Encoding Visual Features By Parallel Ganglion Cell Initiated Pathways In The Healthy Diseased And Artificial Retina

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Encoding Visual Features by Parallel Ganglion Cell Initiated Pathways in the Healthy, Diseased and Artificial Retina

Author : Béla Völgyi
Publisher : Frontiers Media SA
ISBN 13 : 2889631052
Total Pages : 115 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Encoding Visual Features by Parallel Ganglion Cell Initiated Pathways in the Healthy, Diseased and Artificial Retina by : Béla Völgyi

Download or read book Encoding Visual Features by Parallel Ganglion Cell Initiated Pathways in the Healthy, Diseased and Artificial Retina written by Béla Völgyi and published by Frontiers Media SA. This book was released on 2019-10-16 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photons are sensed by retinal photoreceptors whose matrix-like distribution underlies the transformation of illumination patterns of the visual scene into photoreceptor activity patterns in a visuotopic fashion. Activity of neighboring photoreceptors then are compared by secondary bipolar cells to decipher information regarding luminosity- and color-contrast. Bipolar cells achieve this by comparing signals received directly from their center receptive field with those come from spatially offset surrounding receptive field areas mediated by inhibitory, sign-inverting horizontal cells. This information is ultimately sent to retinal ganglion cells, the output neurons of the retina. In addition to the excitatory bipolar cell inputs, spatial and temporal features of ganglion cell activation are robustly modified by inner retinal amacrine cells through inhibitory chemical and/or excitatory electrical synaptic inputs. Ganglion cells sample various bipolar cell subtypes in their dendritic field and utilize collected inputs to generate a spike output code on luminosity-contrast, color-contrast, object motion, background motion, motion direction, changes in background illumination in a subtype specific manner. Ganglion cells in each subtype cover the retinal surface economically, thus collective information across the population provide a feature pattern and through time a feature movie to the brain. Some of these movies are utilized for image perception, whereas others are sent to accessory visual brain centers to control eye-movement, pupil contraction or circadian entrainment. A large body of information has been revealed in the past decade regarding this field, however much of the details still remain unknown or even enigmatic, including: (i) the precise description of neural circuits that serve each ganglion cell subtype to generate a specific feature movie; (ii) the estimation of the number of various ganglion cell subtypes that partake in image forming and non-image forming signaling towards the brain; (iii) the description of changes in the inputs, morphology and signaling of retinal ganglion cells when the tissue is under stress or undergoes disease related degenerative processes; (iv) the comparison of ganglion cell classes with those of the human retina and finally, (v) the practical use of all the above information to establish retina inspired visual algorithms to suit computer, drone and/or robotic vision. Therefore, research articles in this issue were collected to touch upon each of these topics and highlight recent advances of the related field.

Parallel Processing in the Visual System

Author : Jonathan Stone
Publisher : Springer Science & Business Media
ISBN 13 : 1468444336
Total Pages : 439 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Parallel Processing in the Visual System by : Jonathan Stone

Download or read book Parallel Processing in the Visual System written by Jonathan Stone and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the mid-sixties, John Robson and Christina Enroth-Cugell, without realizing what they were doing, set off a virtual revolution in the study of the visual system. They were trying to apply the methods of linear systems analysis (which were already being used to describe the optics of the eye and the psychophysical performance of the human visual system) to the properties of retinal ganglion cells in the cat. Their idea was to stimulate the retina with patterns of stripes and to look at the way that the signals from the center and the antagonistic surround of the respective field of each ganglion cell (first described by Stephen Kuffier) interact to generate the cell's responses. Many of the ganglion cells behaved themselves very nicely and John and Christina got into the habit (they now say) of calling them I (interesting) cells. However. to their annoyance, the majority of neurons they recorded had nasty, nonlinear properties that couldn't be predicted on the basis of simple summ4tion of light within the center and the surround. These uncoop erative ganglion cells, which Enroth-Cugell and Robson at first called D (dull) cells, produced transient bursts of impulses every time the distribution of light falling on the receptive field was changed, even if the total light flux was unaltered.

