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Endocrine And Hormonal Toxicology
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Book Synopsis Endocrine and Hormonal Toxicology by : Philip W. Harvey
Download or read book Endocrine and Hormonal Toxicology written by Philip W. Harvey and published by John Wiley & Sons. This book was released on 1999-06-18 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi-organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.
Book Synopsis Endocrine Toxicology by : J. Charles Eldridge
Download or read book Endocrine Toxicology written by J. Charles Eldridge and published by CRC Press. This book was released on 2016-04-19 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues
Book Synopsis Challenges in Endocrine Disruptor Toxicology and Risk Assessment by : Alexandra Fucic
Download or read book Challenges in Endocrine Disruptor Toxicology and Risk Assessment written by Alexandra Fucic and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
Book Synopsis Endocrine Disrupting Chemicals by : R M Harrison
Download or read book Endocrine Disrupting Chemicals written by R M Harrison and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-term environmental effects of chemical exposure have long been of concern and, more recently, chemicals which cause changes to the sexual development of exposed organisms have been identified. It is thought that low-level exposure to a wide range of chemicals may be affecting endocrine function, leading to a reduction in fertility and an increase in reproductive cancers. Endocrine Disrupting Chemicals reviews the scientific evidence and attempts to put the subject into context. Along with an overview of the issue, there is discussion of the specialised aspects in relation to wildlife; environmental oestrogens and male reproduction; and naturally occurring oestrogenic substances. With contributions from representatives of the Medical Research Council's Institute for Environment and Health and the US Environmental Protection Agency, the articles provide a comprehensive and detailed review of current issues. This book will be of interest to a wide readership, including industrial and environmental scientists, managers and policy makers.
Book Synopsis Endocrine-Disrupting Chemicals by : Andrea C. Gore
Download or read book Endocrine-Disrupting Chemicals written by Andrea C. Gore and published by Springer Science & Business Media. This book was released on 2007-06-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.
Book Synopsis Environmental Endocrine Disruptors by : A Crain
Download or read book Environmental Endocrine Disruptors written by A Crain and published by CRC Press. This book was released on 2000-08-17 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses many aspects of endocrine disruption by environmental encountered toxic substances. Initial chapters provide essential background information whilst later chapters address specific aspects of endocrine disrupting contaminants (EDC)
Download or read book Toxic Bodies written by Nancy Langston and published by Yale University Press. This book was released on 2010-03-02 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.
Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2021-09-19 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology
Book Synopsis Endocrine Toxicology, Second Edition by : John A. Thomas
Download or read book Endocrine Toxicology, Second Edition written by John A. Thomas and published by CRC Press. This book was released on 1997-01-29 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents a range of topics from the molecular events surrounding hormone actions to epidemiologic studies of the effects of environmental and occupational chemicals on reproductive organs. The endocrine systems covered include the adrenal cortex, thyroid and parathyroid, gonads, and the endocrine pancreas. Of particular importance are the chapters covering the general characteristics of the estrogen receptors and the androgen receptors. The book also describes some of the underlying toxic mechanisms involving pancreatic B cells and metal-induced changes in male sex accessory glands.
Book Synopsis Hormonally Active Agents in the Environment by : National Research Council
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Book Synopsis Endocrine Toxicology by : C. K. Atterwill
Download or read book Endocrine Toxicology written by C. K. Atterwill and published by Cambridge University Press. This book was released on 1992-04-09 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to deal comprehensively with endocrine toxicology. It covers the whole spectrum of known toxicant effects on the endocrine system ranging from small disturbances in hormonal secretion to full endocrine neoplasia. In each chapter, internationally recognised authorities have addressed basic endocrine physiology, current techniques for studying endocrine toxicity in vivo and in vitro, known xenobiotic-induced toxicity phenomena and the latest scientific advances in understanding the underlying molecular and cellular events. Consideration is given to important issues such as dietary factors which influence endocrine toxicity, species differences in sensitivity to toxicants, and the toxicity of hormones and drugs. The volume provides a sound basis for understanding the scientific aspects of this complex and important area of toxicology and will be a useful source of information for all those working in this field.
Book Synopsis Endocrine Disruptors by : Rajesh K. Naz
Download or read book Endocrine Disruptors written by Rajesh K. Naz and published by CRC Press. This book was released on 1999-01-21 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruptors: Effects on Male and Female Reproductive Systems examines the epidemiology and etiology of environmental toxicants/hormone imposters, many of which act as reproductive toxicants that cause fertility problems and carcinogenic hazards. Thus far, over fifty such hormone imposters/persistent organic pollutants have been identified, the most common of which are organochlorines and dioxins. This book discusses the hazardous effects of endocrine disruptors on gonads, fertility, and sexual and reproductive function, and health hazards leading to the alarming decline in global fertility and rising incidences of breast and prostate cancer.
Book Synopsis Endocrine Disruptors by : M. Metzler
Download or read book Endocrine Disruptors written by M. Metzler and published by Springer. This book was released on 2006-03-02 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers.
Book Synopsis Environmental Endocrinology and Endocrine Disruptors by : Rosario Pivonello
Download or read book Environmental Endocrinology and Endocrine Disruptors written by Rosario Pivonello and published by Springer Nature. This book was released on 2023-04-20 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.
Book Synopsis Adrenal in Toxicology by : Philip W. Harvey
Download or read book Adrenal in Toxicology written by Philip W. Harvey and published by CRC Press. This book was released on 1996-03-28 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.
Book Synopsis Environmental Impacts on Reproductive Health and Fertility by : Tracey J. Woodruff
Download or read book Environmental Impacts on Reproductive Health and Fertility written by Tracey J. Woodruff and published by Cambridge University Press. This book was released on 2010-01-28 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.
Book Synopsis Endocrine Disruptors in the Environment by : Sushil K. Khetan
Download or read book Endocrine Disruptors in the Environment written by Sushil K. Khetan and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.
