to cause vasoconstriction. However, ETBR are also located on endothelial cells and mediate vasodilation. Overexpression of ET-1, loss of endothelial ETBR and increased expression of ETBR and ETAR on vascular smooth muscle cells all play a role in mediating vascular dysfunction. There are age- and hormone-related changes in the endothelin system which can impact the phenotypic and functional properties of the system. However, data regarding the phenotypic changes in the endothelin system and changes in sensitivity to ET-1 are unknown in women. Additionally, data are lacking on the impact of estradiol (E2) on vascular endothelin receptors, leaving a gap in our understanding of the hormonal modulation of the endothelin system. Accordingly, the central hypothesis was that overactivity of the endothelin system contributes to vascular dysfunction in postmenopausal women and E2 differentially modulates endothelin receptor expression on endothelial compared to vascular smooth muscle cells. Methods: Multiple research techniques were used to test our central hypothesis. Venous endothelial cells were collected from premenopausal (YW) and postmenopausal (PMW) women and protein expression for ET-1 and ETBR was determined using immunocytochemistry. Intradermal microdialysis in combination with laser doppler flowmetry was used to determine the dose-response relation of ET-1 and skin blood flow in the cutaneous microcirculation of YW and PMW. Human umbilical vein endothelial and smooth muscle cells were treated with a range of E2 concentrations (0-100ng/mL) for 24 hours, harvested, and evaluated for endothelin protein receptor expression using western blotting. Vascular smooth muscle cells were pre-treated with glucose for 24hr to upregulate ETAR and ETBR prior to the addition of E2. Results: Venous endothelial cell expression of ET-1 was lower in PMW compared to YW (PMW; 0.58 ℗ł 0.21 vs. YW; 0.85 ℗ł 0.28 a.u, p=0.003). The vasoconstrictor response to exogenous ET-1 was similar in YW and PMW (p=0.51, d=1.08) and there was no difference between groups for the maximal constriction response to ET-1 (p=0.46). Venous endothelial cell ETBR expression was lower in PMW (0.46 ℗ł 0.11 AU) compared to YW (0.58 ℗ł 0.14 AU; P=0.02). In human umbilical vein endothelial cells treated with E2, ETBR expression was significantly increased (p=0.01) at the highest concentration of E2 (100ng/mL) compared to 0, 0.1, and 10ng/mL (all p
Author : A.R. Genazzani
Publisher : CRC Press
ISBN 13 : 9781842140383
Total Pages : 208 pages
Book Rating : 4.1/5 (43 download)
Download or read book Hormone Replacement Therapy and Cardiovascular Disease written by A.R. Genazzani and published by CRC Press. This book was released on 2001-05-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a high-level, clinical reference by world-class specialists on the efficacy of hormone replacement therapy for the primary prevention of cardiovascular risk in postmenopausal women. Specific chapters cover pulsed estrogen therapy with Aerodiol and cardiovascular risk assessment in postmenopausal hormone replacement therapies such as Livial (tibolone). This volume is based on the formal presentations and subsequent discussions that took place at the International Menopause Society specially convened Expert Workshop on Hormone Replacement Therapy and Cardiovascular Disease, London, UK, October 13-16, 2000.
Author : Allyson Schwab
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.3/5 (83 download)
Download or read book Hormone Therapy, Menopause, and Endothelial Function written by Allyson Schwab and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key words: menopause, estrogen, women's health, vascular function, hormone
Author : Pradeep Kumar Dabla
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783848484201
Total Pages : 108 pages
Book Rating : 4.4/5 (842 download)
Download or read book Postmenopausal Coronary Artery Disease Risk written by Pradeep Kumar Dabla and published by LAP Lambert Academic Publishing. This book was released on 2012-04 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Menopause increases the risk for women independent of age. Prior to menopause, the risk of Coronary Artery Disease (CAD) for women lags behind the risk for men. After menopause, women have similar risks of CAD as men of the same age. The functional and morphological alteration in endothelial cells is critical to atherosclerotic process. After menopause, marked decline in Estrogen and Nitric Oxide (NO) levels takes place. Estrogen exerts its various CAD protective actions by arterial endothelium sex steroid receptors. Nitric oxide released from vascular endothelium is one of most known versatile molecules and has a role in almost every biological system. Nitric oxide inhibits various key steps in development of atherosclerosis via inhibition of platelet activity and smooth muscle cell proliferation. Further presence of Endothelial Nitric Oxide Synthase (eNOS) gene polymorphism Glu298Asp may provide additional insult by decreasing NO levels adding to the CAD risk. Hence, postmenopausal women those who presents with eNOS Glu298Asp polymorphic gene may have higher CAD risk.