Understanding Modulatory Computations in Neural Pathways of the Retina

Author : Neda Nategh
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (865 download)

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Book Synopsis Understanding Modulatory Computations in Neural Pathways of the Retina by : Neda Nategh

Download or read book Understanding Modulatory Computations in Neural Pathways of the Retina written by Neda Nategh and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The retina performs multiple simultaneous processing operations on the visual scene using a network of only five basic cell types, but more than fifty subtypes. Like many higher order sensory neurons, retinal ganglion cells integrate input through multiple parallel pathways that are influenced by diverse populations of inhibitory interneurons, nearly all of which have unknown function. Understanding the specific contributions of interneuron pathways is difficult because it requires a quantitative model that includes both the interneuron's input, its output, and its effects on other sensory inputs. Here we present an experimental and computational approach to discover all of these relationships together. We studied the visual computations performed by amacrine cells, a class of inhibitory interneuron. Like inhibitory interneurons in other neural circuits, amacrine cells are highly diverse in their physiology and occupy distinct anatomical layers. To measure how the signals transmitted through individual sustained amacrine cells contribute to retinal output, we presented white noise visual stimuli to the intact, isolated salamander retina. We recorded intracellularly from and injected current into single amacrine cells while recording spiking activity from the ganglion cell population of the salamander retina using a multielectrode array. In this way, many simultaneous paired recordings were performed. To characterize the contribution of the amacrine cell, we first characterized the amacrine cell preferred stimulus feature. Then using the method of Spike-Triggered Covariance (STC), we measured the response of ganglion cells to the subspace of stimuli that was different from the amacrine preferred feature. Using this method, we were able to characterize both modulatory and additive effects of the amacrine pathway on other features encoded by the ganglion cell. We found great diversity in functional effects of amacrine cells, consisting of the linear effect in which amacrine pathway contributes in building the receptive field of the ganglion cell, and nonlinear effects in which amacrine pathway modulates the ganglion cell's response function for other visual features. Our analysis indicates that the amacrine cell population defines a context that modulates the multiple features conveyed by the ganglion cell. Because modulation occurs throughout the nervous system, our approach provides a general strategy to understand the functional contributions of specific neurons to computations in a complex circuit.

Lista de corresponsales

Author :
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.:/5 (432 download)

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Book Synopsis Lista de corresponsales by :

Download or read book Lista de corresponsales written by and published by . This book was released on 1925 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Central Processing of Visual Information A: Integrative Functions and Comparative Data

Author : H. Autrum
Publisher : Springer Science & Business Media
ISBN 13 : 3642653529
Total Pages : 788 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Central Processing of Visual Information A: Integrative Functions and Comparative Data by : H. Autrum

Download or read book Central Processing of Visual Information A: Integrative Functions and Comparative Data written by H. Autrum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume covers the physiology of the visual system beyond the optic nerve. It is a continuation of the two preceding parts on the photochemistry and the physiology of the eye, and forms a bridge from them to the fourth part on visual psychophysics. These fields have all developed as independent speciali ties and need integrating with each other. The processing of visual information in the brain cannot be understood without some knowledge of the preceding mechanisms in the photoreceptor organs. There are two fundamental reasons, ontogenetic and functional, why this is so: 1) the retina of the vertebrate eye has developed from a specialized part of the brain; 2) in processing their data the eyes follow physiological principles similar to the visual brain centres. Peripheral and central functions should also be discussed in context with their final synthesis in subjective experience, i. e. visual perception. Microphysiology and ultramicroscopy have brought new insights into the neuronal basis of vision. These investigations began in the periphery: HARTLINE'S pioneering experiments on single visual elements of Limulus in 1932 started a successful period of neuronal recordings which ascended from the retina to the highest centres in the visual brain. In the last two decades modern electron microscopic techniques and photochemical investigations of single photoreceptors further contributed to vision research.

Circuit Mechanisms Underlying the Encoding of Ethologically Relevant Visual Stimuli in the Retina

Author : Maxwell H. Turner
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Circuit Mechanisms Underlying the Encoding of Ethologically Relevant Visual Stimuli in the Retina by : Maxwell H. Turner