Author : Tanya Marie Spitzig
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (639 download)
Download or read book Endothelial Vasomotor Function in Pre and Postmenopausal Women Assessed by Flow Mediated Dilation Before and After a High-fat Meal written by Tanya Marie Spitzig and published by . This book was released on 2004 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eimantas Svedas
Publisher :
ISBN 13 : 9789173496896
Total Pages : 54 pages
Book Rating : 4.4/5 (968 download)
Download or read book Endothelial Function in Isolated Small Arteries from Women at Reproductive Age and After Menopause - Possibilities for Improvement written by Eimantas Svedas and published by . This book was released on 2003 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gabor M. Rubanyi
Publisher : CRC Press
ISBN 13 : 0203303938
Total Pages : 279 pages
Book Rating : 4.2/5 (33 download)
Download or read book Estrogen and the Vessel Wall written by Gabor M. Rubanyi and published by CRC Press. This book was released on 2003-09-02 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogen and the Vessel Wall marks the start of a new era in understanding the cardiovascular actions of estrogen. It examines the hypothesis, derived from a growing body of epidemiological data, that estrogen acts directly upon the vessel wall to produce beneficial effects in the cardiovascular system. Inspired by a satellite symposium of the IX International Vascular Biology Meeting, additional topics have been included, covered by leading experts. All subjects have been brought together here to produce an outstanding and integral publication, a milestone in the field of Vascular Research.
Author : Marcus I. Portallis
Publisher : Nova Publishers
ISBN 13 : 9781590339633
Total Pages : 188 pages
Book Rating : 4.3/5 (396 download)
Download or read book Focus on Hormone Replacement Research written by Marcus I. Portallis and published by Nova Publishers. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone replacement therapy is now simply called hormone replacement because of research discoveries identifying possible severe risks associated with this treatment which was very favourably viewed earlier. Now the lowest effective dose and the shortest duration of treatment acceptable is advised. This new book presents state-of-the-art research from around the world in HR and its relation to endometrial cancer, cardiovascular disease, Alzheimer's disease, schizophrenia, mood and anxiety disorders, Parkinson's disease, Huntington's disease and bone mass.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309157331
Total Pages : 428 pages
Book Rating : 4.3/5 (91 download)
Download or read book International Differences in Mortality at Older Ages written by National Research Council and published by National Academies Press. This book was released on 2011-02-27 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1950 men and women in the United States had a combined life expectancy of 68.9 years, the 12th highest life expectancy at birth in the world. Today, life expectancy is up to 79.2 years, yet the country is now 28th on the list, behind the United Kingdom, Korea, Canada, and France, among others. The United States does have higher rates of infant mortality and violent deaths than in other developed countries, but these factors do not fully account for the country's relatively poor ranking in life expectancy. International Differences in Mortality at Older Ages: Dimensions and Sources examines patterns in international differences in life expectancy above age 50 and assesses the evidence and arguments that have been advanced to explain the poor position of the United States relative to other countries. The papers in this deeply researched volume identify gaps in measurement, data, theory, and research design and pinpoint areas for future high-priority research in this area. In addition to examining the differences in mortality around the world, the papers in International Differences in Mortality at Older Ages look at health factors and life-style choices commonly believed to contribute to the observed international differences in life expectancy. They also identify strategic opportunities for health-related interventions. This book offers a wide variety of disciplinary and scholarly perspectives to the study of mortality, and it offers in-depth analyses that can serve health professionals, policy makers, statisticians, and researchers.
Author : Mary Clare Luca
Publisher :
ISBN 13 : 9780494973943
Total Pages : pages
Book Rating : 4.9/5 (739 download)
Download or read book Assessment of Endothelial Function and Approaches to Prevent Ischemia and Reperfusion-Induced Endothelial Dysfunction in Humans written by Mary Clare Luca and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Abraham
Publisher : Springer Science & Business Media
ISBN 13 : 1848826370
Total Pages : 448 pages
Book Rating : 4.8/5 (488 download)
Download or read book Advances in Vascular Medicine written by David Abraham and published by Springer Science & Business Media. This book was released on 2010-02-01 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book – Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: “Genetics and Gene Therapy” cover approaches to gene therapy and delivery systems, “Animal Models to Study Vascular Disease” with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.