Download or read book Circuit Mechanisms Underlying the Encoding of Ethologically Relevant Visual Stimuli in the Retina written by Maxwell H. Turner and published by . This book was released on 2017 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the human retina, the axons of roughly 106 retinal ganglion cells (RGCs) carry all of the information underlying visual perception and visually guided behavior. RGC computation is the last processing step before the imposition of this sensory bottleneck. Because of the importance of RGC computation for visual function and because of the accessibility of the retina to physiological investigation, RGCs are among the best studied class of early sensory neurons. Many decades of investigation using artificial visual stimuli (e.g. spots, gratings, white noise etc.) has revealed a great deal about the physiology of RGCs, the computations they can perform, and the circuitry underlying these computations. What is lacking, however, is an understanding of RGC computation and encoding during natural visual stimulation. A complete understanding of RGC function requires extending what we have learned using artificial, mostly static visual stimuli to the dynamic and spatially structured conditions that characterize natural vision. A major focus of the thesis presented here is to begin to bridge this gap. In Chapter 2 I will review some of what is known about how neural circuits in the early visual system encode naturalistic visual inputs. In Chapters 3 & 4 I will present work that connects a ubiquitous concept in early visual processing - the receptive field - to the encoding of natural visual stimuli in the retina. Classical models of the retinal ganglion cell (RGC) receptive field assume linear integration across visual space, and this assumption guides most modern day models that aim to predict RGC responses to visual stimulation. I show that spatial nonlinearities can be important for encoding spatial contrast within a natural scene. Furthermore, we can use what we know about nonlinear receptive field structure to improve models of RGCs. Finally, I show that spatial contrast encoding by RGCs can be modulated by visual context. Regardless of the stimulus being encoded, a fundamental limit to the fidelity with which sensory information can be encoded is the variability of neural responses. Repeated presentations of the same stimulus will elicit variable responses from a single neuron. Noise is a feature of neural population responses as well, and in practice it is often found that this noise is correlated within a population. In Chapter 5, I will present a strategy used by retinal circuits to minimize the effect of noise on the encoding of a behaviorally-relevant feature of the visual world - namely an object's direction of motion.

Physiological Properties of Low-density Ganglion Cells in the Primate Retina

Author : Colleen Elizabeth Rhoades
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Physiological Properties of Low-density Ganglion Cells in the Primate Retina by : Colleen Elizabeth Rhoades

Download or read book Physiological Properties of Low-density Ganglion Cells in the Primate Retina written by Colleen Elizabeth Rhoades and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The retina provides the sole source of visual information to the brain, yet the signal from the retina is only partially understood. In primates, there are ~20 types of output cells of the retina, called retinal ganglion cells, with each type extracting specific information about the visual scene and projecting to distinct targets in the brain. The five numerically dominant retinal ganglion cell types have been extensively studied, but much less is known about the computations of the remaining ganglion cell types. To understand the visual function of the retina in health and in disease, it is necessary to understand how distinctive signals in the diverse retinal ganglion cell types emerge within retinal circuits, and how they collectively encode visual inputs. This thesis explores the physiological properties of the low-density ganglion cell types. In total, large-scale multi-electrode recordings revealed the responses of 12 retinal ganglion cell types, each with distinctive spatial, temporal, and chromatic properties. Focusing on the ON and OFF smooth monostratified cell types, strikingly irregular receptive field structure composed of spatially segregated hotspots were observed, quite different from the classical view of retinal receptive fields. Direct visual stimulation and computational inference demonstrate strong nonlinearities in the retinal circuit which contribute to receptive field hotspots. Surprisingly, visual stimulation of different hotspots produced subtly different extracellular spike waveforms in the same cell, consistent with a dendritic contribution to hotspot structure. These findings suggest a unique visual computation and spike generation mechanism in the signals carried by smooth monostratified cells to the brain.

Circuit Mechanisms of Spontaneous and Light Evoked Activity in the Retina

Author : Alejandro Akrouh
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (961 download)

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Book Synopsis Circuit Mechanisms of Spontaneous and Light Evoked Activity in the Retina by : Alejandro Akrouh

Download or read book Circuit Mechanisms of Spontaneous and Light Evoked Activity in the Retina written by Alejandro Akrouh and published by . This book was released on 2016 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The retina is complex neural network that conveys visual information to the brain. It is composed of a wide variety of cell types that establish specific connections to form functional circuits. During development, circuits in the retina generate spontaneous waves of activity that instruct the wiring of the visual system. We study the circuits that produce stage III waves and desynchronize the firing of neighboring ganglion cells with opposite light responses (ON and OFF RGCs), a feature that is thought to help establish parallel ON and OFF pathways in downstream visual areas. We find that intersecting lateral excitatory and vertical inhibitory circuits give rise to precisely patterned stage III retinal waves. The retina can encode a wide range of visual features due to the variety of signals generated by its circuits. Amacrine cells (ACs) are the most diverse class of neurons in the retina yet of the 30 50 AC types in mammalian species, few have been studied in detail. Here, we identify and morphologically characterize three VIP expressing GABAergic AC types (VIP1 , VIP2 and VIP3 ACs) in mice. We find that the somata of VIP1 , VIP2 and VIP3 ACs are asymmetrically distributed along the dorso-ventral axis of the retina and that their neurite arbors differ in size and stratify in distinct sublaminae of the inner plexiform layer. Next, we target VIP ACs under 2 photon guidance for patch clamp recording to analyze light responses and underlying synaptic inputs. We find that VIP1 , VIP2 and VIP3 ACs differ in response polarity and spatial tuning, and contribute to the diversity of inhibitory and neuromodulatory signals in the retina.Finally, to examine the contribution of VIP ACs to visual possessing, we probe how conditional suppression of neurotransmitter release alters circuit function. First, we identify a RGC synaptic pattern using a combination of optogenetics and patch clamp recordings. Then, we chronically silence GABAergic synapses in VIP ACs by genetic deletion of vesicular GABA transporter (VGAT). Preliminary data indicate that this manipulation does not significantly alter downstream light responses. We are currently pursuing additional RGC partners as well as alternative tools to silence VIP ACs.

Visual Encoding in the Human Retina

Author : Katja Reinhard
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Visual Encoding in the Human Retina by : Katja Reinhard

Download or read book Visual Encoding in the Human Retina written by Katja Reinhard and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Webvision

Author : Helga Kolb
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (53 download)

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Book Synopsis Webvision by : Helga Kolb

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Development and Function of Retinal Ganglion Cell Circuits

Author : Nai-Wen Tien
Publisher :
ISBN 13 :
Total Pages : 103 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Development and Function of Retinal Ganglion Cell Circuits by : Nai-Wen Tien

Download or read book Development and Function of Retinal Ganglion Cell Circuits written by Nai-Wen Tien and published by . This book was released on 2018 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The function of our nervous system relies on specific patterns of synaptic connections between diverse neuronal cell types. My thesis research addressed how cell-type-specific patterns of connectivity emerge in the developing mouse retina and how they enable mature retinal neurons to detect specific sensory stimuli. Spike trains of the approximately 40 retinal ganglion cell (RGC) types in mammals encode specific features and events in the visual world, and are the sole source of visual information to the brain. Recent studies have begun to dissect the presynaptic circuits underlying diverse RGC light responses, but how cell-type-specific retinal circuits emerge during development is poorly understood. The first part of my dissertation explored the plasticity of the ON alpha (ON[alpha]-) RGC circuit. I found that developmental removal of the dominant excitatory input to ON[alpha]-RGCs triggers cell-type-specific rewiring, which precisely preserves ON[alpha]-RGCs' characteristic light responses including high contrast sensitivity. Spiking neurons, including RGCs, typically encode sensory information by increasing firing rates in the presence of preferred stimuli. Suppressed-by-Contrast (SbC-) RGCs are unique in that they signal changes in luminance (i.e., contrast) by decreasing rather than increasing spiking. Taking advantages of mouse genetics, in the second part of my thesis, I characterized SbC-RGCs' responses to complex stimuli and identified the synaptic mechanisms underlying their suppressive contrast encoding. Interestingly, I found that VGluT3-expressing amacrine cells (VG3-ACs) are dual transmitter neurons that release excitatory and inhibitory transmitters in a target-specific manner, and VG3-ACs specifically contributes to OFF inhibition to SbC-RGCs in response to small stimuli. Finally, using an intersectional transgenic approach, I preferentially labeled SbC-RGCs and mapped their central projections to explore the contribution of SbC-RGCs to vision.

Neuronal Circuitry of the Local Edge Detector Retinal Ganglion Cell

Author : Thomas Lee Russell
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (769 download)

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Book Synopsis Neuronal Circuitry of the Local Edge Detector Retinal Ganglion Cell by : Thomas Lee Russell

Download or read book Neuronal Circuitry of the Local Edge Detector Retinal Ganglion Cell written by Thomas Lee Russell and published by . This book was released on 2010 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detection of visual borders is an essential function for transforming the visual scene into perceivable boundaries. Avian predators, for example, are able to recognize complex textured borders of conspicuous prey. It has been suggested that the process of border perception begins as early as in the retina through a class of ganglion cell, the local edge detector (LED), which responds selectively to luminance edges. But what neuronal circuitry is used to accomplish this, and can this circuitry also be used to detect complex textured borders? Here we use patch-clamp electrophysiology to show that selectivity to luminance edges in the LED is accomplished by surround-originated feedback inhibition that suppresses excitation via GABAa and GABAc receptors. Furthermore, we find that excitatory circuitry has several characteristics that facilitate independent responses of individual bipolar cells to features as small as one-eighth the size of the LED's receptive field. This enables the LED to respond to areas of texture even if they contain no net luminance change. We observed that feedback inhibition is similarly activated by small features, which in turn causes excitation not only to respond selectively to luminance edges, but also to boundaries of luminance-neutral texture in synthetic and natural scenes, as well as a noise-suppression function suggested by modeling. We also characterized direct feedforward inhibition to the LED, and found it to be cospatial with excitation, glycinergic, and sensitive to small features as well. These characteristics enable the suppression of spikes during rapid luminance shifts, encoding an "edge in time". Our results suggest mechanisms by which three kinds of edges can be encoded by the retina and transmitted through a specialized channel to higher visual areas in the brain.

Differential Encoding of Spatial Information Among Retinal ON Cone Bipolar Cells

Author : Robert Joseph Purgert
Publisher :
ISBN 13 :
Total Pages : 143 pages
Book Rating : 4.:/5 (914 download)

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Book Synopsis Differential Encoding of Spatial Information Among Retinal ON Cone Bipolar Cells by : Robert Joseph Purgert

Download or read book Differential Encoding of Spatial Information Among Retinal ON Cone Bipolar Cells written by Robert Joseph Purgert and published by . This book was released on 2015 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: ON cone bipolar cells (ON CBCs) are retinal interneurons. They relay visual information from cone photoreceptors, the retina's input cells, to ganglion cells, the retina's output cells. ON CBCs differ in the visual information they encode and subsequently relay. For example, some ON CBCs encode information about the timing of visual stimuli; others encode information about the chromaticity. The information an ON CBC encodes depends greatly on the complement of inputs it receives from cones, inhibitory horizontal cells, and inhibitory amacrine cells, as well as the complement of neurotransmitter receptors it possesses. It is unknown whether spatial information is differentially encoded among ON CBCs as are temporal and chromatic information. We addressed this issue using single-cell electrophysiological methods, and found that it indeed is. Specifically, some ON CBCs were spatially tuned, encoding one stimulus size preferentially above all others. Other ON CBCs were not spatially tuned. This encoding dichotomy was a result of tuned ON CBCs receiving stronger inhibitory amacrine cell input than untuned ON CBCs. Additionally, a morphologic distinction was observed, with tuned cells having axonal arbors terminating more centrally in the inner plexiform layer than untuned cells. Because the retina normally operates over a wide range of ambient light conditions, we examined how ambient illumination affected spatial information encoding among ON CBCs. The encoding dichotomy described above was diminished in bright ambient light, with all ON CBCs exhibiting significant spatial tuning. This was due to alterations of inhibitory amacrine cell input among ON CBCs. Finally, we assessed whether spatial information encoded by ON CBCs reaches higher visual centers. We did so by examining whether ON CBCs relay spatial information to ganglion cells, the output cells of the retina. This was accomplished by recording from ganglion cells and reading out the ON CBC input they received. We found that ON CBCs indeed relayed spatial information to ganglion cells for presumable transmission to the brain. In summary, ON CBCs encode spatial information for relay to ganglion cells. Their ability to do so varies with ambient illumination such that an encoding dichotomy exists in dim light, which diminishes in bright light.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1848 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Retinal Development

Author : Evelyne Sernagor
Publisher : Cambridge University Press
ISBN 13 : 1139459732
Total Pages : 369 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Retinal Development by : Evelyne Sernagor

Download or read book Retinal Development written by Evelyne Sernagor and published by Cambridge University Press. This book was released on 2012-11-29 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.

Ocular Neuroprotection

Author : Leonard A. Levin
Publisher : CRC Press
ISBN 13 : 0203911946
Total Pages : 343 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Ocular Neuroprotection by : Leonard A. Levin

Download or read book Ocular Neuroprotection written by Leonard A. Levin and published by CRC Press. This book was released on 2003-07-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many retinal and optic nerve disorders have no effective therapy, or are treated incompletely and with considerable side effects. Recent advances have suggested the significant benefits associated with neuroprotection - that is, when treatment strategies are directed to photoreceptors, retinal ganglion cells, or other neural targets. Enter Ocular N

Connectome

Author : Sebastian Seung
Publisher : HMH
ISBN 13 : 0547508174
Total Pages : 389 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis Connectome by : Sebastian Seung

Download or read book Connectome written by Sebastian Seung and published by HMH. This book was released on 2012-02-07 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post